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Thoracic aorta calcification

MedGen UID:
370638
•Concept ID:
C1969292
•
Finding; Pathologic Function
Synonyms: Calcification of Thoracic Aorta; Thoracic Aortic Calcification
 
HPO: HP:0004962

Definition

An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall in the thoracic aorta. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThoracic aorta calcification

Professional guidelines

PubMed

Subclinical Atherosclerosis to Guide Treatment in Dyslipidemia and Diabetes Mellitus.
Mszar R, Katz ME, Grandhi GR, Osei AD, Gallo A, Blaha MJ
Curr Atheroscler Rep 2024 Jun;26(6):217-230. Epub 2024 Apr 25 doi: 10.1007/s11883-024-01202-w. PMID: 38662272

Recent clinical studies

Etiology

Subclinical Atherosclerosis to Guide Treatment in Dyslipidemia and Diabetes Mellitus.
Mszar R, Katz ME, Grandhi GR, Osei AD, Gallo A, Blaha MJ
Curr Atheroscler Rep 2024 Jun;26(6):217-230. Epub 2024 Apr 25 doi: 10.1007/s11883-024-01202-w. PMID: 38662272
One-Year Romosozumab Treatment Followed by One-Year Denosumab Treatment for Osteoporosis in Patients on Hemodialysis: An Observational Study.
Saito T, Mizobuchi M, Kato T, Suzuki T, Fujiwara Y, Kanamori N, Makuuchi M, Honda H
Calcif Tissue Int 2023 Jan;112(1):34-44. Epub 2022 Oct 26 doi: 10.1007/s00223-022-01031-6. PMID: 36287217
Thoracic Aorta Calcification and Noncardiovascular Disease-Related Mortality.
Thomas IC, Thompson CA, Yang M, Allison MA, Forbang NI, Michos ED, McClelland RL, Budoff MJ, Criqui MH
Arterioscler Thromb Vasc Biol 2018 Aug;38(8):1926-1932. doi: 10.1161/ATVBAHA.118.310850. PMID: 29954753Free PMC Article
Thoracic aorta calcification but not inflammation is associated with increased cardiovascular disease risk: results of the CAMONA study.
Blomberg BA, de Jong PA, Thomassen A, Lam MGE, Vach W, Olsen MH, Mali WPTM, Narula J, Alavi A, Høilund-Carlsen PF
Eur J Nucl Med Mol Imaging 2017 Feb;44(2):249-258. Epub 2016 Oct 29 doi: 10.1007/s00259-016-3552-9. PMID: 27796543Free PMC Article
Ascending and descending thoracic aorta calcification in type 2 diabetes mellitus.
Churchill TW, Rasania SP, Rafeek H, Mulvey CK, Terembula K, Ferrari V, Jha S, Lilly SM, Eraso LH, Reilly MP, Qasim AN
J Cardiovasc Comput Tomogr 2015 Sep-Oct;9(5):373-81. Epub 2015 May 16 doi: 10.1016/j.jcct.2015.04.008. PMID: 26119363

Diagnosis

Subclinical Atherosclerosis to Guide Treatment in Dyslipidemia and Diabetes Mellitus.
Mszar R, Katz ME, Grandhi GR, Osei AD, Gallo A, Blaha MJ
Curr Atheroscler Rep 2024 Jun;26(6):217-230. Epub 2024 Apr 25 doi: 10.1007/s11883-024-01202-w. PMID: 38662272
Thoracic Aorta Calcium Detection and Quantification Using Convolutional Neural Networks in a Large Cohort of Intermediate-Risk Patients.
Guilenea FN, Casciaro ME, Pascaner AF, Soulat G, Mousseaux E, Craiem D
Tomography 2021 Oct 28;7(4):636-649. doi: 10.3390/tomography7040054. PMID: 34842842Free PMC Article
Thoracic Aorta Calcification and Noncardiovascular Disease-Related Mortality.
Thomas IC, Thompson CA, Yang M, Allison MA, Forbang NI, Michos ED, McClelland RL, Budoff MJ, Criqui MH
Arterioscler Thromb Vasc Biol 2018 Aug;38(8):1926-1932. doi: 10.1161/ATVBAHA.118.310850. PMID: 29954753Free PMC Article
Thoracic aorta calcification but not inflammation is associated with increased cardiovascular disease risk: results of the CAMONA study.
Blomberg BA, de Jong PA, Thomassen A, Lam MGE, Vach W, Olsen MH, Mali WPTM, Narula J, Alavi A, Høilund-Carlsen PF
Eur J Nucl Med Mol Imaging 2017 Feb;44(2):249-258. Epub 2016 Oct 29 doi: 10.1007/s00259-016-3552-9. PMID: 27796543Free PMC Article
Ascending and descending thoracic aorta calcification in type 2 diabetes mellitus.
Churchill TW, Rasania SP, Rafeek H, Mulvey CK, Terembula K, Ferrari V, Jha S, Lilly SM, Eraso LH, Reilly MP, Qasim AN
J Cardiovasc Comput Tomogr 2015 Sep-Oct;9(5):373-81. Epub 2015 May 16 doi: 10.1016/j.jcct.2015.04.008. PMID: 26119363

Therapy

One-Year Romosozumab Treatment Followed by One-Year Denosumab Treatment for Osteoporosis in Patients on Hemodialysis: An Observational Study.
Saito T, Mizobuchi M, Kato T, Suzuki T, Fujiwara Y, Kanamori N, Makuuchi M, Honda H
Calcif Tissue Int 2023 Jan;112(1):34-44. Epub 2022 Oct 26 doi: 10.1007/s00223-022-01031-6. PMID: 36287217
Per- and polyfluoroalkyl substances and calcifications of the coronary and aortic arteries in adults with prediabetes: Results from the diabetes prevention program outcomes study.
Osorio-Yáñez C, Sanchez-Guerra M, Cardenas A, Lin PD, Hauser R, Gold DR, Kleinman KP, Hivert MF, Fleisch AF, Calafat AM, Webster TF, Horton ES, Oken E
Environ Int 2021 Jun;151:106446. Epub 2021 Feb 22 doi: 10.1016/j.envint.2021.106446. PMID: 33631604Free PMC Article
Sex Differences in Coronary Artery and Thoracic Aorta Calcification and Their Association With Cardiovascular Mortality in Heavy Smokers.
Lessmann N, de Jong PA, Celeng C, Takx RAP, Viergever MA, van Ginneken B, Išgum I
JACC Cardiovasc Imaging 2019 Sep;12(9):1808-1817. Epub 2019 Jan 16 doi: 10.1016/j.jcmg.2018.10.026. PMID: 30660540
Thoracic aorta calcification but not inflammation is associated with increased cardiovascular disease risk: results of the CAMONA study.
Blomberg BA, de Jong PA, Thomassen A, Lam MGE, Vach W, Olsen MH, Mali WPTM, Narula J, Alavi A, Høilund-Carlsen PF
Eur J Nucl Med Mol Imaging 2017 Feb;44(2):249-258. Epub 2016 Oct 29 doi: 10.1007/s00259-016-3552-9. PMID: 27796543Free PMC Article
Risk Factors for the Development and Progression of Thoracic Aorta Calcification: The Multi-Ethnic Study of Atherosclerosis.
Youssef G, Guo M, McClelland RL, Shavelle DM, Nasir K, Rivera J, Carr JJ, Wong ND, Budoff MJ
Acad Radiol 2015 Dec;22(12):1536-45. Epub 2015 Sep 26 doi: 10.1016/j.acra.2015.08.017. PMID: 26403646Free PMC Article

Prognosis

Subclinical Atherosclerosis to Guide Treatment in Dyslipidemia and Diabetes Mellitus.
Mszar R, Katz ME, Grandhi GR, Osei AD, Gallo A, Blaha MJ
Curr Atheroscler Rep 2024 Jun;26(6):217-230. Epub 2024 Apr 25 doi: 10.1007/s11883-024-01202-w. PMID: 38662272
Quantitative thoracic aorta calcification assessment by (18)F-NaF PET/CT and its correlation with atherosclerotic cardiovascular disorders and increasing age.
Paydary K, Revheim ME, Emamzadehfard S, Gholami S, Pourhassan S, Werner TJ, Høilund-Carlsen PF, Alavi A
Eur Radiol 2021 Feb;31(2):785-794. Epub 2020 Sep 1 doi: 10.1007/s00330-020-07133-9. PMID: 32870396
Thoracic Aorta Calcification and Noncardiovascular Disease-Related Mortality.
Thomas IC, Thompson CA, Yang M, Allison MA, Forbang NI, Michos ED, McClelland RL, Budoff MJ, Criqui MH
Arterioscler Thromb Vasc Biol 2018 Aug;38(8):1926-1932. doi: 10.1161/ATVBAHA.118.310850. PMID: 29954753Free PMC Article
Thoracic aorta calcification but not inflammation is associated with increased cardiovascular disease risk: results of the CAMONA study.
Blomberg BA, de Jong PA, Thomassen A, Lam MGE, Vach W, Olsen MH, Mali WPTM, Narula J, Alavi A, Høilund-Carlsen PF
Eur J Nucl Med Mol Imaging 2017 Feb;44(2):249-258. Epub 2016 Oct 29 doi: 10.1007/s00259-016-3552-9. PMID: 27796543Free PMC Article
Progression of coronary artery calcification and thoracic aorta calcification in kidney transplant recipients.
Maréchal C, Coche E, Goffin E, Dragean A, Schlieper G, Nguyen P, Floege J, Kanaan N, Devuyst O, Jadoul M
Am J Kidney Dis 2012 Feb;59(2):258-69. Epub 2011 Sep 23 doi: 10.1053/j.ajkd.2011.07.019. PMID: 21944666

Clinical prediction guides

Subclinical Atherosclerosis to Guide Treatment in Dyslipidemia and Diabetes Mellitus.
Mszar R, Katz ME, Grandhi GR, Osei AD, Gallo A, Blaha MJ
Curr Atheroscler Rep 2024 Jun;26(6):217-230. Epub 2024 Apr 25 doi: 10.1007/s11883-024-01202-w. PMID: 38662272
One-Year Romosozumab Treatment Followed by One-Year Denosumab Treatment for Osteoporosis in Patients on Hemodialysis: An Observational Study.
Saito T, Mizobuchi M, Kato T, Suzuki T, Fujiwara Y, Kanamori N, Makuuchi M, Honda H
Calcif Tissue Int 2023 Jan;112(1):34-44. Epub 2022 Oct 26 doi: 10.1007/s00223-022-01031-6. PMID: 36287217
Thoracic Aorta Calcium Detection and Quantification Using Convolutional Neural Networks in a Large Cohort of Intermediate-Risk Patients.
Guilenea FN, Casciaro ME, Pascaner AF, Soulat G, Mousseaux E, Craiem D
Tomography 2021 Oct 28;7(4):636-649. doi: 10.3390/tomography7040054. PMID: 34842842Free PMC Article
Per- and polyfluoroalkyl substances and calcifications of the coronary and aortic arteries in adults with prediabetes: Results from the diabetes prevention program outcomes study.
Osorio-Yáñez C, Sanchez-Guerra M, Cardenas A, Lin PD, Hauser R, Gold DR, Kleinman KP, Hivert MF, Fleisch AF, Calafat AM, Webster TF, Horton ES, Oken E
Environ Int 2021 Jun;151:106446. Epub 2021 Feb 22 doi: 10.1016/j.envint.2021.106446. PMID: 33631604Free PMC Article
Ascending and descending thoracic aorta calcification in type 2 diabetes mellitus.
Churchill TW, Rasania SP, Rafeek H, Mulvey CK, Terembula K, Ferrari V, Jha S, Lilly SM, Eraso LH, Reilly MP, Qasim AN
J Cardiovasc Comput Tomogr 2015 Sep-Oct;9(5):373-81. Epub 2015 May 16 doi: 10.1016/j.jcct.2015.04.008. PMID: 26119363

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