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Primary adrenocortical nodular hyperplasia

MedGen UID:
371818
•Concept ID:
C1834422
•
Disease or Syndrome

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPrimary adrenocortical nodular hyperplasia

Professional guidelines

PubMed

Clinical features, diagnosis, treatment and molecular studies in paediatric Cushing's syndrome due to primary nodular adrenocortical hyperplasia.
Storr HL, Mitchell H, Swords FM, Main KM, Hindmarsh PC, Betts PR, Shaw NJ, Johnston DI, Clark AJ, Reznek RH, Grossman AB, Savage MO
Clin Endocrinol (Oxf) 2004 Nov;61(5):553-9. doi: 10.1111/j.1365-2265.2004.02124.x. PMID: 15521956

Recent clinical studies

Etiology

Overview of the 2022 WHO Classification of Adrenal Cortical Tumors.
Mete O, Erickson LA, Juhlin CC, de Krijger RR, Sasano H, Volante M, Papotti MG
Endocr Pathol 2022 Mar;33(1):155-196. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09710-8. PMID: 35288842Free PMC Article
Update on primary micronodular bilateral adrenocortical diseases.
Maillet M, Bourdeau I, Lacroix A
Curr Opin Endocrinol Diabetes Obes 2020 Jun;27(3):132-139. doi: 10.1097/MED.0000000000000538. PMID: 32209819
Diseases Predisposing to Adrenocortical Malignancy (Li-Fraumeni Syndrome, Beckwith-Wiedemann Syndrome, and Carney Complex).
Jouinot A, Bertherat J
Exp Suppl 2019;111:149-169. doi: 10.1007/978-3-030-25905-1_9. PMID: 31588532
Adrenal tumors: when to search for a germline abnormality?
Gimenez-Roqueplo AP
Curr Opin Oncol 2019 May;31(3):230-235. doi: 10.1097/CCO.0000000000000525. PMID: 30985498
Correctable subsets of primary aldosteronism. Primary adrenal hyperplasia and renin responsive adenoma.
Irony I, Kater CE, Biglieri EG, Shackleton CH
Am J Hypertens 1990 Jul;3(7):576-82. doi: 10.1093/ajh/3.7.576. PMID: 2194512

Diagnosis

Overview of the 2022 WHO Classification of Adrenal Cortical Tumors.
Mete O, Erickson LA, Juhlin CC, de Krijger RR, Sasano H, Volante M, Papotti MG
Endocr Pathol 2022 Mar;33(1):155-196. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09710-8. PMID: 35288842Free PMC Article
Diagnosis and treatment of primary aldosteronism.
Reincke M, Bancos I, Mulatero P, Scholl UI, Stowasser M, Williams TA
Lancet Diabetes Endocrinol 2021 Dec;9(12):876-892. doi: 10.1016/S2213-8587(21)00210-2. PMID: 34798068
Adrenocortical hyperplasia: A multifaceted disease.
Bourdeau I, Parisien-La Salle S, Lacroix A
Best Pract Res Clin Endocrinol Metab 2020 May;34(3):101386. Epub 2020 Feb 4 doi: 10.1016/j.beem.2020.101386. PMID: 32115357
Cushing's disease.
Bertagna X, Guignat L, Groussin L, Bertherat J
Best Pract Res Clin Endocrinol Metab 2009 Oct;23(5):607-23. doi: 10.1016/j.beem.2009.06.001. PMID: 19945026
Rare syndromes.
Jabbour SA, Davidovici BB, Wolf R
Clin Dermatol 2006 Jul-Aug;24(4):299-316. doi: 10.1016/j.clindermatol.2006.04.005. PMID: 16828412

Therapy

c-KIT oncogene expression in PRKAR1A-mutant adrenal cortex.
Nadella K, Faucz FR, Stratakis CA
Endocr Relat Cancer 2020 Oct;27(10):591-599. doi: 10.1530/ERC-20-0270. PMID: 32738126Free PMC Article
Update on primary micronodular bilateral adrenocortical diseases.
Maillet M, Bourdeau I, Lacroix A
Curr Opin Endocrinol Diabetes Obes 2020 Jun;27(3):132-139. doi: 10.1097/MED.0000000000000538. PMID: 32209819
Molecular genetics of adrenocortical tumor formation and potential pharmacologic targets.
Rauschecker M, Stratakis CA
Minerva Endocrinol 2012 Jun;37(2):133-9. PMID: 22691887Free PMC Article
Clinical features, diagnosis, treatment and molecular studies in paediatric Cushing's syndrome due to primary nodular adrenocortical hyperplasia.
Storr HL, Mitchell H, Swords FM, Main KM, Hindmarsh PC, Betts PR, Shaw NJ, Johnston DI, Clark AJ, Reznek RH, Grossman AB, Savage MO
Clin Endocrinol (Oxf) 2004 Nov;61(5):553-9. doi: 10.1111/j.1365-2265.2004.02124.x. PMID: 15521956
Correctable subsets of primary aldosteronism. Primary adrenal hyperplasia and renin responsive adenoma.
Irony I, Kater CE, Biglieri EG, Shackleton CH
Am J Hypertens 1990 Jul;3(7):576-82. doi: 10.1093/ajh/3.7.576. PMID: 2194512

Prognosis

Overview of the 2022 WHO Classification of Adrenal Cortical Tumors.
Mete O, Erickson LA, Juhlin CC, de Krijger RR, Sasano H, Volante M, Papotti MG
Endocr Pathol 2022 Mar;33(1):155-196. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09710-8. PMID: 35288842Free PMC Article
Genetics of tumors of the adrenal cortex.
Bonnet-Serrano F, Bertherat J
Endocr Relat Cancer 2018 Mar;25(3):R131-R152. Epub 2017 Dec 12 doi: 10.1530/ERC-17-0361. PMID: 29233839
Cushing's disease.
Bertagna X, Guignat L, Groussin L, Bertherat J
Best Pract Res Clin Endocrinol Metab 2009 Oct;23(5):607-23. doi: 10.1016/j.beem.2009.06.001. PMID: 19945026
New genes and/or molecular pathways associated with adrenal hyperplasias and related adrenocortical tumors.
Stratakis CA
Mol Cell Endocrinol 2009 Mar 5;300(1-2):152-7. Epub 2008 Nov 21 doi: 10.1016/j.mce.2008.11.010. PMID: 19063937Free PMC Article
Adrenocorticotropic hormone-independent Cushing's syndrome.
Bourdeau I, Lampron A, Costa MH, Tadjine M, Lacroix A
Curr Opin Endocrinol Diabetes Obes 2007 Jun;14(3):219-25. doi: 10.1097/MED.0b013e32814db842. PMID: 17940443

Clinical prediction guides

Overview of the 2022 WHO Classification of Adrenal Cortical Tumors.
Mete O, Erickson LA, Juhlin CC, de Krijger RR, Sasano H, Volante M, Papotti MG
Endocr Pathol 2022 Mar;33(1):155-196. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09710-8. PMID: 35288842Free PMC Article
Update of Genetic and Molecular Causes of Adrenocortical Hyperplasias Causing Cushing Syndrome.
Berthon A, Bertherat J
Horm Metab Res 2020 Aug;52(8):598-606. Epub 2020 Feb 25 doi: 10.1055/a-1061-7349. PMID: 32097969
Genetics of tumors of the adrenal cortex.
Bonnet-Serrano F, Bertherat J
Endocr Relat Cancer 2018 Mar;25(3):R131-R152. Epub 2017 Dec 12 doi: 10.1530/ERC-17-0361. PMID: 29233839
MicroRNA signature of primary pigmented nodular adrenocortical disease: clinical correlations and regulation of Wnt signaling.
Iliopoulos D, Bimpaki EI, Nesterova M, Stratakis CA
Cancer Res 2009 Apr 15;69(8):3278-82. Epub 2009 Apr 7 doi: 10.1158/0008-5472.CAN-09-0155. PMID: 19351815Free PMC Article
Molecular genetics of adrenocortical tumours, from familial to sporadic diseases.
Libé R, Bertherat J
Eur J Endocrinol 2005 Oct;153(4):477-87. doi: 10.1530/eje.1.02004. PMID: 16189167

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