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Feline Acquired Immunodeficiency Syndrome

MedGen UID:
37184
•Concept ID:
C0079335
•
Disease or Syndrome
Synonyms: AIDS, Feline; FAIDS; Feline Acquired Immune Deficiency Syndrome; Feline Acquired Immuno Deficiency Syndrome; Feline Acquired Immuno-Deficiency Syndrome; Feline AIDS

Definition

Acquired defect of cellular immunity that occurs in cats infected with feline immunodeficiency virus (FIV) and in some cats infected with feline leukemia virus (FeLV). [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFeline Acquired Immunodeficiency Syndrome

Professional guidelines

PubMed

The effects of Avemar treatment on feline immunodeficiency virus infected cell cultures.
Tarcsai KR, Hidvégi M, Corolciuc O, Nagy K, Abbas AA, Ablashi DV, Kövesdi V, Ongrádi J
Vet Med Sci 2023 Jul;9(4):1446-1455. Epub 2023 Apr 20 doi: 10.1002/vms3.1141. PMID: 37079719Free PMC Article

Recent clinical studies

Etiology

Lack of association between feline AB blood groups and retroviral status: a multicenter, multicountry study.
Spada E, Jung H, Proverbio D, Perego R, Baggiani L, Ciuti S, Sharp CR, Nash KJ, Westman M, Lait PJ, Davidow EB
J Feline Med Surg 2022 Aug;24(8):e194-e202. Epub 2022 May 30 doi: 10.1177/1098612X221100082. PMID: 35635064Free PMC Article
Clinical aspects of feline retroviruses: a review.
Hartmann K
Viruses 2012 Oct 31;4(11):2684-710. doi: 10.3390/v4112684. PMID: 23202500Free PMC Article
Feline immunodeficiency virus neuropathogenesis: from cats to calcium.
Meeker RB
J Neuroimmune Pharmacol 2007 Jun;2(2):154-70. Epub 2006 Nov 28 doi: 10.1007/s11481-006-9045-z. PMID: 18040840Free PMC Article
Mucosal infection and vaccination against feline immunodeficiency virus.
Stokes CR, Finerty S, Gruffydd-Jones TJ, Sturgess CP, Harbour DA
J Biotechnol 1999 Aug 20;73(2-3):213-21. doi: 10.1016/s0168-1656(99)00139-x. PMID: 10486930
Biological nature of feline immunodeficiency virus.
Miyazawa T, Mikami T
J Vet Med Sci 1993 Aug;55(4):519-26. doi: 10.1292/jvms.55.519. PMID: 8399727

Diagnosis

Molecular survey of feline immunodeficiency virus (FIV) infection in Namibian cats.
Franzo G, de Villiers L, Coetzee LM, Villiers M, Molini U
Acta Trop 2024 May;253:107184. Epub 2024 Mar 11 doi: 10.1016/j.actatropica.2024.107184. PMID: 38479467
Clinical aspects of feline retroviruses: a review.
Hartmann K
Viruses 2012 Oct 31;4(11):2684-710. doi: 10.3390/v4112684. PMID: 23202500Free PMC Article
Probing the interaction between feline immunodeficiency virus and CD134 by using the novel monoclonal antibody 7D6 and the CD134 (Ox40) ligand.
Willett BJ, McMonagle EL, Logan N, Spiller OB, Schneider P, Hosie MJ
J Virol 2007 Sep;81(18):9665-79. Epub 2007 Jul 3 doi: 10.1128/JVI.01020-07. PMID: 17609274Free PMC Article
Feline immunodeficiency virus infection: an overview.
Hartmann K
Vet J 1998 Mar;155(2):123-37. doi: 10.1016/s1090-0233(98)80008-7. PMID: 9564266Free PMC Article
Feline immunodeficiency virus infection--causative agent of an acquired immunodeficiency syndrome in cats.
Hartmann K
Eur J Med Res 1996 Nov 25;1(12):547-50. PMID: 9438159

Therapy

Antiviral treatment of feline immunodeficiency virus-infected cats with (R)-9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine.
Taffin E, Paepe D, Goris N, Auwerx J, Debille M, Neyts J, Van de Maele I, Daminet S
J Feline Med Surg 2015 Feb;17(2):79-86. Epub 2014 Apr 29 doi: 10.1177/1098612X14532089. PMID: 24782459Free PMC Article
Feline immunodeficiency virus neuropathogenesis: from cats to calcium.
Meeker RB
J Neuroimmune Pharmacol 2007 Jun;2(2):154-70. Epub 2006 Nov 28 doi: 10.1007/s11481-006-9045-z. PMID: 18040840Free PMC Article
Lessons from the cat: development of vaccines against lentiviruses.
Dunham SP
Vet Immunol Immunopathol 2006 Jul 15;112(1-2):67-77. Epub 2006 May 5 doi: 10.1016/j.vetimm.2006.03.013. PMID: 16678276
Feline immunodeficiency virus infection--causative agent of an acquired immunodeficiency syndrome in cats.
Hartmann K
Eur J Med Res 1996 Nov 25;1(12):547-50. PMID: 9438159
Simian and feline immunodeficiency viruses: animal lentivirus models for evaluation of AIDS vaccines and antiviral agents.
Gardner MB
Antiviral Res 1991 May;15(4):267-86. doi: 10.1016/0166-3542(91)90009-g. PMID: 1659310

Prognosis

Diversity of trends of viremia and T-cell markers in experimental acute feline immunodeficiency virus infection.
Roche S, El Garch H, Brunet S, Poulet H, Iwaz J, Ecochard R, Vanhems P
PLoS One 2013;8(2):e56135. Epub 2013 Feb 7 doi: 10.1371/journal.pone.0056135. PMID: 23409138Free PMC Article
Feline immunodeficiency virus model to study human immunodeficiency virus/acquired immune deficiency syndrome conditions.
Levine DF, Gutmann JL, Witherspoon DE, Nunn ME, Wiggs RB
J Endod 2001 Jul;27(7):467-9. doi: 10.1097/00004770-200107000-00008. PMID: 11503998
Methamphetamine and HIV-1: potential interactions and the use of the FIV/cat model.
Phillips TR, Billaud JN, Henriksen SJ
J Psychopharmacol 2000;14(3):244-50. doi: 10.1177/026988110001400309. PMID: 11106303
Neuropathology of early HIV-1 infection.
Gray F, Scaravilli F, Everall I, Chretien F, An S, Boche D, Adle-Biassette H, Wingertsmann L, Durigon M, Hurtrel B, Chiodi F, Bell J, Lantos P
Brain Pathol 1996 Jan;6(1):1-15. doi: 10.1111/j.1750-3639.1996.tb00775.x. PMID: 8866743
Feline immunodeficiency virus as a model for study of lentivirus infection of the central nervous system.
Henriksen SJ, Prospero-Garcia O, Phillips TR, Fox HS, Bloom FE, Elder JH
Curr Top Microbiol Immunol 1995;202:167-86. doi: 10.1007/978-3-642-79657-9_12. PMID: 7587362

Clinical prediction guides

Combination Antiretroviral Therapy and Immunophenotype of Feline Immunodeficiency Virus.
Kim J, Behzadi ES, Nehring M, Carver S, Cowan SR, Conry MK, Rawlinson JE, VandeWoude S, Miller CA
Viruses 2023 Mar 24;15(4) doi: 10.3390/v15040822. PMID: 37112803Free PMC Article
Antiviral treatment of feline immunodeficiency virus-infected cats with (R)-9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine.
Taffin E, Paepe D, Goris N, Auwerx J, Debille M, Neyts J, Van de Maele I, Daminet S
J Feline Med Surg 2015 Feb;17(2):79-86. Epub 2014 Apr 29 doi: 10.1177/1098612X14532089. PMID: 24782459Free PMC Article
Mucosal infection and vaccination against feline immunodeficiency virus.
Stokes CR, Finerty S, Gruffydd-Jones TJ, Sturgess CP, Harbour DA
J Biotechnol 1999 Aug 20;73(2-3):213-21. doi: 10.1016/s0168-1656(99)00139-x. PMID: 10486930
Neuropathology of early HIV-1 infection.
Gray F, Scaravilli F, Everall I, Chretien F, An S, Boche D, Adle-Biassette H, Wingertsmann L, Durigon M, Hurtrel B, Chiodi F, Bell J, Lantos P
Brain Pathol 1996 Jan;6(1):1-15. doi: 10.1111/j.1750-3639.1996.tb00775.x. PMID: 8866743
Feline immunodeficiency virus as a model for study of lentivirus infection of the central nervous system.
Henriksen SJ, Prospero-Garcia O, Phillips TR, Fox HS, Bloom FE, Elder JH
Curr Top Microbiol Immunol 1995;202:167-86. doi: 10.1007/978-3-642-79657-9_12. PMID: 7587362

Recent systematic reviews

Variation in Intra-individual Lentiviral Evolution Rates: a Systematic Review of Human, Nonhuman Primate, and Felid Species.
Krakoff E, Gagne RB, VandeWoude S, Carver S
J Virol 2019 Aug 15;93(16) Epub 2019 Jul 30 doi: 10.1128/JVI.00538-19. PMID: 31167917Free PMC Article

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