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Demyelinating disease of central nervous system

MedGen UID:
3719
•Concept ID:
C0011302
•
Disease or Syndrome
Synonyms: Demyelinating CNS disease; demyelinating CNS disease; Demyelinating disease central nervous system (CNS); demyelinating disease central nervous system (CNS); Demyelinating Disease of Central Nervous System; demyelinating disease of central nervous system; Demyelinating Disorder of Central Nervous System; demyelinating disorder of central nervous system; Demyelinating disorders of the central nervous system; demyelinating disorders of the central nervous system
SNOMED CT: Demyelinating disease of central nervous system (6118003); Demyelinating disorders of the central nervous system (6118003); Demyelinating CNS disease (6118003); Demyelinating disease central nervous system (CNS) (6118003)
 
Monarch Initiative: MONDO:0020800

Definition

Any condition in which there is degeneration of the myelin sheath that covers the nerves of the central nervous system. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDemyelinating disease of central nervous system

Professional guidelines

PubMed

Osteopontin; as a target molecule for the treatment of inflammatory diseases.
Morimoto J, Kon S, Matsui Y, Uede T
Curr Drug Targets 2010 Apr;11(4):494-505. doi: 10.2174/138945010790980321. PMID: 20196720
Pathogenesis and treatment of central nervous system demyelinating disease.
Zamvil SS, Soos JM, Weiner HL
Rev Neurol (Paris) 1998 Sep;154(8-9):573-5. PMID: 9809371
Intravenous gammaglobulin treatment in multiple sclerosis and experimental autoimmune encephalomyelitis: delineation of usage and mode of action.
Achiron A, Gilad R, Margalit R, Gabbay U, Sarova-Pinhas I, Cohen IR, Melamed E, Lider O, Noy S, Ziv I
J Neurol Neurosurg Psychiatry 1994 Nov;57 Suppl(Suppl):57-61. doi: 10.1136/jnnp.57.suppl.57. PMID: 7964856Free PMC Article

Recent clinical studies

Etiology

Movement disorders in a cohort of Algerian patients with multiple sclerosis.
Hatteb SA, Daoudi S
Rev Neurol (Paris) 2018 Mar;174(3):167-172. Epub 2017 Nov 16 doi: 10.1016/j.neurol.2017.06.022. PMID: 29153981
VDBP, CYP27B1, and 25-Hydroxyvitamin D Gene Polymorphism Analyses in a Group of Sicilian Multiple Sclerosis Patients.
Agnello L, Scazzone C, Lo Sasso B, Bellia C, Bivona G, Realmuto S, Brighina F, Schillaci R, Ragonese P, Salemi G, Ciaccio M
Biochem Genet 2017 Apr;55(2):183-192. Epub 2016 Nov 30 doi: 10.1007/s10528-016-9783-4. PMID: 27904983
Therapeutic Impact of Sphingosine 1-phosphate Receptor Signaling in Multiple Sclerosis.
Candido K, Soufi H, Bandyopadhyay M, Dasgupta S
Mini Rev Med Chem 2016;16(7):547-54. doi: 10.2174/1389557515666150709122517. PMID: 26156414
Functional relevance for multiple sclerosis-associated genetic variants.
Lin X, Deng FY, Mo XB, Wu LF, Lei SF
Immunogenetics 2015 Jan;67(1):7-14. Epub 2014 Oct 12 doi: 10.1007/s00251-014-0803-4. PMID: 25308886
Oxidative and antioxidative activity in the patients with disseminated demyelinating disease of central nervous system.
Jovicić A, Jovanović M, Dordević D, Magdić B, Dincić E, Malicević Z
Vojnosanit Pregl 1997 May-Jun;54(3):193-202. PMID: 9269127

Diagnosis

Functional connectivity in multiple sclerosis after robotic rehabilitative treatment: A case report.
Bonanno L, Russo M, Bramanti A, Calabrò RS, Marino S
Medicine (Baltimore) 2019 Apr;98(17):e15047. doi: 10.1097/MD.0000000000015047. PMID: 31027053Free PMC Article
Concurrence of juvenile idiopathic arthritis and primary demyelinating disease in a young child.
Coşkun AN, Günbey C, Göçmen R, Turan KE, Sönmez HE, Özen S, Anlar B
Mult Scler Relat Disord 2019 Jan;27:20-22. Epub 2018 Oct 3 doi: 10.1016/j.msard.2018.10.002. PMID: 30300848
Acute disseminated encephalomyelitis: complication of a vaccine preventable disease.
Banerjee A, Suthar R, Vyas S, Singh MP
BMJ Case Rep 2018 Dec 27;11(1) doi: 10.1136/bcr-2018-225710. PMID: 30593525Free PMC Article
Insights into Initial Demyelinating Episodes of Central Nervous System during Puerperium.
Wu Q, Chen B, Liu N, Hu Y, Pan C, Zhang P, Tang ZP, Bu BT
Chin Med J (Engl) 2017 Aug 5;130(15):1791-1795. doi: 10.4103/0366-6999.211542. PMID: 28748851Free PMC Article
Balo's concentric sclerosis involving bilateral thalami.
Badar F, Azfar SF, Ahmad I, Kirmani S, Rashid M
Neurol India 2011 Jul-Aug;59(4):597-600. doi: 10.4103/0028-3886.84345. PMID: 21891941

Therapy

Acute disseminated encephalomyelitis: complication of a vaccine preventable disease.
Banerjee A, Suthar R, Vyas S, Singh MP
BMJ Case Rep 2018 Dec 27;11(1) doi: 10.1136/bcr-2018-225710. PMID: 30593525Free PMC Article
Therapeutic Impact of Sphingosine 1-phosphate Receptor Signaling in Multiple Sclerosis.
Candido K, Soufi H, Bandyopadhyay M, Dasgupta S
Mini Rev Med Chem 2016;16(7):547-54. doi: 10.2174/1389557515666150709122517. PMID: 26156414
Effect of lipoic acid consumption on oxidative stress among multiple sclerosis patients: a randomized controlled clinical trial.
Khalili M, Eghtesadi S, Mirshafiey A, Eskandari G, Sanoobar M, Sahraian MA, Motevalian A, Norouzi A, Moftakhar S, Azimi A
Nutr Neurosci 2014 Jan;17(1):16-20. Epub 2013 Nov 26 doi: 10.1179/1476830513Y.0000000060. PMID: 23485514
Pharmacogenomic update on multiple sclerosis: a focus on actual and new therapeutic strategies.
Foti Cuzzola V, Palella E, Celi D, Barresi M, Giacoppo S, Bramanti P, Marino S
Pharmacogenomics J 2012 Dec;12(6):453-61. Epub 2012 Oct 9 doi: 10.1038/tpj.2012.41. PMID: 23044601
Osteopontin; as a target molecule for the treatment of inflammatory diseases.
Morimoto J, Kon S, Matsui Y, Uede T
Curr Drug Targets 2010 Apr;11(4):494-505. doi: 10.2174/138945010790980321. PMID: 20196720

Prognosis

Functional relevance for multiple sclerosis-associated genetic variants.
Lin X, Deng FY, Mo XB, Wu LF, Lei SF
Immunogenetics 2015 Jan;67(1):7-14. Epub 2014 Oct 12 doi: 10.1007/s00251-014-0803-4. PMID: 25308886
Long-term prognosis of pediatric patients with relapsing acute disseminated encephalomyelitis.
Mar S, Lenox J, Benzinger T, Brown S, Noetzel M
J Child Neurol 2010 Jun;25(6):681-8. Epub 2009 Oct 6 doi: 10.1177/0883073809343320. PMID: 19808990
Balò's concentric sclerosis presenting with benign clinical course and multiple sclerosis-like lesions on magnetic resonance images.
Li Y, Xie P, Fan X, Tang H
Neurol India 2009 Jan-Feb;57(1):66-8. doi: 10.4103/0028-3886.48815. PMID: 19305082
Prognosis in initial stage of disseminated primary demyelinating disease of central nervous system.
THYGESEN P
Arch Neurol Psychiatry 1949 Apr;61(4):339-51. doi: 10.1001/archneurpsyc.1949.02310100003001. PMID: 18121057

Clinical prediction guides

Three Dimensional Brain Parameters of Multiple Sclerosis (MS) Patients.
Barc ED, Yucel F, Kutlu C
Mult Scler Relat Disord 2023 Feb;70:104475. Epub 2022 Dec 19 doi: 10.1016/j.msard.2022.104475. PMID: 36584653
Insights into Initial Demyelinating Episodes of Central Nervous System during Puerperium.
Wu Q, Chen B, Liu N, Hu Y, Pan C, Zhang P, Tang ZP, Bu BT
Chin Med J (Engl) 2017 Aug 5;130(15):1791-1795. doi: 10.4103/0366-6999.211542. PMID: 28748851Free PMC Article
VDBP, CYP27B1, and 25-Hydroxyvitamin D Gene Polymorphism Analyses in a Group of Sicilian Multiple Sclerosis Patients.
Agnello L, Scazzone C, Lo Sasso B, Bellia C, Bivona G, Realmuto S, Brighina F, Schillaci R, Ragonese P, Salemi G, Ciaccio M
Biochem Genet 2017 Apr;55(2):183-192. Epub 2016 Nov 30 doi: 10.1007/s10528-016-9783-4. PMID: 27904983
Functional relevance for multiple sclerosis-associated genetic variants.
Lin X, Deng FY, Mo XB, Wu LF, Lei SF
Immunogenetics 2015 Jan;67(1):7-14. Epub 2014 Oct 12 doi: 10.1007/s00251-014-0803-4. PMID: 25308886

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