Abnormal thickening of the skin localized to the palm of the hand.

Excessive sensitivity to light with the sensation of discomfort or pain in the eyes due to exposure to bright light.

A congenital defect characterized by the absence of one or more permanent teeth, including oligodontia, hypodontia, and adontia of the of permanent teeth.

Decreased density/number of eyebrow hairs.

Decreased number of hairs per unit area of skin of the scalp.

Any abnormality of the primary tooth.

The absence of one or more teeth from the normal series by a failure to develop

A tooth crown with its mesial and distal sides converging or tapering toward the incisal edge causing severe reduction of mesiodistal diameter

Abnormally diminished capacity to sweat.

Skin characterized by the lack of natural or normal moisture.

Reduction in thickness of the skin, generally associated with a loss of suppleness and elasticity of the skin.

Hyperhidrosis palmaris et plantaris (HYPRPP) is characterized by excessive perspiration of the eccrine sweat gland in the palm, sole, and axilla. Perspiration in those affected may be aggravated by emotional stimuli (summary by Higashimoto et al., 2006). Stolman (1998) noted that hyperhidrosis may be complicated by skin maceration as well as secondary microbial infections, and that treatment modalities are associated with complications.

Toenail changes apart from changes of the color of the toenail (nail dyschromia) that involve partial or complete disruption of the various keratinous layers of the nail plate.

Sparseness of the body hair.

Decreased length of the eyelashes (subjective).

The presence of misshapen or partially destroyed nail plates, often with accumulation of soft, yellow keratin between the dystrophic nail plate and nail bed, resulting in elevation of the nail plate.