U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Congenital laryngeal web

MedGen UID:
372058
Concept ID:
C1835494
Disease or Syndrome
Synonyms: GLOTTIC WEB, CONGENITAL ANTERIOR; Laryngeal web, familial; SUBGLOTTIC BAR; SUBGLOTTIC WEB
 
Monarch Initiative: MONDO:0007880
OMIM®: 150360
Orphanet: ORPHA2374

Definition

Congenital laryngeal (glottic) webs are uncommon, membrane-like structures that extend across the laryngeal lumen near the level of the vocal cords. They are thought to result from incomplete resorption of an epithelial layer that normally obliterates the developing laryngeal opening at about the sixth week of embryologic life. This layer is usually completely eliminated by the tenth week. Most laryngeal webs occur at the glottic level and affect the vocal cords. More than 90% are located anteriorly and extend toward the arytenoids. While affected persons may have onset of manifestations at any age, with hoarse or weak voice and frequent upper respiratory infections, they usually manifest the condition as infants, with respiratory distress, stridor, and an unusual cry (Strakowski et al., 1988; Singh et al., 2009). [from OMIM]

Clinical features

From HPO
Stridor
MedGen UID:
11613
Concept ID:
C0038450
Sign or Symptom
Stridor is a high pitched sound resulting from turbulent air flow in the upper airway.
Laryngeal web
MedGen UID:
84297
Concept ID:
C0281890
Disease or Syndrome
A membrane-like structure that extends across the laryngeal lumen close to the level of the vocal cords.
Respiratory distress
MedGen UID:
96907
Concept ID:
C0476273
Sign or Symptom
Respiratory distress is objectively observable as the physical or emotional consequences from the experience of dyspnea. The physical presentation of respiratory distress is generally referred to as labored breathing, while the sensation of respiratory distress is called shortness of breath or dyspnea.
Recurrent upper respiratory tract infections
MedGen UID:
154380
Concept ID:
C0581381
Disease or Syndrome
An increased susceptibility to upper respiratory tract infections as manifested by a history of recurrent upper respiratory tract infections (running ears - otitis, sinusitis, pharyngitis, tonsillitis).
Hoarse voice
MedGen UID:
5602
Concept ID:
C0019825
Sign or Symptom
Hoarseness refers to a change in the pitch or quality of the voice, with the voice sounding weak, very breathy, scratchy, or husky.
Weak voice
MedGen UID:
66033
Concept ID:
C0241700
Finding
Reduced intensity (volume) of speech.

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCongenital laryngeal web

Professional guidelines

PubMed

Timashpolsky A, Schild SD, Ballard DP, Leventer SP, Rosenfeld RM, Plum AW
Otolaryngol Head Neck Surg 2021 Mar;164(3):489-500. Epub 2020 Aug 18 doi: 10.1177/0194599820947742. PMID: 32807006
Benmansour N, Remacle M, Matar N, Lawson G, Bachy V, Van Der Vorst S
Eur Arch Otorhinolaryngol 2012 Sep;269(9):2075-80. Epub 2012 Mar 28 doi: 10.1007/s00405-012-2001-z. PMID: 22454231
Amir M, Youssef T
Clin Respir J 2010 Oct;4(4):202-7. doi: 10.1111/j.1752-699X.2009.00176.x. PMID: 20887342

Recent clinical studies

Etiology

Avelino MAG, Pazinatto DB, Rodrigues SO, Maunsell R
Braz J Otorhinolaryngol 2022 Jul-Aug;88(4):497-504. Epub 2020 Aug 3 doi: 10.1016/j.bjorl.2020.06.018. PMID: 32855093Free PMC Article
de Trey LA, Lambercy K, Monnier P, Sandu K
Int J Pediatr Otorhinolaryngol 2016 Jul;86:82-6. Epub 2016 Apr 7 doi: 10.1016/j.ijporl.2016.04.006. PMID: 27260586
Sorichetti B, Moxham JP, Kozak FK
Am J Otolaryngol 2016 Mar-Apr;37(2):148-51. Epub 2015 Nov 10 doi: 10.1016/j.amjoto.2015.11.001. PMID: 26954872
Men S, Ikiz AO, Topcu I, Cakmakci H, Ecevit C
Int J Pediatr Otorhinolaryngol 2006 Jun;70(6):1125-7. Epub 2005 Dec 15 doi: 10.1016/j.ijporl.2005.10.023. PMID: 16359736
Benjamin B
Ann Otol Rhinol Laryngol 1983 Jul-Aug;92(4 Pt 1):317-26. doi: 10.1177/000348948309200401. PMID: 6881830

Diagnosis

Avelino MAG, Pazinatto DB, Rodrigues SO, Maunsell R
Braz J Otorhinolaryngol 2022 Jul-Aug;88(4):497-504. Epub 2020 Aug 3 doi: 10.1016/j.bjorl.2020.06.018. PMID: 32855093Free PMC Article
Sorichetti B, Moxham JP, Kozak FK
Am J Otolaryngol 2016 Mar-Apr;37(2):148-51. Epub 2015 Nov 10 doi: 10.1016/j.amjoto.2015.11.001. PMID: 26954872
McElhinney DB, Jacobs I, McDonald-McGinn DM, Zackai EH, Goldmuntz E
Int J Pediatr Otorhinolaryngol 2002 Oct 21;66(1):23-27. doi: 10.1016/s0165-5876(02)00184-2. PMID: 12363418
van den Broek P, Brinkman WF
Int J Pediatr Otorhinolaryngol 1979 Jul;1(1):71-8. doi: 10.1016/0165-5876(79)90030-2. PMID: 553886
CAVANAGH F
Proc R Soc Med 1965 Apr;58(4):272-7. PMID: 14263741Free PMC Article

Therapy

LeRiger MM, Franzen MH, Sewell RK, Duncan-Wiebe GL
A A Pract 2018 Sep 15;11(6):162-164. doi: 10.1213/XAA.0000000000000773. PMID: 29621014
de Trey LA, Lambercy K, Monnier P, Sandu K
Int J Pediatr Otorhinolaryngol 2016 Jul;86:82-6. Epub 2016 Apr 7 doi: 10.1016/j.ijporl.2016.04.006. PMID: 27260586
Roh JL
Acta Otolaryngol 2006 Apr;126(4):438-41. doi: 10.1080/00016480500395203. PMID: 16608801
Unal M
Int J Pediatr Otorhinolaryngol 2004 Feb;68(2):231-5. doi: 10.1016/j.ijporl.2003.09.018. PMID: 14725992

Prognosis

de Trey LA, Lambercy K, Monnier P, Sandu K
Int J Pediatr Otorhinolaryngol 2016 Jul;86:82-6. Epub 2016 Apr 7 doi: 10.1016/j.ijporl.2016.04.006. PMID: 27260586
Sorichetti B, Moxham JP, Kozak FK
Am J Otolaryngol 2016 Mar-Apr;37(2):148-51. Epub 2015 Nov 10 doi: 10.1016/j.amjoto.2015.11.001. PMID: 26954872
Men S, Ikiz AO, Topcu I, Cakmakci H, Ecevit C
Int J Pediatr Otorhinolaryngol 2006 Jun;70(6):1125-7. Epub 2005 Dec 15 doi: 10.1016/j.ijporl.2005.10.023. PMID: 16359736

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...