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Dengue disease

MedGen UID:
3721
Concept ID:
C0011311
Disease or Syndrome
Synonym: Dengue fever
SNOMED CT: Dengue (38362002); Dengue fever (38362002); Breakbone fever (38362002)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0005502
Orphanet: ORPHA99828

Definition

Dengue fever (DF), caused by dengue virus, is an arboviral disease characterized by an initial non-specific febrile illness that can sometimes progress to more severe forms manifesting capillary leakage and hemorrhage (dengue hemorrhagic fever, or DHF) and shock (dengue shock syndrome, or DSS). [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDengue disease
Follow this link to review classifications for Dengue disease in Orphanet.

Professional guidelines

PubMed

K Shahid S
Pharm Pat Anal 2020 Dec;9(6):173-185. Epub 2020 Dec 22 doi: 10.4155/ppa-2020-0012. PMID: 33350353
Calvo EP, Coronel-Ruiz C, Velazco S, Velandia-Romero M, Castellanos JE
Biomedica 2015 Oct 26;36(0):35-43. doi: 10.7705/biomedica.v36i0.2982. PMID: 27622791
Halstead SB, Cohen SN
Microbiol Mol Biol Rev 2015 Sep;79(3):281-91. doi: 10.1128/MMBR.00009-15. PMID: 26085471Free PMC Article

Recent clinical studies

Etiology

Kallás EG, Cintra MAT, Moreira JA, Patiño EG, Braga PE, Tenório JCV, Infante V, Palacios R, de Lacerda MVG, Batista Pereira D, da Fonseca AJ, Gurgel RQ, Coelho IC, Fontes CJF, Marques ETA, Romero GAS, Teixeira MM, Siqueira AM, Barral AMP, Boaventura VS, Ramos F, Elias Júnior E, Cassio de Moraes J, Covas DT, Kalil J, Precioso AR, Whitehead SS, Esteves-Jaramillo A, Shekar T, Lee JJ, Macey J, Kelner SG, Coller BG, Boulos FC, Nogueira ML
N Engl J Med 2024 Feb 1;390(5):397-408. doi: 10.1056/NEJMoa2301790. PMID: 38294972
Sangkaew S, Ming D, Boonyasiri A, Honeyford K, Kalayanarooj S, Yacoub S, Dorigatti I, Holmes A
Lancet Infect Dis 2021 Jul;21(7):1014-1026. Epub 2021 Feb 25 doi: 10.1016/S1473-3099(20)30601-0. PMID: 33640077Free PMC Article
Wang WH, Urbina AN, Chang MR, Assavalapsakul W, Lu PL, Chen YH, Wang SF
J Microbiol Immunol Infect 2020 Dec;53(6):963-978. Epub 2020 Mar 26 doi: 10.1016/j.jmii.2020.03.007. PMID: 32265181
Katzelnick LC, Gresh L, Halloran ME, Mercado JC, Kuan G, Gordon A, Balmaseda A, Harris E
Science 2017 Nov 17;358(6365):929-932. Epub 2017 Nov 2 doi: 10.1126/science.aan6836. PMID: 29097492Free PMC Article
Verhagen LM, de Groot R
J Infect 2014 Nov;69 Suppl 1:S77-86. Epub 2014 Sep 13 doi: 10.1016/j.jinf.2014.07.020. PMID: 25225163

Diagnosis

Wang WH, Urbina AN, Chang MR, Assavalapsakul W, Lu PL, Chen YH, Wang SF
J Microbiol Immunol Infect 2020 Dec;53(6):963-978. Epub 2020 Mar 26 doi: 10.1016/j.jmii.2020.03.007. PMID: 32265181
Muller DA, Depelsenaire AC, Young PR
J Infect Dis 2017 Mar 1;215(suppl_2):S89-S95. doi: 10.1093/infdis/jiw649. PMID: 28403441
Khetarpal N, Khanna I
J Immunol Res 2016;2016:6803098. Epub 2016 Jul 20 doi: 10.1155/2016/6803098. PMID: 27525287Free PMC Article
Guzman MG, Harris E
Lancet 2015 Jan 31;385(9966):453-65. Epub 2014 Sep 14 doi: 10.1016/S0140-6736(14)60572-9. PMID: 25230594
Verhagen LM, de Groot R
J Infect 2014 Nov;69 Suppl 1:S77-86. Epub 2014 Sep 13 doi: 10.1016/j.jinf.2014.07.020. PMID: 25225163

Therapy

Kallás EG, Cintra MAT, Moreira JA, Patiño EG, Braga PE, Tenório JCV, Infante V, Palacios R, de Lacerda MVG, Batista Pereira D, da Fonseca AJ, Gurgel RQ, Coelho IC, Fontes CJF, Marques ETA, Romero GAS, Teixeira MM, Siqueira AM, Barral AMP, Boaventura VS, Ramos F, Elias Júnior E, Cassio de Moraes J, Covas DT, Kalil J, Precioso AR, Whitehead SS, Esteves-Jaramillo A, Shekar T, Lee JJ, Macey J, Kelner SG, Coller BG, Boulos FC, Nogueira ML
N Engl J Med 2024 Feb 1;390(5):397-408. doi: 10.1056/NEJMoa2301790. PMID: 38294972
Tricou V, Yu D, Reynales H, Biswal S, Saez-Llorens X, Sirivichayakul C, Lopez P, Borja-Tabora C, Bravo L, Kosalaraksa P, Vargas LM, Alera MT, Rivera L, Watanaveeradej V, Dietze R, Fernando L, Wickramasinghe VP, Moreira ED Jr, Fernando AD, Gunasekera D, Luz K, Oliveira AL, Tuboi S, Escudero I, Hutagalung Y, Lloyd E, Rauscher M, Zent O, Folschweiller N, LeFevre I, Espinoza F, Wallace D
Lancet Glob Health 2024 Feb;12(2):e257-e270. doi: 10.1016/S2214-109X(23)00522-3. PMID: 38245116
Goethals O, Kaptein SJF, Kesteleyn B, Bonfanti JF, Van Wesenbeeck L, Bardiot D, Verschoor EJ, Verstrepen BE, Fagrouch Z, Putnak JR, Kiemel D, Ackaert O, Straetemans R, Lachau-Durand S, Geluykens P, Crabbe M, Thys K, Stoops B, Lenz O, Tambuyzer L, De Meyer S, Dallmeier K, McCracken MK, Gromowski GD, Rutvisuttinunt W, Jarman RG, Karasavvas N, Touret F, Querat G, de Lamballerie X, Chatel-Chaix L, Milligan GN, Beasley DWC, Bourne N, Barrett ADT, Marchand A, Jonckers THM, Raboisson P, Simmen K, Chaltin P, Bartenschlager R, Bogers WM, Neyts J, Van Loock M
Nature 2023 Mar;615(7953):678-686. Epub 2023 Mar 15 doi: 10.1038/s41586-023-05790-6. PMID: 36922586Free PMC Article
Sangkaew S, Ming D, Boonyasiri A, Honeyford K, Kalayanarooj S, Yacoub S, Dorigatti I, Holmes A
Lancet Infect Dis 2021 Jul;21(7):1014-1026. Epub 2021 Feb 25 doi: 10.1016/S1473-3099(20)30601-0. PMID: 33640077Free PMC Article
Khetarpal N, Khanna I
J Immunol Res 2016;2016:6803098. Epub 2016 Jul 20 doi: 10.1155/2016/6803098. PMID: 27525287Free PMC Article

Prognosis

Kallás EG, Cintra MAT, Moreira JA, Patiño EG, Braga PE, Tenório JCV, Infante V, Palacios R, de Lacerda MVG, Batista Pereira D, da Fonseca AJ, Gurgel RQ, Coelho IC, Fontes CJF, Marques ETA, Romero GAS, Teixeira MM, Siqueira AM, Barral AMP, Boaventura VS, Ramos F, Elias Júnior E, Cassio de Moraes J, Covas DT, Kalil J, Precioso AR, Whitehead SS, Esteves-Jaramillo A, Shekar T, Lee JJ, Macey J, Kelner SG, Coller BG, Boulos FC, Nogueira ML
N Engl J Med 2024 Feb 1;390(5):397-408. doi: 10.1056/NEJMoa2301790. PMID: 38294972
Sangkaew S, Ming D, Boonyasiri A, Honeyford K, Kalayanarooj S, Yacoub S, Dorigatti I, Holmes A
Lancet Infect Dis 2021 Jul;21(7):1014-1026. Epub 2021 Feb 25 doi: 10.1016/S1473-3099(20)30601-0. PMID: 33640077Free PMC Article
Hashan MR, Ghozy S, El-Qushayri AE, Pial RH, Hossain MA, Al Kibria GM
Rev Med Virol 2021 Jan;31(1):1-9. Epub 2020 Aug 10 doi: 10.1002/rmv.2147. PMID: 32776660
Katzelnick LC, Bos S, Harris E
Curr Opin Virol 2020 Aug;43:59-70. Epub 2020 Sep 24 doi: 10.1016/j.coviro.2020.08.006. PMID: 32979816Free PMC Article
Muller DA, Depelsenaire AC, Young PR
J Infect Dis 2017 Mar 1;215(suppl_2):S89-S95. doi: 10.1093/infdis/jiw649. PMID: 28403441

Clinical prediction guides

Tricou V, Yu D, Reynales H, Biswal S, Saez-Llorens X, Sirivichayakul C, Lopez P, Borja-Tabora C, Bravo L, Kosalaraksa P, Vargas LM, Alera MT, Rivera L, Watanaveeradej V, Dietze R, Fernando L, Wickramasinghe VP, Moreira ED Jr, Fernando AD, Gunasekera D, Luz K, Oliveira AL, Tuboi S, Escudero I, Hutagalung Y, Lloyd E, Rauscher M, Zent O, Folschweiller N, LeFevre I, Espinoza F, Wallace D
Lancet Glob Health 2024 Feb;12(2):e257-e270. doi: 10.1016/S2214-109X(23)00522-3. PMID: 38245116
O'Driscoll M, Buddhari D, Huang AT, Waickman A, Kaewhirun S, Iamsirithaworn S, Khampaen D, Farmer A, Fernandez S, Rodriguez-Barraquer I, Srikiatkhachorn A, Thomas S, Endy T, Rothman AL, Anderson K, Cummings DAT, Salje H
Proc Natl Acad Sci U S A 2023 Oct 10;120(41):e2308221120. Epub 2023 Sep 29 doi: 10.1073/pnas.2308221120. PMID: 37774093Free PMC Article
Sangkaew S, Ming D, Boonyasiri A, Honeyford K, Kalayanarooj S, Yacoub S, Dorigatti I, Holmes A
Lancet Infect Dis 2021 Jul;21(7):1014-1026. Epub 2021 Feb 25 doi: 10.1016/S1473-3099(20)30601-0. PMID: 33640077Free PMC Article
Hashan MR, Ghozy S, El-Qushayri AE, Pial RH, Hossain MA, Al Kibria GM
Rev Med Virol 2021 Jan;31(1):1-9. Epub 2020 Aug 10 doi: 10.1002/rmv.2147. PMID: 32776660
Katzelnick LC, Gresh L, Halloran ME, Mercado JC, Kuan G, Gordon A, Balmaseda A, Harris E
Science 2017 Nov 17;358(6365):929-932. Epub 2017 Nov 2 doi: 10.1126/science.aan6836. PMID: 29097492Free PMC Article

Recent systematic reviews

Sangkaew S, Ming D, Boonyasiri A, Honeyford K, Kalayanarooj S, Yacoub S, Dorigatti I, Holmes A
Lancet Infect Dis 2021 Jul;21(7):1014-1026. Epub 2021 Feb 25 doi: 10.1016/S1473-3099(20)30601-0. PMID: 33640077Free PMC Article
Hashan MR, Ghozy S, El-Qushayri AE, Pial RH, Hossain MA, Al Kibria GM
Rev Med Virol 2021 Jan;31(1):1-9. Epub 2020 Aug 10 doi: 10.1002/rmv.2147. PMID: 32776660
Wang WH, Urbina AN, Chang MR, Assavalapsakul W, Lu PL, Chen YH, Wang SF
J Microbiol Immunol Infect 2020 Dec;53(6):963-978. Epub 2020 Mar 26 doi: 10.1016/j.jmii.2020.03.007. PMID: 32265181
Ganeshkumar P, Murhekar MV, Poornima V, Saravanakumar V, Sukumaran K, Anandaselvasankar A, John D, Mehendale SM
PLoS Negl Trop Dis 2018 Jul;12(7):e0006618. Epub 2018 Jul 16 doi: 10.1371/journal.pntd.0006618. PMID: 30011275Free PMC Article
Runge-Ranzinger S, McCall PJ, Kroeger A, Horstick O
Trop Med Int Health 2014 Sep;19(9):1116-60. Epub 2014 May 28 doi: 10.1111/tmi.12333. PMID: 24889501Free PMC Article

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