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Dengue disease

MedGen UID:
3721
•Concept ID:
C0011311
•
Disease or Syndrome
Synonym: Dengue fever
SNOMED CT: Dengue (38362002); Dengue fever (38362002); Breakbone fever (38362002)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0005502
Orphanet: ORPHA99828

Definition

Dengue fever (DF), caused by dengue virus, is an arboviral disease characterized by an initial non-specific febrile illness that can sometimes progress to more severe forms manifesting capillary leakage and hemorrhage (dengue hemorrhagic fever, or DHF) and shock (dengue shock syndrome, or DSS). [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDengue disease
Follow this link to review classifications for Dengue disease in Orphanet.

Professional guidelines

PubMed

Recent patents in dengue disease management.
K Shahid S
Pharm Pat Anal 2020 Dec;9(6):173-185. Epub 2020 Dec 22 doi: 10.4155/ppa-2020-0012. PMID: 33350353
Dengue and Chikungunya differential diagnosis in pediatric patients.
Calvo EP, Coronel-Ruiz C, Velazco S, Velandia-Romero M, Castellanos JE
Biomedica 2015 Oct 26;36(0):35-43. doi: 10.7705/biomedica.v36i0.2982. PMID: 27622791
Dengue Hemorrhagic Fever at 60 Years: Early Evolution of Concepts of Causation and Treatment.
Halstead SB, Cohen SN
Microbiol Mol Biol Rev 2015 Sep;79(3):281-91. doi: 10.1128/MMBR.00009-15. PMID: 26085471Free PMC Article

Recent clinical studies

Etiology

Live, Attenuated, Tetravalent Butantan-Dengue Vaccine in Children and Adults.
Kallás EG, Cintra MAT, Moreira JA, Patiño EG, Braga PE, Tenório JCV, Infante V, Palacios R, de Lacerda MVG, Batista Pereira D, da Fonseca AJ, Gurgel RQ, Coelho IC, Fontes CJF, Marques ETA, Romero GAS, Teixeira MM, Siqueira AM, Barral AMP, Boaventura VS, Ramos F, Elias Júnior E, Cassio de Moraes J, Covas DT, Kalil J, Precioso AR, Whitehead SS, Esteves-Jaramillo A, Shekar T, Lee JJ, Macey J, Kelner SG, Coller BG, Boulos FC, Nogueira ML
N Engl J Med 2024 Feb 1;390(5):397-408. doi: 10.1056/NEJMoa2301790. PMID: 38294972
Risk predictors of progression to severe disease during the febrile phase of dengue: a systematic review and meta-analysis.
Sangkaew S, Ming D, Boonyasiri A, Honeyford K, Kalayanarooj S, Yacoub S, Dorigatti I, Holmes A
Lancet Infect Dis 2021 Jul;21(7):1014-1026. Epub 2021 Feb 25 doi: 10.1016/S1473-3099(20)30601-0. PMID: 33640077Free PMC Article
Dengue hemorrhagic fever - A systemic literature review of current perspectives on pathogenesis, prevention and control.
Wang WH, Urbina AN, Chang MR, Assavalapsakul W, Lu PL, Chen YH, Wang SF
J Microbiol Immunol Infect 2020 Dec;53(6):963-978. Epub 2020 Mar 26 doi: 10.1016/j.jmii.2020.03.007. PMID: 32265181
Antibody-dependent enhancement of severe dengue disease in humans.
Katzelnick LC, Gresh L, Halloran ME, Mercado JC, Kuan G, Gordon A, Balmaseda A, Harris E
Science 2017 Nov 17;358(6365):929-932. Epub 2017 Nov 2 doi: 10.1126/science.aan6836. PMID: 29097492Free PMC Article
Dengue in children.
Verhagen LM, de Groot R
J Infect 2014 Nov;69 Suppl 1:S77-86. Epub 2014 Sep 13 doi: 10.1016/j.jinf.2014.07.020. PMID: 25225163

Diagnosis

Dengue hemorrhagic fever - A systemic literature review of current perspectives on pathogenesis, prevention and control.
Wang WH, Urbina AN, Chang MR, Assavalapsakul W, Lu PL, Chen YH, Wang SF
J Microbiol Immunol Infect 2020 Dec;53(6):963-978. Epub 2020 Mar 26 doi: 10.1016/j.jmii.2020.03.007. PMID: 32265181
Clinical and Laboratory Diagnosis of Dengue Virus Infection.
Muller DA, Depelsenaire AC, Young PR
J Infect Dis 2017 Mar 1;215(suppl_2):S89-S95. doi: 10.1093/infdis/jiw649. PMID: 28403441
Dengue Fever: Causes, Complications, and Vaccine Strategies.
Khetarpal N, Khanna I
J Immunol Res 2016;2016:6803098. Epub 2016 Jul 20 doi: 10.1155/2016/6803098. PMID: 27525287Free PMC Article
Dengue.
Guzman MG, Harris E
Lancet 2015 Jan 31;385(9966):453-65. Epub 2014 Sep 14 doi: 10.1016/S0140-6736(14)60572-9. PMID: 25230594
Dengue in children.
Verhagen LM, de Groot R
J Infect 2014 Nov;69 Suppl 1:S77-86. Epub 2014 Sep 13 doi: 10.1016/j.jinf.2014.07.020. PMID: 25225163

Therapy

Live, Attenuated, Tetravalent Butantan-Dengue Vaccine in Children and Adults.
Kallás EG, Cintra MAT, Moreira JA, Patiño EG, Braga PE, Tenório JCV, Infante V, Palacios R, de Lacerda MVG, Batista Pereira D, da Fonseca AJ, Gurgel RQ, Coelho IC, Fontes CJF, Marques ETA, Romero GAS, Teixeira MM, Siqueira AM, Barral AMP, Boaventura VS, Ramos F, Elias Júnior E, Cassio de Moraes J, Covas DT, Kalil J, Precioso AR, Whitehead SS, Esteves-Jaramillo A, Shekar T, Lee JJ, Macey J, Kelner SG, Coller BG, Boulos FC, Nogueira ML
N Engl J Med 2024 Feb 1;390(5):397-408. doi: 10.1056/NEJMoa2301790. PMID: 38294972
Long-term efficacy and safety of a tetravalent dengue vaccine (TAK-003): 4·5-year results from a phase 3, randomised, double-blind, placebo-controlled trial.
Tricou V, Yu D, Reynales H, Biswal S, Saez-Llorens X, Sirivichayakul C, Lopez P, Borja-Tabora C, Bravo L, Kosalaraksa P, Vargas LM, Alera MT, Rivera L, Watanaveeradej V, Dietze R, Fernando L, Wickramasinghe VP, Moreira ED Jr, Fernando AD, Gunasekera D, Luz K, Oliveira AL, Tuboi S, Escudero I, Hutagalung Y, Lloyd E, Rauscher M, Zent O, Folschweiller N, LeFevre I, Espinoza F, Wallace D
Lancet Glob Health 2024 Feb;12(2):e257-e270. doi: 10.1016/S2214-109X(23)00522-3. PMID: 38245116
Blocking NS3-NS4B interaction inhibits dengue virus in non-human primates.
Goethals O, Kaptein SJF, Kesteleyn B, Bonfanti JF, Van Wesenbeeck L, Bardiot D, Verschoor EJ, Verstrepen BE, Fagrouch Z, Putnak JR, Kiemel D, Ackaert O, Straetemans R, Lachau-Durand S, Geluykens P, Crabbe M, Thys K, Stoops B, Lenz O, Tambuyzer L, De Meyer S, Dallmeier K, McCracken MK, Gromowski GD, Rutvisuttinunt W, Jarman RG, Karasavvas N, Touret F, Querat G, de Lamballerie X, Chatel-Chaix L, Milligan GN, Beasley DWC, Bourne N, Barrett ADT, Marchand A, Jonckers THM, Raboisson P, Simmen K, Chaltin P, Bartenschlager R, Bogers WM, Neyts J, Van Loock M
Nature 2023 Mar;615(7953):678-686. Epub 2023 Mar 15 doi: 10.1038/s41586-023-05790-6. PMID: 36922586Free PMC Article
Risk predictors of progression to severe disease during the febrile phase of dengue: a systematic review and meta-analysis.
Sangkaew S, Ming D, Boonyasiri A, Honeyford K, Kalayanarooj S, Yacoub S, Dorigatti I, Holmes A
Lancet Infect Dis 2021 Jul;21(7):1014-1026. Epub 2021 Feb 25 doi: 10.1016/S1473-3099(20)30601-0. PMID: 33640077Free PMC Article
Dengue Fever: Causes, Complications, and Vaccine Strategies.
Khetarpal N, Khanna I
J Immunol Res 2016;2016:6803098. Epub 2016 Jul 20 doi: 10.1155/2016/6803098. PMID: 27525287Free PMC Article

Prognosis

Live, Attenuated, Tetravalent Butantan-Dengue Vaccine in Children and Adults.
Kallás EG, Cintra MAT, Moreira JA, Patiño EG, Braga PE, Tenório JCV, Infante V, Palacios R, de Lacerda MVG, Batista Pereira D, da Fonseca AJ, Gurgel RQ, Coelho IC, Fontes CJF, Marques ETA, Romero GAS, Teixeira MM, Siqueira AM, Barral AMP, Boaventura VS, Ramos F, Elias Júnior E, Cassio de Moraes J, Covas DT, Kalil J, Precioso AR, Whitehead SS, Esteves-Jaramillo A, Shekar T, Lee JJ, Macey J, Kelner SG, Coller BG, Boulos FC, Nogueira ML
N Engl J Med 2024 Feb 1;390(5):397-408. doi: 10.1056/NEJMoa2301790. PMID: 38294972
Antibody fucosylation predicts disease severity in secondary dengue infection.
Bournazos S, Vo HTM, Duong V, Auerswald H, Ly S, Sakuntabhai A, Dussart P, Cantaert T, Ravetch JV
Science 2021 Jun 4;372(6546):1102-1105. doi: 10.1126/science.abc7303. PMID: 34083490Free PMC Article
Risk predictors of progression to severe disease during the febrile phase of dengue: a systematic review and meta-analysis.
Sangkaew S, Ming D, Boonyasiri A, Honeyford K, Kalayanarooj S, Yacoub S, Dorigatti I, Holmes A
Lancet Infect Dis 2021 Jul;21(7):1014-1026. Epub 2021 Feb 25 doi: 10.1016/S1473-3099(20)30601-0. PMID: 33640077Free PMC Article
Association of dengue disease severity and blood group: A systematic review and meta-analysis.
Hashan MR, Ghozy S, El-Qushayri AE, Pial RH, Hossain MA, Al Kibria GM
Rev Med Virol 2021 Jan;31(1):1-9. Epub 2020 Aug 10 doi: 10.1002/rmv.2147. PMID: 32776660
Clinical and Laboratory Diagnosis of Dengue Virus Infection.
Muller DA, Depelsenaire AC, Young PR
J Infect Dis 2017 Mar 1;215(suppl_2):S89-S95. doi: 10.1093/infdis/jiw649. PMID: 28403441

Clinical prediction guides

Long-term efficacy and safety of a tetravalent dengue vaccine (TAK-003): 4·5-year results from a phase 3, randomised, double-blind, placebo-controlled trial.
Tricou V, Yu D, Reynales H, Biswal S, Saez-Llorens X, Sirivichayakul C, Lopez P, Borja-Tabora C, Bravo L, Kosalaraksa P, Vargas LM, Alera MT, Rivera L, Watanaveeradej V, Dietze R, Fernando L, Wickramasinghe VP, Moreira ED Jr, Fernando AD, Gunasekera D, Luz K, Oliveira AL, Tuboi S, Escudero I, Hutagalung Y, Lloyd E, Rauscher M, Zent O, Folschweiller N, LeFevre I, Espinoza F, Wallace D
Lancet Glob Health 2024 Feb;12(2):e257-e270. doi: 10.1016/S2214-109X(23)00522-3. PMID: 38245116
Risk predictors of progression to severe disease during the febrile phase of dengue: a systematic review and meta-analysis.
Sangkaew S, Ming D, Boonyasiri A, Honeyford K, Kalayanarooj S, Yacoub S, Dorigatti I, Holmes A
Lancet Infect Dis 2021 Jul;21(7):1014-1026. Epub 2021 Feb 25 doi: 10.1016/S1473-3099(20)30601-0. PMID: 33640077Free PMC Article
Association of dengue disease severity and blood group: A systematic review and meta-analysis.
Hashan MR, Ghozy S, El-Qushayri AE, Pial RH, Hossain MA, Al Kibria GM
Rev Med Virol 2021 Jan;31(1):1-9. Epub 2020 Aug 10 doi: 10.1002/rmv.2147. PMID: 32776660
Antibody-dependent enhancement of severe dengue disease in humans.
Katzelnick LC, Gresh L, Halloran ME, Mercado JC, Kuan G, Gordon A, Balmaseda A, Harris E
Science 2017 Nov 17;358(6365):929-932. Epub 2017 Nov 2 doi: 10.1126/science.aan6836. PMID: 29097492Free PMC Article
Biomarkers of severe dengue disease - a review.
John DV, Lin YS, Perng GC
J Biomed Sci 2015 Oct 14;22:83. doi: 10.1186/s12929-015-0191-6. PMID: 26462910Free PMC Article

Recent systematic reviews

Risk predictors of progression to severe disease during the febrile phase of dengue: a systematic review and meta-analysis.
Sangkaew S, Ming D, Boonyasiri A, Honeyford K, Kalayanarooj S, Yacoub S, Dorigatti I, Holmes A
Lancet Infect Dis 2021 Jul;21(7):1014-1026. Epub 2021 Feb 25 doi: 10.1016/S1473-3099(20)30601-0. PMID: 33640077Free PMC Article
Association of dengue disease severity and blood group: A systematic review and meta-analysis.
Hashan MR, Ghozy S, El-Qushayri AE, Pial RH, Hossain MA, Al Kibria GM
Rev Med Virol 2021 Jan;31(1):1-9. Epub 2020 Aug 10 doi: 10.1002/rmv.2147. PMID: 32776660
Dengue hemorrhagic fever - A systemic literature review of current perspectives on pathogenesis, prevention and control.
Wang WH, Urbina AN, Chang MR, Assavalapsakul W, Lu PL, Chen YH, Wang SF
J Microbiol Immunol Infect 2020 Dec;53(6):963-978. Epub 2020 Mar 26 doi: 10.1016/j.jmii.2020.03.007. PMID: 32265181
Dengue infection in India: A systematic review and meta-analysis.
Ganeshkumar P, Murhekar MV, Poornima V, Saravanakumar V, Sukumaran K, Anandaselvasankar A, John D, Mehendale SM
PLoS Negl Trop Dis 2018 Jul;12(7):e0006618. Epub 2018 Jul 16 doi: 10.1371/journal.pntd.0006618. PMID: 30011275Free PMC Article
Epidemiology of dengue disease in Malaysia (2000-2012): a systematic literature review.
Mohd-Zaki AH, Brett J, Ismail E, L'Azou M
PLoS Negl Trop Dis 2014;8(11):e3159. Epub 2014 Nov 6 doi: 10.1371/journal.pntd.0003159. PMID: 25375211Free PMC Article

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