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Dengue disease

MedGen UID:
3721
•Concept ID:
C0011311
•
Disease or Syndrome
Synonym: Dengue fever
SNOMED CT: Dengue (38362002); Dengue fever (38362002); Breakbone fever (38362002)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0005502
Orphanet: ORPHA99828

Definition

Dengue fever (DF), caused by dengue virus, is an arboviral disease characterized by an initial non-specific febrile illness that can sometimes progress to more severe forms manifesting capillary leakage and hemorrhage (dengue hemorrhagic fever, or DHF) and shock (dengue shock syndrome, or DSS). [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDengue disease
Follow this link to review classifications for Dengue disease in Orphanet.

Professional guidelines

PubMed

Recent patents in dengue disease management.
K Shahid S
Pharm Pat Anal 2020 Dec;9(6):173-185. Epub 2020 Dec 22 doi: 10.4155/ppa-2020-0012. PMID: 33350353
Dengue and Chikungunya differential diagnosis in pediatric patients.
Calvo EP, Coronel-Ruiz C, Velazco S, Velandia-Romero M, Castellanos JE
Biomedica 2015 Oct 26;36(0):35-43. doi: 10.7705/biomedica.v36i0.2982. PMID: 27622791
Dengue Hemorrhagic Fever at 60 Years: Early Evolution of Concepts of Causation and Treatment.
Halstead SB, Cohen SN
Microbiol Mol Biol Rev 2015 Sep;79(3):281-91. doi: 10.1128/MMBR.00009-15. PMID: 26085471Free PMC Article

Recent clinical studies

Etiology

Risk predictors of progression to severe disease during the febrile phase of dengue: a systematic review and meta-analysis.
Sangkaew S, Ming D, Boonyasiri A, Honeyford K, Kalayanarooj S, Yacoub S, Dorigatti I, Holmes A
Lancet Infect Dis 2021 Jul;21(7):1014-1026. Epub 2021 Feb 25 doi: 10.1016/S1473-3099(20)30601-0. PMID: 33640077Free PMC Article
Dengue hemorrhagic fever - A systemic literature review of current perspectives on pathogenesis, prevention and control.
Wang WH, Urbina AN, Chang MR, Assavalapsakul W, Lu PL, Chen YH, Wang SF
J Microbiol Immunol Infect 2020 Dec;53(6):963-978. Epub 2020 Mar 26 doi: 10.1016/j.jmii.2020.03.007. PMID: 32265181
Antibody-dependent enhancement of severe dengue disease in humans.
Katzelnick LC, Gresh L, Halloran ME, Mercado JC, Kuan G, Gordon A, Balmaseda A, Harris E
Science 2017 Nov 17;358(6365):929-932. Epub 2017 Nov 2 doi: 10.1126/science.aan6836. PMID: 29097492Free PMC Article
Dengue in children.
Verhagen LM, de Groot R
J Infect 2014 Nov;69 Suppl 1:S77-86. Epub 2014 Sep 13 doi: 10.1016/j.jinf.2014.07.020. PMID: 25225163
Dengue in India.
Gupta N, Srivastava S, Jain A, Chaturvedi UC
Indian J Med Res 2012 Sep;136(3):373-90. PMID: 23041731Free PMC Article

Diagnosis

Dengue hemorrhagic fever - A systemic literature review of current perspectives on pathogenesis, prevention and control.
Wang WH, Urbina AN, Chang MR, Assavalapsakul W, Lu PL, Chen YH, Wang SF
J Microbiol Immunol Infect 2020 Dec;53(6):963-978. Epub 2020 Mar 26 doi: 10.1016/j.jmii.2020.03.007. PMID: 32265181
Clinical and Laboratory Diagnosis of Dengue Virus Infection.
Muller DA, Depelsenaire AC, Young PR
J Infect Dis 2017 Mar 1;215(suppl_2):S89-S95. doi: 10.1093/infdis/jiw649. PMID: 28403441
Dengue Fever: Causes, Complications, and Vaccine Strategies.
Khetarpal N, Khanna I
J Immunol Res 2016;2016:6803098. Epub 2016 Jul 20 doi: 10.1155/2016/6803098. PMID: 27525287Free PMC Article
Dengue.
Guzman MG, Harris E
Lancet 2015 Jan 31;385(9966):453-65. Epub 2014 Sep 14 doi: 10.1016/S0140-6736(14)60572-9. PMID: 25230594
Dengue in children.
Verhagen LM, de Groot R
J Infect 2014 Nov;69 Suppl 1:S77-86. Epub 2014 Sep 13 doi: 10.1016/j.jinf.2014.07.020. PMID: 25225163

Therapy

Blocking NS3-NS4B interaction inhibits dengue virus in non-human primates.
Goethals O, Kaptein SJF, Kesteleyn B, Bonfanti JF, Van Wesenbeeck L, Bardiot D, Verschoor EJ, Verstrepen BE, Fagrouch Z, Putnak JR, Kiemel D, Ackaert O, Straetemans R, Lachau-Durand S, Geluykens P, Crabbe M, Thys K, Stoops B, Lenz O, Tambuyzer L, De Meyer S, Dallmeier K, McCracken MK, Gromowski GD, Rutvisuttinunt W, Jarman RG, Karasavvas N, Touret F, Querat G, de Lamballerie X, Chatel-Chaix L, Milligan GN, Beasley DWC, Bourne N, Barrett ADT, Marchand A, Jonckers THM, Raboisson P, Simmen K, Chaltin P, Bartenschlager R, Bogers WM, Neyts J, Van Loock M
Nature 2023 Mar;615(7953):678-686. Epub 2023 Mar 15 doi: 10.1038/s41586-023-05790-6. PMID: 36922586Free PMC Article
Biologics for dengue prevention: up-to-date.
Waickman AT, Newell K, Endy TP, Thomas SJ
Expert Opin Biol Ther 2023 Jan;23(1):73-87. Epub 2022 Dec 5 doi: 10.1080/14712598.2022.2151837. PMID: 36417290
Risk predictors of progression to severe disease during the febrile phase of dengue: a systematic review and meta-analysis.
Sangkaew S, Ming D, Boonyasiri A, Honeyford K, Kalayanarooj S, Yacoub S, Dorigatti I, Holmes A
Lancet Infect Dis 2021 Jul;21(7):1014-1026. Epub 2021 Feb 25 doi: 10.1016/S1473-3099(20)30601-0. PMID: 33640077Free PMC Article
Recent patents in dengue disease management.
K Shahid S
Pharm Pat Anal 2020 Dec;9(6):173-185. Epub 2020 Dec 22 doi: 10.4155/ppa-2020-0012. PMID: 33350353
Dengue Fever: Causes, Complications, and Vaccine Strategies.
Khetarpal N, Khanna I
J Immunol Res 2016;2016:6803098. Epub 2016 Jul 20 doi: 10.1155/2016/6803098. PMID: 27525287Free PMC Article

Prognosis

Risk predictors of progression to severe disease during the febrile phase of dengue: a systematic review and meta-analysis.
Sangkaew S, Ming D, Boonyasiri A, Honeyford K, Kalayanarooj S, Yacoub S, Dorigatti I, Holmes A
Lancet Infect Dis 2021 Jul;21(7):1014-1026. Epub 2021 Feb 25 doi: 10.1016/S1473-3099(20)30601-0. PMID: 33640077Free PMC Article
Association of dengue disease severity and blood group: A systematic review and meta-analysis.
Hashan MR, Ghozy S, El-Qushayri AE, Pial RH, Hossain MA, Al Kibria GM
Rev Med Virol 2021 Jan;31(1):1-9. Epub 2020 Aug 10 doi: 10.1002/rmv.2147. PMID: 32776660
Protective and enhancing interactions among dengue viruses 1-4 and Zika virus.
Katzelnick LC, Bos S, Harris E
Curr Opin Virol 2020 Aug;43:59-70. Epub 2020 Sep 24 doi: 10.1016/j.coviro.2020.08.006. PMID: 32979816Free PMC Article
Unusual clinical manifestations of dengue disease - Real or imagined?
Estofolete CF, de Oliveira Mota MT, Bernardes Terzian AC, de Aguiar Milhim BHG, Ribeiro MR, Nunes DV, Mourão MP, Rossi SL, Nogueira ML, Vasilakis N
Acta Trop 2019 Nov;199:105134. Epub 2019 Aug 12 doi: 10.1016/j.actatropica.2019.105134. PMID: 31415737
Clinical and Laboratory Diagnosis of Dengue Virus Infection.
Muller DA, Depelsenaire AC, Young PR
J Infect Dis 2017 Mar 1;215(suppl_2):S89-S95. doi: 10.1093/infdis/jiw649. PMID: 28403441

Clinical prediction guides

Risk predictors of progression to severe disease during the febrile phase of dengue: a systematic review and meta-analysis.
Sangkaew S, Ming D, Boonyasiri A, Honeyford K, Kalayanarooj S, Yacoub S, Dorigatti I, Holmes A
Lancet Infect Dis 2021 Jul;21(7):1014-1026. Epub 2021 Feb 25 doi: 10.1016/S1473-3099(20)30601-0. PMID: 33640077Free PMC Article
Association of dengue disease severity and blood group: A systematic review and meta-analysis.
Hashan MR, Ghozy S, El-Qushayri AE, Pial RH, Hossain MA, Al Kibria GM
Rev Med Virol 2021 Jan;31(1):1-9. Epub 2020 Aug 10 doi: 10.1002/rmv.2147. PMID: 32776660
Protective and enhancing interactions among dengue viruses 1-4 and Zika virus.
Katzelnick LC, Bos S, Harris E
Curr Opin Virol 2020 Aug;43:59-70. Epub 2020 Sep 24 doi: 10.1016/j.coviro.2020.08.006. PMID: 32979816Free PMC Article
Antibody-dependent enhancement of severe dengue disease in humans.
Katzelnick LC, Gresh L, Halloran ME, Mercado JC, Kuan G, Gordon A, Balmaseda A, Harris E
Science 2017 Nov 17;358(6365):929-932. Epub 2017 Nov 2 doi: 10.1126/science.aan6836. PMID: 29097492Free PMC Article
What does dengue disease surveillance contribute to predicting and detecting outbreaks and describing trends?
Runge-Ranzinger S, Horstick O, Marx M, Kroeger A
Trop Med Int Health 2008 Aug;13(8):1022-41. doi: 10.1111/j.1365-3156.2008.02112.x. PMID: 18768080

Recent systematic reviews

Risk predictors of progression to severe disease during the febrile phase of dengue: a systematic review and meta-analysis.
Sangkaew S, Ming D, Boonyasiri A, Honeyford K, Kalayanarooj S, Yacoub S, Dorigatti I, Holmes A
Lancet Infect Dis 2021 Jul;21(7):1014-1026. Epub 2021 Feb 25 doi: 10.1016/S1473-3099(20)30601-0. PMID: 33640077Free PMC Article
Association of dengue disease severity and blood group: A systematic review and meta-analysis.
Hashan MR, Ghozy S, El-Qushayri AE, Pial RH, Hossain MA, Al Kibria GM
Rev Med Virol 2021 Jan;31(1):1-9. Epub 2020 Aug 10 doi: 10.1002/rmv.2147. PMID: 32776660
Dengue hemorrhagic fever - A systemic literature review of current perspectives on pathogenesis, prevention and control.
Wang WH, Urbina AN, Chang MR, Assavalapsakul W, Lu PL, Chen YH, Wang SF
J Microbiol Immunol Infect 2020 Dec;53(6):963-978. Epub 2020 Mar 26 doi: 10.1016/j.jmii.2020.03.007. PMID: 32265181
Dengue infection in India: A systematic review and meta-analysis.
Ganeshkumar P, Murhekar MV, Poornima V, Saravanakumar V, Sukumaran K, Anandaselvasankar A, John D, Mehendale SM
PLoS Negl Trop Dis 2018 Jul;12(7):e0006618. Epub 2018 Jul 16 doi: 10.1371/journal.pntd.0006618. PMID: 30011275Free PMC Article
Association between nutritional status and dengue infection: a systematic review and meta-analysis.
Trang NTH, Long NP, Hue TTM, Hung LP, Trung TD, Dinh DN, Luan NT, Huy NT, Hirayama K
BMC Infect Dis 2016 Apr 20;16:172. doi: 10.1186/s12879-016-1498-y. PMID: 27097934Free PMC Article

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