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Thymoma, familial

MedGen UID:
376447
Concept ID:
C1848814
Neoplastic Process
Synonym: THYMIC NEOPLASIA
 
Monarch Initiative: MONDO:0010127
OMIM®: 274230

Definition

Thymomas are low-grade epithelial cancers of the thymus. Familial occurrence of thymoma is rare. [from OMIM]

Clinical features

From HPO
Neoplasm
MedGen UID:
10294
Concept ID:
C0027651
Neoplastic Process
An organ or organ-system abnormality that consists of uncontrolled autonomous cell-proliferation which can occur in any part of the body as a benign or malignant neoplasm (tumor).
Thymoma
MedGen UID:
52743
Concept ID:
C0040100
Neoplastic Process
A tumor originating from the epithelial cells of the thymus.
Respiratory insufficiency
MedGen UID:
11197
Concept ID:
C0035229
Pathologic Function
Impairment of gas exchange within the lungs secondary to a disease process, neoplasm, or trauma, possibly resulting in hypoxia, hypercarbia, or both, but not requiring intubation or mechanical ventilation. Patients are normally managed with pharmaceutical therapy, supplemental oxygen, or both.

Recent clinical studies

Etiology

Suwal S, Chen YY, Huang SD, Li WF, Chen H
Curr Med Imaging 2024;20:1-8. doi: 10.2174/0115734056259584231112105510. PMID: 38389359
Qiu G, Wang F, Wang Y
J Cancer Res Clin Oncol 2024 Jan 16;150(1):11. doi: 10.1007/s00432-023-05522-3. PMID: 38227201Free PMC Article
Alkaaki A, Abo Al-Saud A, Di Lena É, Ramirez-GarciaLuna JL, Najmeh S, Spicer J, Ferri L, Mulder D, Sirois C, Cools-Lartigue J
Eur J Cardiothorac Surg 2022 Oct 4;62(5) doi: 10.1093/ejcts/ezac274. PMID: 35471455
Wang ZM, Li F, Sarigül L, Nachira D, Gonzalez-Rivas D, Badakhshi H, Rückert JC, Ng CSH, Ismail M
Eur J Cardiothorac Surg 2022 Oct 4;62(5) doi: 10.1093/ejcts/ezac210. PMID: 35404403
Billè A, Bilkhu R, Benedetti G, Lucchese G
Tumori 2022 Oct;108(5):477-485. Epub 2021 Jun 22 doi: 10.1177/03008916211023154. PMID: 34156895Free PMC Article

Diagnosis

Li LY, Zhao HY, Tong HC, Li YC, Xu HT, Ma S, Yang LH, Zhang WL, Wildes T, Wang E
Medicine (Baltimore) 2023 Jun 2;102(22):e33847. doi: 10.1097/MD.0000000000033847. PMID: 37266641Free PMC Article
Alkaaki A, Abo Al-Saud A, Di Lena É, Ramirez-GarciaLuna JL, Najmeh S, Spicer J, Ferri L, Mulder D, Sirois C, Cools-Lartigue J
Eur J Cardiothorac Surg 2022 Oct 4;62(5) doi: 10.1093/ejcts/ezac274. PMID: 35471455
Wang ZM, Li F, Sarigül L, Nachira D, Gonzalez-Rivas D, Badakhshi H, Rückert JC, Ng CSH, Ismail M
Eur J Cardiothorac Surg 2022 Oct 4;62(5) doi: 10.1093/ejcts/ezac210. PMID: 35404403
Shin DW, Cho JH, Ha J, Jung KW
J Thorac Oncol 2022 Jun;17(6):827-837. Epub 2022 Feb 11 doi: 10.1016/j.jtho.2022.02.001. PMID: 35158083
Pan J, Lin W, Zong L, Wen J, Jiang F, Chen G
Ann Palliat Med 2022 Apr;11(4):1575-1581. Epub 2021 Jun 25 doi: 10.21037/apm-21-86. PMID: 34263608

Therapy

Darwish D
Asian Pac J Cancer Prev 2016;17(2):771-4. doi: 10.7314/apjcp.2016.17.2.771. PMID: 26925678
CHALMERS JN, BOHEIMER K
Br Med J 1954 Dec 25;2(4903):1514-8. doi: 10.1136/bmj.2.4903.1514. PMID: 13209164Free PMC Article

Prognosis

Qiu G, Wang F, Wang Y
J Cancer Res Clin Oncol 2024 Jan 16;150(1):11. doi: 10.1007/s00432-023-05522-3. PMID: 38227201Free PMC Article
Li LY, Zhao HY, Tong HC, Li YC, Xu HT, Ma S, Yang LH, Zhang WL, Wildes T, Wang E
Medicine (Baltimore) 2023 Jun 2;102(22):e33847. doi: 10.1097/MD.0000000000033847. PMID: 37266641Free PMC Article
Alkaaki A, Abo Al-Saud A, Di Lena É, Ramirez-GarciaLuna JL, Najmeh S, Spicer J, Ferri L, Mulder D, Sirois C, Cools-Lartigue J
Eur J Cardiothorac Surg 2022 Oct 4;62(5) doi: 10.1093/ejcts/ezac274. PMID: 35471455
Wang ZM, Li F, Sarigül L, Nachira D, Gonzalez-Rivas D, Badakhshi H, Rückert JC, Ng CSH, Ismail M
Eur J Cardiothorac Surg 2022 Oct 4;62(5) doi: 10.1093/ejcts/ezac210. PMID: 35404403
Shin DW, Cho JH, Ha J, Jung KW
J Thorac Oncol 2022 Jun;17(6):827-837. Epub 2022 Feb 11 doi: 10.1016/j.jtho.2022.02.001. PMID: 35158083

Clinical prediction guides

Suwal S, Chen YY, Huang SD, Li WF, Chen H
Curr Med Imaging 2024;20:1-8. doi: 10.2174/0115734056259584231112105510. PMID: 38389359
Alkaaki A, Abo Al-Saud A, Di Lena É, Ramirez-GarciaLuna JL, Najmeh S, Spicer J, Ferri L, Mulder D, Sirois C, Cools-Lartigue J
Eur J Cardiothorac Surg 2022 Oct 4;62(5) doi: 10.1093/ejcts/ezac274. PMID: 35471455
Wang ZM, Li F, Sarigül L, Nachira D, Gonzalez-Rivas D, Badakhshi H, Rückert JC, Ng CSH, Ismail M
Eur J Cardiothorac Surg 2022 Oct 4;62(5) doi: 10.1093/ejcts/ezac210. PMID: 35404403
Vardhana S, Hamlin PA, Yang J, Zelenetz A, Sauter CS, Matasar MJ, Ni A, Yahalom J, Moskowitz CH
Biol Blood Marrow Transplant 2018 Oct;24(10):2133-2138. Epub 2018 Jun 15 doi: 10.1016/j.bbmt.2018.06.009. PMID: 29909154Free PMC Article
Darwish D
Asian Pac J Cancer Prev 2016;17(2):771-4. doi: 10.7314/apjcp.2016.17.2.771. PMID: 26925678

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