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Male germ cell tumors (GCT), 2 subtypes -

MedGen UID:
376465
•Concept ID:
C1848889
•
Finding

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMale germ cell tumors (GCT), 2 subtypes -

Professional guidelines

PubMed

The role of surgical management in pediatric germ cell tumors (GCTs), NCI case series.
Fakhr IM, Khalil el-SA, El-Baradie TS, Shaalan MA, Shalaby LM, Nassif SL, Farahat IG
J Egypt Natl Canc Inst 2008 Mar;20(1):70-9. PMID: 19847284
Mismatch repair gene expression and genetic instability in testicular germ cell tumor.
Velasco A, Riquelme E, Schultz M, Wistuba II, Villarroel L, Pizarro J, Berlin A, Ittmann M, Koh MS, Leach FS
Cancer Biol Ther 2004 Oct;3(10):977-82. Epub 2004 Oct 2 doi: 10.4161/cbt.3.10.1135. PMID: 15467433

Recent clinical studies

Etiology

Associations between birth defects and childhood and adolescent germ cell tumors according to sex, histologic subtype, and site.
Schraw JM, Sok P, Desrosiers TA, Janitz AE, Langlois PH, Canfield MA, Frazier AL, Plon SE, Lupo PJ, Poynter JN
Cancer 2023 Oct 15;129(20):3300-3308. Epub 2023 Jun 27 doi: 10.1002/cncr.34906. PMID: 37366624Free PMC Article
Pediatric Extracranial Germ Cell Tumors: Expression of microRNA.
Saliyeva S, Boranbayeva R, Konoplya N, Bulegenova M, Blau O, Belousov V, Granica J, Mukushkina D, Altynbayeva G
J Pediatr Hematol Oncol 2023 Mar 1;45(2):e174-e179. Epub 2022 Jun 7 doi: 10.1097/MPH.0000000000002495. PMID: 35700382
Histopathology and prognosis of germ cell tumors metastatic to brain: cohort study.
Takami H, Graffeo CS, Perry A, Ohno M, Ishida J, Giannini C, Narita Y, Nakazato Y, Saito N, Nishikawa R, Matsutani M, Ichimura K, Daniels DJ
J Neurooncol 2021 Aug;154(1):121-130. Epub 2021 Jul 16 doi: 10.1007/s11060-021-03810-x. PMID: 34272633
Increased levels of XPA might be the basis of cisplatin resistance in germ cell tumours.
Cierna Z, Miskovska V, Roska J, Jurkovicova D, Pulzova LB, Sestakova Z, Hurbanova L, Machalekova K, Chovanec M, Rejlekova K, Svetlovska D, Kalavska K, Kajo K, Babal P, Mardiak J, Ward TA, Mego M, Chovanec M
BMC Cancer 2020 Jan 6;20(1):17. doi: 10.1186/s12885-019-6496-1. PMID: 31906898Free PMC Article
Testicular epidermoid cysts: a reevaluation.
Anheuser P, Kranz J, Stolle E, Höflmayer D, Büscheck F, Mühlstädt S, Lock G, Dieckmann KP
BMC Urol 2019 Jun 11;19(1):52. doi: 10.1186/s12894-019-0477-1. PMID: 31185974Free PMC Article

Diagnosis

Pediatric Extracranial Germ Cell Tumors: Expression of microRNA.
Saliyeva S, Boranbayeva R, Konoplya N, Bulegenova M, Blau O, Belousov V, Granica J, Mukushkina D, Altynbayeva G
J Pediatr Hematol Oncol 2023 Mar 1;45(2):e174-e179. Epub 2022 Jun 7 doi: 10.1097/MPH.0000000000002495. PMID: 35700382
Histopathology and prognosis of germ cell tumors metastatic to brain: cohort study.
Takami H, Graffeo CS, Perry A, Ohno M, Ishida J, Giannini C, Narita Y, Nakazato Y, Saito N, Nishikawa R, Matsutani M, Ichimura K, Daniels DJ
J Neurooncol 2021 Aug;154(1):121-130. Epub 2021 Jul 16 doi: 10.1007/s11060-021-03810-x. PMID: 34272633
Imaging diagnosis of basal ganglia germ cell tumors: subtype features subtype imaging features of GCTs.
Li W, Kong X, Ma J
Br J Radiol 2021 Jun 1;94(1122):20201453. Epub 2021 Apr 29 doi: 10.1259/bjr.20201453. PMID: 33914622Free PMC Article
Parental occupation and childhood germ cell tumors: a case-control study in Denmark, 1968-2016.
Hall C, Hansen J, Olsen J, He D, von Ehrenstein OS, Ritz B, Heck JE
Cancer Causes Control 2021 Aug;32(8):827-836. Epub 2021 Apr 28 doi: 10.1007/s10552-021-01434-0. PMID: 33907877Free PMC Article
Testicular epidermoid cysts: a reevaluation.
Anheuser P, Kranz J, Stolle E, Höflmayer D, Büscheck F, Mühlstädt S, Lock G, Dieckmann KP
BMC Urol 2019 Jun 11;19(1):52. doi: 10.1186/s12894-019-0477-1. PMID: 31185974Free PMC Article

Therapy

Parental occupation and childhood germ cell tumors: a case-control study in Denmark, 1968-2016.
Hall C, Hansen J, Olsen J, He D, von Ehrenstein OS, Ritz B, Heck JE
Cancer Causes Control 2021 Aug;32(8):827-836. Epub 2021 Apr 28 doi: 10.1007/s10552-021-01434-0. PMID: 33907877Free PMC Article
Long-term follow-up of intensive chemotherapy followed by reduced-dose and reduced-field irradiation for intracranial germ cell tumor.
Takada A, Ii N, Hirayama M, Toyoda H, Matsubara T, Toyomasu Y, Kawamura T, Daimon T, Sakuma H, Nomoto Y
J Neurosurg Pediatr 2018 Nov 23;23(3):317-324. doi: 10.3171/2018.9.PEDS18181. PMID: 30497152
Risk of malignant childhood germ cell tumors in relation to demographic, gestational, and perinatal characteristics.
Hall C, Ritz B, Cockburn M, Davidson TB, Heck JE
Cancer Epidemiol 2017 Feb;46:42-49. Epub 2016 Dec 23 doi: 10.1016/j.canep.2016.12.002. PMID: 28013088Free PMC Article

Prognosis

Histopathology and prognosis of germ cell tumors metastatic to brain: cohort study.
Takami H, Graffeo CS, Perry A, Ohno M, Ishida J, Giannini C, Narita Y, Nakazato Y, Saito N, Nishikawa R, Matsutani M, Ichimura K, Daniels DJ
J Neurooncol 2021 Aug;154(1):121-130. Epub 2021 Jul 16 doi: 10.1007/s11060-021-03810-x. PMID: 34272633
Lymph node density in retroperitoneal lymph node dissection as a novel marker for predicting recurrence in patients with germ cell testicular cancer: A case-control study and long-term clinical experience of a tertiary referral hospital.
Sarikaya S, Karsiyakali N, Kaya E, Topuz B, Ebiloglu T, Zor M
Actas Urol Esp (Engl Ed) 2021 Jan-Feb;45(1):30-38. Epub 2020 Oct 1 doi: 10.1016/j.acuro.2020.03.014. PMID: 33010987
Increased levels of XPA might be the basis of cisplatin resistance in germ cell tumours.
Cierna Z, Miskovska V, Roska J, Jurkovicova D, Pulzova LB, Sestakova Z, Hurbanova L, Machalekova K, Chovanec M, Rejlekova K, Svetlovska D, Kalavska K, Kajo K, Babal P, Mardiak J, Ward TA, Mego M, Chovanec M
BMC Cancer 2020 Jan 6;20(1):17. doi: 10.1186/s12885-019-6496-1. PMID: 31906898Free PMC Article
Long-term follow-up of intensive chemotherapy followed by reduced-dose and reduced-field irradiation for intracranial germ cell tumor.
Takada A, Ii N, Hirayama M, Toyoda H, Matsubara T, Toyomasu Y, Kawamura T, Daimon T, Sakuma H, Nomoto Y
J Neurosurg Pediatr 2018 Nov 23;23(3):317-324. doi: 10.3171/2018.9.PEDS18181. PMID: 30497152
βcatenin is a marker of poor clinical characteristics and suppressed immune infiltration in testicular germ cell tumors.
Chovanec M, Cierna Z, Miskovska V, Machalekova K, Kalavska K, Rejlekova K, Svetlovska D, Macak D, Spanik S, Kajo K, Babal P, Mego M, Mardiak J
BMC Cancer 2018 Nov 3;18(1):1062. doi: 10.1186/s12885-018-4929-x. PMID: 30390643Free PMC Article

Clinical prediction guides

Associations between birth defects and childhood and adolescent germ cell tumors according to sex, histologic subtype, and site.
Schraw JM, Sok P, Desrosiers TA, Janitz AE, Langlois PH, Canfield MA, Frazier AL, Plon SE, Lupo PJ, Poynter JN
Cancer 2023 Oct 15;129(20):3300-3308. Epub 2023 Jun 27 doi: 10.1002/cncr.34906. PMID: 37366624Free PMC Article
Pediatric Extracranial Germ Cell Tumors: Expression of microRNA.
Saliyeva S, Boranbayeva R, Konoplya N, Bulegenova M, Blau O, Belousov V, Granica J, Mukushkina D, Altynbayeva G
J Pediatr Hematol Oncol 2023 Mar 1;45(2):e174-e179. Epub 2022 Jun 7 doi: 10.1097/MPH.0000000000002495. PMID: 35700382
Histopathology and prognosis of germ cell tumors metastatic to brain: cohort study.
Takami H, Graffeo CS, Perry A, Ohno M, Ishida J, Giannini C, Narita Y, Nakazato Y, Saito N, Nishikawa R, Matsutani M, Ichimura K, Daniels DJ
J Neurooncol 2021 Aug;154(1):121-130. Epub 2021 Jul 16 doi: 10.1007/s11060-021-03810-x. PMID: 34272633
Parental occupation and childhood germ cell tumors: a case-control study in Denmark, 1968-2016.
Hall C, Hansen J, Olsen J, He D, von Ehrenstein OS, Ritz B, Heck JE
Cancer Causes Control 2021 Aug;32(8):827-836. Epub 2021 Apr 28 doi: 10.1007/s10552-021-01434-0. PMID: 33907877Free PMC Article
Proteomic Comparison of Malignant Human Germ Cell Tumor Cell Lines.
Bremmer F, Bohnenberger H, Küffer S, Oellerich T, Serve H, Urlaub H, Strauss A, Maatoug Y, Behnes CL, Oing C, Radzun HJ, Ströbel P, Balabanov S, Honecker F
Dis Markers 2019;2019:8298524. Epub 2019 Sep 3 doi: 10.1155/2019/8298524. PMID: 31565104Free PMC Article

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