U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Zygodactyly type 1

MedGen UID:
377870
•Concept ID:
C1853294
•
Disease or Syndrome
Synonym: Zygodactyly 1
 
Monarch Initiative: MONDO:0012351
OMIM®: 609815
Orphanet: ORPHA295187

Definition

Syndactyly type I (185900) is an autosomal dominant limb malformation characterized in its classic form by complete or partial webbing between the third and fourth fingers and/or the second and third toes. Malik et al. (2005) classified a subtype of type I syndactyly in which webbing of second and third toes occurs without hand involvement as 'zygodactyly.' [from OMIM]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVZygodactyly type 1
Follow this link to review classifications for Zygodactyly type 1 in Orphanet.

Recent clinical studies

Etiology

Utilization of electronic portal referrals to a community agency for children presenting with an asthma exacerbation to a pediatric emergency department.
Kannikeswaran N, Spencer P, Carcone A, Huth M, Mehmood Y, Ellis D
J Asthma 2024 Apr;61(4):307-312. Epub 2023 Oct 25 doi: 10.1080/02770903.2023.2272796. PMID: 37847783Free PMC Article
Peripartum hysterectomy clinical characteristics and outcomes- a hospital based retrospective audit study.
Nor AM, Jagdeesh K, Mohd FAS, Kamraul AK, Yusmadi A, Noraslawati R, Malina O, Roziana R
Med J Malaysia 2023 Nov;78(6):756-762. PMID: 38031217
Heart rate variability at rest and in response to stress: Comparative study between hemodialysis and peritoneal dialysis patients.
Faitatzidou D, Dipla K, Theodorakopoulou MP, Koutlas A, Tsitouridis A, Dimitriadis C, Pateinakis P, Zafeiridis A, Papagianni A, Jadoul M, Sarafidis P
Exp Biol Med (Maywood) 2023 Oct;248(20):1745-1753. Epub 2023 Nov 2 doi: 10.1177/15353702231198081. PMID: 37916412Free PMC Article
Probiotics of Lacticaseibacillus paracasei SD1 and Lacticaseibacillus rhamnosus SD11 attenuate inflammation and β-cell death in streptozotocin-induced type 1 diabetic mice.
Nopparat J, Khuituan P, Peerakietkhajorn S, Teanpaisan R
PLoS One 2023;18(4):e0284303. Epub 2023 Apr 11 doi: 10.1371/journal.pone.0284303. PMID: 37040355Free PMC Article
Evidence for clinical and genetic heterogeneity of syndactyly type I: the phenotype of second and third toe syndactyly maps to chromosome 3p21.31.
Malik S, Schott J, Ali SW, Oeffner F, Amin-ud-Din M, Ahmad W, Grzeschik KH, Koch MC
Eur J Hum Genet 2005 Dec;13(12):1268-74. doi: 10.1038/sj.ejhg.5201492. PMID: 16189548

Diagnosis

Utilization of electronic portal referrals to a community agency for children presenting with an asthma exacerbation to a pediatric emergency department.
Kannikeswaran N, Spencer P, Carcone A, Huth M, Mehmood Y, Ellis D
J Asthma 2024 Apr;61(4):307-312. Epub 2023 Oct 25 doi: 10.1080/02770903.2023.2272796. PMID: 37847783Free PMC Article
Peripartum hysterectomy clinical characteristics and outcomes- a hospital based retrospective audit study.
Nor AM, Jagdeesh K, Mohd FAS, Kamraul AK, Yusmadi A, Noraslawati R, Malina O, Roziana R
Med J Malaysia 2023 Nov;78(6):756-762. PMID: 38031217
The Effect of Auditory Stimulation on the Nonlinear Dynamics of Heart Rate: The Impact of Emotional Valence and Arousal.
Dimitriev D, Indeykina O, Dimitriev A
Noise Health 2023 Jul-Sep;25(118):165-175. doi: 10.4103/nah.nah_15_22. PMID: 37815078Free PMC Article
Muscle metaboreflex activation during hypercapnia modifies nonlinear heart rhythm dynamics, increasing the complexity of the sinus node autonomic regulation in humans.
Delliaux S, Ichinose M, Watanabe K, Fujii N, Nishiyasu T
Pflugers Arch 2023 Apr;475(4):527-539. Epub 2023 Jan 16 doi: 10.1007/s00424-022-02780-x. PMID: 36645512
Study on the nonfatigue and fatigue states of orchard workers based on electrocardiogram signal analysis.
Gao R, Yan H, Duan J, Gao Y, Cao C, Li L, Guo L
Sci Rep 2022 Mar 22;12(1):4858. doi: 10.1038/s41598-022-08705-z. PMID: 35318355Free PMC Article

Therapy

Peripartum hysterectomy clinical characteristics and outcomes- a hospital based retrospective audit study.
Nor AM, Jagdeesh K, Mohd FAS, Kamraul AK, Yusmadi A, Noraslawati R, Malina O, Roziana R
Med J Malaysia 2023 Nov;78(6):756-762. PMID: 38031217
A Nonrandomized Trial of the Effects of Passive Simulated Jogging on Short-Term Heart Rate Variability in Type 2 Diabetic Subjects.
Adams JA, Lopez JR, Banderas V, Sackner MA
J Diabetes Res 2023;2023:4454396. Epub 2023 Apr 11 doi: 10.1155/2023/4454396. PMID: 37082380Free PMC Article
Probiotics of Lacticaseibacillus paracasei SD1 and Lacticaseibacillus rhamnosus SD11 attenuate inflammation and β-cell death in streptozotocin-induced type 1 diabetic mice.
Nopparat J, Khuituan P, Peerakietkhajorn S, Teanpaisan R
PLoS One 2023;18(4):e0284303. Epub 2023 Apr 11 doi: 10.1371/journal.pone.0284303. PMID: 37040355Free PMC Article
Study on the nonfatigue and fatigue states of orchard workers based on electrocardiogram signal analysis.
Gao R, Yan H, Duan J, Gao Y, Cao C, Li L, Guo L
Sci Rep 2022 Mar 22;12(1):4858. doi: 10.1038/s41598-022-08705-z. PMID: 35318355Free PMC Article
Limb anomalies in chromosomal aberrations.
Pfeiffer RA, Santelmann R
Birth Defects Orig Artic Ser 1977;13(1):319-37. PMID: 322750

Prognosis

Effect of Delta and Omicron Mutations on the RBD-SD1 Domain of the Spike Protein in SARS-CoV-2 and the Omicron Mutations on RBD-ACE2 Interface Complex.
Ching WY, Adhikari P, Jawad B, Podgornik R
Int J Mol Sci 2022 Sep 3;23(17) doi: 10.3390/ijms231710091. PMID: 36077490Free PMC Article
Factors important in the correct evaluation of oral high-risk lesions during the telehealth era.
Czerninski R, Mordekovich N, Basile J
J Oral Pathol Med 2022 Sep;51(8):747-754. Epub 2022 Aug 23 doi: 10.1111/jop.13343. PMID: 36053963Free PMC Article
Evidence for clinical and genetic heterogeneity of syndactyly type I: the phenotype of second and third toe syndactyly maps to chromosome 3p21.31.
Malik S, Schott J, Ali SW, Oeffner F, Amin-ud-Din M, Ahmad W, Grzeschik KH, Koch MC
Eur J Hum Genet 2005 Dec;13(12):1268-74. doi: 10.1038/sj.ejhg.5201492. PMID: 16189548

Clinical prediction guides

Peripartum hysterectomy clinical characteristics and outcomes- a hospital based retrospective audit study.
Nor AM, Jagdeesh K, Mohd FAS, Kamraul AK, Yusmadi A, Noraslawati R, Malina O, Roziana R
Med J Malaysia 2023 Nov;78(6):756-762. PMID: 38031217
Heart rate variability at rest and in response to stress: Comparative study between hemodialysis and peritoneal dialysis patients.
Faitatzidou D, Dipla K, Theodorakopoulou MP, Koutlas A, Tsitouridis A, Dimitriadis C, Pateinakis P, Zafeiridis A, Papagianni A, Jadoul M, Sarafidis P
Exp Biol Med (Maywood) 2023 Oct;248(20):1745-1753. Epub 2023 Nov 2 doi: 10.1177/15353702231198081. PMID: 37916412Free PMC Article
Linked homozygous BMPR1B and PDHA2 variants in a consanguineous family with complex digit malformation and male infertility.
Yıldırım Y, Ouriachi T, Woehlbier U, Ouahioune W, Balkan M, Malik S, Tolun A
Eur J Hum Genet 2018 Jun;26(6):876-885. Epub 2018 Mar 26 doi: 10.1038/s41431-018-0121-7. PMID: 29581481Free PMC Article
Evidence for clinical and genetic heterogeneity of syndactyly type I: the phenotype of second and third toe syndactyly maps to chromosome 3p21.31.
Malik S, Schott J, Ali SW, Oeffner F, Amin-ud-Din M, Ahmad W, Grzeschik KH, Koch MC
Eur J Hum Genet 2005 Dec;13(12):1268-74. doi: 10.1038/sj.ejhg.5201492. PMID: 16189548
Limb anomalies in chromosomal aberrations.
Pfeiffer RA, Santelmann R
Birth Defects Orig Artic Ser 1977;13(1):319-37. PMID: 322750

Supplemental Content

Table of contents

    Clinical resources

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • OMIM
      Related records in OMIM
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed
    • PubMed (OMIM)
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...