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Zygodactyly type 1

MedGen UID:
377870
•Concept ID:
C1853294
•
Disease or Syndrome
Synonym: Zygodactyly 1
 
Monarch Initiative: MONDO:0012351
OMIM®: 609815
Orphanet: ORPHA295187

Definition

Syndactyly type I (185900) is an autosomal dominant limb malformation characterized in its classical form by complete or partial webbing between the third and fourth fingers and/or the second and third toes. Zygodactyly is a subtype of type I syndactyly in which webbing of second and third toes occurs without hand involvement (summary by Malik et al., 2005). [from OMIM]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVZygodactyly type 1
Follow this link to review classifications for Zygodactyly type 1 in Orphanet.

Recent clinical studies

Etiology

Peripartum hysterectomy clinical characteristics and outcomes- a hospital based retrospective audit study.
Nor AM, Jagdeesh K, Mohd FAS, Kamraul AK, Yusmadi A, Noraslawati R, Malina O, Roziana R
Med J Malaysia 2023 Nov;78(6):756-762. PMID: 38031217
Heart rate variability at rest and in response to stress: Comparative study between hemodialysis and peritoneal dialysis patients.
Faitatzidou D, Dipla K, Theodorakopoulou MP, Koutlas A, Tsitouridis A, Dimitriadis C, Pateinakis P, Zafeiridis A, Papagianni A, Jadoul M, Sarafidis P
Exp Biol Med (Maywood) 2023 Oct;248(20):1745-1753. Epub 2023 Nov 2 doi: 10.1177/15353702231198081. PMID: 37916412Free PMC Article
Longitudinal outcomes for educational placement and quality of life in a prospectively recruited multinational cohort of children with cochlear implants.
Muller L, Goh BS, Cordovés AP, Sargsyan G, Sikka K, Singh S, Qiu J, Xu L, Graham PL, James CJ, Greenham P
Int J Pediatr Otorhinolaryngol 2023 Jul;170:111583. Epub 2023 May 23 doi: 10.1016/j.ijporl.2023.111583. PMID: 37245391
Probiotics of Lacticaseibacillus paracasei SD1 and Lacticaseibacillus rhamnosus SD11 attenuate inflammation and β-cell death in streptozotocin-induced type 1 diabetic mice.
Nopparat J, Khuituan P, Peerakietkhajorn S, Teanpaisan R
PLoS One 2023;18(4):e0284303. Epub 2023 Apr 11 doi: 10.1371/journal.pone.0284303. PMID: 37040355Free PMC Article
Evidence for clinical and genetic heterogeneity of syndactyly type I: the phenotype of second and third toe syndactyly maps to chromosome 3p21.31.
Malik S, Schott J, Ali SW, Oeffner F, Amin-ud-Din M, Ahmad W, Grzeschik KH, Koch MC
Eur J Hum Genet 2005 Dec;13(12):1268-74. doi: 10.1038/sj.ejhg.5201492. PMID: 16189548

Diagnosis

Utilization of electronic portal referrals to a community agency for children presenting with an asthma exacerbation to a pediatric emergency department.
Kannikeswaran N, Spencer P, Carcone A, Huth M, Mehmood Y, Ellis D
J Asthma 2024 Apr;61(4):307-312. Epub 2023 Oct 25 doi: 10.1080/02770903.2023.2272796. PMID: 37847783Free PMC Article
Peripartum hysterectomy clinical characteristics and outcomes- a hospital based retrospective audit study.
Nor AM, Jagdeesh K, Mohd FAS, Kamraul AK, Yusmadi A, Noraslawati R, Malina O, Roziana R
Med J Malaysia 2023 Nov;78(6):756-762. PMID: 38031217
Muscle metaboreflex activation during hypercapnia modifies nonlinear heart rhythm dynamics, increasing the complexity of the sinus node autonomic regulation in humans.
Delliaux S, Ichinose M, Watanabe K, Fujii N, Nishiyasu T
Pflugers Arch 2023 Apr;475(4):527-539. Epub 2023 Jan 16 doi: 10.1007/s00424-022-02780-x. PMID: 36645512
Factors important in the correct evaluation of oral high-risk lesions during the telehealth era.
Czerninski R, Mordekovich N, Basile J
J Oral Pathol Med 2022 Sep;51(8):747-754. Epub 2022 Aug 23 doi: 10.1111/jop.13343. PMID: 36053963Free PMC Article
Study on the nonfatigue and fatigue states of orchard workers based on electrocardiogram signal analysis.
Gao R, Yan H, Duan J, Gao Y, Cao C, Li L, Guo L
Sci Rep 2022 Mar 22;12(1):4858. doi: 10.1038/s41598-022-08705-z. PMID: 35318355Free PMC Article

Therapy

Peripartum hysterectomy clinical characteristics and outcomes- a hospital based retrospective audit study.
Nor AM, Jagdeesh K, Mohd FAS, Kamraul AK, Yusmadi A, Noraslawati R, Malina O, Roziana R
Med J Malaysia 2023 Nov;78(6):756-762. PMID: 38031217
A Nonrandomized Trial of the Effects of Passive Simulated Jogging on Short-Term Heart Rate Variability in Type 2 Diabetic Subjects.
Adams JA, Lopez JR, Banderas V, Sackner MA
J Diabetes Res 2023;2023:4454396. Epub 2023 Apr 11 doi: 10.1155/2023/4454396. PMID: 37082380Free PMC Article
Probiotics of Lacticaseibacillus paracasei SD1 and Lacticaseibacillus rhamnosus SD11 attenuate inflammation and β-cell death in streptozotocin-induced type 1 diabetic mice.
Nopparat J, Khuituan P, Peerakietkhajorn S, Teanpaisan R
PLoS One 2023;18(4):e0284303. Epub 2023 Apr 11 doi: 10.1371/journal.pone.0284303. PMID: 37040355Free PMC Article
Study on the nonfatigue and fatigue states of orchard workers based on electrocardiogram signal analysis.
Gao R, Yan H, Duan J, Gao Y, Cao C, Li L, Guo L
Sci Rep 2022 Mar 22;12(1):4858. doi: 10.1038/s41598-022-08705-z. PMID: 35318355Free PMC Article
Limb anomalies in chromosomal aberrations.
Pfeiffer RA, Santelmann R
Birth Defects Orig Artic Ser 1977;13(1):319-37. PMID: 322750

Prognosis

Effect of Delta and Omicron Mutations on the RBD-SD1 Domain of the Spike Protein in SARS-CoV-2 and the Omicron Mutations on RBD-ACE2 Interface Complex.
Ching WY, Adhikari P, Jawad B, Podgornik R
Int J Mol Sci 2022 Sep 3;23(17) doi: 10.3390/ijms231710091. PMID: 36077490Free PMC Article
Factors important in the correct evaluation of oral high-risk lesions during the telehealth era.
Czerninski R, Mordekovich N, Basile J
J Oral Pathol Med 2022 Sep;51(8):747-754. Epub 2022 Aug 23 doi: 10.1111/jop.13343. PMID: 36053963Free PMC Article
Evidence for clinical and genetic heterogeneity of syndactyly type I: the phenotype of second and third toe syndactyly maps to chromosome 3p21.31.
Malik S, Schott J, Ali SW, Oeffner F, Amin-ud-Din M, Ahmad W, Grzeschik KH, Koch MC
Eur J Hum Genet 2005 Dec;13(12):1268-74. doi: 10.1038/sj.ejhg.5201492. PMID: 16189548

Clinical prediction guides

Peripartum hysterectomy clinical characteristics and outcomes- a hospital based retrospective audit study.
Nor AM, Jagdeesh K, Mohd FAS, Kamraul AK, Yusmadi A, Noraslawati R, Malina O, Roziana R
Med J Malaysia 2023 Nov;78(6):756-762. PMID: 38031217
Is Musical Auditory Stimulation Able to Influence the Recovery of Autonomic Modulation After Exercise?
Loch Gomes R, Ribeiro F, Engrácia Valenti V, França Da Silva AK, Almeida Gonzaga L, Martins Pérego S, Luiz de Marco R, Marques Vanderlei LC
Altern Ther Health Med 2023 Mar;29(2):236-242. PMID: 33609347
Linked homozygous BMPR1B and PDHA2 variants in a consanguineous family with complex digit malformation and male infertility.
Yıldırım Y, Ouriachi T, Woehlbier U, Ouahioune W, Balkan M, Malik S, Tolun A
Eur J Hum Genet 2018 Jun;26(6):876-885. Epub 2018 Mar 26 doi: 10.1038/s41431-018-0121-7. PMID: 29581481Free PMC Article
Evidence for clinical and genetic heterogeneity of syndactyly type I: the phenotype of second and third toe syndactyly maps to chromosome 3p21.31.
Malik S, Schott J, Ali SW, Oeffner F, Amin-ud-Din M, Ahmad W, Grzeschik KH, Koch MC
Eur J Hum Genet 2005 Dec;13(12):1268-74. doi: 10.1038/sj.ejhg.5201492. PMID: 16189548
Limb anomalies in chromosomal aberrations.
Pfeiffer RA, Santelmann R
Birth Defects Orig Artic Ser 1977;13(1):319-37. PMID: 322750

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