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Skin squamous cell carcinoma in situ

MedGen UID:
378389
Concept ID:
C2314897
Neoplastic Process
Synonyms: Cancer in situ skin, squamous cell; IEC - Intraepidermal carcinoma of skin; Intraepidermal carcinoma of skin; Intraepidermal Squamous Cell Carcinoma; intraepidermal squamous cell carcinoma; SCC - Squamous cell carcinoma in situ of skin; skin squamous cell cancer in situ; Skin Squamous Cell Carcinoma In Situ; skin squamous cell carcinoma in situ; Squamous cell carcinoma in situ of skin; Squamous Cell Carcinoma in situ of Skin; squamous cell carcinoma in situ of skin; Squamous Cell Carcinoma in situ of the Skin; squamous cell carcinoma in situ of the skin
SNOMED CT: Cancer in situ skin, squamous cell (254656002); IEC - Intraepidermal carcinoma of skin (254656002); SCC - Squamous cell carcinoma in situ of skin (254656002); Intraepidermal carcinoma of skin (254656002); Squamous cell carcinoma in situ of skin (254656002)
 
Monarch Initiative: MONDO:0020760

Definition

Intraepidermal squamous cell carcinoma, confined to the epidermis. There is no evidence of invasion. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSkin squamous cell carcinoma in situ

Professional guidelines

PubMed

Chattopadhyay S, Hemminki A, Försti A, Sundquist K, Sundquist J, Hemminki K
J Invest Dermatol 2020 Jan;140(1):48-55.e1. Epub 2019 Jul 6 doi: 10.1016/j.jid.2019.04.031. PMID: 31288011

Recent clinical studies

Etiology

Firnhaber JM
Am Fam Physician 2020 Sep 15;102(6):339-346. PMID: 32931212
Willenbrink TJ, Ruiz ES, Cornejo CM, Schmults CD, Arron ST, Jambusaria-Pahlajani A
J Am Acad Dermatol 2020 Sep;83(3):709-717. Epub 2020 May 7 doi: 10.1016/j.jaad.2020.03.126. PMID: 32387665
Ventura A, Pellegrini C, Cardelli L, Rocco T, Ciciarelli V, Peris K, Fargnoli MC
Int J Mol Sci 2019 Mar 16;20(6) doi: 10.3390/ijms20061333. PMID: 30884806Free PMC Article
Moch H, Cubilla AL, Humphrey PA, Reuter VE, Ulbright TM
Eur Urol 2016 Jul;70(1):93-105. Epub 2016 Feb 28 doi: 10.1016/j.eururo.2016.02.029. PMID: 26935559
Thompson AK, Kelley BF, Prokop LJ, Murad MH, Baum CL
JAMA Dermatol 2016 Apr;152(4):419-28. doi: 10.1001/jamadermatol.2015.4994. PMID: 26762219Free PMC Article

Diagnosis

Firnhaber JM
Am Fam Physician 2020 Sep 15;102(6):339-346. PMID: 32931212
Weber P, Tschandl P, Sinz C, Kittler H
Curr Treat Options Oncol 2018 Sep 20;19(11):56. doi: 10.1007/s11864-018-0573-6. PMID: 30238167Free PMC Article
Wozniak-Rito AM, Rudnicka L
Acta Dermatovenerol Croat 2018 Jun;26(2):157-161. PMID: 29989873
Ferrándiz C, Malvehy J, Guillén C, Ferrándiz-Pulido C, Fernández-Figueras M
Actas Dermosifiliogr 2017 Jan-Feb;108(1):31-41. Epub 2016 Sep 20 doi: 10.1016/j.ad.2016.07.016. PMID: 27658688
Watson PH, Leygue ER, Murphy LC
Int J Biochem Cell Biol 1998 May;30(5):567-71. doi: 10.1016/s1357-2725(97)00066-6. PMID: 9693957

Therapy

Li Y, Wu J, Cao Z
Environ Sci Pollut Res Int 2023 Dec;30(58):122011-122023. Epub 2023 Nov 14 doi: 10.1007/s11356-023-30535-3. PMID: 37962759Free PMC Article
Willenbrink TJ, Ruiz ES, Cornejo CM, Schmults CD, Arron ST, Jambusaria-Pahlajani A
J Am Acad Dermatol 2020 Sep;83(3):709-717. Epub 2020 May 7 doi: 10.1016/j.jaad.2020.03.126. PMID: 32387665
Ferrándiz C, Malvehy J, Guillén C, Ferrándiz-Pulido C, Fernández-Figueras M
Actas Dermosifiliogr 2017 Jan-Feb;108(1):31-41. Epub 2016 Sep 20 doi: 10.1016/j.ad.2016.07.016. PMID: 27658688
Thompson AK, Kelley BF, Prokop LJ, Murad MH, Baum CL
JAMA Dermatol 2016 Apr;152(4):419-28. doi: 10.1001/jamadermatol.2015.4994. PMID: 26762219Free PMC Article
Shannon RL, Strayer DS
Hum Toxicol 1989 Mar;8(2):99-104. doi: 10.1177/096032718900800203. PMID: 2663702

Prognosis

Zou DD, Sun YZ, Li XJ, Wu WJ, Xu D, He YT, Qi J, Tu Y, Tang Y, Tu YH, Wang XL, Li X, Lu FY, Huang L, Long H, He L, Li X
Elife 2023 Dec 15;12 doi: 10.7554/eLife.85270. PMID: 38099574Free PMC Article
Li Y, Wu J, Cao Z
Environ Sci Pollut Res Int 2023 Dec;30(58):122011-122023. Epub 2023 Nov 14 doi: 10.1007/s11356-023-30535-3. PMID: 37962759Free PMC Article
Willenbrink TJ, Ruiz ES, Cornejo CM, Schmults CD, Arron ST, Jambusaria-Pahlajani A
J Am Acad Dermatol 2020 Sep;83(3):709-717. Epub 2020 May 7 doi: 10.1016/j.jaad.2020.03.126. PMID: 32387665
Ventura A, Pellegrini C, Cardelli L, Rocco T, Ciciarelli V, Peris K, Fargnoli MC
Int J Mol Sci 2019 Mar 16;20(6) doi: 10.3390/ijms20061333. PMID: 30884806Free PMC Article
Murphy R
Dermatol Clin 2010 Oct;28(4):707-15. doi: 10.1016/j.det.2010.07.006. PMID: 20883914

Clinical prediction guides

Li Y, Wu J, Cao Z
Environ Sci Pollut Res Int 2023 Dec;30(58):122011-122023. Epub 2023 Nov 14 doi: 10.1007/s11356-023-30535-3. PMID: 37962759Free PMC Article
Ventura A, Pellegrini C, Cardelli L, Rocco T, Ciciarelli V, Peris K, Fargnoli MC
Int J Mol Sci 2019 Mar 16;20(6) doi: 10.3390/ijms20061333. PMID: 30884806Free PMC Article
Teichman JM, Sea J, Thompson IM, Elston DM
Am Fam Physician 2010 Jan 15;81(2):167-74. PMID: 20082512
Brash DE, Pontén J
Cancer Surv 1998;32:69-113. PMID: 10489624
Shannon RL, Strayer DS
Hum Toxicol 1989 Mar;8(2):99-104. doi: 10.1177/096032718900800203. PMID: 2663702

Recent systematic reviews

Labadie JG, Ibrahim SA, Worley B, Kang BY, Rakita U, Rigali S, Arndt KA, Bernstein E, Brauer JA, Chandra S, Didwania A, DiGiorgio C, Donelan M, Dover JS, Galadari H, Geronemus RG, Goldman MP, Haedersdal M, Hruza G, Ibrahimi OA, Kauvar A, Kelly KM, Krakowski AC, Miest R, Orringer JS, Ozog DM, Ross EV, Shumaker PR, Sobanko JF, Suozzi K, Taylor MB, Teng JMC, Uebelhoer NS, Waibel J, Wanner M, Ratchev I, Christensen RE, Poon E, Miller CH, Alam M
JAMA Dermatol 2022 Oct 1;158(10):1193-1201. doi: 10.1001/jamadermatol.2022.3234. PMID: 35976634
Ning AY, Levoska MA, Zheng DX, Carroll BT, Wong CY
Dermatol Surg 2022 Mar 1;48(3):267-273. doi: 10.1097/DSS.0000000000003319. PMID: 34889218
Ang JM, Riaz IB, Kamal MU, Paragh G, Zeitouni NC
Photodiagnosis Photodyn Ther 2017 Sep;19:308-344. Epub 2017 Jul 15 doi: 10.1016/j.pdpdt.2017.07.002. PMID: 28716738
Nguyen KP, Peppelman M, Hoogedoorn L, Van Erp PE, Gerritsen MP
Eur J Dermatol 2016 Dec 1;26(6):549-565. doi: 10.1684/ejd.2016.2872. PMID: 28007674
Thompson AK, Kelley BF, Prokop LJ, Murad MH, Baum CL
JAMA Dermatol 2016 Apr;152(4):419-28. doi: 10.1001/jamadermatol.2015.4994. PMID: 26762219Free PMC Article

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