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IgM Multiple Myeloma (not Waldenstrom Macroglobulinemia)

MedGen UID:
378602
•Concept ID:
C2347304
•
Finding
Synonym: IgM Type Multiple Myeloma (not Waldenstrom Macroglobulinemia)

Definition

A finding of multiple myeloma in which the heavy chain of the immunoglobulin M is defective. This finding is seen in other lymphocytic/plasmacytic disorders as well, including Waldenstrom macroglobulinemia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIgM Multiple Myeloma (not Waldenstrom Macroglobulinemia)

Professional guidelines

PubMed

Ibrutinib and venetoclax as primary therapy in symptomatic, treatment-naïve Waldenström macroglobulinemia.
Castillo JJ, Branagan AR, Sermer D, Flynn CA, Meid K, Little M, Stockman K, White T, Canning A, Guerrera ML, Kofides A, Liu S, Liu X, Richardson K, Tsakmaklis N, Patterson CJ, Hunter ZR, Treon SP, Sarosiek S
Blood 2024 Feb 15;143(7):582-591. doi: 10.1182/blood.2023022420. PMID: 37971194Free PMC Article
Report of consensus Panel 4 from the 11th International Workshop on Waldenstrom's macroglobulinemia on diagnostic and response criteria.
Treon SP, Tedeschi A, San-Miguel J, Garcia-Sanz R, Anderson KC, Kimby E, Minnema MC, Benevolo G, Qiu L, Yi S, Terpos E, Tam CS, Castillo JJ, Morel P, Dimopoulos M, Owen RG
Semin Hematol 2023 Mar;60(2):97-106. Epub 2023 Apr 20 doi: 10.1053/j.seminhematol.2023.03.009. PMID: 37173155
Lymphoplasmacytic lymphoma and Waldenström macroglobulinaemia: clinicopathological features and differential diagnosis.
Wang W, Lin P
Pathology 2020 Jan;52(1):6-14. Epub 2019 Nov 22 doi: 10.1016/j.pathol.2019.09.009. PMID: 31767130

Recent clinical studies

Etiology

Report of consensus Panel 4 from the 11th International Workshop on Waldenstrom's macroglobulinemia on diagnostic and response criteria.
Treon SP, Tedeschi A, San-Miguel J, Garcia-Sanz R, Anderson KC, Kimby E, Minnema MC, Benevolo G, Qiu L, Yi S, Terpos E, Tam CS, Castillo JJ, Morel P, Dimopoulos M, Owen RG
Semin Hematol 2023 Mar;60(2):97-106. Epub 2023 Apr 20 doi: 10.1053/j.seminhematol.2023.03.009. PMID: 37173155
IgM Plasma Cell Myeloma.
Lu H, Durkin L, Zhao X, Nakashima MO
Am J Clin Pathol 2022 Jan 6;157(1):47-53. doi: 10.1093/ajcp/aqab095. PMID: 34508562
Are you sure this is Waldenstrom macroglobulinemia?
Ghobrial IM
Hematology Am Soc Hematol Educ Program 2012;2012:586-94. doi: 10.1182/asheducation-2012.1.586. PMID: 23233639
Paraproteinemic neuropathies.
Vital A
Brain Pathol 2001 Oct;11(4):399-407. doi: 10.1111/j.1750-3639.2001.tb00407.x. PMID: 11556684Free PMC Article
Benign monoclonal gammapathy.
Waldenström JG
Acta Med Scand 1984;216(5):435-47. doi: 10.1111/j.0954-6820.1984.tb05032.x. PMID: 6441456

Diagnosis

Report of consensus Panel 4 from the 11th International Workshop on Waldenstrom's macroglobulinemia on diagnostic and response criteria.
Treon SP, Tedeschi A, San-Miguel J, Garcia-Sanz R, Anderson KC, Kimby E, Minnema MC, Benevolo G, Qiu L, Yi S, Terpos E, Tam CS, Castillo JJ, Morel P, Dimopoulos M, Owen RG
Semin Hematol 2023 Mar;60(2):97-106. Epub 2023 Apr 20 doi: 10.1053/j.seminhematol.2023.03.009. PMID: 37173155
IgM Plasma Cell Myeloma.
Lu H, Durkin L, Zhao X, Nakashima MO
Am J Clin Pathol 2022 Jan 6;157(1):47-53. doi: 10.1093/ajcp/aqab095. PMID: 34508562
Lymphoplasmacytic lymphoma and Waldenström macroglobulinaemia: clinicopathological features and differential diagnosis.
Wang W, Lin P
Pathology 2020 Jan;52(1):6-14. Epub 2019 Nov 22 doi: 10.1016/j.pathol.2019.09.009. PMID: 31767130
MYD88 L265P somatic mutation in Waldenström's macroglobulinemia.
Treon SP, Xu L, Yang G, Zhou Y, Liu X, Cao Y, Sheehy P, Manning RJ, Patterson CJ, Tripsas C, Arcaini L, Pinkus GS, Rodig SJ, Sohani AR, Harris NL, Laramie JM, Skifter DA, Lincoln SE, Hunter ZR
N Engl J Med 2012 Aug 30;367(9):826-33. doi: 10.1056/NEJMoa1200710. PMID: 22931316
Polyneuropathy in paraproteinaemia.
Meier C
J Neurol 1985;232(4):204-14. doi: 10.1007/BF00313781. PMID: 2995596

Therapy

Systemic Amyloidosis due to Low-Grade Lymphoma.
Wechalekar AD, Chakraborty R, Lentzsch S
Hematol Oncol Clin North Am 2020 Dec;34(6):1027-1039. Epub 2020 Oct 1 doi: 10.1016/j.hoc.2020.08.016. PMID: 33099421
A safety profile of medications used to treat Waldenström's macroglobulinemia.
García-Sanz R, Jiménez C, González De La Calle V, Sarasquete ME
Expert Opin Drug Saf 2018 Jun;17(6):609-621. Epub 2018 Jun 6 doi: 10.1080/14740338.2018.1477936. PMID: 29768934
Atypical IgM multiple myeloma with deletion of c-MAF.
Juárez Salcedo LM, López Rubio M, Gil Fernández JJ, Garcia-Suarez J, Magro E, Arranz E, Gutiérrez Jomarrón I, Marcellini Antonio S, Blasco A, Burgaleta C
Int J Lab Hematol 2015 Oct;37(5):686-9. Epub 2015 May 20 doi: 10.1111/ijlh.12385. PMID: 25996654
Renal involvement in Waldenström's macroglobulinemia: case report and review of literature.
Salviani C, Guido G, Serriello I, Giannakakis K, Rocca AR
Ren Fail 2014 Feb;36(1):114-8. Epub 2013 Sep 24 doi: 10.3109/0886022X.2013.832859. PMID: 24059636
Neuropathy and monoclonal gammopathy.
Nobile-Orazio E
Handb Clin Neurol 2013;115:443-59. doi: 10.1016/B978-0-444-52902-2.00025-4. PMID: 23931795

Prognosis

Monoclonal Gammopathy of Undetermined Significance (MGUS)Monoclonal Gammopathy of Undetermined Significance (MGUS).
Viera S, Ludek P, Zdeněk A, Marta K, Martin Š, Sabina Š, Zdeněk K
Klin Onkol 2018 Summer;31(4):270-276. doi: 10.14735/amko2018270. PMID: 30541309
Are you sure this is Waldenstrom macroglobulinemia?
Ghobrial IM
Hematology Am Soc Hematol Educ Program 2012;2012:586-94. doi: 10.1182/asheducation-2012.1.586. PMID: 23233639
MYD88 L265P somatic mutation in Waldenström's macroglobulinemia.
Treon SP, Xu L, Yang G, Zhou Y, Liu X, Cao Y, Sheehy P, Manning RJ, Patterson CJ, Tripsas C, Arcaini L, Pinkus GS, Rodig SJ, Sohani AR, Harris NL, Laramie JM, Skifter DA, Lincoln SE, Hunter ZR
N Engl J Med 2012 Aug 30;367(9):826-33. doi: 10.1056/NEJMoa1200710. PMID: 22931316
IgM multiple myeloma: disease definition, prognosis, and differentiation from Waldenstrom's macroglobulinemia.
Schuster SR, Rajkumar SV, Dispenzieri A, Morice W, Aspitia AM, Ansell S, Kyle R, Mikhael J
Am J Hematol 2010 Nov;85(11):853-5. doi: 10.1002/ajh.21845. PMID: 20842638Free PMC Article
Benign monoclonal gammapathy.
Waldenström JG
Acta Med Scand 1984;216(5):435-47. doi: 10.1111/j.0954-6820.1984.tb05032.x. PMID: 6441456

Clinical prediction guides

Monoclonal Gammopathy of Undetermined Significance (MGUS)Monoclonal Gammopathy of Undetermined Significance (MGUS).
Viera S, Ludek P, Zdeněk A, Marta K, Martin Š, Sabina Š, Zdeněk K
Klin Onkol 2018 Summer;31(4):270-276. doi: 10.14735/amko2018270. PMID: 30541309
The clinical relevance and management of monoclonal gammopathy of undetermined significance and related disorders: recommendations from the European Myeloma Network.
van de Donk NW, Palumbo A, Johnsen HE, Engelhardt M, Gay F, Gregersen H, Hajek R, Kleber M, Ludwig H, Morgan G, Musto P, Plesner T, Sezer O, Terpos E, Waage A, Zweegman S, Einsele H, Sonneveld P, Lokhorst HM; European Myeloma Network
Haematologica 2014 Jun;99(6):984-96. Epub 2014 Mar 21 doi: 10.3324/haematol.2013.100552. PMID: 24658815Free PMC Article
MYD88 L265P somatic mutation in Waldenström's macroglobulinemia.
Treon SP, Xu L, Yang G, Zhou Y, Liu X, Cao Y, Sheehy P, Manning RJ, Patterson CJ, Tripsas C, Arcaini L, Pinkus GS, Rodig SJ, Sohani AR, Harris NL, Laramie JM, Skifter DA, Lincoln SE, Hunter ZR
N Engl J Med 2012 Aug 30;367(9):826-33. doi: 10.1056/NEJMoa1200710. PMID: 22931316
Benign monoclonal gammapathy.
Waldenström JG
Acta Med Scand 1984;216(5):435-47. doi: 10.1111/j.0954-6820.1984.tb05032.x. PMID: 6441456
Blood volume in monoclonal gammopathy.
Alexanian R
Blood 1977 Feb;49(2):301-7. PMID: 401657

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