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IgM Multiple Myeloma (not Waldenstrom Macroglobulinemia)

MedGen UID:
378602
Concept ID:
C2347304
Finding
Synonym: IgM Type Multiple Myeloma (not Waldenstrom Macroglobulinemia)

Definition

A finding of multiple myeloma in which the heavy chain of the immunoglobulin M is defective. This finding is seen in other lymphocytic/plasmacytic disorders as well, including Waldenstrom macroglobulinemia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIgM Multiple Myeloma (not Waldenstrom Macroglobulinemia)

Professional guidelines

PubMed

Castillo JJ, Branagan AR, Sermer D, Flynn CA, Meid K, Little M, Stockman K, White T, Canning A, Guerrera ML, Kofides A, Liu S, Liu X, Richardson K, Tsakmaklis N, Patterson CJ, Hunter ZR, Treon SP, Sarosiek S
Blood 2024 Feb 15;143(7):582-591. doi: 10.1182/blood.2023022420. PMID: 37971194Free PMC Article
Wang W, Lin P
Pathology 2020 Jan;52(1):6-14. Epub 2019 Nov 22 doi: 10.1016/j.pathol.2019.09.009. PMID: 31767130
Rosenbaum E, Marks D, Raza S
Hematol Oncol 2018 Feb;36(1):3-14. Epub 2017 Apr 10 doi: 10.1002/hon.2417. PMID: 28397326

Recent clinical studies

Etiology

Lu H, Durkin L, Zhao X, Nakashima MO
Am J Clin Pathol 2022 Jan 6;157(1):47-53. doi: 10.1093/ajcp/aqab095. PMID: 34508562
Bazarbachi AH, Avet-Loiseau H, Szalat R, Samur AA, Hunter Z, Shammas M, Corre J, Fulciniti M, Anderson KC, Parmigiani G, Treon SP, Mohty M, Munshi NC, Samur MK
Blood 2021 Nov 18;138(20):1980-1985. doi: 10.1182/blood.2021011452. PMID: 34792571Free PMC Article
Ghobrial IM
Hematology Am Soc Hematol Educ Program 2012;2012:586-94. doi: 10.1182/asheducation-2012.1.586. PMID: 23233639
Vital A
Brain Pathol 2001 Oct;11(4):399-407. doi: 10.1111/j.1750-3639.2001.tb00407.x. PMID: 11556684Free PMC Article
Waldenström JG
Acta Med Scand 1984;216(5):435-47. doi: 10.1111/j.0954-6820.1984.tb05032.x. PMID: 6441456

Diagnosis

Mahmood F, Ahmed B, Thalody V, Mehdi S
BMJ Case Rep 2024 Jan 4;17(1) doi: 10.1136/bcr-2022-253328. PMID: 38176750Free PMC Article
Lu H, Durkin L, Zhao X, Nakashima MO
Am J Clin Pathol 2022 Jan 6;157(1):47-53. doi: 10.1093/ajcp/aqab095. PMID: 34508562
Wang W, Lin P
Pathology 2020 Jan;52(1):6-14. Epub 2019 Nov 22 doi: 10.1016/j.pathol.2019.09.009. PMID: 31767130
Tedeschi A, Conticello C, Rizzi R, Benevolo G, Laurenti L, Petrucci MT, Zaja F, Varettoni M
Hematol Oncol 2019 Apr;37(2):117-128. Epub 2018 Sep 7 doi: 10.1002/hon.2539. PMID: 30192023
Winfield JB
Hum Pathol 1983 Apr;14(4):350-4. doi: 10.1016/s0046-8177(83)80121-x. PMID: 6219936

Therapy

Wechalekar AD, Chakraborty R, Lentzsch S
Hematol Oncol Clin North Am 2020 Dec;34(6):1027-1039. Epub 2020 Oct 1 doi: 10.1016/j.hoc.2020.08.016. PMID: 33099421
Elba S, Castellino A, Soriasio R, Castellino C, Bonferroni M, Mattei D, Strola G, Drandi D, Mordini N, Foglietta M, Rapezzi D, Celeghini I, Grasso M, Giordano F, Fraternali Orcioni G, Massaia M
J Med Case Rep 2020 Jun 22;14(1):75. doi: 10.1186/s13256-020-02380-2. PMID: 32564775Free PMC Article
García-Sanz R, Jiménez C, González De La Calle V, Sarasquete ME
Expert Opin Drug Saf 2018 Jun;17(6):609-621. Epub 2018 Jun 6 doi: 10.1080/14740338.2018.1477936. PMID: 29768934
Juárez Salcedo LM, López Rubio M, Gil Fernández JJ, Garcia-Suarez J, Magro E, Arranz E, Gutiérrez Jomarrón I, Marcellini Antonio S, Blasco A, Burgaleta C
Int J Lab Hematol 2015 Oct;37(5):686-9. Epub 2015 May 20 doi: 10.1111/ijlh.12385. PMID: 25996654
Nobile-Orazio E
Handb Clin Neurol 2013;115:443-59. doi: 10.1016/B978-0-444-52902-2.00025-4. PMID: 23931795

Prognosis

Elba S, Castellino A, Soriasio R, Castellino C, Bonferroni M, Mattei D, Strola G, Drandi D, Mordini N, Foglietta M, Rapezzi D, Celeghini I, Grasso M, Giordano F, Fraternali Orcioni G, Massaia M
J Med Case Rep 2020 Jun 22;14(1):75. doi: 10.1186/s13256-020-02380-2. PMID: 32564775Free PMC Article
Viera S, Ludek P, Zdeněk A, Marta K, Martin Š, Sabina Š, Zdeněk K
Klin Onkol 2018 Summer;31(4):270-276. doi: 10.14735/amko2018270. PMID: 30541309
Ghobrial IM
Hematology Am Soc Hematol Educ Program 2012;2012:586-94. doi: 10.1182/asheducation-2012.1.586. PMID: 23233639
Schuster SR, Rajkumar SV, Dispenzieri A, Morice W, Aspitia AM, Ansell S, Kyle R, Mikhael J
Am J Hematol 2010 Nov;85(11):853-5. doi: 10.1002/ajh.21845. PMID: 20842638Free PMC Article
Waldenström JG
Acta Med Scand 1984;216(5):435-47. doi: 10.1111/j.0954-6820.1984.tb05032.x. PMID: 6441456

Clinical prediction guides

Viera S, Ludek P, Zdeněk A, Marta K, Martin Š, Sabina Š, Zdeněk K
Klin Onkol 2018 Summer;31(4):270-276. doi: 10.14735/amko2018270. PMID: 30541309
Steiner N, Schwärzler A, Göbel G, Löscher W, Wanschitz J, Gunsilius E
Oncotarget 2017 Jan 17;8(3):5081-5091. doi: 10.18632/oncotarget.13861. PMID: 27974705Free PMC Article
van de Donk NW, Palumbo A, Johnsen HE, Engelhardt M, Gay F, Gregersen H, Hajek R, Kleber M, Ludwig H, Morgan G, Musto P, Plesner T, Sezer O, Terpos E, Waage A, Zweegman S, Einsele H, Sonneveld P, Lokhorst HM; European Myeloma Network
Haematologica 2014 Jun;99(6):984-96. Epub 2014 Mar 21 doi: 10.3324/haematol.2013.100552. PMID: 24658815Free PMC Article
Morra E, Cesana C, Klersy C, Barbarano L, Varettoni M, Cavanna L, Canesi B, Tresoldi E, Miqueleiz S, Bernuzzi P, Nosari AM, Lazzarino M
Leukemia 2004 Sep;18(9):1512-7. doi: 10.1038/sj.leu.2403442. PMID: 15322559
Waldenström JG
Acta Med Scand 1984;216(5):435-47. doi: 10.1111/j.0954-6820.1984.tb05032.x. PMID: 6441456

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