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Progression of Multiple Myeloma or Plasma Cell Leukemia

MedGen UID:
378702
Concept ID:
C2347692
Finding
Synonym: Progressive Disease of Multiple Myeloma or Plasma Cell Leukemia

Definition

Progression of multiple myeloma or plasma cell leukemia requires any one or more of the following: Increase of 25% or more from baseline in: serum M-component with an absolute increase 0.5 g/dL or more (for progressive disease, serum M-component increases of 1 g/dL or more are sufficient to define relapse if the starting M component is 5 g/dL or more); urine M-component with an absolute increase 200 mg. or more/ 24 hours; for recipients without measurable serum and urine M-protein levels: the difference between involved and uninvolved free light chain levels (absolute increase more than 10 mg/dL); bone marrow plasma cell percentage (absolute percentage 10% or more); definite development of new bone lesions or soft tissue plasmacytomas, or definite increase in the size of any existing bone lesions or soft tissue plasmacytomas; development of hypercalcemia (corrected serum calcium more than 11.5 mg/dL or 2.65 mmol) that can be attributed solely to the plasma cell proliferative disorder. Progression of disease requires two consecutive assessments made at any time before classification as disease progression, and/or the institution of any new therapy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVProgression of Multiple Myeloma or Plasma Cell Leukemia

Professional guidelines

PubMed

Rajkumar SV
Am J Hematol 2022 Aug;97(8):1086-1107. Epub 2022 May 23 doi: 10.1002/ajh.26590. PMID: 35560063Free PMC Article
Cowan AJ, Green DJ, Kwok M, Lee S, Coffey DG, Holmberg LA, Tuazon S, Gopal AK, Libby EN
JAMA 2022 Feb 1;327(5):464-477. doi: 10.1001/jama.2022.0003. PMID: 35103762
Rajkumar SV
Am Soc Clin Oncol Educ Book 2016;35:e418-23. doi: 10.1200/EDBK_159009. PMID: 27249749

Recent clinical studies

Etiology

Gonsalves WI, Rajkumar SV
Ann Intern Med 2022 Dec;175(12):ITC177-ITC192. Epub 2022 Dec 13 doi: 10.7326/AITC202212200. PMID: 36508741
Rajkumar SV, Kumar S, Lonial S, Mateos MV
Blood Cancer J 2022 Sep 5;12(9):129. doi: 10.1038/s41408-022-00719-0. PMID: 36064707Free PMC Article
van de Donk NWCJ, Pawlyn C, Yong KL
Lancet 2021 Jan 30;397(10272):410-427. doi: 10.1016/S0140-6736(21)00135-5. PMID: 33516340
Brigle K, Rogers B
Semin Oncol Nurs 2017 Aug;33(3):225-236. Epub 2017 Jul 5 doi: 10.1016/j.soncn.2017.05.012. PMID: 28688533
Rajkumar SV, Landgren O, Mateos MV
Blood 2015 May 14;125(20):3069-75. Epub 2015 Apr 2 doi: 10.1182/blood-2014-09-568899. PMID: 25838344Free PMC Article

Diagnosis

Gowin K, Skerget S, Keats JJ, Mikhael J, Cowan AJ
Leuk Res 2021 Dec;111:106687. Epub 2021 Aug 17 doi: 10.1016/j.leukres.2021.106687. PMID: 34425325
van de Donk NWCJ, Pawlyn C, Yong KL
Lancet 2021 Jan 30;397(10272):410-427. doi: 10.1016/S0140-6736(21)00135-5. PMID: 33516340
Gundesen MT, Lund T, Moeller HEH, Abildgaard N
Curr Oncol Rep 2019 Jan 28;21(1):8. doi: 10.1007/s11912-019-0754-x. PMID: 30689121Free PMC Article
Brigle K, Rogers B
Semin Oncol Nurs 2017 Aug;33(3):225-236. Epub 2017 Jul 5 doi: 10.1016/j.soncn.2017.05.012. PMID: 28688533
Rajkumar SV, Landgren O, Mateos MV
Blood 2015 May 14;125(20):3069-75. Epub 2015 Apr 2 doi: 10.1182/blood-2014-09-568899. PMID: 25838344Free PMC Article

Therapy

John L, Poos AM, Brobeil A, Schinke C, Huhn S, Prokoph N, Lutz R, Wagner B, Zangari M, Tirier SM, Mallm JP, Schumacher S, Vonficht D, Solé-Boldo L, Quick S, Steiger S, Przybilla MJ, Bauer K, Baumann A, Hemmer S, Rehnitz C, Lückerath C, Sachpekidis C, Mechtersheimer G, Haberkorn U, Dimitrakopoulou-Strauss A, Reichert P, Barlogie B, Müller-Tidow C, Goldschmidt H, Hillengass J, Rasche L, Haas SF, van Rhee F, Rippe K, Raab MS, Sauer S, Weinhold N
Nat Commun 2023 Aug 17;14(1):5011. doi: 10.1038/s41467-023-40584-4. PMID: 37591845Free PMC Article
Sonneveld P, Chanan-Khan A, Weisel K, Nooka AK, Masszi T, Beksac M, Spicka I, Hungria V, Munder M, Mateos MV, Mark TM, Levin MD, Ahmadi T, Qin X, Garvin Mayo W, Gai X, Carey J, Carson R, Spencer A
J Clin Oncol 2023 Mar 10;41(8):1600-1609. Epub 2022 Nov 22 doi: 10.1200/JCO.21.02734. PMID: 36413710Free PMC Article
Sklavenitis-Pistofidis R, Aranha MP, Redd RA, Baginska J, Haradhvala NJ, Hallisey M, Dutta AK, Savell A, Varmeh S, Heilpern-Mallory D, Ujwary S, Zavidij O, Aguet F, Su NK, Lightbody ED, Bustoros M, Tahri S, Mouhieddine TH, Wu T, Flechon L, Anand S, Rosenblatt JM, Zonder J, Vredenburgh JJ, Boruchov A, Bhutani M, Usmani SZ, Matous J, Yee AJ, Jakubowiak A, Laubach J, Manier S, Nadeem O, Richardson P, Badros AZ, Mateos MV, Trippa L, Getz G, Ghobrial IM
Cancer Cell 2022 Nov 14;40(11):1358-1373.e8. doi: 10.1016/j.ccell.2022.10.017. PMID: 36379208Free PMC Article
McCarthy PL, Holstein SA, Petrucci MT, Richardson PG, Hulin C, Tosi P, Bringhen S, Musto P, Anderson KC, Caillot D, Gay F, Moreau P, Marit G, Jung SH, Yu Z, Winograd B, Knight RD, Palumbo A, Attal M
J Clin Oncol 2017 Oct 10;35(29):3279-3289. Epub 2017 Jul 25 doi: 10.1200/JCO.2017.72.6679. PMID: 28742454Free PMC Article
Yong K, Delforge M, Driessen C, Fink L, Flinois A, Gonzalez-McQuire S, Safaei R, Karlin L, Mateos MV, Raab MS, Schoen P, Cavo M
Br J Haematol 2016 Oct;175(2):252-264. Epub 2016 Jul 13 doi: 10.1111/bjh.14213. PMID: 27411022Free PMC Article

Prognosis

Gowin K, Skerget S, Keats JJ, Mikhael J, Cowan AJ
Leuk Res 2021 Dec;111:106687. Epub 2021 Aug 17 doi: 10.1016/j.leukres.2021.106687. PMID: 34425325
Gundesen MT, Lund T, Moeller HEH, Abildgaard N
Curr Oncol Rep 2019 Jan 28;21(1):8. doi: 10.1007/s11912-019-0754-x. PMID: 30689121Free PMC Article
Brigle K, Rogers B
Semin Oncol Nurs 2017 Aug;33(3):225-236. Epub 2017 Jul 5 doi: 10.1016/j.soncn.2017.05.012. PMID: 28688533
Rajkumar SV, Landgren O, Mateos MV
Blood 2015 May 14;125(20):3069-75. Epub 2015 Apr 2 doi: 10.1182/blood-2014-09-568899. PMID: 25838344Free PMC Article
Kyle RA, Durie BG, Rajkumar SV, Landgren O, Blade J, Merlini G, Kröger N, Einsele H, Vesole DH, Dimopoulos M, San Miguel J, Avet-Loiseau H, Hajek R, Chen WM, Anderson KC, Ludwig H, Sonneveld P, Pavlovsky S, Palumbo A, Richardson PG, Barlogie B, Greipp P, Vescio R, Turesson I, Westin J, Boccadoro M; International Myeloma Working Group
Leukemia 2010 Jun;24(6):1121-7. Epub 2010 Apr 22 doi: 10.1038/leu.2010.60. PMID: 20410922Free PMC Article

Clinical prediction guides

Dang M, Wang R, Lee HC, Patel KK, Becnel MR, Han G, Thomas SK, Hao D, Chu Y, Weber DM, Lin P, Lutter-Berka Z, Berrios Nolasco DA, Huang M, Bansal H, Song X, Zhang J, Futreal A, Moreno Rueda LY, Symer DE, Green MR, Rojas Hernandez CM, Kroll M, Afshar-Khargan V, Ndacayisaba LJ, Kuhn P, Neelapu SS, Orlowski RZ, Wang L, Manasanch EE
Cancer Cell 2023 Jun 12;41(6):1032-1047.e4. doi: 10.1016/j.ccell.2023.05.007. PMID: 37311413Free PMC Article
Rajkumar SV, Kumar S, Lonial S, Mateos MV
Blood Cancer J 2022 Sep 5;12(9):129. doi: 10.1038/s41408-022-00719-0. PMID: 36064707Free PMC Article
Gundesen MT, Lund T, Moeller HEH, Abildgaard N
Curr Oncol Rep 2019 Jan 28;21(1):8. doi: 10.1007/s11912-019-0754-x. PMID: 30689121Free PMC Article
McCarthy PL, Holstein SA, Petrucci MT, Richardson PG, Hulin C, Tosi P, Bringhen S, Musto P, Anderson KC, Caillot D, Gay F, Moreau P, Marit G, Jung SH, Yu Z, Winograd B, Knight RD, Palumbo A, Attal M
J Clin Oncol 2017 Oct 10;35(29):3279-3289. Epub 2017 Jul 25 doi: 10.1200/JCO.2017.72.6679. PMID: 28742454Free PMC Article
Brigle K, Rogers B
Semin Oncol Nurs 2017 Aug;33(3):225-236. Epub 2017 Jul 5 doi: 10.1016/j.soncn.2017.05.012. PMID: 28688533

Recent systematic reviews

Minakata D, Fujiwara SI, Yokoyama D, Noguchi A, Aoe S, Oyama T, Koyama S, Murahashi R, Nakashima H, Hyodo K, Ikeda T, Kawaguchi SI, Toda Y, Ito S, Nagayama T, Mashima K, Umino K, Morita K, Ashizawa M, Yamamoto C, Hatano K, Sato K, Ohmine K, Kanda Y
Br J Haematol 2023 Mar;200(6):694-703. Epub 2023 Jan 20 doi: 10.1111/bjh.18654. PMID: 36661264
Pasqui DM, Latorraca CDOC, Pacheco RL, Riera R
Eur J Haematol 2022 Dec;109(6):601-618. Epub 2022 Sep 18 doi: 10.1111/ejh.13851. PMID: 36018500
Yang Q, Li X, Zhang F, Yang Q, Zhou W, Liu J
Int J Med Sci 2021;18(8):1786-1797. Epub 2021 Feb 18 doi: 10.7150/ijms.46811. PMID: 33746596Free PMC Article
Roex G, Timmers M, Wouters K, Campillo-Davo D, Flumens D, Schroyens W, Chu Y, Berneman ZN, Lion E, Luo F, Anguille S
J Hematol Oncol 2020 Dec 3;13(1):164. doi: 10.1186/s13045-020-01001-1. PMID: 33272302Free PMC Article
Scott K, Hayden PJ, Will A, Wheatley K, Coyne I
Cochrane Database Syst Rev 2016 Apr 20;4(4):CD010816. doi: 10.1002/14651858.CD010816.pub2. PMID: 27096326Free PMC Article

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