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Saccadic intrusion

MedGen UID:
381405
•Concept ID:
C1854375
•
Anatomical Abnormality
Synonym: Saccadic intrusions
 
HPO: HP:0032114

Definition

An involuntary abnormality of fixation in which there is an abnormal saccade away from fixation followed by a delayed corrective saccade. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSaccadic intrusion

Professional guidelines

PubMed

Opsoclonus and ocular flutter: evaluation and management.
Grossman SN, Rucker JC
Curr Opin Ophthalmol 2023 Nov 1;34(6):465-469. Epub 2023 Aug 21 doi: 10.1097/ICU.0000000000000998. PMID: 37603546
The differential diagnostic value of a battery of oculomotor evaluation in Parkinson's Disease and Multiple System Atrophy.
Zhou H, Wang X, Ma D, Jiang Y, Li F, Sun Y, Chen J, Sun W, Pinkhardt EH, Landwehrmeyer B, Ludolph A, Zhang L, Zhao G, Wang Z
Brain Behav 2021 Jul;11(7):e02184. Epub 2021 May 30 doi: 10.1002/brb3.2184. PMID: 34056874Free PMC Article
Classification of vestibular signs and examination techniques: Nystagmus and nystagmus-like movements.
Eggers SDZ, Bisdorff A, von Brevern M, Zee DS, Kim JS, Perez-Fernandez N, Welgampola MS, Della Santina CC, Newman-Toker DE
J Vestib Res 2019;29(2-3):57-87. doi: 10.3233/VES-190658. PMID: 31256095Free PMC Article

Recent clinical studies

Etiology

Saccadic oscillations as a biomarker of clinical symptoms in amyotrophic lateral sclerosis.
Nakamagoe K, Matsumoto S, Touno N, Tateno I, Koganezawa T
Neurol Sci 2023 Aug;44(8):2787-2793. Epub 2023 Mar 6 doi: 10.1007/s10072-023-06719-7. PMID: 36872386
Abnormal Saccadic Intrusions with Alzheimer's Disease in Darkness.
Nakamagoe K, Yamada S, Kawakami R, Koganezawa T, Tamaoka A
Curr Alzheimer Res 2019;16(4):293-301. doi: 10.2174/1567205016666190311102130. PMID: 30854969
Saccades during attempted fixation in parkinsonian disorders and recessive ataxia: from microsaccades to square-wave jerks.
Otero-Millan J, Schneider R, Leigh RJ, Macknik SL, Martinez-Conde S
PLoS One 2013;8(3):e58535. Epub 2013 Mar 13 doi: 10.1371/journal.pone.0058535. PMID: 23516502Free PMC Article

Diagnosis

Saccadic oscillations as a biomarker of clinical symptoms in amyotrophic lateral sclerosis.
Nakamagoe K, Matsumoto S, Touno N, Tateno I, Koganezawa T
Neurol Sci 2023 Aug;44(8):2787-2793. Epub 2023 Mar 6 doi: 10.1007/s10072-023-06719-7. PMID: 36872386
Neurovisual Assessment in Children with Ataxia Telangiectasia.
Iodice A, Galli J, Molinaro A, Franzoni A, Micheli R, Pinelli L, Plebani A, Soresina A, Fazzi E
Neuropediatrics 2018 Feb;49(1):26-34. Epub 2017 Oct 9 doi: 10.1055/s-0037-1607216. PMID: 28992644
Saccades during attempted fixation in parkinsonian disorders and recessive ataxia: from microsaccades to square-wave jerks.
Otero-Millan J, Schneider R, Leigh RJ, Macknik SL, Martinez-Conde S
PLoS One 2013;8(3):e58535. Epub 2013 Mar 13 doi: 10.1371/journal.pone.0058535. PMID: 23516502Free PMC Article
Ocular fixation instabilities in motor neurone disease. A marker of frontal lobe dysfunction?
Donaghy C, Pinnock R, Abrahams S, Cardwell C, Hardiman O, Patterson V, McGivern RC, Gibson JM
J Neurol 2009 Mar;256(3):420-6. Epub 2009 Mar 18 doi: 10.1007/s00415-009-0109-x. PMID: 19306041
Characterisation of ocular fixation in humans by analysis of saccadic intrusions and fixation periods: a pragmatic approach.
Canice McGivern R, Mark Gibson J
Vision Res 2006 Oct;46(21):3741-7. Epub 2006 Aug 4 doi: 10.1016/j.visres.2006.05.016. PMID: 16889812

Prognosis

Saccadic oscillations as a biomarker of clinical symptoms in amyotrophic lateral sclerosis.
Nakamagoe K, Matsumoto S, Touno N, Tateno I, Koganezawa T
Neurol Sci 2023 Aug;44(8):2787-2793. Epub 2023 Mar 6 doi: 10.1007/s10072-023-06719-7. PMID: 36872386

Clinical prediction guides

Saccadic oscillations as a biomarker of clinical symptoms in amyotrophic lateral sclerosis.
Nakamagoe K, Matsumoto S, Touno N, Tateno I, Koganezawa T
Neurol Sci 2023 Aug;44(8):2787-2793. Epub 2023 Mar 6 doi: 10.1007/s10072-023-06719-7. PMID: 36872386
Abnormal Saccadic Intrusions with Alzheimer's Disease in Darkness.
Nakamagoe K, Yamada S, Kawakami R, Koganezawa T, Tamaoka A
Curr Alzheimer Res 2019;16(4):293-301. doi: 10.2174/1567205016666190311102130. PMID: 30854969
Neurovisual Assessment in Children with Ataxia Telangiectasia.
Iodice A, Galli J, Molinaro A, Franzoni A, Micheli R, Pinelli L, Plebani A, Soresina A, Fazzi E
Neuropediatrics 2018 Feb;49(1):26-34. Epub 2017 Oct 9 doi: 10.1055/s-0037-1607216. PMID: 28992644
Characterisation of ocular fixation in humans by analysis of saccadic intrusions and fixation periods: a pragmatic approach.
Canice McGivern R, Mark Gibson J
Vision Res 2006 Oct;46(21):3741-7. Epub 2006 Aug 4 doi: 10.1016/j.visres.2006.05.016. PMID: 16889812
Saccadic intrusions in strabismus.
Ciuffreda KJ, Kenyon RV, Stark L
Arch Ophthalmol 1979 Sep;97(9):1673-9. doi: 10.1001/archopht.1979.01020020241012. PMID: 475639

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