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Agenesis of central incisor

MedGen UID:
381532
•Concept ID:
C1855000
•
Finding
Synonyms: Absent central incisor; Absent central incisors
 
HPO: HP:0006289

Definition

Agenesis of one or more central incisors, i.e., of lower secondary incisor, lower primary incisor, upper secondary incisor, or of upper central primary incisor. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAgenesis of central incisor

Conditions with this feature

Mohr syndrome
MedGen UID:
10077
•Concept ID:
C0026363
•
Disease or Syndrome
Oral-facial-digital (OFD) type 2 is characterized by hand and feet deformities, facial deformities, midline cleft of the upper lip and tongue hamartomas.
See: Condition Record
Central incisors, absence of
MedGen UID:
337110
•Concept ID:
C1844886
•
Finding
See: Condition Record
Central incisors, absence of
Mohr syndrome

Professional guidelines

PubMed

Management of excessive gingival display using botulinum toxin type A: a descriptive study.
Andriola FO, Chieza GS, Cavagni J, Freddo AL, Corsetti A
Toxicon 2021 Jun;196:56-62. Epub 2021 Mar 29 doi: 10.1016/j.toxicon.2021.03.016. PMID: 33794266
Factors affecting treatment duration of labial inversely impacted maxillary central incisors.
Bhikoo C, Xu J, Sun H, Jin C, Jiang H, Hu R
Am J Orthod Dentofacial Orthop 2018 May;153(5):708-715. doi: 10.1016/j.ajodo.2017.09.017. PMID: 29706219
Nine Novel PAX9 Mutations and a Distinct Tooth Agenesis Genotype-Phenotype.
Wong SW, Han D, Zhang H, Liu Y, Zhang X, Miao MZ, Wang Y, Zhao N, Zeng L, Bai B, Wang YX, Liu H, Frazier-Bowers SA, Feng H
J Dent Res 2018 Feb;97(2):155-162. Epub 2017 Sep 14 doi: 10.1177/0022034517729322. PMID: 28910570Free PMC Article

Recent clinical studies

Etiology

Prevalence of dental anomalies in a sample of growing subjects: a retrospective study.
Di Spirito F, Scelza G, Amato A, Rosa D, Gallotti A, Martina S
Epidemiol Prev 2022 Sep-Dec;46(5-6):376-381. doi: 10.19191/EP22.A486.061. PMID: 36628642
Influence of maxillary lateral incisor width ratio on perception of smile esthetics among orthodontists and laypersons.
Martinez Florez D, Rinchuse D, Zullo T
J Esthet Restor Dent 2021 Apr;33(3):510-515. Epub 2020 Nov 6 doi: 10.1111/jerd.12664. PMID: 33155745
Surgical removal versus retention for the management of asymptomatic disease-free impacted wisdom teeth.
Ghaeminia H, Nienhuijs ME, Toedtling V, Perry J, Tummers M, Hoppenreijs TJ, Van der Sanden WJ, Mettes TG
Cochrane Database Syst Rev 2020 May 4;5(5):CD003879. doi: 10.1002/14651858.CD003879.pub5. PMID: 32368796Free PMC Article
A study of prevalence and distribution of tooth agenesis.
Bozga A, Stanciu RP, Mănuc D
J Med Life 2014 Oct-Dec;7(4):551-4. PMID: 25713620Free PMC Article
Natal teeth.
Leung AK
Am J Dis Child 1986 Mar;140(3):249-51. doi: 10.1001/archpedi.1986.02140170075033. PMID: 3946356

Diagnosis

Sonography of fetal holoprosencephaly: a guide to recognize the lesser varieties.
Montaguti E, Cariello L, Brunelli E, Youssef A, Livi A, Salsi G, Pilu G
J Matern Fetal Neonatal Med 2022 Dec;35(25):9717-9723. Epub 2022 Mar 10 doi: 10.1080/14767058.2022.2050900. PMID: 35272544
Frequency and association of maxillary ectopic canine with incisor root resorption and dental agenesis.
Nagani NI, Ahmed I, Rizwan S, Pervez H, Khan T, Arif T
J Pak Med Assoc 2021 Jan;71(1(B)):277-280. doi: 10.47391/JPMA.782. PMID: 35157664
Molar incisor hypomineralization: Analysis of asymmetry of lesions.
Biondi AM, Córtese SG, Babino L, Toscano MA
Acta Odontol Latinoam 2019 Apr 1;32(1):44-48. PMID: 31206574
The solitary median maxillary central incisor (SMMCI) syndrome: Associations, prenatal diagnosis, and outcomes.
Garcia Rodriguez R, Garcia Cruz L, Novoa Medina Y, Garcia Delgado R, Perez Gonzalez J, Palma Milla C, Lopez Siles J, Medina Castellano M, Garcia Hernandez JA, Santana Rodriguez A
Prenat Diagn 2019 May;39(6):415-419. Epub 2019 Apr 26 doi: 10.1002/pd.5451. PMID: 30900264
KBG syndrome.
Brancati F, Sarkozy A, Dallapiccola B
Orphanet J Rare Dis 2006 Dec 12;1:50. doi: 10.1186/1750-1172-1-50. PMID: 17163996Free PMC Article

Therapy

Prevalence and Etiological Factors of Dental Trauma among 12- and 15-Year-Old Schoolchildren of Lebanon: A National Study.
Abdel Malak C, Chakar C, Romanos A, Rachidi S
ScientificWorldJournal 2021;2021:5587431. Epub 2021 Mar 5 doi: 10.1155/2021/5587431. PMID: 33746633Free PMC Article
Impact of oral-health-related quality of life and self-esteem on patients with missing maxillary lateral incisor after orthodontic space closure: a single-blinded, randomized, controlled trial.
Pithon MM, Vargas EOA, da Silva Coqueiro R, Lacerda-Santos R, Tanaka OM, Maia LC
Eur J Orthod 2021 Apr 3;43(2):208-214. doi: 10.1093/ejo/cjaa075. PMID: 33367539
Surgical removal versus retention for the management of asymptomatic disease-free impacted wisdom teeth.
Ghaeminia H, Nienhuijs ME, Toedtling V, Perry J, Tummers M, Hoppenreijs TJ, Van der Sanden WJ, Mettes TG
Cochrane Database Syst Rev 2020 May 4;5(5):CD003879. doi: 10.1002/14651858.CD003879.pub5. PMID: 32368796Free PMC Article
Prosthetic replacement vs space closure for maxillary lateral incisor agenesis: A systematic review.
Silveira GS, de Almeida NV, Pereira DM, Mattos CT, Mucha JN
Am J Orthod Dentofacial Orthop 2016 Aug;150(2):228-37. doi: 10.1016/j.ajodo.2016.01.018. PMID: 27476355
Effectiveness of TAD-anchored maxillary protraction in late mixed dentition.
Feng X, Li J, Li Y, Zhao Z, Zhao S, Wang J
Angle Orthod 2012 Nov;82(6):1107-14. Epub 2012 Mar 29 doi: 10.2319/111411-705.1. PMID: 22458766Free PMC Article

Prognosis

The solitary median maxillary central incisor (SMMCI) syndrome: Associations, prenatal diagnosis, and outcomes.
Garcia Rodriguez R, Garcia Cruz L, Novoa Medina Y, Garcia Delgado R, Perez Gonzalez J, Palma Milla C, Lopez Siles J, Medina Castellano M, Garcia Hernandez JA, Santana Rodriguez A
Prenat Diagn 2019 May;39(6):415-419. Epub 2019 Apr 26 doi: 10.1002/pd.5451. PMID: 30900264
Impacted and transmigrant mandibular canines incidence, aetiology, and treatment: a systematic review.
Dalessandri D, Parrini S, Rubiano R, Gallone D, Migliorati M
Eur J Orthod 2017 Apr 1;39(2):161-169. doi: 10.1093/ejo/cjw027. PMID: 27036134
Impacted central incisors: factors affecting prognosis and treatment duration.
Chaushu S, Becker T, Becker A
Am J Orthod Dentofacial Orthop 2015 Mar;147(3):355-62. doi: 10.1016/j.ajodo.2014.11.019. PMID: 25726403
Solitary median maxillary central incisor (SMMCI) syndrome.
Hall RK
Orphanet J Rare Dis 2006 Apr 9;1:12. doi: 10.1186/1750-1172-1-12. PMID: 16722608Free PMC Article
Solitary median maxillary central incisor, short stature, choanal atresia/midnasal stenosis (SMMCI) syndrome.
Hall RK, Bankier A, Aldred MJ, Kan K, Lucas JO, Perks AG
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1997 Dec;84(6):651-62. doi: 10.1016/s1079-2104(97)90368-1. PMID: 9431535

Clinical prediction guides

KBG syndrome: Clinical features and molecular findings in seven unrelated Korean families with a review of the literature.
Choi Y, Choi J, Do H, Hwang S, Seo GH, Choi IH, Keum C, Choi JH, Kang M, Kim GH, Yoo HW, Lee BH
Mol Genet Genomic Med 2023 Apr;11(4):e2127. Epub 2022 Dec 23 doi: 10.1002/mgg3.2127. PMID: 36564961Free PMC Article
Does primary trauma lead to developmental defects in permanent teeth?
Gibbison R, Crozier R
Evid Based Dent 2022 Sep;23(3):112-113. Epub 2022 Sep 23 doi: 10.1038/s41432-022-0808-z. PMID: 36151286
Molar incisor hypomineralization: Analysis of asymmetry of lesions.
Biondi AM, Córtese SG, Babino L, Toscano MA
Acta Odontol Latinoam 2019 Apr 1;32(1):44-48. PMID: 31206574
A study of prevalence and distribution of tooth agenesis.
Bozga A, Stanciu RP, Mănuc D
J Med Life 2014 Oct-Dec;7(4):551-4. PMID: 25713620Free PMC Article
KBG syndrome.
Brancati F, Sarkozy A, Dallapiccola B
Orphanet J Rare Dis 2006 Dec 12;1:50. doi: 10.1186/1750-1172-1-50. PMID: 17163996Free PMC Article

Recent systematic reviews

Molar-root incisor malformation - a systematic review of case reports and case series.
Jensen ED, Smart G, Poirier BF, Sethi S
BMC Oral Health 2023 Aug 18;23(1):576. doi: 10.1186/s12903-023-03275-6. PMID: 37596569Free PMC Article
Does primary trauma lead to developmental defects in permanent teeth?
Gibbison R, Crozier R
Evid Based Dent 2022 Sep;23(3):112-113. Epub 2022 Sep 23 doi: 10.1038/s41432-022-0808-z. PMID: 36151286
Surgical removal versus retention for the management of asymptomatic disease-free impacted wisdom teeth.
Ghaeminia H, Nienhuijs ME, Toedtling V, Perry J, Tummers M, Hoppenreijs TJ, Van der Sanden WJ, Mettes TG
Cochrane Database Syst Rev 2020 May 4;5(5):CD003879. doi: 10.1002/14651858.CD003879.pub5. PMID: 32368796Free PMC Article
Impacted and transmigrant mandibular canines incidence, aetiology, and treatment: a systematic review.
Dalessandri D, Parrini S, Rubiano R, Gallone D, Migliorati M
Eur J Orthod 2017 Apr 1;39(2):161-169. doi: 10.1093/ejo/cjw027. PMID: 27036134
Prosthetic replacement vs space closure for maxillary lateral incisor agenesis: A systematic review.
Silveira GS, de Almeida NV, Pereira DM, Mattos CT, Mucha JN
Am J Orthod Dentofacial Orthop 2016 Aug;150(2):228-37. doi: 10.1016/j.ajodo.2016.01.018. PMID: 27476355

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