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Peripheral T-cell lymphoma

MedGen UID:
38240
•Concept ID:
C0079774
•
Neoplastic Process
Synonym: Primary cutaneous peripheral T-cell lymphoma not otherwise specified
SNOMED CT: Peripheral T-cell lymphoma (clinical) (109977009); Peripheral T-cell lymphoma (109977009); Mature T-cell lymphoma (1163404000); Peripheral T-cell lymphoma (1163404000); T-cell lymphoma (1163404000)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0019476
Orphanet: ORPHA86885

Definition

An extremely rare, primary cutaneous T-cell lymphoma disorder characterized by solitary, or multifocal and diffuse, cutaneous lesions, ranging from tumor-like patches, plaques, papules, nodules, and/or erythroderma, located on any area of the body, which rapidly progress and may become ulcerated and/or infected. Systemic involvement may be associated. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPeripheral T-cell lymphoma
Follow this link to review classifications for Peripheral T-cell lymphoma in Orphanet.

Professional guidelines

PubMed

Current Treatment of Peripheral T-cell Lymphoma.
Stuver R, Epstein-Peterson ZD, Johnson WT, Khan N, Lewis N, Moskowitz AJ, Sauter CS, Horwitz S
Oncology (Williston Park) 2022 May 9;36(5):293-305. doi: 10.46883/2022.25920960. PMID: 35576176
Epigenetic alterations and advancement of treatment in peripheral T-cell lymphoma.
Zhang P, Zhang M
Clin Epigenetics 2020 Nov 7;12(1):169. doi: 10.1186/s13148-020-00962-x. PMID: 33160401Free PMC Article
Management of NK/T-Cell Lymphoma, Nasal Type.
Allen PB, Lechowicz MJ
J Oncol Pract 2019 Oct;15(10):513-520. doi: 10.1200/JOP.18.00719. PMID: 31600461Free PMC Article

Recent clinical studies

Etiology

Management of Peripheral T-cell Lymphomas and the Role of Transplant.
Foley NC, Mehta-Shah N
Curr Oncol Rep 2022 Nov;24(11):1489-1499. Epub 2022 Aug 10 doi: 10.1007/s11912-022-01310-3. PMID: 35947286Free PMC Article
T-Cell Lymphomas, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology.
Horwitz SM, Ansell S, Ai WZ, Barnes J, Barta SK, Brammer J, Clemens MW, Dogan A, Foss F, Ghione P, Goodman AM, Guitart J, Halwani A, Haverkos BM, Hoppe RT, Jacobsen E, Jagadeesh D, Jones A, Kallam A, Kim YH, Kumar K, Mehta-Shah N, Olsen EA, Rajguru SA, Rozati S, Said J, Shaver A, Shea L, Shinohara MM, Sokol L, Torres-Cabala C, Wilcox R, Wu P, Zain J, Dwyer M, Sundar H
J Natl Compr Canc Netw 2022 Mar;20(3):285-308. doi: 10.6004/jnccn.2022.0015. PMID: 35276674
Epigenetic alterations and advancement of treatment in peripheral T-cell lymphoma.
Zhang P, Zhang M
Clin Epigenetics 2020 Nov 7;12(1):169. doi: 10.1186/s13148-020-00962-x. PMID: 33160401Free PMC Article
Peripheral T-Cell Lymphoma, not Otherwise Specified (PTCL-NOS).
Oluwasanjo A, Kartan S, Johnson W, Alpdogan O, Gru A, Mishra A, Haverkos BM, Gong J, Porcu P
Cancer Treat Res 2019;176:83-98. doi: 10.1007/978-3-319-99716-2_4. PMID: 30596214
T-cell Lymphoma Epidemiology: the Known and Unknown.
Phan A, Veldman R, Lechowicz MJ
Curr Hematol Malig Rep 2016 Dec;11(6):492-503. doi: 10.1007/s11899-016-0353-y. PMID: 27995419

Diagnosis

T time: Emerging and new therapies for peripheral T-cell lymphoma.
Mina A, Pro B
Blood Rev 2022 Mar;52:100889. Epub 2021 Sep 9 doi: 10.1016/j.blre.2021.100889. PMID: 34716031
Recent Advances in Diagnosis and Therapy of Angioimmunoblastic T Cell Lymphoma.
Mohammed Saleh MF, Kotb A, Abdallah GEM, Muhsen IN, El Fakih R, Aljurf M
Curr Oncol 2021 Dec 20;28(6):5480-5498. doi: 10.3390/curroncol28060456. PMID: 34940095Free PMC Article
How I Diagnose Angioimmunoblastic T-Cell Lymphoma.
Xie Y, Jaffe ES
Am J Clin Pathol 2021 Jun 17;156(1):1-14. doi: 10.1093/ajcp/aqab090. PMID: 34117736Free PMC Article
Aggressive T-cell lymphomas: 2021 Updates on diagnosis, risk stratification and management.
Zain JM, Hanona P
Am J Hematol 2021 Aug 1;96(8):1027-1046. Epub 2021 Jun 26 doi: 10.1002/ajh.26270. PMID: 34111312
Aggressive T-cell lymphomas: 2019 updates on diagnosis, risk stratification, and management.
Zain JM
Am J Hematol 2019 Aug;94(8):929-946. Epub 2019 Jun 11 doi: 10.1002/ajh.25513. PMID: 31119775

Therapy

The ECHELON-2 Trial: 5-year results of a randomized, phase III study of brentuximab vedotin with chemotherapy for CD30-positive peripheral T-cell lymphoma.
Horwitz S, O'Connor OA, Pro B, Trümper L, Iyer S, Advani R, Bartlett NL, Christensen JH, Morschhauser F, Domingo-Domenech E, Rossi G, Kim WS, Feldman T, Menne T, Belada D, Illés Á, Tobinai K, Tsukasaki K, Yeh SP, Shustov A, Hüttmann A, Savage KJ, Yuen S, Zinzani PL, Miao H, Bunn V, Fenton K, Fanale M, Puhlmann M, Illidge T
Ann Oncol 2022 Mar;33(3):288-298. Epub 2021 Dec 16 doi: 10.1016/j.annonc.2021.12.002. PMID: 34921960Free PMC Article
NK-/T-cell lymphomas.
Wang H, Fu BB, Gale RP, Liang Y
Leukemia 2021 Sep;35(9):2460-2468. Epub 2021 Jun 11 doi: 10.1038/s41375-021-01313-2. PMID: 34117356Free PMC Article
Epigenetic alterations and advancement of treatment in peripheral T-cell lymphoma.
Zhang P, Zhang M
Clin Epigenetics 2020 Nov 7;12(1):169. doi: 10.1186/s13148-020-00962-x. PMID: 33160401Free PMC Article
NK/T-cell lymphomas.
Tse E, Kwong YL
Best Pract Res Clin Haematol 2019 Sep;32(3):253-261. Epub 2019 Jun 12 doi: 10.1016/j.beha.2019.06.005. PMID: 31585625
Peripheral T-Cell Lymphoma, not Otherwise Specified (PTCL-NOS).
Oluwasanjo A, Kartan S, Johnson W, Alpdogan O, Gru A, Mishra A, Haverkos BM, Gong J, Porcu P
Cancer Treat Res 2019;176:83-98. doi: 10.1007/978-3-319-99716-2_4. PMID: 30596214

Prognosis

Recent Advances in Diagnosis and Therapy of Angioimmunoblastic T Cell Lymphoma.
Mohammed Saleh MF, Kotb A, Abdallah GEM, Muhsen IN, El Fakih R, Aljurf M
Curr Oncol 2021 Dec 20;28(6):5480-5498. doi: 10.3390/curroncol28060456. PMID: 34940095Free PMC Article
NK-/T-cell lymphomas.
Wang H, Fu BB, Gale RP, Liang Y
Leukemia 2021 Sep;35(9):2460-2468. Epub 2021 Jun 11 doi: 10.1038/s41375-021-01313-2. PMID: 34117356Free PMC Article
Epigenetic alterations and advancement of treatment in peripheral T-cell lymphoma.
Zhang P, Zhang M
Clin Epigenetics 2020 Nov 7;12(1):169. doi: 10.1186/s13148-020-00962-x. PMID: 33160401Free PMC Article
Reproducing the molecular subclassification of peripheral T-cell lymphoma-NOS by immunohistochemistry.
Amador C, Greiner TC, Heavican TB, Smith LM, Galvis KT, Lone W, Bouska A, D'Amore F, Pedersen MB, Pileri S, Agostinelli C, Feldman AL, Rosenwald A, Ott G, Mottok A, Savage KJ, de Leval L, Gaulard P, Lim ST, Ong CK, Ondrejka SL, Song J, Campo E, Jaffe ES, Staudt LM, Rimsza LM, Vose J, Weisenburger DD, Chan WC, Iqbal J
Blood 2019 Dec 12;134(24):2159-2170. doi: 10.1182/blood.2019000779. PMID: 31562134Free PMC Article
T-cell Lymphoma Epidemiology: the Known and Unknown.
Phan A, Veldman R, Lechowicz MJ
Curr Hematol Malig Rep 2016 Dec;11(6):492-503. doi: 10.1007/s11899-016-0353-y. PMID: 27995419

Clinical prediction guides

Current Treatment of Peripheral T-cell Lymphoma.
Stuver R, Epstein-Peterson ZD, Johnson WT, Khan N, Lewis N, Moskowitz AJ, Sauter CS, Horwitz S
Oncology (Williston Park) 2022 May 9;36(5):293-305. doi: 10.46883/2022.25920960. PMID: 35576176
NK-/T-cell lymphomas.
Wang H, Fu BB, Gale RP, Liang Y
Leukemia 2021 Sep;35(9):2460-2468. Epub 2021 Jun 11 doi: 10.1038/s41375-021-01313-2. PMID: 34117356Free PMC Article
Epigenetic alterations and advancement of treatment in peripheral T-cell lymphoma.
Zhang P, Zhang M
Clin Epigenetics 2020 Nov 7;12(1):169. doi: 10.1186/s13148-020-00962-x. PMID: 33160401Free PMC Article
Anaplastic Large Cell Lymphoma: Contemporary Concepts and Optimal Management.
Shustov A, Soma L
Cancer Treat Res 2019;176:127-144. doi: 10.1007/978-3-319-99716-2_6. PMID: 30596216
T-cell Lymphoma Epidemiology: the Known and Unknown.
Phan A, Veldman R, Lechowicz MJ
Curr Hematol Malig Rep 2016 Dec;11(6):492-503. doi: 10.1007/s11899-016-0353-y. PMID: 27995419

Recent systematic reviews

The efficiency of autologous stem cell transplantation as the first-line treatment for nodal peripheral T-cell lymphoma: results of a systematic review and meta-analysis.
Zhai Y, Wang J, Jiang Y, Wu W, Lv Y, Xu H, Tian L, Sun H, Zhao Z, Li L
Expert Rev Hematol 2022 Mar;15(3):265-272. Epub 2022 Feb 21 doi: 10.1080/17474086.2022.2042247. PMID: 35152814
The clinical and economic burden of peripheral T-cell lymphoma: a systematic literature review.
Ashaye AO, Burnett H, Abogunrin S, Panchmatia H, Ovcinnikova O, Dalal M
Future Oncol 2022 Feb;18(4):519-535. Epub 2021 Dec 1 doi: 10.2217/fon-2021-1032. PMID: 34851173
Comparison of Allogeneic Stem Cell Transplant and Autologous Stem Cell Transplant in Refractory or Relapsed Peripheral T-Cell Lymphoma: A Systematic Review and Meta-analysis.
Du J, Yu D, Han X, Zhu L, Huang Z
JAMA Netw Open 2021 May 3;4(5):e219807. doi: 10.1001/jamanetworkopen.2021.9807. PMID: 34042995Free PMC Article
Highly Diverse Efficacy of Salvage Treatment Regimens for Relapsed or Refractory Peripheral T-Cell Lymphoma: A Systematic Review.
Yang YT, Tai CJ, Chen C, Wu HC, Mikhaylichenko N, Chiu HT, Chen YY, Hsu YE
PLoS One 2016;11(10):e0161811. Epub 2016 Oct 6 doi: 10.1371/journal.pone.0161811. PMID: 27711130Free PMC Article
Efficacy of High-Dose Therapy and Autologous Hematopoietic Cell Transplantation in Peripheral T Cell Lymphomas as Front-Line Consolidation or in the Relapsed/Refractory Setting: A Systematic Review/Meta-Analysis.
El-Asmar J, Reljic T, Ayala E, Hamadani M, Nishihori T, Kumar A, Kharfan-Dabaja MA
Biol Blood Marrow Transplant 2016 May;22(5):802-14. Epub 2015 Dec 20 doi: 10.1016/j.bbmt.2015.12.004. PMID: 26713431

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