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Peripheral T-cell lymphoma

MedGen UID:
38240
Concept ID:
C0079774
Neoplastic Process
Synonym: Primary cutaneous peripheral T-cell lymphoma not otherwise specified
SNOMED CT: Peripheral T-cell lymphoma (clinical) (109977009); Peripheral T-cell lymphoma (109977009); Mature T-cell lymphoma (1163404000); Peripheral T-cell lymphoma (1163404000); T-cell lymphoma (1163404000)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0019476
Orphanet: ORPHA86885

Definition

An extremely rare, primary cutaneous T-cell lymphoma disorder characterized by solitary, or multifocal and diffuse, cutaneous lesions, ranging from tumor-like patches, plaques, papules, nodules, and/or erythroderma, located on any area of the body, which rapidly progress and may become ulcerated and/or infected. Systemic involvement may be associated. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPeripheral T-cell lymphoma
Follow this link to review classifications for Peripheral T-cell lymphoma in Orphanet.

Professional guidelines

PubMed

Stuver R, Epstein-Peterson ZD, Johnson WT, Khan N, Lewis N, Moskowitz AJ, Sauter CS, Horwitz S
Oncology (Williston Park) 2022 May 9;36(5):293-305. doi: 10.46883/2022.25920960. PMID: 35576176
Zhang P, Zhang M
Clin Epigenetics 2020 Nov 7;12(1):169. doi: 10.1186/s13148-020-00962-x. PMID: 33160401Free PMC Article
Allen PB, Lechowicz MJ
J Oncol Pract 2019 Oct;15(10):513-520. doi: 10.1200/JOP.18.00719. PMID: 31600461Free PMC Article

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), T-Cell Lymphomas, 2024

Recent clinical studies

Etiology

Horwitz SM, Ansell S, Ai WZ, Barnes J, Barta SK, Brammer J, Clemens MW, Dogan A, Foss F, Ghione P, Goodman AM, Guitart J, Halwani A, Haverkos BM, Hoppe RT, Jacobsen E, Jagadeesh D, Jones A, Kallam A, Kim YH, Kumar K, Mehta-Shah N, Olsen EA, Rajguru SA, Rozati S, Said J, Shaver A, Shea L, Shinohara MM, Sokol L, Torres-Cabala C, Wilcox R, Wu P, Zain J, Dwyer M, Sundar H
J Natl Compr Canc Netw 2022 Mar;20(3):285-308. doi: 10.6004/jnccn.2022.0015. PMID: 35276674
Zhang P, Zhang M
Clin Epigenetics 2020 Nov 7;12(1):169. doi: 10.1186/s13148-020-00962-x. PMID: 33160401Free PMC Article
Amador C, Greiner TC, Heavican TB, Smith LM, Galvis KT, Lone W, Bouska A, D'Amore F, Pedersen MB, Pileri S, Agostinelli C, Feldman AL, Rosenwald A, Ott G, Mottok A, Savage KJ, de Leval L, Gaulard P, Lim ST, Ong CK, Ondrejka SL, Song J, Campo E, Jaffe ES, Staudt LM, Rimsza LM, Vose J, Weisenburger DD, Chan WC, Iqbal J
Blood 2019 Dec 12;134(24):2159-2170. doi: 10.1182/blood.2019000779. PMID: 31562134Free PMC Article
Zain J
Cancer Treat Res 2019;176:269-287. doi: 10.1007/978-3-319-99716-2_13. PMID: 30596223
Iqbal J, Wright G, Wang C, Rosenwald A, Gascoyne RD, Weisenburger DD, Greiner TC, Smith L, Guo S, Wilcox RA, Teh BT, Lim ST, Tan SY, Rimsza LM, Jaffe ES, Campo E, Martinez A, Delabie J, Braziel RM, Cook JR, Tubbs RR, Ott G, Geissinger E, Gaulard P, Piccaluga PP, Pileri SA, Au WY, Nakamura S, Seto M, Berger F, de Leval L, Connors JM, Armitage J, Vose J, Chan WC, Staudt LM; Lymphoma Leukemia Molecular Profiling Project and the International Peripheral T-cell Lymphoma Project
Blood 2014 May 8;123(19):2915-23. Epub 2014 Mar 14 doi: 10.1182/blood-2013-11-536359. PMID: 24632715Free PMC Article

Diagnosis

Mohammed Saleh MF, Kotb A, Abdallah GEM, Muhsen IN, El Fakih R, Aljurf M
Curr Oncol 2021 Dec 20;28(6):5480-5498. doi: 10.3390/curroncol28060456. PMID: 34940095Free PMC Article
Lisa M, Verma PK, Nishi, Shuchismita, Hussain MA
J Cancer Res Ther 2021 Oct-Dec;17(6):1568-1571. doi: 10.4103/jcrt.JCRT_486_19. PMID: 34916399
Xie Y, Jaffe ES
Am J Clin Pathol 2021 Jun 17;156(1):1-14. doi: 10.1093/ajcp/aqab090. PMID: 34117736Free PMC Article
Zain J
Cancer Treat Res 2019;176:269-287. doi: 10.1007/978-3-319-99716-2_13. PMID: 30596223
Gowda L, Foss F
Cancer Treat Res 2019;176:185-193. doi: 10.1007/978-3-319-99716-2_9. PMID: 30596219

Therapy

Broccoli A, Zinzani PL
Hematol Oncol 2023 Jun;41 Suppl 1:82-87. doi: 10.1002/hon.3142. PMID: 37294962
Horwitz S, O'Connor OA, Pro B, Trümper L, Iyer S, Advani R, Bartlett NL, Christensen JH, Morschhauser F, Domingo-Domenech E, Rossi G, Kim WS, Feldman T, Menne T, Belada D, Illés Á, Tobinai K, Tsukasaki K, Yeh SP, Shustov A, Hüttmann A, Savage KJ, Yuen S, Zinzani PL, Miao H, Bunn V, Fenton K, Fanale M, Puhlmann M, Illidge T
Ann Oncol 2022 Mar;33(3):288-298. Epub 2021 Dec 16 doi: 10.1016/j.annonc.2021.12.002. PMID: 34921960Free PMC Article
Wang H, Fu BB, Gale RP, Liang Y
Leukemia 2021 Sep;35(9):2460-2468. Epub 2021 Jun 11 doi: 10.1038/s41375-021-01313-2. PMID: 34117356Free PMC Article
Tse E, Kwong YL
Best Pract Res Clin Haematol 2019 Sep;32(3):253-261. Epub 2019 Jun 12 doi: 10.1016/j.beha.2019.06.005. PMID: 31585625
Zain J
Cancer Treat Res 2019;176:269-287. doi: 10.1007/978-3-319-99716-2_13. PMID: 30596223

Prognosis

Broccoli A, Zinzani PL
Hematol Oncol 2023 Jun;41 Suppl 1:82-87. doi: 10.1002/hon.3142. PMID: 37294962
Mohammed Saleh MF, Kotb A, Abdallah GEM, Muhsen IN, El Fakih R, Aljurf M
Curr Oncol 2021 Dec 20;28(6):5480-5498. doi: 10.3390/curroncol28060456. PMID: 34940095Free PMC Article
Wang H, Fu BB, Gale RP, Liang Y
Leukemia 2021 Sep;35(9):2460-2468. Epub 2021 Jun 11 doi: 10.1038/s41375-021-01313-2. PMID: 34117356Free PMC Article
Zhang P, Zhang M
Clin Epigenetics 2020 Nov 7;12(1):169. doi: 10.1186/s13148-020-00962-x. PMID: 33160401Free PMC Article
Amador C, Greiner TC, Heavican TB, Smith LM, Galvis KT, Lone W, Bouska A, D'Amore F, Pedersen MB, Pileri S, Agostinelli C, Feldman AL, Rosenwald A, Ott G, Mottok A, Savage KJ, de Leval L, Gaulard P, Lim ST, Ong CK, Ondrejka SL, Song J, Campo E, Jaffe ES, Staudt LM, Rimsza LM, Vose J, Weisenburger DD, Chan WC, Iqbal J
Blood 2019 Dec 12;134(24):2159-2170. doi: 10.1182/blood.2019000779. PMID: 31562134Free PMC Article

Clinical prediction guides

Wang H, Fu BB, Gale RP, Liang Y
Leukemia 2021 Sep;35(9):2460-2468. Epub 2021 Jun 11 doi: 10.1038/s41375-021-01313-2. PMID: 34117356Free PMC Article
Zhang P, Zhang M
Clin Epigenetics 2020 Nov 7;12(1):169. doi: 10.1186/s13148-020-00962-x. PMID: 33160401Free PMC Article
Amador C, Greiner TC, Heavican TB, Smith LM, Galvis KT, Lone W, Bouska A, D'Amore F, Pedersen MB, Pileri S, Agostinelli C, Feldman AL, Rosenwald A, Ott G, Mottok A, Savage KJ, de Leval L, Gaulard P, Lim ST, Ong CK, Ondrejka SL, Song J, Campo E, Jaffe ES, Staudt LM, Rimsza LM, Vose J, Weisenburger DD, Chan WC, Iqbal J
Blood 2019 Dec 12;134(24):2159-2170. doi: 10.1182/blood.2019000779. PMID: 31562134Free PMC Article
Shustov A, Soma L
Cancer Treat Res 2019;176:127-144. doi: 10.1007/978-3-319-99716-2_6. PMID: 30596216
Iqbal J, Wright G, Wang C, Rosenwald A, Gascoyne RD, Weisenburger DD, Greiner TC, Smith L, Guo S, Wilcox RA, Teh BT, Lim ST, Tan SY, Rimsza LM, Jaffe ES, Campo E, Martinez A, Delabie J, Braziel RM, Cook JR, Tubbs RR, Ott G, Geissinger E, Gaulard P, Piccaluga PP, Pileri SA, Au WY, Nakamura S, Seto M, Berger F, de Leval L, Connors JM, Armitage J, Vose J, Chan WC, Staudt LM; Lymphoma Leukemia Molecular Profiling Project and the International Peripheral T-cell Lymphoma Project
Blood 2014 May 8;123(19):2915-23. Epub 2014 Mar 14 doi: 10.1182/blood-2013-11-536359. PMID: 24632715Free PMC Article

Recent systematic reviews

Zhai Y, Wang J, Jiang Y, Wu W, Lv Y, Xu H, Tian L, Sun H, Zhao Z, Li L
Expert Rev Hematol 2022 Mar;15(3):265-272. Epub 2022 Feb 21 doi: 10.1080/17474086.2022.2042247. PMID: 35152814
Ashaye AO, Burnett H, Abogunrin S, Panchmatia H, Ovcinnikova O, Dalal M
Future Oncol 2022 Feb;18(4):519-535. Epub 2021 Dec 1 doi: 10.2217/fon-2021-1032. PMID: 34851173
Kim J, Cho J, Byeon S, Kim WS, Kim SJ
Hematol Oncol 2021 Dec;39(5):664-673. Epub 2021 Sep 6 doi: 10.1002/hon.2924. PMID: 34487565
Du J, Yu D, Han X, Zhu L, Huang Z
JAMA Netw Open 2021 May 3;4(5):e219807. doi: 10.1001/jamanetworkopen.2021.9807. PMID: 34042995Free PMC Article
Wei J, Xu J, Cao Y, Zhou J, Zhang Y
Acta Haematol 2015;133(2):136-44. Epub 2014 Sep 20 doi: 10.1159/000358579. PMID: 25247746

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), T-Cell Lymphomas, 2024

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