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Refractory macrocytic anemia

MedGen UID:
382516
Concept ID:
C2675059
Disease or Syndrome; Finding
Synonym: Macrocytic anemia, refractory
 
HPO: HP:0004861

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory macrocytic anemia

Conditions with this feature

Myelodysplastic syndrome associated with isolated del(5q)
MedGen UID:
196625
Concept ID:
C0740302
Disease or Syndrome
The 5q- syndrome is a myelodysplastic syndrome characterized by a defect in erythroid differentiation. Patients have severe macrocytic anemia, normal or elevated platelet counts, normal or reduced neutrophil counts, erythroid hypoplasia in the bone marrow, and hypolobated micromegakaryocytes (Ebert et al., 2008).

Professional guidelines

PubMed

Ramaekers VT, Sequeira JM, Quadros EV
Biochimie 2016 Jul;126:79-90. Epub 2016 Apr 8 doi: 10.1016/j.biochi.2016.04.005. PMID: 27068282
Padron E, Komrokji R, List AF
Curr Treat Options Oncol 2011 Dec;12(4):354-68. doi: 10.1007/s11864-011-0165-1. PMID: 21964863
Halperin DS, Freedman MH
Am J Pediatr Hematol Oncol 1989 Winter;11(4):380-94. PMID: 2694854

Recent clinical studies

Etiology

Stuart RK, Mangan KF
Am J Med 1986 Mar;80(3):503-7. doi: 10.1016/0002-9343(86)90728-x. PMID: 3082200
Kaur P, Miller DR, Andreeff M, Chaganti R, Meyers PA
Med Pediatr Oncol 1981;9(1):69-80. doi: 10.1002/mpo.2950090110. PMID: 7007854

Diagnosis

Stringaris K, Bain B
Leuk Lymphoma 2008 Nov;49(11):2196-7. doi: 10.1080/10428190802419665. PMID: 19021064
Brusamolino E, Orlandi E, Morra E, Bernasconi P, Pagnucco G, Colombo A, Lazzarino M, Bernasconi C
Med Pediatr Oncol 1988;16(2):88-94. doi: 10.1002/mpo.2950160204. PMID: 3352540
Stuart RK, Mangan KF
Am J Med 1986 Mar;80(3):503-7. doi: 10.1016/0002-9343(86)90728-x. PMID: 3082200
Kaur P, Miller DR, Andreeff M, Chaganti R, Meyers PA
Med Pediatr Oncol 1981;9(1):69-80. doi: 10.1002/mpo.2950090110. PMID: 7007854
Kass L
Postgrad Med 1975 Nov;58(6):161-6. doi: 10.1080/00325481.1975.11714208. PMID: 1059074

Therapy

Stuart RK, Mangan KF
Am J Med 1986 Mar;80(3):503-7. doi: 10.1016/0002-9343(86)90728-x. PMID: 3082200
Kass L
Postgrad Med 1975 Nov;58(6):161-6. doi: 10.1080/00325481.1975.11714208. PMID: 1059074

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