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Healing scar

MedGen UID:
384469
•Concept ID:
C2004491
•
Pathologic Function
Synonyms: Cicatrix; Scar; Scars
SNOMED CT: Scar (12402003); Scar tissue (12402003); Cicatrix (12402003); Fibrous scar (12402003); Scar (275322007); Healing scar (48677004); Scarring (48677004)

Definition

A permanent mark left on the skin in the process of wound healing. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHealing scar

Professional guidelines

PubMed

Cleft Care Packages and the Impact on Postoperative Care Following a Primary Cleft Lip Repair.
Roy MG, Davies LA, Guillen DE, Sequitin JD, Buchanan EP, Maricevich RS, Truong TA, Monson LA
J Craniofac Surg 2021 Oct 1;32(7):2282-2284. doi: 10.1097/SCS.0000000000007561. PMID: 33606437
The Role of Topical Vitamin E in Scar Management: A Systematic Review.
Tanaydin V, Conings J, Malyar M, van der Hulst R, van der Lei B
Aesthet Surg J 2016 Sep;36(8):959-65. Epub 2016 Mar 14 doi: 10.1093/asj/sjw046. PMID: 26977069
Ambulatory management of burns.
Morgan ED, Bledsoe SC, Barker J
Am Fam Physician 2000 Nov 1;62(9):2015-26, 2029-30, 2032. PMID: 11087185

Recent clinical studies

Etiology

Single-Cell Transcriptomics Analysis of the Pathogenesis of Tendon Injury.
Zhao H, Liang T, Tang Y, Zhu D, Lin Q, Chen J, Fei J, Yu T, Zhang Y
Oxid Med Cell Longev 2022;2022:7887782. Epub 2022 Sep 13 doi: 10.1155/2022/7887782. PMID: 36148412Free PMC Article
Genetic polymorphism of matrix metalloproteinases in breast cancer.
Wieczorek E, Reszka E, Gromadzinska J, Wasowicz W
Neoplasma 2012;59(3):237-47. doi: 10.4149/neo_2012_031. PMID: 22296495
5-Fluorouracil treatment of problematic scars.
Haurani MJ, Foreman K, Yang JJ, Siddiqui A
Plast Reconstr Surg 2009 Jan;123(1):139-148. doi: 10.1097/PRS.0b013e3181904d1b. PMID: 19116547Free PMC Article
Improved scar quality following primary and secondary healing of cutaneous wounds.
Atiyeh BS, Amm CA, El Musa KA
Aesthetic Plast Surg 2003 Sep-Oct;27(5):411-7. Epub 2003 Dec 4 doi: 10.1007/s00266-003-3049-3. PMID: 14648065
Scar quality and physiologic barrier function restoration after moist and moist-exposed dressings of partial-thickness wounds.
Atiyeh BS, El-Musa KA, Dham R
Dermatol Surg 2003 Jan;29(1):14-20. doi: 10.1046/j.1524-4725.2003.29002.x. PMID: 12534506

Diagnosis

Proteomics and metabolomics approach in adult and pediatric glioma diagnostics.
Pienkowski T, Kowalczyk T, Garcia-Romero N, Ayuso-Sacido A, Ciborowski M
Biochim Biophys Acta Rev Cancer 2022 May;1877(3):188721. Epub 2022 Mar 16 doi: 10.1016/j.bbcan.2022.188721. PMID: 35304294
Direct Repair of Chronic Achilles Tendon Ruptures Using Scar Tissue Located Between the Tendon Stumps.
Yasuda T, Shima H, Mori K, Kizawa M, Neo M
J Bone Joint Surg Am 2016 Jul 20;98(14):1168-75. doi: 10.2106/JBJS.15.00865. PMID: 27440564
Recurrent cutaneous leishmaniasis.
Gomes CM, Damasco Fdos S, Morais OO, Paula CD, Sampaio RN
An Bras Dermatol 2013 May-Jun;88(3):462-4. doi: 10.1590/abd1806-4841.20131885. PMID: 23793208Free PMC Article
Ambulatory management of burns.
Morgan ED, Bledsoe SC, Barker J
Am Fam Physician 2000 Nov 1;62(9):2015-26, 2029-30, 2032. PMID: 11087185
Complications of cutaneous cryosurgery.
Elton RF
J Am Acad Dermatol 1983 Apr;8(4):513-9. doi: 10.1016/s0190-9622(83)70057-5. PMID: 6853784

Therapy

Recurrent cutaneous leishmaniasis.
Gomes CM, Damasco Fdos S, Morais OO, Paula CD, Sampaio RN
An Bras Dermatol 2013 May-Jun;88(3):462-4. doi: 10.1590/abd1806-4841.20131885. PMID: 23793208Free PMC Article
5-Fluorouracil treatment of problematic scars.
Haurani MJ, Foreman K, Yang JJ, Siddiqui A
Plast Reconstr Surg 2009 Jan;123(1):139-148. doi: 10.1097/PRS.0b013e3181904d1b. PMID: 19116547Free PMC Article
When wound healing goes awry. A review of normal and abnormal wound healing, scar pathophysiology, and therapeutics.
Watkins SA, Zippin JH
J Drugs Dermatol 2008 Oct;7(10):997-1005. PMID: 19112769
Improved scar quality following primary and secondary healing of cutaneous wounds.
Atiyeh BS, Amm CA, El Musa KA
Aesthetic Plast Surg 2003 Sep-Oct;27(5):411-7. Epub 2003 Dec 4 doi: 10.1007/s00266-003-3049-3. PMID: 14648065
Scar quality and physiologic barrier function restoration after moist and moist-exposed dressings of partial-thickness wounds.
Atiyeh BS, El-Musa KA, Dham R
Dermatol Surg 2003 Jan;29(1):14-20. doi: 10.1046/j.1524-4725.2003.29002.x. PMID: 12534506

Prognosis

Single-Cell RNA Sequencing Analysis Reveals a Crucial Role for CTHRC1 (Collagen Triple Helix Repeat Containing 1) Cardiac Fibroblasts After Myocardial Infarction.
Ruiz-Villalba A, Romero JP, Hernández SC, Vilas-Zornoza A, Fortelny N, Castro-Labrador L, San Martin-Uriz P, Lorenzo-Vivas E, García-Olloqui P, Palacio M, Gavira JJ, Bastarrika G, Janssens S, Wu M, Iglesias E, Abizanda G, de Morentin XM, Lasaga M, Planell N, Bock C, Alignani D, Medal G, Prudovsky I, Jin YR, Ryzhov S, Yin H, Pelacho B, Gomez-Cabrero D, Lindner V, Lara-Astiaso D, Prósper F
Circulation 2020 Nov 10;142(19):1831-1847. Epub 2020 Sep 25 doi: 10.1161/CIRCULATIONAHA.119.044557. PMID: 32972203Free PMC Article
Physiological Implications of Myocardial Scar Structure.
Richardson WJ, Clarke SA, Quinn TA, Holmes JW
Compr Physiol 2015 Sep 20;5(4):1877-909. doi: 10.1002/cphy.c140067. PMID: 26426470Free PMC Article
Genetic polymorphism of matrix metalloproteinases in breast cancer.
Wieczorek E, Reszka E, Gromadzinska J, Wasowicz W
Neoplasma 2012;59(3):237-47. doi: 10.4149/neo_2012_031. PMID: 22296495
5-Fluorouracil treatment of problematic scars.
Haurani MJ, Foreman K, Yang JJ, Siddiqui A
Plast Reconstr Surg 2009 Jan;123(1):139-148. doi: 10.1097/PRS.0b013e3181904d1b. PMID: 19116547Free PMC Article
Collagen gel contraction assay.
Ngo P, Ramalingam P, Phillips JA, Furuta GT
Methods Mol Biol 2006;341:103-9. doi: 10.1385/1-59745-113-4:103. PMID: 16799192

Clinical prediction guides

Single-Cell Transcriptomics Analysis of the Pathogenesis of Tendon Injury.
Zhao H, Liang T, Tang Y, Zhu D, Lin Q, Chen J, Fei J, Yu T, Zhang Y
Oxid Med Cell Longev 2022;2022:7887782. Epub 2022 Sep 13 doi: 10.1155/2022/7887782. PMID: 36148412Free PMC Article
Physiological Implications of Myocardial Scar Structure.
Richardson WJ, Clarke SA, Quinn TA, Holmes JW
Compr Physiol 2015 Sep 20;5(4):1877-909. doi: 10.1002/cphy.c140067. PMID: 26426470Free PMC Article
Second-look arthroscopic findings after repairs of posterior root tears of the medial meniscus.
Seo HS, Lee SC, Jung KA
Am J Sports Med 2011 Jan;39(1):99-107. Epub 2010 Nov 3 doi: 10.1177/0363546510382225. PMID: 21051426
Collagen gel contraction assay.
Ngo P, Ramalingam P, Phillips JA, Furuta GT
Methods Mol Biol 2006;341:103-9. doi: 10.1385/1-59745-113-4:103. PMID: 16799192
Scar quality and physiologic barrier function restoration after moist and moist-exposed dressings of partial-thickness wounds.
Atiyeh BS, El-Musa KA, Dham R
Dermatol Surg 2003 Jan;29(1):14-20. doi: 10.1046/j.1524-4725.2003.29002.x. PMID: 12534506

Recent systematic reviews

The Physician's Guide to Platelet-Rich Plasma in Dermatologic Surgery Part II: Clinical Evidence.
Hausauer AK, Humphrey S
Dermatol Surg 2020 Apr;46(4):447-456. doi: 10.1097/DSS.0000000000002148. PMID: 31770154
Time to start putting down the knife: A systematic review of burns excision tools of randomised and non-randomised trials.
Edmondson SJ, Ali Jumabhoy I, Murray A
Burns 2018 Nov;44(7):1721-1737. Epub 2018 Feb 16 doi: 10.1016/j.burns.2018.01.012. PMID: 29456099

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