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Benign Ovarian Endometrioid Tumor

MedGen UID:
384480
•Concept ID:
C2063099
•
Neoplastic Process

Definition

A non-metastasizing neoplasm that arises from the ovary and is characterized by the presence of glands or cysts lined by benign endometrial-type cells. It includes endometrioid adenofibroma, endometrioid cystadenofibroma, and endometrioid cystadenoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign Ovarian Endometrioid Tumor

Professional guidelines

PubMed

Magnetic resonance imaging findings of cystic ovarian tumors: major differential diagnoses in five types frequently encountered in daily clinical practice.
Ohya A, Fujinaga Y
Jpn J Radiol 2022 Dec;40(12):1213-1234. Epub 2022 Aug 2 doi: 10.1007/s11604-022-01321-x. PMID: 35916971Free PMC Article
Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues.
Ulbright TM
Mod Pathol 2005 Feb;18 Suppl 2:S61-79. doi: 10.1038/modpathol.3800310. PMID: 15761467
Diagnostic criteria and behavior of ovarian seromucinous (endocervical-type mucinous and mixed cell-type) tumors: atypical proliferative (borderline) tumors, intraepithelial, microinvasive, and invasive carcinomas.
Shappell HW, Riopel MA, Smith Sehdev AE, Ronnett BM, Kurman RJ
Am J Surg Pathol 2002 Dec;26(12):1529-41. doi: 10.1097/00000478-200212000-00001. PMID: 12459620

Recent clinical studies

Etiology

Mucinous Ovarian Tumors.
Mills AM, Shanes ED
Surg Pathol Clin 2019 Jun;12(2):565-585. doi: 10.1016/j.path.2019.01.008. PMID: 31097115
Ovarian sex cord-stromal tumours and their mimics.
Young RH
Pathology 2018 Jan;50(1):5-15. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.007. PMID: 29132723
Cancer Implications for Patients with Endometriosis.
Wilbur MA, Shih IM, Segars JH, Fader AN
Semin Reprod Med 2017 Jan;35(1):110-116. Epub 2017 Jan 3 doi: 10.1055/s-0036-1597120. PMID: 28049216
The Dualistic Model of Ovarian Carcinogenesis: Revisited, Revised, and Expanded.
Kurman RJ, Shih IeM
Am J Pathol 2016 Apr;186(4):733-47. doi: 10.1016/j.ajpath.2015.11.011. PMID: 27012190Free PMC Article
The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory.
Kurman RJ, Shih IeM
Am J Surg Pathol 2010 Mar;34(3):433-43. doi: 10.1097/PAS.0b013e3181cf3d79. PMID: 20154587Free PMC Article

Diagnosis

Mucinous Ovarian Tumors.
Mills AM, Shanes ED
Surg Pathol Clin 2019 Jun;12(2):565-585. doi: 10.1016/j.path.2019.01.008. PMID: 31097115
Frozen Section Diagnosis of Ovarian Epithelial Tumors: Diagnostic Pearls and Pitfalls.
Buza N
Arch Pathol Lab Med 2019 Jan;143(1):47-64. doi: 10.5858/arpa.2018-0289-RA. PMID: 30785337
Ovarian sex cord-stromal tumours and their mimics.
Young RH
Pathology 2018 Jan;50(1):5-15. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.007. PMID: 29132723
Pathology of borderline and invasive cancers.
Prat J
Best Pract Res Clin Obstet Gynaecol 2017 May;41:15-30. Epub 2016 Oct 3 doi: 10.1016/j.bpobgyn.2016.08.007. PMID: 28277307
Cancer Implications for Patients with Endometriosis.
Wilbur MA, Shih IM, Segars JH, Fader AN
Semin Reprod Med 2017 Jan;35(1):110-116. Epub 2017 Jan 3 doi: 10.1055/s-0036-1597120. PMID: 28049216

Therapy

Hysterectomy and risk of ovarian cancer: a systematic review and meta-analysis.
Huo X, Yao L, Han X, Li W, Liu J, Zhou L, Gou Y, Yang K, Liu H
Arch Gynecol Obstet 2019 Mar;299(3):599-607. Epub 2019 Jan 4 doi: 10.1007/s00404-018-5020-1. PMID: 30607584
Ovarian cancer in endometriosis: epidemiology, natural history, and clinical diagnosis.
Kobayashi H
Int J Clin Oncol 2009 Oct;14(5):378-82. Epub 2009 Oct 25 doi: 10.1007/s10147-009-0931-2. PMID: 19856043
Wnt signaling in ovarian tumorigenesis.
Gatcliffe TA, Monk BJ, Planutis K, Holcombe RF
Int J Gynecol Cancer 2008 Sep-Oct;18(5):954-62. Epub 2007 Nov 6 doi: 10.1111/j.1525-1438.2007.01127.x. PMID: 17986238Free PMC Article
Endometriosis and the development of malignant tumours of the pelvis. A review of literature.
Van Gorp T, Amant F, Neven P, Vergote I, Moerman P
Best Pract Res Clin Obstet Gynaecol 2004 Apr;18(2):349-71. doi: 10.1016/j.bpobgyn.2003.03.001. PMID: 15157647
The secondary müllerian system revisited.
Lauchlan SC
Int J Gynecol Pathol 1994 Jan;13(1):73-9. doi: 10.1097/00004347-199401000-00009. PMID: 8112958

Prognosis

Ovarian tumors: a survey of selected advances of note during the life of this journal.
Young RH
Hum Pathol 2020 Jan;95:169-206. Epub 2019 Oct 22 doi: 10.1016/j.humpath.2019.09.002. PMID: 31654691
Pathology of borderline and invasive cancers.
Prat J
Best Pract Res Clin Obstet Gynaecol 2017 May;41:15-30. Epub 2016 Oct 3 doi: 10.1016/j.bpobgyn.2016.08.007. PMID: 28277307
Recent concepts of ovarian carcinogenesis: type I and type II.
Koshiyama M, Matsumura N, Konishi I
Biomed Res Int 2014;2014:934261. Epub 2014 Apr 23 doi: 10.1155/2014/934261. PMID: 24868556Free PMC Article
Precursors and pathogenesis of ovarian carcinoma.
Lim D, Oliva E
Pathology 2013 Apr;45(3):229-42. doi: 10.1097/PAT.0b013e32835f2264. PMID: 23478230
TP53 and ovarian cancer.
Schuijer M, Berns EM
Hum Mutat 2003 Mar;21(3):285-91. doi: 10.1002/humu.10181. PMID: 12619114

Clinical prediction guides

Ciliated Cells in Ovarian Cancer Decrease with Increasing Tumor Grade and Disease Progression.
Richardson MT, Recouvreux MS, Karlan BY, Walts AE, Orsulic S
Cells 2022 Dec 11;11(24) doi: 10.3390/cells11244009. PMID: 36552773Free PMC Article
Ovarian tumors: a survey of selected advances of note during the life of this journal.
Young RH
Hum Pathol 2020 Jan;95:169-206. Epub 2019 Oct 22 doi: 10.1016/j.humpath.2019.09.002. PMID: 31654691
Hysterectomy and risk of ovarian cancer: a systematic review and meta-analysis.
Huo X, Yao L, Han X, Li W, Liu J, Zhou L, Gou Y, Yang K, Liu H
Arch Gynecol Obstet 2019 Mar;299(3):599-607. Epub 2019 Jan 4 doi: 10.1007/s00404-018-5020-1. PMID: 30607584
Ovarian cancer in endometriosis: epidemiology, natural history, and clinical diagnosis.
Kobayashi H
Int J Clin Oncol 2009 Oct;14(5):378-82. Epub 2009 Oct 25 doi: 10.1007/s10147-009-0931-2. PMID: 19856043
TP53 and ovarian cancer.
Schuijer M, Berns EM
Hum Mutat 2003 Mar;21(3):285-91. doi: 10.1002/humu.10181. PMID: 12619114

Recent systematic reviews

Hysterectomy and risk of ovarian cancer: a systematic review and meta-analysis.
Huo X, Yao L, Han X, Li W, Liu J, Zhou L, Gou Y, Yang K, Liu H
Arch Gynecol Obstet 2019 Mar;299(3):599-607. Epub 2019 Jan 4 doi: 10.1007/s00404-018-5020-1. PMID: 30607584
The role of human epididymis protein 4 as a biomarker in gynecologic malignancies.
Plotti F, Scaletta G, Terranova C, Montera R, De Cicco Nardone C, Luvero D, Rossini G, Gatti A, Schirò T, Moncelli M, Guzzo F, Angioli R
Minerva Ginecol 2019 Feb;71(1):36-43. Epub 2018 Oct 11 doi: 10.23736/S0026-4784.18.04328-9. PMID: 30318876
Wnt signaling in ovarian tumorigenesis.
Gatcliffe TA, Monk BJ, Planutis K, Holcombe RF
Int J Gynecol Cancer 2008 Sep-Oct;18(5):954-62. Epub 2007 Nov 6 doi: 10.1111/j.1525-1438.2007.01127.x. PMID: 17986238Free PMC Article

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