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Adrenal Cortical Low Grade Carcinoma

MedGen UID:
385205
•Concept ID:
C2349148
•
Neoplastic Process
Synonyms: Adrenal Cortex Low Grade Carcinoma; Adrenal Cortex Low-Grade Carcinoma; Adrenal Cortical Low-Grade Carcinoma; Well Differentiated Adrenal Cortex Carcinoma

Definition

A carcinoma that arises from the adrenal cortex and is characterized by the presence of twenty or less mitoses per ten square millimeters. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdrenal Cortical Low Grade Carcinoma

Professional guidelines

PubMed

ENDOCRINE TUMOURS: Our experience with the management of patients with non-metastatic adrenocortical carcinoma.
Terzolo M, Fassnacht M
Eur J Endocrinol 2022 Sep 1;187(3):R27-R40. Epub 2022 Jul 19 doi: 10.1530/EJE-22-0260. PMID: 35695575
European Society of Endocrine Surgeons (ESES) and European Network for the Study of Adrenal Tumours (ENSAT) recommendations for the surgical management of adrenocortical carcinoma.
Gaujoux S, Mihai R; joint working group of ESES and ENSAT
Br J Surg 2017 Mar;104(4):358-376. doi: 10.1002/bjs.10414. PMID: 28199015
Impact of monitoring plasma 1,1-dichlorodiphenildichloroethane (o,p'DDD) levels on the treatment of patients with adrenocortical carcinoma.
Baudin E, Pellegriti G, Bonnay M, Penfornis A, Laplanche A, Vassal G, Schlumberger M
Cancer 2001 Sep 15;92(6):1385-92. doi: 10.1002/1097-0142(20010915)92:6<1385::aid-cncr1461>3.0.co;2-2. PMID: 11745214

Recent clinical studies

Etiology

Overview of the 2022 WHO Classification of Adrenal Cortical Tumors.
Mete O, Erickson LA, Juhlin CC, de Krijger RR, Sasano H, Volante M, Papotti MG
Endocr Pathol 2022 Mar;33(1):155-196. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09710-8. PMID: 35288842Free PMC Article
What Did We Learn from the Molecular Biology of Adrenal Cortical Neoplasia? From Histopathology to Translational Genomics.
Juhlin CC, Bertherat J, Giordano TJ, Hammer GD, Sasano H, Mete O
Endocr Pathol 2021 Mar;32(1):102-133. Epub 2021 Feb 3 doi: 10.1007/s12022-021-09667-0. PMID: 33534120
Data set for reporting of carcinoma of the adrenal cortex: explanations and recommendations of the guidelines from the International Collaboration on Cancer Reporting.
Giordano TJ, Berney D, de Krijger RR, Erickson L, Fassnacht M, Mete O, Papathomas T, Papotti M, Sasano H, Thompson LDR, Volante M, Gill AJ
Hum Pathol 2021 Apr;110:50-61. Epub 2020 Oct 12 doi: 10.1016/j.humpath.2020.10.001. PMID: 33058949
A human mode of intestinal type gastric carcinoma.
Lai S
Med Hypotheses 2019 Feb;123:27-29. Epub 2018 Dec 14 doi: 10.1016/j.mehy.2018.12.009. PMID: 30696587
Well-differentiated thymic carcinoma. An organotypical low-grade carcinoma with relationship to cortical thymoma.
Kirchner T, Schalke B, Buchwald J, Ritter M, Marx A, Müller-Hermelink HK
Am J Surg Pathol 1992 Dec;16(12):1153-69. PMID: 1463094

Diagnosis

Overview of the 2022 WHO Classification of Adrenal Cortical Tumors.
Mete O, Erickson LA, Juhlin CC, de Krijger RR, Sasano H, Volante M, Papotti MG
Endocr Pathol 2022 Mar;33(1):155-196. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09710-8. PMID: 35288842Free PMC Article
What Did We Learn from the Molecular Biology of Adrenal Cortical Neoplasia? From Histopathology to Translational Genomics.
Juhlin CC, Bertherat J, Giordano TJ, Hammer GD, Sasano H, Mete O
Endocr Pathol 2021 Mar;32(1):102-133. Epub 2021 Feb 3 doi: 10.1007/s12022-021-09667-0. PMID: 33534120
Diagnostic and Prognostic Biomarkers of Adrenal Cortical Carcinoma.
Mete O, Gucer H, Kefeli M, Asa SL
Am J Surg Pathol 2018 Feb;42(2):201-213. doi: 10.1097/PAS.0000000000000943. PMID: 28877067
Fine-needle aspiration of adrenal cortical carcinoma: cytologic spectrum and diagnostic challenges.
Ren R, Guo M, Sneige N, Moran CA, Gong Y
Am J Clin Pathol 2006 Sep;126(3):389-98. doi: 10.1309/AQFEB5WEMU41N9K1. PMID: 16880150
New developments in the pathologic diagnosis of adrenal cortical neoplasms. A review.
Medeiros LJ, Weiss LM
Am J Clin Pathol 1992 Jan;97(1):73-83. doi: 10.1093/ajcp/97.1.73. PMID: 1728867

Therapy

Adjuvant mitotane versus surveillance in low-grade, localised adrenocortical carcinoma (ADIUVO): an international, multicentre, open-label, randomised, phase 3 trial and observational study.
Terzolo M, Fassnacht M, Perotti P, Libé R, Kastelan D, Lacroix A, Arlt W, Haak HR, Loli P, Decoudier B, Lasolle H, Quinkler M, Haissaguerre M, Chabre O, Caron P, Stigliano A, Giordano R, Zatelli MC, Bancos I, Fragoso MCBV, Canu L, Luconi M, Puglisi S, Basile V, Reimondo G, Kroiss M, Megerle F, Hahner S, Kimpel O, Dusek T, Nölting S, Bourdeau I, Chortis V, Ettaieb MH, Cosentini D, Grisanti S, Baudin E, Berchialla P, Bovis F, Sormani MP, Bruzzi P, Beuschlein F, Bertherat J, Berruti A
Lancet Diabetes Endocrinol 2023 Oct;11(10):720-730. Epub 2023 Aug 21 doi: 10.1016/S2213-8587(23)00193-6. PMID: 37619579Free PMC Article
Favourable prognosis in metastatic adrenal carcinoma: An unexpected outcome.
Hassan I, Sheikh A
J Pak Med Assoc 2022 Oct;72(10):2101-2104. doi: 10.47391/JPMA.3494. PMID: 36661007
ENDOCRINE TUMOURS: Our experience with the management of patients with non-metastatic adrenocortical carcinoma.
Terzolo M, Fassnacht M
Eur J Endocrinol 2022 Sep 1;187(3):R27-R40. Epub 2022 Jul 19 doi: 10.1530/EJE-22-0260. PMID: 35695575
Peritoneal metastases from adrenal cortical carcinoma treated by cytoreductive surgery and hyperthermic intraperitoneal chemotherapy.
Sugarbaker PH
Tumori 2016 Dec 1;102(6):588-592. Epub 2016 Sep 27 doi: 10.5301/tj.5000567. PMID: 27716880
Well-differentiated thymic carcinoma. An organotypical low-grade carcinoma with relationship to cortical thymoma.
Kirchner T, Schalke B, Buchwald J, Ritter M, Marx A, Müller-Hermelink HK
Am J Surg Pathol 1992 Dec;16(12):1153-69. PMID: 1463094

Prognosis

Favourable prognosis in metastatic adrenal carcinoma: An unexpected outcome.
Hassan I, Sheikh A
J Pak Med Assoc 2022 Oct;72(10):2101-2104. doi: 10.47391/JPMA.3494. PMID: 36661007
Overview of the 2022 WHO Classification of Adrenal Cortical Tumors.
Mete O, Erickson LA, Juhlin CC, de Krijger RR, Sasano H, Volante M, Papotti MG
Endocr Pathol 2022 Mar;33(1):155-196. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09710-8. PMID: 35288842Free PMC Article
What Did We Learn from the Molecular Biology of Adrenal Cortical Neoplasia? From Histopathology to Translational Genomics.
Juhlin CC, Bertherat J, Giordano TJ, Hammer GD, Sasano H, Mete O
Endocr Pathol 2021 Mar;32(1):102-133. Epub 2021 Feb 3 doi: 10.1007/s12022-021-09667-0. PMID: 33534120
Diagnostic and Prognostic Biomarkers of Adrenal Cortical Carcinoma.
Mete O, Gucer H, Kefeli M, Asa SL
Am J Surg Pathol 2018 Feb;42(2):201-213. doi: 10.1097/PAS.0000000000000943. PMID: 28877067
New developments in the pathologic diagnosis of adrenal cortical neoplasms. A review.
Medeiros LJ, Weiss LM
Am J Clin Pathol 1992 Jan;97(1):73-83. doi: 10.1093/ajcp/97.1.73. PMID: 1728867

Clinical prediction guides

Overview of the 2022 WHO Classification of Adrenal Cortical Tumors.
Mete O, Erickson LA, Juhlin CC, de Krijger RR, Sasano H, Volante M, Papotti MG
Endocr Pathol 2022 Mar;33(1):155-196. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09710-8. PMID: 35288842Free PMC Article
Approach to patients with European Network for the Study of Adrenal Tumor stages I and II adrenocortical carcinomas.
Kastelan D, Muzurovic E, Dusek T
Curr Opin Endocrinol Diabetes Obes 2021 Jun 1;28(3):265-270. doi: 10.1097/MED.0000000000000626. PMID: 33709971
Erosive Vulvar Lichen Planus and Risk of Vulvar Neoplasia.
Lyra J, Melo C, Figueiredo R, Polonia-Valente R, Falcão V, Beires J, Vieira-Baptista P
J Low Genit Tract Dis 2021 Jan 1;25(1):71-75. doi: 10.1097/LGT.0000000000000581. PMID: 33214502
Data set for reporting of carcinoma of the adrenal cortex: explanations and recommendations of the guidelines from the International Collaboration on Cancer Reporting.
Giordano TJ, Berney D, de Krijger RR, Erickson L, Fassnacht M, Mete O, Papathomas T, Papotti M, Sasano H, Thompson LDR, Volante M, Gill AJ
Hum Pathol 2021 Apr;110:50-61. Epub 2020 Oct 12 doi: 10.1016/j.humpath.2020.10.001. PMID: 33058949
Diagnostic and Prognostic Biomarkers of Adrenal Cortical Carcinoma.
Mete O, Gucer H, Kefeli M, Asa SL
Am J Surg Pathol 2018 Feb;42(2):201-213. doi: 10.1097/PAS.0000000000000943. PMID: 28877067

Recent systematic reviews

Assessment of prognostic factors in pediatric adrenocortical tumors: a systematic review and evaluation of a modified S-GRAS score.
Riedmeier M, Decarolis B, Haubitz I, Reibetanz J, Wiegering A, Härtel C, Schlegel PG, Fassnacht M, Wiegering V
Eur J Endocrinol 2022 Dec 1;187(6):751-763. Epub 2022 Oct 26 doi: 10.1530/EJE-22-0173. PMID: 36193775

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