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Mild Anemia

MedGen UID:
388097
•Concept ID:
C1858586
•
Finding
Synonyms: Anemia (mild); Anemia, mild; Mild anemia

Definition

Anemia not associated with symptoms of fatigue, headaches, palpitations, or shortness of breath. In asymptomatic anemia the hematocrit levels usually range from 32 to 35%. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMild Anemia

Professional guidelines

PubMed

Unexplained anemia of aging: Etiology, health consequences, and diagnostic criteria.
Guralnik J, Ershler W, Artz A, Lazo-Langner A, Walston J, Pahor M, Ferrucci L, Evans WJ
J Am Geriatr Soc 2022 Mar;70(3):891-899. Epub 2021 Nov 19 doi: 10.1111/jgs.17565. PMID: 34796957Free PMC Article
Diagnosis and management of iron deficiency anemia in inflammatory bowel disease.
Bohm N
Am J Manag Care 2021 Jul;27(11 Suppl):S211-S218. doi: 10.37765/ajmc.2021.88714. PMID: 34255450
Anemia at older age: etiologies, clinical implications, and management.
Stauder R, Valent P, Theurl I
Blood 2018 Feb 1;131(5):505-514. Epub 2017 Nov 15 doi: 10.1182/blood-2017-07-746446. PMID: 29141943

Recent clinical studies

Etiology

Scurvy.
Krečak I, Babić G, Skelin M
Acta Dermatovenerol Croat 2022 Jul;30(1):59-60. PMID: 36153722
Global Prevalence of Anemia in Pregnant Women: A Comprehensive Systematic Review and Meta-Analysis.
Karami M, Chaleshgar M, Salari N, Akbari H, Mohammadi M
Matern Child Health J 2022 Jul;26(7):1473-1487. Epub 2022 May 24 doi: 10.1007/s10995-022-03450-1. PMID: 35608810
Severity of Anemia During Pregnancy and Adverse Maternal and Fetal Outcomes.
Shi H, Chen L, Wang Y, Sun M, Guo Y, Ma S, Wang X, Jiang H, Wang X, Lu J, Ge L, Dong S, Zhuang Y, Zhao Y, Wei Y, Ma X, Qiao J
JAMA Netw Open 2022 Feb 1;5(2):e2147046. doi: 10.1001/jamanetworkopen.2021.47046. PMID: 35113162Free PMC Article
Maternal and Perinatal Morbidity and Mortality Associated With Anemia in Pregnancy.
Smith C, Teng F, Branch E, Chu S, Joseph KS
Obstet Gynecol 2019 Dec;134(6):1234-1244. doi: 10.1097/AOG.0000000000003557. PMID: 31764734Free PMC Article
Iron deficiency anemia in pregnancy.
Di Renzo GC, Spano F, Giardina I, Brillo E, Clerici G, Roura LC
Womens Health (Lond) 2015 Nov;11(6):891-900. Epub 2015 Oct 16 doi: 10.2217/whe.15.35. PMID: 26472066

Diagnosis

Severity of Anemia During Pregnancy and Adverse Maternal and Fetal Outcomes.
Shi H, Chen L, Wang Y, Sun M, Guo Y, Ma S, Wang X, Jiang H, Wang X, Lu J, Ge L, Dong S, Zhuang Y, Zhao Y, Wei Y, Ma X, Qiao J
JAMA Netw Open 2022 Feb 1;5(2):e2147046. doi: 10.1001/jamanetworkopen.2021.47046. PMID: 35113162Free PMC Article
Iron Deficiency Anemia in Pregnancy.
James AH
Obstet Gynecol 2021 Oct 1;138(4):663-674. doi: 10.1097/AOG.0000000000004559. PMID: 34623079
Maternal and Perinatal Morbidity and Mortality Associated With Anemia in Pregnancy.
Smith C, Teng F, Branch E, Chu S, Joseph KS
Obstet Gynecol 2019 Dec;134(6):1234-1244. doi: 10.1097/AOG.0000000000003557. PMID: 31764734Free PMC Article
Anemia at older age: etiologies, clinical implications, and management.
Stauder R, Valent P, Theurl I
Blood 2018 Feb 1;131(5):505-514. Epub 2017 Nov 15 doi: 10.1182/blood-2017-07-746446. PMID: 29141943
Laboratory diagnosis of thalassemia.
Brancaleoni V, Di Pierro E, Motta I, Cappellini MD
Int J Lab Hematol 2016 May;38 Suppl 1:32-40. Epub 2016 May 16 doi: 10.1111/ijlh.12527. PMID: 27183541

Therapy

Scurvy.
Krečak I, Babić G, Skelin M
Acta Dermatovenerol Croat 2022 Jul;30(1):59-60. PMID: 36153722
Iron Deficiency Anemia in Pregnancy.
James AH
Obstet Gynecol 2021 Oct 1;138(4):663-674. doi: 10.1097/AOG.0000000000004559. PMID: 34623079
Diagnosis and therapeutic strategies for small bowel vascular lesions.
Sakai E, Ohata K, Nakajima A, Matsuhashi N
World J Gastroenterol 2019 Jun 14;25(22):2720-2733. doi: 10.3748/wjg.v25.i22.2720. PMID: 31235995Free PMC Article
Micronutrient supplementation during pregnancy and the risk of pregnancy-induced hypertension: A randomized clinical trial.
Chen S, Li N, Mei Z, Ye R, Li Z, Liu J, Serdula MK
Clin Nutr 2019 Feb;38(1):146-151. Epub 2018 Feb 15 doi: 10.1016/j.clnu.2018.01.029. PMID: 29428785Free PMC Article
Iron deficiency anemia in pregnancy.
Di Renzo GC, Spano F, Giardina I, Brillo E, Clerici G, Roura LC
Womens Health (Lond) 2015 Nov;11(6):891-900. Epub 2015 Oct 16 doi: 10.2217/whe.15.35. PMID: 26472066

Prognosis

Maternal and Perinatal Morbidity and Mortality Associated With Anemia in Pregnancy.
Smith C, Teng F, Branch E, Chu S, Joseph KS
Obstet Gynecol 2019 Dec;134(6):1234-1244. doi: 10.1097/AOG.0000000000003557. PMID: 31764734Free PMC Article
Laboratory diagnosis of thalassemia.
Brancaleoni V, Di Pierro E, Motta I, Cappellini MD
Int J Lab Hematol 2016 May;38 Suppl 1:32-40. Epub 2016 May 16 doi: 10.1111/ijlh.12527. PMID: 27183541
Hospital-acquired anemia.
Wong P, Intragumtornchai T
J Med Assoc Thai 2006 Jan;89(1):63-7. PMID: 16583583
Noninvasive diagnosis by Doppler ultrasonography of fetal anemia due to maternal red-cell alloimmunization. Collaborative Group for Doppler Assessment of the Blood Velocity in Anemic Fetuses.
Mari G, Deter RL, Carpenter RL, Rahman F, Zimmerman R, Moise KJ Jr, Dorman KF, Ludomirsky A, Gonzalez R, Gomez R, Oz U, Detti L, Copel JA, Bahado-Singh R, Berry S, Martinez-Poyer J, Blackwell SC
N Engl J Med 2000 Jan 6;342(1):9-14. doi: 10.1056/NEJM200001063420102. PMID: 10620643
Pubertal metrorrhagia.
Duflos-Cohade C, Amandruz M, Thibaud E
J Pediatr Adolesc Gynecol 1996 Feb;9(1):16-20. doi: 10.1016/s1083-3188(96)70005-0. PMID: 9551371

Clinical prediction guides

Ineffective Erythropoietin Response to Anemia in Sepsis.
Apple CG, Kelly LS, Kannan KB, Ungaro RF, Moore FA, Brakenridge SC, Moldawer LL, Efron PA, Mohr AM
Surg Infect (Larchmt) 2022 Mar;23(2):142-149. Epub 2021 Dec 24 doi: 10.1089/sur.2021.152. PMID: 34958257Free PMC Article
Maternal and Perinatal Morbidity and Mortality Associated With Anemia in Pregnancy.
Smith C, Teng F, Branch E, Chu S, Joseph KS
Obstet Gynecol 2019 Dec;134(6):1234-1244. doi: 10.1097/AOG.0000000000003557. PMID: 31764734Free PMC Article
Laboratory diagnosis of thalassemia.
Brancaleoni V, Di Pierro E, Motta I, Cappellini MD
Int J Lab Hematol 2016 May;38 Suppl 1:32-40. Epub 2016 May 16 doi: 10.1111/ijlh.12527. PMID: 27183541
Anemia, renal transplantation, and the anemia paradox.
Rigatto C
Semin Nephrol 2006 Jul;26(4):307-12. doi: 10.1016/j.semnephrol.2006.05.007. PMID: 16949469
Noninvasive diagnosis by Doppler ultrasonography of fetal anemia due to maternal red-cell alloimmunization. Collaborative Group for Doppler Assessment of the Blood Velocity in Anemic Fetuses.
Mari G, Deter RL, Carpenter RL, Rahman F, Zimmerman R, Moise KJ Jr, Dorman KF, Ludomirsky A, Gonzalez R, Gomez R, Oz U, Detti L, Copel JA, Bahado-Singh R, Berry S, Martinez-Poyer J, Blackwell SC
N Engl J Med 2000 Jan 6;342(1):9-14. doi: 10.1056/NEJM200001063420102. PMID: 10620643

Recent systematic reviews

Prevalence and types of anemia among people with tuberculosis in Africa: a systematic review and meta-analysis.
Abaynew Y, Ali A, Taye G, Shenkut M
Sci Rep 2023 Apr 3;13(1):5385. doi: 10.1038/s41598-023-32609-1. PMID: 37012387Free PMC Article
Global Prevalence of Anemia in Pregnant Women: A Comprehensive Systematic Review and Meta-Analysis.
Karami M, Chaleshgar M, Salari N, Akbari H, Mohammadi M
Matern Child Health J 2022 Jul;26(7):1473-1487. Epub 2022 May 24 doi: 10.1007/s10995-022-03450-1. PMID: 35608810
Lactoferrin or ferrous salts for iron deficiency anemia in pregnancy: A meta-analysis of randomized trials.
Abu Hashim H, Foda O, Ghayaty E
Eur J Obstet Gynecol Reprod Biol 2017 Dec;219:45-52. Epub 2017 Oct 4 doi: 10.1016/j.ejogrb.2017.10.003. PMID: 29059584
Effects of transplantation of olfactory ensheathing cells in chronic spinal cord injury: a systematic review and meta-analysis.
Li L, Adnan H, Xu B, Wang J, Wang C, Li F, Tang K
Eur Spine J 2015 May;24(5):919-30. Epub 2014 Jul 8 doi: 10.1007/s00586-014-3416-6. PMID: 25001890
Prevalence and outcomes of anemia in rheumatoid arthritis: a systematic review of the literature.
Wilson A, Yu HT, Goodnough LT, Nissenson AR
Am J Med 2004 Apr 5;116 Suppl 7A:50S-57S. doi: 10.1016/j.amjmed.2003.12.012. PMID: 15050886

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