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Reactive arthritis

MedGen UID:
39047
•Concept ID:
C0085435
•
Disease or Syndrome
Synonyms: Reiter syndrome; Reiter's syndrome
SNOMED CT: Post-bacterial arthropathy (129133005); Reactive arthritis (201736002); Post-infective arthritis (239783001); Post-infective arthropathy (239783001); Arthritis occurring after infection (239783001)
Modes of inheritance:
Non-Mendelian inheritance
MedGen UID:
109109
•Concept ID:
C0600599
•
Genetic Function
Source: Orphanet
A mode of inheritance that depends on a mixture of major and minor genetic determinants possibly together with environmental factors. Diseases inherited in this manner are termed complex diseases.
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Non-Mendelian inheritance (Orphanet)
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0017376
Orphanet: ORPHA29207

Definition

A rare spondyloarthritis characterized by acute or chronic sterile synovitis with or without extra-articular manifestations, becoming manifest after an infection. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReactive arthritis

Professional guidelines

PubMed

Reactive Arthritis: Treatment Challenges and Future Perspectives.
Wendling D, Prati C, Chouk M, Verhoeven F
Curr Rheumatol Rep 2020 May 26;22(7):29. doi: 10.1007/s11926-020-00904-9. PMID: 32458153
Evaluation and Management of Septic Arthritis and its Mimics in the Emergency Department.
Long B, Koyfman A, Gottlieb M
West J Emerg Med 2019 Mar;20(2):331-341. Epub 2018 Dec 6 doi: 10.5811/westjem.2018.10.40974. PMID: 30881554Free PMC Article
Hepatitis A: clinical manifestations and management.
Jeong SH, Lee HS
Intervirology 2010;53(1):15-9. Epub 2010 Jan 5 doi: 10.1159/000252779. PMID: 20068336

Recent clinical studies

Etiology

Reactive arthritis: a clinical review.
Jubber A, Moorthy A
J R Coll Physicians Edinb 2021 Sep;51(3):288-297. doi: 10.4997/JRCPE.2021.319. PMID: 34528623
Understanding the Pathogenesis of Spondyloarthritis.
Sharip A, Kunz J
Biomolecules 2020 Oct 20;10(10) doi: 10.3390/biom10101461. PMID: 33092023Free PMC Article
Post-Streptococcal Reactive Arthritis.
Bawazir Y, Towheed T, Anastassiades T
Curr Rheumatol Rev 2020;16(1):2-8. doi: 10.2174/1573397115666190808110337. PMID: 31393253
The Seronegative Spondyloarthropathies.
Duba AS, Mathew SD
Prim Care 2018 Jun;45(2):271-287. doi: 10.1016/j.pop.2018.02.005. PMID: 29759124
Spondyloarthritis.
Dougados M, Baeten D
Lancet 2011 Jun 18;377(9783):2127-37. doi: 10.1016/S0140-6736(11)60071-8. PMID: 21684383

Diagnosis

Post-Streptococcal Reactive Arthritis.
Bawazir Y, Towheed T, Anastassiades T
Curr Rheumatol Rev 2020;16(1):2-8. doi: 10.2174/1573397115666190808110337. PMID: 31393253
The Seronegative Spondyloarthropathies.
Duba AS, Mathew SD
Prim Care 2018 Jun;45(2):271-287. doi: 10.1016/j.pop.2018.02.005. PMID: 29759124
Reactive arthritis: update 2018.
García-Kutzbach A, Chacón-Súchite J, García-Ferrer H, Iraheta I
Clin Rheumatol 2018 Apr;37(4):869-874. Epub 2018 Feb 17 doi: 10.1007/s10067-018-4022-5. PMID: 29455267
Reactive Arthritis.
Schmitt SK
Infect Dis Clin North Am 2017 Jun;31(2):265-277. Epub 2017 Mar 11 doi: 10.1016/j.idc.2017.01.002. PMID: 28292540
Diagnosis and classification of reactive arthritis.
Selmi C, Gershwin ME
Autoimmun Rev 2014 Apr-May;13(4-5):546-9. Epub 2014 Jan 10 doi: 10.1016/j.autrev.2014.01.005. PMID: 24418301

Therapy

Reactive Arthritis: Treatment Challenges and Future Perspectives.
Wendling D, Prati C, Chouk M, Verhoeven F
Curr Rheumatol Rep 2020 May 26;22(7):29. doi: 10.1007/s11926-020-00904-9. PMID: 32458153
Post-Streptococcal Reactive Arthritis.
Bawazir Y, Towheed T, Anastassiades T
Curr Rheumatol Rev 2020;16(1):2-8. doi: 10.2174/1573397115666190808110337. PMID: 31393253
The use of biologics for uveitis associated with spondyloarthritis.
Arepalli S, Rosenbaum JT
Curr Opin Rheumatol 2019 Jul;31(4):349-354. doi: 10.1097/BOR.0000000000000619. PMID: 31107288
Evaluation and Management of Septic Arthritis and its Mimics in the Emergency Department.
Long B, Koyfman A, Gottlieb M
West J Emerg Med 2019 Mar;20(2):331-341. Epub 2018 Dec 6 doi: 10.5811/westjem.2018.10.40974. PMID: 30881554Free PMC Article
Reactive Arthritis.
Schmitt SK
Infect Dis Clin North Am 2017 Jun;31(2):265-277. Epub 2017 Mar 11 doi: 10.1016/j.idc.2017.01.002. PMID: 28292540

Prognosis

Reactive arthritis before and after the onset of the COVID-19 pandemic.
Bekaryssova D, Yessirkepov M, Zimba O, Gasparyan AY, Ahmed S
Clin Rheumatol 2022 Jun;41(6):1641-1652. Epub 2022 Mar 5 doi: 10.1007/s10067-022-06120-3. PMID: 35247132Free PMC Article
Reactive arthritis: a clinical review.
Jubber A, Moorthy A
J R Coll Physicians Edinb 2021 Sep;51(3):288-297. doi: 10.4997/JRCPE.2021.319. PMID: 34528623
Reactive Arthritis.
Schmitt SK
Infect Dis Clin North Am 2017 Jun;31(2):265-277. Epub 2017 Mar 11 doi: 10.1016/j.idc.2017.01.002. PMID: 28292540
Reactive arthritis.
Hannu T
Best Pract Res Clin Rheumatol 2011 Jun;25(3):347-57. doi: 10.1016/j.berh.2011.01.018. PMID: 22100285
Hepatitis A: clinical manifestations and management.
Jeong SH, Lee HS
Intervirology 2010;53(1):15-9. Epub 2010 Jan 5 doi: 10.1159/000252779. PMID: 20068336

Clinical prediction guides

Reactive arthritis before and after the onset of the COVID-19 pandemic.
Bekaryssova D, Yessirkepov M, Zimba O, Gasparyan AY, Ahmed S
Clin Rheumatol 2022 Jun;41(6):1641-1652. Epub 2022 Mar 5 doi: 10.1007/s10067-022-06120-3. PMID: 35247132Free PMC Article
COVID-19 and the clinical course of rheumatic manifestations.
Ahmed S, Zimba O, Gasparyan AY
Clin Rheumatol 2021 Jul;40(7):2611-2619. Epub 2021 Mar 17 doi: 10.1007/s10067-021-05691-x. PMID: 33733315Free PMC Article
EULAR points to consider for the diagnosis and management of rheumatic immune-related adverse events due to cancer immunotherapy with checkpoint inhibitors.
Kostine M, Finckh A, Bingham CO, Visser K, Leipe J, Schulze-Koops H, Choy EH, Benesova K, Radstake TRDJ, Cope AP, Lambotte O, Gottenberg JE, Allenbach Y, Visser M, Rusthoven C, Thomasen L, Jamal S, Marabelle A, Larkin J, Haanen JBAG, Calabrese LH, Mariette X, Schaeverbeke T
Ann Rheum Dis 2021 Jan;80(1):36-48. Epub 2020 Apr 23 doi: 10.1136/annrheumdis-2020-217139. PMID: 32327425Free PMC Article
Diagnosis and classification of reactive arthritis.
Selmi C, Gershwin ME
Autoimmun Rev 2014 Apr-May;13(4-5):546-9. Epub 2014 Jan 10 doi: 10.1016/j.autrev.2014.01.005. PMID: 24418301
Hepatitis A: clinical manifestations and management.
Jeong SH, Lee HS
Intervirology 2010;53(1):15-9. Epub 2010 Jan 5 doi: 10.1159/000252779. PMID: 20068336

Recent systematic reviews

Reactive arthritis following COVID-19 current evidence, diagnosis, and management strategies.
Migliorini F, Bell A, Vaishya R, Eschweiler J, Hildebrand F, Maffulli N
J Orthop Surg Res 2023 Mar 15;18(1):205. doi: 10.1186/s13018-023-03651-6. PMID: 36922870Free PMC Article
Reactive Arthritis following Bacillus Calmette-Guerin Therapy for Bladder Cancer: a Systematic Literature Review.
Abdelghani KB, Nacef L, Miladi S, Sellami M, Ouenniche K, Souabni L, Kassab S, Chekili S, Fazaa A, Laatar A
Curr Rheumatol Rep 2021 Apr 28;23(6):39. doi: 10.1007/s11926-021-01004-y. PMID: 33913026
Global Prevalence of Spondyloarthritis: A Systematic Review and Meta-Regression Analysis.
Stolwijk C, van Onna M, Boonen A, van Tubergen A
Arthritis Care Res (Hoboken) 2016 Sep;68(9):1320-31. Epub 2016 Jul 27 doi: 10.1002/acr.22831. PMID: 26713432
EULAR recommendations for the use of imaging in the diagnosis and management of spondyloarthritis in clinical practice.
Mandl P, Navarro-Compán V, Terslev L, Aegerter P, van der Heijde D, D'Agostino MA, Baraliakos X, Pedersen SJ, Jurik AG, Naredo E, Schueller-Weidekamm C, Weber U, Wick MC, Bakker PA, Filippucci E, Conaghan PG, Rudwaleit M, Schett G, Sieper J, Tarp S, Marzo-Ortega H, Østergaard M; European League Against Rheumatism (EULAR)
Ann Rheum Dis 2015 Jul;74(7):1327-39. Epub 2015 Apr 2 doi: 10.1136/annrheumdis-2014-206971. PMID: 25837448
Antibiotics for treatment of reactive arthritis: a systematic review and metaanalysis.
Barber CE, Kim J, Inman RD, Esdaile JM, James MT
J Rheumatol 2013 Jun;40(6):916-28. Epub 2013 Apr 15 doi: 10.3899/jrheum.121192. PMID: 23588936

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