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Frontal lobe epilepsy

MedGen UID:
39074
Concept ID:
C0085541
Disease or Syndrome
Synonyms: Epilepsy, Frontal Lobe; Frontal Lobe Epilepsies; Frontal Lobe Epilepsy
SNOMED CT: Frontal lobe epilepsy (230394006)
 
Monarch Initiative: MONDO:0002612

Definition

A localization-related (focal) form of epilepsy characterized by seizures which arise in the frontal lobe. A variety of clinical syndromes exist depending on the exact location of the seizure focus. Frontal lobe seizures may be idiopathic (cryptogenic) or caused by an identifiable disease process such as traumatic injuries, neoplasms, or other macroscopic or microscopic lesions of the frontal lobes (symptomatic frontal lobe seizures). (From Adams et al., Principles of Neurology, 6th ed, pp318-9) [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFrontal lobe epilepsy

Professional guidelines

PubMed

Ljunggren S, Winblad S, Hällgren Graneheim U, Malmgren K, Ozanne A
Epilepsy Behav 2021 Aug;121(Pt A):108077. Epub 2021 Jun 1 doi: 10.1016/j.yebeh.2021.108077. PMID: 34087680
Tinuper P, Bisulli F, Cross JH, Hesdorffer D, Kahane P, Nobili L, Provini F, Scheffer IE, Tassi L, Vignatelli L, Bassetti C, Cirignotta F, Derry C, Gambardella A, Guerrini R, Halasz P, Licchetta L, Mahowald M, Manni R, Marini C, Mostacci B, Naldi I, Parrino L, Picard F, Pugliatti M, Ryvlin P, Vigevano F, Zucconi M, Berkovic S, Ottman R
Neurology 2016 May 10;86(19):1834-42. Epub 2016 Apr 15 doi: 10.1212/WNL.0000000000002666. PMID: 27164717Free PMC Article
Tinuper P, Bisulli F, Provini F
Epilepsia 2012 Dec;53 Suppl 7:12-9. doi: 10.1111/j.1528-1167.2012.03710.x. PMID: 23153205

Recent clinical studies

Etiology

Khoo A, de Tisi J, Foong J, Bindman D, O'Keeffe AG, Sander JW, Miserocchi A, McEvoy AW, Duncan JS
Epilepsy Res 2022 Oct;186:106998. Epub 2022 Aug 13 doi: 10.1016/j.eplepsyres.2022.106998. PMID: 35985250
Ljunggren S, Winblad S, Hällgren Graneheim U, Malmgren K, Ozanne A
Epilepsy Behav 2021 Aug;121(Pt A):108077. Epub 2021 Jun 1 doi: 10.1016/j.yebeh.2021.108077. PMID: 34087680
Asadi-Pooya AA, Wyeth D, Sperling MR
Epilepsy Behav 2016 Jun;59:1-3. Epub 2016 Apr 13 doi: 10.1016/j.yebeh.2016.03.012. PMID: 27084975
Bonini F, McGonigal A, Trébuchon A, Gavaret M, Bartolomei F, Giusiano B, Chauvel P
Epilepsia 2014 Feb;55(2):264-77. Epub 2013 Dec 24 doi: 10.1111/epi.12490. PMID: 24372328
Sohn YH, Lee PH
Handb Clin Neurol 2011;100:367-73. doi: 10.1016/B978-0-444-52014-2.00028-8. PMID: 21496595

Diagnosis

Augustine A
J Clin Neurophysiol 2023 Mar 1;40(3):224-229. Epub 2022 Sep 20 doi: 10.1097/WNP.0000000000000945. PMID: 36872501
McGonigal A
J Neurol 2022 Jun;269(6):3363-3371. Epub 2022 Jan 10 doi: 10.1007/s00415-021-10949-0. PMID: 35006387
Bonini F, McGonigal A, Trébuchon A, Gavaret M, Bartolomei F, Giusiano B, Chauvel P
Epilepsia 2014 Feb;55(2):264-77. Epub 2013 Dec 24 doi: 10.1111/epi.12490. PMID: 24372328
Derry CP, Duncan S
Epilepsy Behav 2013 Mar;26(3):394-404. doi: 10.1016/j.yebeh.2012.10.033. PMID: 23465654
Beleza P, Pinho J
J Clin Neurosci 2011 May;18(5):593-600. Epub 2011 Feb 23 doi: 10.1016/j.jocn.2010.08.018. PMID: 21349720

Therapy

Jiang Y, Zhou X
J Int Med Res 2020 Sep;48(9):300060520946166. doi: 10.1177/0300060520946166. PMID: 32877235Free PMC Article
Lee RW, Worrell GA
J Clin Neurophysiol 2012 Oct;29(5):379-84. doi: 10.1097/WNP.0b013e31826b3c7c. PMID: 23027094Free PMC Article
Braakman HM, Vaessen MJ, Hofman PA, Debeij-van Hall MH, Backes WH, Vles JS, Aldenkamp AP
Epilepsia 2011 May;52(5):849-56. Epub 2011 Apr 11 doi: 10.1111/j.1528-1167.2011.03057.x. PMID: 21480882
Eriksson SH
Curr Opin Neurol 2011 Apr;24(2):171-6. doi: 10.1097/WCO.0b013e3283445355. PMID: 21386677
Kellinghaus C, Lüders HO
Epileptic Disord 2004 Dec;6(4):223-39. PMID: 15634619

Prognosis

Khoo A, de Tisi J, Foong J, Bindman D, O'Keeffe AG, Sander JW, Miserocchi A, McEvoy AW, Duncan JS
Epilepsy Res 2022 Oct;186:106998. Epub 2022 Aug 13 doi: 10.1016/j.eplepsyres.2022.106998. PMID: 35985250
McGonigal A
J Neurol 2022 Jun;269(6):3363-3371. Epub 2022 Jan 10 doi: 10.1007/s00415-021-10949-0. PMID: 35006387
Asadi-Pooya AA, Wyeth D, Sperling MR
Epilepsy Behav 2016 Jun;59:1-3. Epub 2016 Apr 13 doi: 10.1016/j.yebeh.2016.03.012. PMID: 27084975
Lee RW, Worrell GA
J Clin Neurophysiol 2012 Oct;29(5):379-84. doi: 10.1097/WNP.0b013e31826b3c7c. PMID: 23027094Free PMC Article
Kellinghaus C, Lüders HO
Epileptic Disord 2004 Dec;6(4):223-39. PMID: 15634619

Clinical prediction guides

Augustine A
J Clin Neurophysiol 2023 Mar 1;40(3):224-229. Epub 2022 Sep 20 doi: 10.1097/WNP.0000000000000945. PMID: 36872501
Asadi-Pooya AA, Wyeth D, Sperling MR
Epilepsy Behav 2016 Jun;59:1-3. Epub 2016 Apr 13 doi: 10.1016/j.yebeh.2016.03.012. PMID: 27084975
Schmitt B
Neuropediatrics 2015 Jun;46(3):171-80. Epub 2015 May 12 doi: 10.1055/s-0035-1551574. PMID: 25965811
Lee RW, Worrell GA
J Clin Neurophysiol 2012 Oct;29(5):379-84. doi: 10.1097/WNP.0b013e31826b3c7c. PMID: 23027094Free PMC Article
Unnwongse K, Wehner T, Foldvary-Schaefer N
J Clin Neurophysiol 2012 Oct;29(5):371-8. doi: 10.1097/WNP.0b013e31826b3c60. PMID: 23027093

Recent systematic reviews

Ziaei M, Arnold C, Thompson K, Reutens DC
J Int Neuropsychol Soc 2023 Feb;29(2):205-229. Epub 2022 Mar 7 doi: 10.1017/S1355617722000066. PMID: 35249578
Li H, Ji S, Dong B, Chen L
Epilepsy Behav 2021 Dec;125:108369. Epub 2021 Oct 29 doi: 10.1016/j.yebeh.2021.108369. PMID: 34731717
Gold JA, Sher Y, Maldonado JR
Psychosomatics 2016 Sep-Oct;57(5):445-64. Epub 2016 May 16 doi: 10.1016/j.psym.2016.05.005. PMID: 27494984
Stewart E, Catroppa C, Lah S
Neuropsychol Rev 2016 Mar;26(1):3-24. Epub 2016 Jan 21 doi: 10.1007/s11065-015-9313-x. PMID: 26797753
Metternich B, Buschmann F, Wagner K, Schulze-Bonhage A, Kriston L
Neuropsychol Rev 2014 Jun;24(2):200-18. Epub 2014 Mar 26 doi: 10.1007/s11065-014-9255-8. PMID: 24667998

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