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Fungal meningitis

MedGen UID:
39285
•Concept ID:
C0085438
•
Disease or Syndrome
Synonyms: Fungal Meningitides; Fungal Meningitis; Meningitides, Fungal; Meningitis, Fungal
SNOMED CT: Fungal meningitis (24321005)
 
HPO: HP:0032159
Monarch Initiative: MONDO:0006764

Definition

An infection of the meninges caused by a fungus. Generally, only individuals with deficiencies of the immune system contract fungal meningitis. [from HPO]

Professional guidelines

PubMed

Microbiological diagnosis of tuberculous meningitis: Phenotype to genotype.
Garg RK
Indian J Med Res 2019 Nov;150(5):448-457. doi: 10.4103/ijmr.IJMR_1145_19. PMID: 31939388Free PMC Article
Systematic review of caudal epidural injections in the management of chronic back pain.
Friedman JH, Dighe G
R I Med J (2013) 2013 Jan 4;96(1):12-6. PMID: 23638452
Fungal infections and their management.
Graybill JR, Sharkey PK
Br J Clin Pract Suppl 1990 Sep;71:23-31. PMID: 1965416

Recent clinical studies

Etiology

The Practice of Compounding, Associated Compounding Regulations, and the Impact on Dermatologists.
Quertermous J, Desai S, Harper J, Lebwohl M, Torres A, Kircik LH
J Drugs Dermatol 2018 Jul 1;17(7):s17-s22. PMID: 30005109
Neuroinfections caused by fungi.
Góralska K, Blaszkowska J, Dzikowiec M
Infection 2018 Aug;46(4):443-459. Epub 2018 May 21 doi: 10.1007/s15010-018-1152-2. PMID: 29785613Free PMC Article
Sterile compounding: clinical, legal, and regulatory implications for patient safety.
Qureshi N, Wesolowicz L, Stievater T, Lin AT
J Manag Care Spec Pharm 2014 Dec;20(12):1183-91. doi: 10.18553/jmcp.2014.20.12.1183. PMID: 25443512Free PMC Article
Neonatal Candida meningitis.
Moylett EH
Semin Pediatr Infect Dis 2003 Apr;14(2):115-22. doi: 10.1053/spid.2003.127128. PMID: 12881799
Fungal meningitis.
Gottfredsson M, Perfect JR
Semin Neurol 2000;20(3):307-22. doi: 10.1055/s-2000-9394. PMID: 11051295

Diagnosis

Burden of fungal meningitis.
Pagliano P, Esposito S, Ascione T, Spera AM
Future Microbiol 2020 May;15:469-472. Epub 2020 May 7 doi: 10.2217/fmb-2020-0006. PMID: 32378964
Methods for rapid diagnosis of meningitis etiology in adults.
Poplin V, Boulware DR, Bahr NC
Biomark Med 2020 Apr;14(6):459-479. Epub 2020 Apr 9 doi: 10.2217/bmm-2019-0333. PMID: 32270693Free PMC Article
Neuroinfections caused by fungi.
Góralska K, Blaszkowska J, Dzikowiec M
Infection 2018 Aug;46(4):443-459. Epub 2018 May 21 doi: 10.1007/s15010-018-1152-2. PMID: 29785613Free PMC Article
Coccidioidal meningitis.
Williams PL
Ann N Y Acad Sci 2007 Sep;1111:377-84. Epub 2007 Mar 15 doi: 10.1196/annals.1406.037. PMID: 17363442
Fungal meningitis.
Gottfredsson M, Perfect JR
Semin Neurol 2000;20(3):307-22. doi: 10.1055/s-2000-9394. PMID: 11051295

Therapy

CNS fungal infections: A review.
Nathan CL, Emmert BE, Nelson E, Berger JR
J Neurol Sci 2021 Mar 15;422:117325. Epub 2021 Jan 22 doi: 10.1016/j.jns.2021.117325. PMID: 33516057
Iatrogenic meningitis.
Mutarelli EG, Adoni T
Arq Neuropsiquiatr 2013 Sep;71(9B):659-60. doi: 10.1590/0004-282X20130145. PMID: 24141499
Coccidioidal meningitis.
Williams PL
Ann N Y Acad Sci 2007 Sep;1111:377-84. Epub 2007 Mar 15 doi: 10.1196/annals.1406.037. PMID: 17363442
Therapy of fungal meningitis.
Slavoski LA, Tunkel AR
Clin Neuropharmacol 1995 Apr;18(2):95-112. doi: 10.1097/00002826-199504000-00001. PMID: 8635178
Cryptococcal meningitis.
Jones GA, Nathwani D
Br J Hosp Med 1995 Nov 1-14;54(9):439-45. PMID: 8564179

Prognosis

Bird's Eye View of a Neonatologist: Clinical Approach to Emergency Neonatal Infection.
Huang FK, Chen HL, Yang PH, Lin HC
Pediatr Neonatol 2016 Jun;57(3):167-73. Epub 2015 Oct 23 doi: 10.1016/j.pedneo.2015.06.004. PMID: 26701838
Chronic and subacute meningitis.
Zunt JR, Baldwin KJ
Continuum (Minneap Minn) 2012 Dec;18(6 Infectious Disease):1290-318. doi: 10.1212/01.CON.0000423848.17276.21. PMID: 23221842
Laboratory diagnosis of central nervous system infections.
Thomson RB Jr, Bertram H
Infect Dis Clin North Am 2001 Dec;15(4):1047-71. doi: 10.1016/s0891-5520(05)70186-0. PMID: 11780267
Cryptococcal meningitis.
Jones GA, Nathwani D
Br J Hosp Med 1995 Nov 1-14;54(9):439-45. PMID: 8564179
Cerebral phaeohyphomycosis.
Palaoglu S, Sav A, Basak T, Yalcinlar Y, Scheithauer BW
Neurosurgery 1993 Nov;33(5):894-7. doi: 10.1227/00006123-199311000-00018. PMID: 8264889

Clinical prediction guides

Study of cerebrospinal fluid levels of lactate, lactate dehydrogenase and adenosine deaminase in the diagnosis and outcome of acute meningitis.
Singh L, Javali M, Mehta A, Pradeep R, Srinivasa R, Acharya PT
Neurol Res 2022 May;44(5):463-467. Epub 2021 Dec 1 doi: 10.1080/01616412.2021.2004366. PMID: 34850673
Postcryptococcal Moyamoya Syndrome: Case Report and Review of Literature.
Maramattom BV
Neurol India 2020 May-Jun;68(3):660-664. doi: 10.4103/0028-3886.288983. PMID: 32643683
Bird's Eye View of a Neonatologist: Clinical Approach to Emergency Neonatal Infection.
Huang FK, Chen HL, Yang PH, Lin HC
Pediatr Neonatol 2016 Jun;57(3):167-73. Epub 2015 Oct 23 doi: 10.1016/j.pedneo.2015.06.004. PMID: 26701838
Trends in bacterial, mycobacterial, and fungal meningitis in England and Wales 2004-11: an observational study.
Okike IO, Ribeiro S, Ramsay ME, Heath PT, Sharland M, Ladhani SN
Lancet Infect Dis 2014 Apr;14(4):301-7. Epub 2014 Feb 7 doi: 10.1016/S1473-3099(13)70332-3. PMID: 24508198
Laboratory diagnosis of central nervous system infections.
Thomson RB Jr, Bertram H
Infect Dis Clin North Am 2001 Dec;15(4):1047-71. doi: 10.1016/s0891-5520(05)70186-0. PMID: 11780267

Recent systematic reviews

Efficacy of Cerebrospinal Fluid Beta-d-Glucan Diagnostic Testing for Fungal Meningitis: a Systematic Review.
Davis C, Wheat LJ, Myint T, Boulware DR, Bahr NC
J Clin Microbiol 2020 Mar 25;58(4) doi: 10.1128/JCM.02094-19. PMID: 31996446Free PMC Article
An updated comprehensive systematic review of Cladophialophora bantiana and analysis of epidemiology, clinical characteristics, and outcome of cerebral cases.
Kantarcioglu AS, Guarro J, De Hoog S, Apaydin H, Kiraz N
Med Mycol 2017 Aug 1;55(6):579-604. doi: 10.1093/mmy/myw124. PMID: 28007938
Clinical Response, Outbreak Investigation, and Epidemiology of the Fungal Meningitis Epidemic in the United States: Systematic Review.
Abbas KM, Dorratoltaj N, O'Dell ML, Bordwine P, Kerkering TM, Redican KJ
Disaster Med Public Health Prep 2016 Feb;10(1):145-51. Epub 2015 Dec 18 doi: 10.1017/dmp.2015.137. PMID: 26681583Free PMC Article
Antifungal therapy for newborn infants with invasive fungal infection.
Clerihew L, McGuire W
Cochrane Database Syst Rev 2012 Jun 13;2012(6):CD003953. doi: 10.1002/14651858.CD003953.pub3. PMID: 22696338Free PMC Article
Systemic antifungal drugs for invasive fungal infection in preterm infants.
Clerihew L, McGuire W
Cochrane Database Syst Rev 2004;(1):CD003953. doi: 10.1002/14651858.CD003953.pub2. PMID: 14974045

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