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Sicca syndrome

MedGen UID:
39529
•Concept ID:
C0086981
•
Disease or Syndrome
Synonyms: Sicca Syndrome; Syndrome, Sicca
SNOMED CT: Sicca syndrome (83901003)
 
OMIM®: 270150

Definition

A constellation of symptoms that include abnormal dryness of the mouth, eyes and other mucous membranes. The condition is seen in patients with Sjogren syndrome, sarcoidosis, amyloidosis, and deficiencies of vitamins A and C. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSicca syndrome

Professional guidelines

PubMed

Clinical Characterization and Predictive Factors for Progression in a Cohort of Patients with Interstitial Lung Disease and Features of Autoimmunity: The Need for a Revision of IPAF Classification Criteria.
Bozzao F, Tomietto P, Baratella E, Kodric M, Cifaldi R, Della Porta R, Prearo I, Pirronello SMG, Confalonieri P, Ruaro B, Fischetti F, Fabris B
Medicina (Kaunas) 2023 Apr 19;59(4) doi: 10.3390/medicina59040794. PMID: 37109752Free PMC Article
Treatment of rheumatic adverse events of cancer immunotherapy.
Reid P, Cappelli LC
Best Pract Res Clin Rheumatol 2022 Dec;36(4):101805. Epub 2022 Dec 18 doi: 10.1016/j.berh.2022.101805. PMID: 36539321Free PMC Article
A Clinical Review of Primary Biliary Cholangitis.
Pullen R
Gastroenterol Nurs 2020 Mar/Apr;43(2):E48-E55. doi: 10.1097/SGA.0000000000000480. PMID: 32251226

Recent clinical studies

Etiology

Causal association between common rheumatic diseases and glaucoma: a Mendelian randomization study.
Meng Y, Tan Z, Su Y, Li L, Chen C
Front Immunol 2023;14:1227138. Epub 2023 Sep 19 doi: 10.3389/fimmu.2023.1227138. PMID: 37799717Free PMC Article
Chemosensory dysfunction in primary Sjögren's syndrome: a topical review.
Foguem C, Seror R, Gosset M
Clin Rheumatol 2023 Jan;42(1):1-14. Epub 2022 Sep 5 doi: 10.1007/s10067-022-06359-w. PMID: 36063255Free PMC Article
Sjögren's syndrome: shedding light on emerging and key drug targets.
Ridgewell D, Thalayasingam N, Ng WF
Expert Opin Ther Targets 2022 Oct;26(10):869-882. Epub 2022 Dec 28 doi: 10.1080/14728222.2022.2157259. PMID: 36576336
HCV-Related Rheumatic Manifestations and Therapeutic Strategies.
Sebastiani M, Giuggioli D, Colaci M, Fallahi P, Gragnani L, Antonelli A, Zignego AL, Ferri C
Curr Drug Targets 2017;18(7):803-810. doi: 10.2174/1389450116666150907103622. PMID: 26343108
Primary Sjögren's syndrome.
Rischmueller M, Tieu J, Lester S
Best Pract Res Clin Rheumatol 2016 Feb;30(1):189-220. Epub 2016 May 13 doi: 10.1016/j.berh.2016.04.003. PMID: 27421224

Diagnosis

Causal association between common rheumatic diseases and glaucoma: a Mendelian randomization study.
Meng Y, Tan Z, Su Y, Li L, Chen C
Front Immunol 2023;14:1227138. Epub 2023 Sep 19 doi: 10.3389/fimmu.2023.1227138. PMID: 37799717Free PMC Article
Non-primary Sjogren's Syndrome: Secondary or associated?
Felten R, Meyer A, Gottenberg JE
Joint Bone Spine 2023 Mar;90(2):105502. Epub 2022 Dec 1 doi: 10.1016/j.jbspin.2022.105502. PMID: 36464213
TAFRO syndrome: A severe manifestation of Sjogren's syndrome? A systematic review.
Grange L, Chalayer E, Boutboul D, Paul S, Galicier L, Gramont B, Killian M
Autoimmun Rev 2022 Aug;21(8):103137. Epub 2022 Jul 6 doi: 10.1016/j.autrev.2022.103137. PMID: 35803499
Pulmonary involvement in Sjögren's syndrome.
Mestre-Torres J, Solans-Laque R
Med Clin (Barc) 2022 Feb 25;158(4):181-185. Epub 2021 Aug 13 doi: 10.1016/j.medcli.2021.06.016. PMID: 34392987
Primary Sjögren's syndrome.
Rischmueller M, Tieu J, Lester S
Best Pract Res Clin Rheumatol 2016 Feb;30(1):189-220. Epub 2016 May 13 doi: 10.1016/j.berh.2016.04.003. PMID: 27421224

Therapy

Causal association between common rheumatic diseases and glaucoma: a Mendelian randomization study.
Meng Y, Tan Z, Su Y, Li L, Chen C
Front Immunol 2023;14:1227138. Epub 2023 Sep 19 doi: 10.3389/fimmu.2023.1227138. PMID: 37799717Free PMC Article
Treatment of rheumatic adverse events of cancer immunotherapy.
Reid P, Cappelli LC
Best Pract Res Clin Rheumatol 2022 Dec;36(4):101805. Epub 2022 Dec 18 doi: 10.1016/j.berh.2022.101805. PMID: 36539321Free PMC Article
Sicca syndrome associated with immune checkpoint inhibitor therapy.
Harris JA, Huang K, Miloslavsky E, Hanna GJ
Oral Dis 2022 Nov;28(8):2083-2092. Epub 2021 Aug 17 doi: 10.1111/odi.14000. PMID: 34379884
Sicca Syndrome Associated with Immune Checkpoint Inhibitor Therapy.
Warner BM, Baer AN, Lipson EJ, Allen C, Hinrichs C, Rajan A, Pelayo E, Beach M, Gulley JL, Madan RA, Feliciano J, Grisius M, Long L, Powers A, Kleiner DE, Cappelli L, Alevizos I
Oncologist 2019 Sep;24(9):1259-1269. Epub 2019 Apr 17 doi: 10.1634/theoncologist.2018-0823. PMID: 30996010Free PMC Article
Graft-vs.-host disease.
Woo SB, Lee SJ, Schubert MM
Crit Rev Oral Biol Med 1997;8(2):201-16. doi: 10.1177/10454411970080020701. PMID: 9167093

Prognosis

Not all autoantibodies are clinically relevant. Classic and novel autoantibodies in Sjögren's syndrome: A critical review.
Vílchez-Oya F, Balastegui Martin H, García-Martínez E, Corominas H
Front Immunol 2022;13:1003054. Epub 2022 Oct 17 doi: 10.3389/fimmu.2022.1003054. PMID: 36325321Free PMC Article
Pulmonary involvement in Sjögren's syndrome.
Mestre-Torres J, Solans-Laque R
Med Clin (Barc) 2022 Feb 25;158(4):181-185. Epub 2021 Aug 13 doi: 10.1016/j.medcli.2021.06.016. PMID: 34392987
Minor salivary gland biopsy: Its role in the classification and prognosis of Sjögren's syndrome.
Bautista-Vargas M, Vivas AJ, Tobón GJ
Autoimmun Rev 2020 Dec;19(12):102690. Epub 2020 Oct 22 doi: 10.1016/j.autrev.2020.102690. PMID: 33099041
Considering hepatitis C virus infection as a systemic disease.
Cacoub P, Comarmond C
Semin Dial 2019 Mar;32(2):99-107. Epub 2018 Dec 13 doi: 10.1111/sdi.12758. PMID: 30549107
Sjogren's syndrome is associated with and not secondary to systemic sclerosis.
Salliot C, Mouthon L, Ardizzone M, Sibilia J, Guillevin L, Gottenberg JE, Mariette X
Rheumatology (Oxford) 2007 Feb;46(2):321-6. Epub 2006 Jul 28 doi: 10.1093/rheumatology/kel252. PMID: 16877466

Clinical prediction guides

Causal association between common rheumatic diseases and glaucoma: a Mendelian randomization study.
Meng Y, Tan Z, Su Y, Li L, Chen C
Front Immunol 2023;14:1227138. Epub 2023 Sep 19 doi: 10.3389/fimmu.2023.1227138. PMID: 37799717Free PMC Article
Salivary gland ultrasound in clinical practice: What is its real usefulness?
Carpio Astudillo K, Montero Reyes F, Janta I, Molina Collada J, Anzola AM, Caballero Motta LR, Serrano-Benavente B, Martínez-Barrio J, Ariza Lapuente A, Rivera Redondo J, González-Fernández C, Monteagudo I, Álvaro-Gracia JM, Nieto-González JC
Reumatol Clin (Engl Ed) 2023 May;19(5):260-265. doi: 10.1016/j.reumae.2022.09.002. PMID: 37147062
Clinical Characterization and Predictive Factors for Progression in a Cohort of Patients with Interstitial Lung Disease and Features of Autoimmunity: The Need for a Revision of IPAF Classification Criteria.
Bozzao F, Tomietto P, Baratella E, Kodric M, Cifaldi R, Della Porta R, Prearo I, Pirronello SMG, Confalonieri P, Ruaro B, Fischetti F, Fabris B
Medicina (Kaunas) 2023 Apr 19;59(4) doi: 10.3390/medicina59040794. PMID: 37109752Free PMC Article
Not all autoantibodies are clinically relevant. Classic and novel autoantibodies in Sjögren's syndrome: A critical review.
Vílchez-Oya F, Balastegui Martin H, García-Martínez E, Corominas H
Front Immunol 2022;13:1003054. Epub 2022 Oct 17 doi: 10.3389/fimmu.2022.1003054. PMID: 36325321Free PMC Article
Clinical characteristics of rheumatic syndromes associated with checkpoint inhibitors therapy.
Kostine M, Truchetet ME, Schaeverbeke T
Rheumatology (Oxford) 2019 Dec 1;58(Suppl 7):vii68-vii74. doi: 10.1093/rheumatology/kez295. PMID: 31816082Free PMC Article

Recent systematic reviews

Recommendations for evaluation and diagnosis of extra-glandular manifestations of primary Sjögren syndrome: results of an epidemiologic systematic review/meta-analysis and a consensus guideline from the Brazilian society of rheumatology (hepatic, gastrointestinal and pancreatic).
Trevisani VFM, Pinheiro AC, de Magalhães Souza Fialho SC, Fernandes MLMS, Pugliesi A, Pasoto SG, Lopes MLL, Guedes LKN, Miyamoto ST, Dos Santos LC, Appenzeller S, Fidelix T, Ribeiro SLE, de Brito DCSE, Libório-Kimura TN, Santos MCLFS, Cantali DU, Gennari JD', Capobianco KG, Civile VT, Pinto ACPN, da Rocha AP, Rocha-Filho CR, Oliveira FR, Valim V
Adv Rheumatol 2022 Oct 10;62(1):35. doi: 10.1186/s42358-022-00267-y. PMID: 36217186
TAFRO syndrome: A severe manifestation of Sjogren's syndrome? A systematic review.
Grange L, Chalayer E, Boutboul D, Paul S, Galicier L, Gramont B, Killian M
Autoimmun Rev 2022 Aug;21(8):103137. Epub 2022 Jul 6 doi: 10.1016/j.autrev.2022.103137. PMID: 35803499
Diagnostic performance of serology against histologic assessment to diagnose Sjogren's syndrome: a systematic review.
Viegas-Costa LC, Friesen R, Flores-Mir C, McGaw T
Clin Rheumatol 2021 Dec;40(12):4817-4828. Epub 2021 Jun 17 doi: 10.1007/s10067-021-05813-5. PMID: 34142295
Unstimulated whole salivary flow in Sjögren's Syndrome: systematic literature review and meta-analysis.
Martínez-Ceballos MA, Aguilera N, Garzón-González KC, Cajamarca-Baron J, Alzate-Granados JP, Rojas-Villarraga A
Adv Rheumatol 2021 Feb 3;61(1):8. doi: 10.1186/s42358-020-00158-0. PMID: 33536075
Diagnostic value of labial minor salivary gland biopsy for Sjögren's syndrome: a systematic review.
Guellec D, Cornec D, Jousse-Joulin S, Marhadour T, Marcorelles P, Pers JO, Saraux A, Devauchelle-Pensec V
Autoimmun Rev 2013 Jan;12(3):416-20. Epub 2012 Aug 7 doi: 10.1016/j.autrev.2012.08.001. PMID: 22889617

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