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Increased risk in heterozygotes

MedGen UID:
395307
Concept ID:
C1859622
Finding

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased risk in heterozygotes

Professional guidelines

PubMed

Capalbo A, Valero RA, Jimenez-Almazan J, Pardo PM, Fabiani M, Jiménez D, Simon C, Rodriguez JM
PLoS Genet 2019 Oct;15(10):e1008409. Epub 2019 Oct 7 doi: 10.1371/journal.pgen.1008409. PMID: 31589614Free PMC Article
Kowdley KV, Brown KE, Ahn J, Sundaram V
Am J Gastroenterol 2019 Aug;114(8):1202-1218. doi: 10.14309/ajg.0000000000000315. PMID: 31335359
Nordestgaard BG, Chapman MJ, Humphries SE, Ginsberg HN, Masana L, Descamps OS, Wiklund O, Hegele RA, Raal FJ, Defesche JC, Wiegman A, Santos RD, Watts GF, Parhofer KG, Hovingh GK, Kovanen PT, Boileau C, Averna M, Borén J, Bruckert E, Catapano AL, Kuivenhoven JA, Pajukanta P, Ray K, Stalenhoef AF, Stroes E, Taskinen MR, Tybjærg-Hansen A; European Atherosclerosis Society Consensus Panel
Eur Heart J 2013 Dec;34(45):3478-90a. Epub 2013 Aug 15 doi: 10.1093/eurheartj/eht273. PMID: 23956253Free PMC Article

Recent clinical studies

Etiology

Deng J, Altintas B, Haley JS, Kim J, Ramos M, Carey DJ, Stewart DR, McReynolds LJ
Genet Med 2024 Mar;26(3):101042. Epub 2023 Dec 5 doi: 10.1016/j.gim.2023.101042. PMID: 38063144Free PMC Article
Polgreen PM, Comellas AP
Annu Rev Med 2022 Jan 27;73:563-574. doi: 10.1146/annurev-med-042120-020148. PMID: 35084992Free PMC Article
Bacchelli E, Cameli C, Viggiano M, Igliozzi R, Mancini A, Tancredi R, Battaglia A, Maestrini E
Sci Rep 2020 Feb 21;10(1):3198. doi: 10.1038/s41598-020-59922-3. PMID: 32081867Free PMC Article
Salzer U, Bacchelli C, Buckridge S, Pan-Hammarström Q, Jennings S, Lougaris V, Bergbreiter A, Hagena T, Birmelin J, Plebani A, Webster AD, Peter HH, Suez D, Chapel H, McLean-Tooke A, Spickett GP, Anover-Sombke S, Ochs HD, Urschel S, Belohradsky BH, Ugrinovic S, Kumararatne DS, Lawrence TC, Holm AM, Franco JL, Schulze I, Schneider P, Gertz EM, Schäffer AA, Hammarström L, Thrasher AJ, Gaspar HB, Grimbacher B
Blood 2009 Feb 26;113(9):1967-76. Epub 2008 Nov 3 doi: 10.1182/blood-2008-02-141937. PMID: 18981294Free PMC Article
Fouchier SW, Kastelein JJ, Defesche JC
Hum Mutat 2005 Dec;26(6):550-6. doi: 10.1002/humu.20256. PMID: 16250003

Diagnosis

Zakiudin DP, Thyssen JP, Zachariae C, Videm V, Øien T, Simpson MR
Acta Derm Venereol 2024 Apr 24;104:adv24360. doi: 10.2340/actadv.v104.24360. PMID: 38655655Free PMC Article
Polgreen PM, Comellas AP
Annu Rev Med 2022 Jan 27;73:563-574. doi: 10.1146/annurev-med-042120-020148. PMID: 35084992Free PMC Article
Yang X, Song H, Leslie G, Engel C, Hahnen E, Auber B, Horváth J, Kast K, Niederacher D, Turnbull C, Houlston R, Hanson H, Loveday C, Dolinsky JS, LaDuca H, Ramus SJ, Menon U, Rosenthal AN, Jacobs I, Gayther SA, Dicks E, Nevanlinna H, Aittomäki K, Pelttari LM, Ehrencrona H, Borg Å, Kvist A, Rivera B, Hansen TVO, Djursby M, Lee A, Dennis J, Bowtell DD, Traficante N, Diez O, Balmaña J, Gruber SB, Chenevix-Trench G, Investigators K, Jensen A, Kjær SK, Høgdall E, Castéra L, Garber J, Janavicius R, Osorio A, Golmard L, Vega A, Couch FJ, Robson M, Gronwald J, Domchek SM, Culver JO, de la Hoya M, Easton DF, Foulkes WD, Tischkowitz M, Meindl A, Schmutzler RK, Pharoah PDP, Antoniou AC
J Natl Cancer Inst 2020 Dec 14;112(12):1242-1250. doi: 10.1093/jnci/djaa030. PMID: 32107557Free PMC Article
Nordestgaard BG, Chapman MJ, Humphries SE, Ginsberg HN, Masana L, Descamps OS, Wiklund O, Hegele RA, Raal FJ, Defesche JC, Wiegman A, Santos RD, Watts GF, Parhofer KG, Hovingh GK, Kovanen PT, Boileau C, Averna M, Borén J, Bruckert E, Catapano AL, Kuivenhoven JA, Pajukanta P, Ray K, Stalenhoef AF, Stroes E, Taskinen MR, Tybjærg-Hansen A; European Atherosclerosis Society Consensus Panel
Eur Heart J 2013 Dec;34(45):3478-90a. Epub 2013 Aug 15 doi: 10.1093/eurheartj/eht273. PMID: 23956253Free PMC Article
Fouchier SW, Kastelein JJ, Defesche JC
Hum Mutat 2005 Dec;26(6):550-6. doi: 10.1002/humu.20256. PMID: 16250003

Therapy

Huber D, Seitz S, Kast K, Emons G, Ortmann O
J Cancer Res Clin Oncol 2021 Jul;147(7):2035-2045. Epub 2021 Apr 22 doi: 10.1007/s00432-021-03629-z. PMID: 33885953Free PMC Article
Harper AR, Goel A, Grace C, Thomson KL, Petersen SE, Xu X, Waring A, Ormondroyd E, Kramer CM, Ho CY, Neubauer S; HCMR Investigators, Tadros R, Ware JS, Bezzina CR, Farrall M, Watkins H
Nat Genet 2021 Feb;53(2):135-142. Epub 2021 Jan 25 doi: 10.1038/s41588-020-00764-0. PMID: 33495597Free PMC Article
Jonsson P, Bandlamudi C, Cheng ML, Srinivasan P, Chavan SS, Friedman ND, Rosen EY, Richards AL, Bouvier N, Selcuklu SD, Bielski CM, Abida W, Mandelker D, Birsoy O, Zhang L, Zehir A, Donoghue MTA, Baselga J, Offit K, Scher HI, O'Reilly EM, Stadler ZK, Schultz N, Socci ND, Viale A, Ladanyi M, Robson ME, Hyman DM, Berger MF, Solit DB, Taylor BS
Nature 2019 Jul;571(7766):576-579. Epub 2019 Jul 10 doi: 10.1038/s41586-019-1382-1. PMID: 31292550Free PMC Article
van Vlijmen EF, Wiewel-Verschueren S, Monster TB, Meijer K
J Thromb Haemost 2016 Jul;14(7):1393-403. Epub 2016 Jun 16 doi: 10.1111/jth.13349. PMID: 27121914
Nordestgaard BG, Chapman MJ, Humphries SE, Ginsberg HN, Masana L, Descamps OS, Wiklund O, Hegele RA, Raal FJ, Defesche JC, Wiegman A, Santos RD, Watts GF, Parhofer KG, Hovingh GK, Kovanen PT, Boileau C, Averna M, Borén J, Bruckert E, Catapano AL, Kuivenhoven JA, Pajukanta P, Ray K, Stalenhoef AF, Stroes E, Taskinen MR, Tybjærg-Hansen A; European Atherosclerosis Society Consensus Panel
Eur Heart J 2013 Dec;34(45):3478-90a. Epub 2013 Aug 15 doi: 10.1093/eurheartj/eht273. PMID: 23956253Free PMC Article

Prognosis

Fox S, Speirs V, Shaaban AM
Virchows Arch 2022 Jan;480(1):85-93. Epub 2021 Aug 30 doi: 10.1007/s00428-021-03190-7. PMID: 34458944
Burn J, Sheth H, Elliott F, Reed L, Macrae F, Mecklin JP, Möslein G, McRonald FE, Bertario L, Evans DG, Gerdes AM, Ho JWC, Lindblom A, Morrison PJ, Rashbass J, Ramesar R, Seppälä T, Thomas HJW, Pylvänäinen K, Borthwick GM, Mathers JC, Bishop DT; CAPP2 Investigators
Lancet 2020 Jun 13;395(10240):1855-1863. doi: 10.1016/S0140-6736(20)30366-4. PMID: 32534647Free PMC Article
Yang X, Song H, Leslie G, Engel C, Hahnen E, Auber B, Horváth J, Kast K, Niederacher D, Turnbull C, Houlston R, Hanson H, Loveday C, Dolinsky JS, LaDuca H, Ramus SJ, Menon U, Rosenthal AN, Jacobs I, Gayther SA, Dicks E, Nevanlinna H, Aittomäki K, Pelttari LM, Ehrencrona H, Borg Å, Kvist A, Rivera B, Hansen TVO, Djursby M, Lee A, Dennis J, Bowtell DD, Traficante N, Diez O, Balmaña J, Gruber SB, Chenevix-Trench G, Investigators K, Jensen A, Kjær SK, Høgdall E, Castéra L, Garber J, Janavicius R, Osorio A, Golmard L, Vega A, Couch FJ, Robson M, Gronwald J, Domchek SM, Culver JO, de la Hoya M, Easton DF, Foulkes WD, Tischkowitz M, Meindl A, Schmutzler RK, Pharoah PDP, Antoniou AC
J Natl Cancer Inst 2020 Dec 14;112(12):1242-1250. doi: 10.1093/jnci/djaa030. PMID: 32107557Free PMC Article
Jonsson T, Stefansson H, Steinberg S, Jonsdottir I, Jonsson PV, Snaedal J, Bjornsson S, Huttenlocher J, Levey AI, Lah JJ, Rujescu D, Hampel H, Giegling I, Andreassen OA, Engedal K, Ulstein I, Djurovic S, Ibrahim-Verbaas C, Hofman A, Ikram MA, van Duijn CM, Thorsteinsdottir U, Kong A, Stefansson K
N Engl J Med 2013 Jan 10;368(2):107-16. Epub 2012 Nov 14 doi: 10.1056/NEJMoa1211103. PMID: 23150908Free PMC Article
King MC, Marks JH, Mandell JB; New York Breast Cancer Study Group
Science 2003 Oct 24;302(5645):643-6. doi: 10.1126/science.1088759. PMID: 14576434

Clinical prediction guides

Ibrahim S, Hartgers ML, Reeskamp LF, Zuurbier L, Defesche J, Kastelein JJP, Stroes ESG, Hovingh GK, Huijgen R
Atherosclerosis 2024 Oct;397:117610. Epub 2024 Jun 10 doi: 10.1016/j.atherosclerosis.2024.117610. PMID: 39085000
Yang X, Song H, Leslie G, Engel C, Hahnen E, Auber B, Horváth J, Kast K, Niederacher D, Turnbull C, Houlston R, Hanson H, Loveday C, Dolinsky JS, LaDuca H, Ramus SJ, Menon U, Rosenthal AN, Jacobs I, Gayther SA, Dicks E, Nevanlinna H, Aittomäki K, Pelttari LM, Ehrencrona H, Borg Å, Kvist A, Rivera B, Hansen TVO, Djursby M, Lee A, Dennis J, Bowtell DD, Traficante N, Diez O, Balmaña J, Gruber SB, Chenevix-Trench G, Investigators K, Jensen A, Kjær SK, Høgdall E, Castéra L, Garber J, Janavicius R, Osorio A, Golmard L, Vega A, Couch FJ, Robson M, Gronwald J, Domchek SM, Culver JO, de la Hoya M, Easton DF, Foulkes WD, Tischkowitz M, Meindl A, Schmutzler RK, Pharoah PDP, Antoniou AC
J Natl Cancer Inst 2020 Dec 14;112(12):1242-1250. doi: 10.1093/jnci/djaa030. PMID: 32107557Free PMC Article
Bacchelli E, Cameli C, Viggiano M, Igliozzi R, Mancini A, Tancredi R, Battaglia A, Maestrini E
Sci Rep 2020 Feb 21;10(1):3198. doi: 10.1038/s41598-020-59922-3. PMID: 32081867Free PMC Article
Wang J, Dron JS, Ban MR, Robinson JF, McIntyre AD, Alazzam M, Zhao PJ, Dilliott AA, Cao H, Huff MW, Rhainds D, Low-Kam C, Dubé MP, Lettre G, Tardif JC, Hegele RA
Arterioscler Thromb Vasc Biol 2016 Dec;36(12):2439-2445. Epub 2016 Oct 20 doi: 10.1161/ATVBAHA.116.308027. PMID: 27765764
Jonsson T, Stefansson H, Steinberg S, Jonsdottir I, Jonsson PV, Snaedal J, Bjornsson S, Huttenlocher J, Levey AI, Lah JJ, Rujescu D, Hampel H, Giegling I, Andreassen OA, Engedal K, Ulstein I, Djurovic S, Ibrahim-Verbaas C, Hofman A, Ikram MA, van Duijn CM, Thorsteinsdottir U, Kong A, Stefansson K
N Engl J Med 2013 Jan 10;368(2):107-16. Epub 2012 Nov 14 doi: 10.1056/NEJMoa1211103. PMID: 23150908Free PMC Article

Recent systematic reviews

Davidoff DF, De Abreu Lourenco R, Tsang VHM, Benn DE, Clifton-Bligh RJ
J Clin Endocrinol Metab 2024 Aug 13;109(9):2400-2410. doi: 10.1210/clinem/dgae233. PMID: 38605204Free PMC Article
Fang Y, Cui Y, Yin Z, Hou M, Guo P, Wang H, Liu N, Cai C, Wang M
Gene 2023 Dec 15;887:147723. Epub 2023 Aug 18 doi: 10.1016/j.gene.2023.147723. PMID: 37598788
Huber D, Seitz S, Kast K, Emons G, Ortmann O
J Cancer Res Clin Oncol 2021 Jul;147(7):2035-2045. Epub 2021 Apr 22 doi: 10.1007/s00432-021-03629-z. PMID: 33885953Free PMC Article
Matanes E, Volodarsky-Perel A, Eisenberg N, Rottenstreich M, Yasmeen A, Mitric C, Lau S, Salvador S, Gotlieb WH, Kogan L
J Minim Invasive Gynecol 2021 May;28(5):947-956. Epub 2020 Nov 27 doi: 10.1016/j.jmig.2020.11.023. PMID: 33249269
van Vlijmen EF, Wiewel-Verschueren S, Monster TB, Meijer K
J Thromb Haemost 2016 Jul;14(7):1393-403. Epub 2016 Jun 16 doi: 10.1111/jth.13349. PMID: 27121914

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