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B-lymphoblastic leukemia/lymphoma with recurrent genetic abnormality

MedGen UID:
396322
•Concept ID:
C2698313
•
Neoplastic Process
Synonyms: B Lymphoblastic Leukemia/Lymphoma with Recurrent Genetic Abnormalities; B-Lymphoblastic Leukemia/Lymphoma with Recurrent Genetic Abnormalities
 
Monarch Initiative: MONDO:0035605
Orphanet: ORPHA585877

Definition

The term refers to precursor lymphoid neoplasms which are composed of B-lymphoblasts and characterized by the presence of recurrent genetic abnormalities. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVB-lymphoblastic leukemia/lymphoma with recurrent genetic abnormality

Professional guidelines

PubMed

Beyond the 2008 World Health Organization classification: the role of the hematopathology laboratory in the diagnosis and management of acute lymphoblastic leukemia.
McGregor S, McNeer J, Gurbuxani S
Semin Diagn Pathol 2012 Feb;29(1):2-11. doi: 10.1053/j.semdp.2011.07.004. PMID: 22372201Free PMC Article

Recent clinical studies

Etiology

Recurrent genetic abnormalities detected by FISH in adult B ALL and association with hematological parameters.
Tarigopula A, Chandrashekar V, Perumal G
Cancer Rep (Hoboken) 2020 Dec;3(6):e21290. Epub 2020 Sep 9 doi: 10.1002/cnr2.1290. PMID: 32902203Free PMC Article
Analysis of clinicopathological and cytogenetic differences between B-lymphoblastic lymphoma and B-lymphoblastic leukemia in childhood.
Knez V, Bao L, Carstens B, Liang X
Leuk Lymphoma 2020 Sep;61(9):2129-2135. Epub 2020 May 19 doi: 10.1080/10428194.2020.1761970. PMID: 32427530
Beyond the 2008 World Health Organization classification: the role of the hematopathology laboratory in the diagnosis and management of acute lymphoblastic leukemia.
McGregor S, McNeer J, Gurbuxani S
Semin Diagn Pathol 2012 Feb;29(1):2-11. doi: 10.1053/j.semdp.2011.07.004. PMID: 22372201Free PMC Article
Pediatric B-lymphoblastic leukemia with RUNX1 amplification: clinicopathologic study of eight cases.
Reichard KK, Kang H, Robinett S
Mod Pathol 2011 Dec;24(12):1606-11. Epub 2011 Aug 5 doi: 10.1038/modpathol.2011.118. PMID: 21822204
Classification of acute leukemias.
Brunning RD
Semin Diagn Pathol 2003 Aug;20(3):142-53. doi: 10.1016/s0740-2570(03)00031-5. PMID: 14552428

Diagnosis

Genetics and Diagnostic Approach to Lymphoblastic Leukemia/Lymphoma.
Afkhami M, Ally F, Pullarkat V, Pillai RK
Cancer Treat Res 2021;181:17-43. doi: 10.1007/978-3-030-78311-2_2. PMID: 34626353
Update on Lymphoblastic Leukemia/Lymphoma.
Luca DC
Clin Lab Med 2021 Sep;41(3):405-416. doi: 10.1016/j.cll.2021.04.003. PMID: 34304772
CAR T-cell therapy is effective for CD19-dim B-lymphoblastic leukemia but is impacted by prior blinatumomab therapy.
Pillai V, Muralidharan K, Meng W, Bagashev A, Oldridge DA, Rosenthal J, Van Arnam J, Melenhorst JJ, Mohan D, DiNofia AM, Luo M, Cherian S, Fromm JR, Wertheim G, Thomas-Tikhonenko A, Paessler M, June CH, Luning Prak ET, Bhoj VG, Grupp SA, Maude SL, Rheingold SR
Blood Adv 2019 Nov 26;3(22):3539-3549. doi: 10.1182/bloodadvances.2019000692. PMID: 31738832Free PMC Article
Beyond the 2008 World Health Organization classification: the role of the hematopathology laboratory in the diagnosis and management of acute lymphoblastic leukemia.
McGregor S, McNeer J, Gurbuxani S
Semin Diagn Pathol 2012 Feb;29(1):2-11. doi: 10.1053/j.semdp.2011.07.004. PMID: 22372201Free PMC Article
Classification of acute leukemias.
Brunning RD
Semin Diagn Pathol 2003 Aug;20(3):142-53. doi: 10.1016/s0740-2570(03)00031-5. PMID: 14552428

Therapy

Philadelphia chromosome-positive B-lymphoblastic lymphoma successfully treated with chemotherapy regimen containing imatinib: A rare case report and literature review.
Li X, Cao W, Zhang S, Li L, Li Y, Jiang Z, Wan D, Yu J
Medicine (Baltimore) 2021 Jun 11;100(23):e26323. doi: 10.1097/MD.0000000000026323. PMID: 34115047Free PMC Article
CAR T-cell therapy is effective for CD19-dim B-lymphoblastic leukemia but is impacted by prior blinatumomab therapy.
Pillai V, Muralidharan K, Meng W, Bagashev A, Oldridge DA, Rosenthal J, Van Arnam J, Melenhorst JJ, Mohan D, DiNofia AM, Luo M, Cherian S, Fromm JR, Wertheim G, Thomas-Tikhonenko A, Paessler M, June CH, Luning Prak ET, Bhoj VG, Grupp SA, Maude SL, Rheingold SR
Blood Adv 2019 Nov 26;3(22):3539-3549. doi: 10.1182/bloodadvances.2019000692. PMID: 31738832Free PMC Article

Prognosis

Genetics and Diagnostic Approach to Lymphoblastic Leukemia/Lymphoma.
Afkhami M, Ally F, Pullarkat V, Pillai RK
Cancer Treat Res 2021;181:17-43. doi: 10.1007/978-3-030-78311-2_2. PMID: 34626353
Update on Lymphoblastic Leukemia/Lymphoma.
Luca DC
Clin Lab Med 2021 Sep;41(3):405-416. doi: 10.1016/j.cll.2021.04.003. PMID: 34304772
Recurrent genetic abnormalities detected by FISH in adult B ALL and association with hematological parameters.
Tarigopula A, Chandrashekar V, Perumal G
Cancer Rep (Hoboken) 2020 Dec;3(6):e21290. Epub 2020 Sep 9 doi: 10.1002/cnr2.1290. PMID: 32902203Free PMC Article
Genomic characterization of pediatric B-lymphoblastic lymphoma and B-lymphoblastic leukemia using formalin-fixed tissues.
Meyer JA, Zhou D, Mason CC, Downie JM, Rodic V, Abromowitch M, Wistinghausen B, Termuhlen AM, Angiolillo AL, Perkins SL, Lones MA, Barnette P, Schiffman JD, Miles RR
Pediatr Blood Cancer 2017 Jul;64(7) Epub 2016 Dec 13 doi: 10.1002/pbc.26363. PMID: 27957801
Classification of acute leukemias.
Brunning RD
Semin Diagn Pathol 2003 Aug;20(3):142-53. doi: 10.1016/s0740-2570(03)00031-5. PMID: 14552428

Clinical prediction guides

Analysis of clinicopathological and cytogenetic differences between B-lymphoblastic lymphoma and B-lymphoblastic leukemia in childhood.
Knez V, Bao L, Carstens B, Liang X
Leuk Lymphoma 2020 Sep;61(9):2129-2135. Epub 2020 May 19 doi: 10.1080/10428194.2020.1761970. PMID: 32427530
CAR T-cell therapy is effective for CD19-dim B-lymphoblastic leukemia but is impacted by prior blinatumomab therapy.
Pillai V, Muralidharan K, Meng W, Bagashev A, Oldridge DA, Rosenthal J, Van Arnam J, Melenhorst JJ, Mohan D, DiNofia AM, Luo M, Cherian S, Fromm JR, Wertheim G, Thomas-Tikhonenko A, Paessler M, June CH, Luning Prak ET, Bhoj VG, Grupp SA, Maude SL, Rheingold SR
Blood Adv 2019 Nov 26;3(22):3539-3549. doi: 10.1182/bloodadvances.2019000692. PMID: 31738832Free PMC Article
Genomic analysis of adult B-ALL identifies potential markers of shorter survival.
Patel S, Mason CC, Glenn MJ, Paxton CN, South ST, Cessna MH, Asch J, Cobain EF, Bixby DL, Smith LB, Reshmi S, Gastier-Foster JM, Schiffman JD, Miles RR
Leuk Res 2017 May;56:44-51. Epub 2017 Feb 3 doi: 10.1016/j.leukres.2017.01.034. PMID: 28193567
Genomic characterization of pediatric B-lymphoblastic lymphoma and B-lymphoblastic leukemia using formalin-fixed tissues.
Meyer JA, Zhou D, Mason CC, Downie JM, Rodic V, Abromowitch M, Wistinghausen B, Termuhlen AM, Angiolillo AL, Perkins SL, Lones MA, Barnette P, Schiffman JD, Miles RR
Pediatr Blood Cancer 2017 Jul;64(7) Epub 2016 Dec 13 doi: 10.1002/pbc.26363. PMID: 27957801
Acute lymphoblastic leukemia with low hypodiploid/near triploid karyotype is a specific clinical entity and exhibits a very high TP53 mutation frequency of 93%.
Mühlbacher V, Zenger M, Schnittger S, Weissmann S, Kunze F, Kohlmann A, Bellos F, Kern W, Haferlach T, Haferlach C
Genes Chromosomes Cancer 2014 Jun;53(6):524-36. Epub 2014 Mar 11 doi: 10.1002/gcc.22163. PMID: 24619868

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