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B Acute Lymphoblastic Leukemia with t(v;11q23.3); KMT2A Rearranged

MedGen UID:
397153
•Concept ID:
C2698308
•
Neoplastic Process
Synonyms: B Acute Lymphoblastic Leukemia with KMT2A Rearrangement; B Acute Lymphoblastic Leukemia with t(v;11q23.3); MLL Rearranged; B-Acute Lymphoblastic Leukemia with KMT2A Rearrangement; B-Acute Lymphoblastic Leukemia with t(v;11q23.3); KMT2A Rearranged; B-Acute Lymphoblastic Leukemia with t(v;11q23.3); MLL Rearranged; B-ALL with t(v;11q23.3)/KMT2A Rearranged; B-ALL with t(v;11q23.3); KMT2A Rearranged; B-Cell Acute Lymphoblastic Leukemia with t(v;11q23.3); MLL Rearranged

Definition

A B-cell acute leukemia characterized by the presence of lymphoblasts that carry a translocation between the KMT2A gene at 11q23.3 and another gene partner resulting in the production of an KMT2A related fusion protein. It is the most commonly seen leukemia in the pediatric population under the age of one year. The prognosis is unfavorable. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVB Acute Lymphoblastic Leukemia with t(v;11q23.3); KMT2A Rearranged

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