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B Acute Lymphoblastic Leukemia with t(v;11q23.3); MLL Rearranged

MedGen UID:
397153
•Concept ID:
C2698308
•
Neoplastic Process
Synonyms: B Acute Lymphoblastic Leukemia with t(v;11q23.3); KMT2A Rearranged; B-Acute Lymphoblastic Leukemia with t(v;11q23); MLL Rearranged; B-Cell Acute Lymphoblastic Leukemia with t(v;11q23); MLL Rearranged

Definition

A B-cell acute leukemia characterized by the presence of lymphoblasts that carry a translocation between the MLL (KMT2A) gene at 11q23.3 and another gene partner resulting in the production of an MLL related fusion protein. It is the most commonly seen leukemia in the pediatric population under the age of one year. The prognosis is unfavorable. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVB Acute Lymphoblastic Leukemia with t(v;11q23.3); MLL Rearranged

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