Panagopoulos I, Gorunova L, Andersen K, Lobmaier I, Heim S
Cancer Genomics Proteomics 2021 Jul-Aug;18(4):531-542. doi: 10.21873/cgp.20278. PMID: 34183386 Free PMC Article

Historical and Clinical Perspectives on Chromosomal Translocations.

Wilch ES, Morton CC
Adv Exp Med Biol 2018;1044:1-14. doi: 10.1007/978-981-13-0593-1_1. PMID: 29956287

Gain of chromosome 21 or amplification of chromosome arm 21q is one mechanism for increased ERG expression in acute myeloid leukemia.

Weber S, Haferlach C, Jeromin S, Nadarajah N, Dicker F, Noël L, Zenger M, Alpermann T, Kern W, Haferlach T, Schnittger S
Genes Chromosomes Cancer 2016 Feb;55(2):148-57. Epub 2015 Nov 6 doi: 10.1002/gcc.22321. PMID: 26542308

Gains, losses and complex karyotypes in myeloid disorders: a light at the end of the tunnel.

Alvarez S, Cigudosa JC
Hematol Oncol 2005 Mar;23(1):18-25. doi: 10.1002/hon.744. PMID: 16142824

Characterization of an unusual and complex chromosome 21 rearrangement using somatic cell genetics and cloned DNA probes.

Van Keuren ML, Stewart GD, Bradley CM, Kurnit DM, Neve RL, Watkins PC, Tanzi RE, Gusella JF, Patterson D
Am J Med Genet 1989 Jul;33(3):369-75. doi: 10.1002/ajmg.1320330316. PMID: 2529766

See all (21)

Diagnosis

Prenatal diagnosis of isochromosome 21p and isochromosome 21q in a fetus with Down syndrome.

Yakut S, Sanhal C, Manguoglu E, Cetin Z
Genet Couns 2014;25(3):257-64. PMID: 25365847

Detailed molecular and clinical characterization of three patients with 21q deletions.

Lindstrand A, Malmgren H, Sahlén S, Schoumans J, Nordgren A, Ergander U, Holm E, Anderlid BM, Blennow E
Clin Genet 2010 Feb;77(2):145-54. Epub 2009 Oct 23 doi: 10.1111/j.1399-0004.2009.01289.x. PMID: 19863549

Cytogenetic, molecular genetic, and clinical characteristics of acute myeloid leukemia with a complex karyotype.

Mrózek K
Semin Oncol 2008 Aug;35(4):365-77. doi: 10.1053/j.seminoncol.2008.04.007. PMID: 18692687 Free PMC Article

Application of a comprehensive subtelomere array in clinical diagnosis of mental retardation.

Kok K, Dijkhuizen T, Swart YE, Zorgdrager H, van der Vlies P, Fehrmann R, te Meerman GJ, Gerssen-Schoorl KB, van Essen T, Sikkema-Raddatz B, Buys CH
Eur J Med Genet 2005 Jul-Sep;48(3):250-62. doi: 10.1016/j.ejmg.2005.04.007. PMID: 16179221

A brief review of cryptic duplications of 21q as an emerging cause of Down syndrome: practical considerations for accurate detection.

Garcia-Heras J, Rao PN
Clin Genet 1999 Mar;55(3):207-11. doi: 10.1034/j.1399-0004.1999.550310.x. PMID: 10334476

See all (37)

Therapy

Gains, losses and complex karyotypes in myeloid disorders: a light at the end of the tunnel.

Alvarez S, Cigudosa JC
Hematol Oncol 2005 Mar;23(1):18-25. doi: 10.1002/hon.744. PMID: 16142824

Novel cryptic, complex rearrangements involving ETV6-CBFA2 (TEL-AML1) genes identified by fluorescence in situ hybridization in pediatric patients with acute lymphoblastic leukemia.

Mathew S, Shurtleff SA, Raimondi SC
Genes Chromosomes Cancer 2001 Oct;32(2):188-93. doi: 10.1002/gcc.1182. PMID: 11550288

Telomeric associations and chromosome instability in ataxia telangiectasia T cells characterized by TCL1 expression.

Petrinelli P, Elli R, Marcucci L, Tabolacci E, Barbieri C, Antonelli A
Cancer Genet Cytogenet 2001 Feb;125(1):46-51. doi: 10.1016/s0165-4608(00)00358-7. PMID: 11297767

Chromosome 21 rearrangement in acute biphenotypic leukemia.

Theodossiou C, Scalise A, Silverman L, Najfeld V
Cancer Genet Cytogenet 1992 Nov;64(1):56-9. doi: 10.1016/0165-4608(92)90323-z. PMID: 1360869

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Prognosis

Gain of chromosome 21 or amplification of chromosome arm 21q is one mechanism for increased ERG expression in acute myeloid leukemia.

Cytogenetic, molecular genetic, and clinical characteristics of acute myeloid leukemia with a complex karyotype.

Mrózek K
Semin Oncol 2008 Aug;35(4):365-77. doi: 10.1053/j.seminoncol.2008.04.007. PMID: 18692687 Free PMC Article

Genetic alterations in gynecological malignancies.

Krkavcová M, Jancárková N, Janashia M, Freitag P, Dusková J
Neoplasma 2008;55(3):205-14. PMID: 18348653

Chromosomal aberrations in prostate cancer.

Saramaki O, Visakorpi T
Front Biosci 2007 May 1;12:3287-301. doi: 10.2741/2312. PMID: 17485299

Gains, losses and complex karyotypes in myeloid disorders: a light at the end of the tunnel.

Alvarez S, Cigudosa JC
Hematol Oncol 2005 Mar;23(1):18-25. doi: 10.1002/hon.744. PMID: 16142824

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Clinical prediction guides

Isochromosome 21q is overrepresented among false-negative cell-free DNA prenatal screening results involving Down syndrome.

Huijsdens-van Amsterdam K, Page-Christiaens L, Flowers N, Bonifacio MD, Ellis KMB, Vogel I, Vestergaard EM, Miguelez J, de Carvalho MHB, Sistermans EA, Pertile MD
Eur J Hum Genet 2018 Oct;26(10):1490-1496. Epub 2018 Jun 13 doi: 10.1038/s41431-018-0188-1. PMID: 29899373 Free PMC Article

Genetic alterations in gynecological malignancies.

Krkavcová M, Jancárková N, Janashia M, Freitag P, Dusková J
Neoplasma 2008;55(3):205-14. PMID: 18348653

Chromosomal aberrations in prostate cancer.

Saramaki O, Visakorpi T
Front Biosci 2007 May 1;12:3287-301. doi: 10.2741/2312. PMID: 17485299

Gains, losses and complex karyotypes in myeloid disorders: a light at the end of the tunnel.

Alvarez S, Cigudosa JC
Hematol Oncol 2005 Mar;23(1):18-25. doi: 10.1002/hon.744. PMID: 16142824

Characterization of human laryngeal primary and metastatic squamous cell carcinoma cell lines UM-SCC-17A and UM-SCC-17B.

Carey TE, Van Dyke DL, Worsham MJ, Bradford CR, Babu VR, Schwartz DR, Hsu S, Baker SR
Cancer Res 1989 Nov 1;49(21):6098-107. PMID: 2790823

See all (28)