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Split hand

MedGen UID:
397570
Concept ID:
C2699510
Congenital Abnormality
Synonym: Split hand (disease)
SNOMED CT: Congenital cleft hand (13624003); Lobster-claw hand (13624003); Lobster claw hand (13624003)
 
HPO: HP:0001171
Monarch Initiative: MONDO:0017449

Definition

A condition in which middle parts of the hand (fingers and metacarpals) are missing giving a cleft appearance. The severity is very variable ranging from slightly hypoplastic middle fingers over absent middle fingers as far as oligo- or monodactyl hands. [from HPO]

Conditions with this feature

Professional guidelines

PubMed

Mei LB, Zhang YY, Huang XJ, Ji H, Qiu PP, Ding L, He X, Li P
Yi Chuan 2024 Sep;46(9):750-756. doi: 10.16288/j.yczz.24-141. PMID: 39275874
Prado MB Jr, Hamoy-Jimenez G, Adiao KJ
J Clin Neurosci 2023 Jun;112:68-72. Epub 2023 Apr 25 doi: 10.1016/j.jocn.2023.04.016. PMID: 37104886
Sowińska-Seidler A, Socha M, Jamsheer A
J Appl Genet 2014 Feb;55(1):105-15. Epub 2013 Oct 27 doi: 10.1007/s13353-013-0178-5. PMID: 24163146Free PMC Article

Recent clinical studies

Etiology

Avidan R, Fainmesser Y, Drory VE, Bril V, Abraham A
Can J Neurol Sci 2023 Mar;50(2):228-233. Epub 2022 Feb 22 doi: 10.1017/cjn.2022.20. PMID: 35190003
Hu N, Wang J, Liu M
J Clin Neurosci 2021 Aug;90:293-301. Epub 2021 Jun 21 doi: 10.1016/j.jocn.2021.06.015. PMID: 34275566
Guero S, Holder-Espinasse M
J Hand Surg Eur Vol 2019 Jan;44(1):80-87. Epub 2018 Oct 31 doi: 10.1177/1753193418807375. PMID: 30380990
Gurrieri F, Everman DB
Am J Med Genet A 2013 Nov;161A(11):2860-72. Epub 2013 Sep 24 doi: 10.1002/ajmg.a.36239. PMID: 24115638
Digilio MC, Dallapiccola B
Orphanet J Rare Dis 2010 Sep 29;5:25. doi: 10.1186/1750-1172-5-25. PMID: 20920258Free PMC Article

Diagnosis

Pavey N, Hannaford A, Higashihara M, van den Bos M, Kiernan MC, Menon P, Vucic S
Clin Neurophysiol 2023 Dec;156:175-182. Epub 2023 Oct 26 doi: 10.1016/j.clinph.2023.09.018. PMID: 37967511
Lu WZ, Lin HA, Hou SK, Lee CF, Bai CH, Lin SF
Clin Neurophysiol 2022 Nov;143:56-66. Epub 2022 Sep 6 doi: 10.1016/j.clinph.2022.08.020. PMID: 36116424
Corcia P, Bede P, Pradat PF, Couratier P, Vucic S, de Carvalho M
J Neurol Neurosurg Psychiatry 2021 Oct;92(10):1126-1130. Epub 2021 Jul 20 doi: 10.1136/jnnp-2021-326266. PMID: 34285065
Wilcox WR, Coulter CP, Schmitz ML
Clin Perinatol 2015 Jun;42(2):281-300, viii. doi: 10.1016/j.clp.2015.02.004. PMID: 26042905
Digilio MC, Dallapiccola B
Orphanet J Rare Dis 2010 Sep 29;5:25. doi: 10.1186/1750-1172-5-25. PMID: 20920258Free PMC Article

Therapy

Alajmi A, Niaz G, Chen C, Lee K
Dermatol Surg 2024 May 1;50(5):467-470. Epub 2024 Mar 8 doi: 10.1097/DSS.0000000000004114. PMID: 38460193Free PMC Article
Jacobsen NL, Bloch M, Millard PS, Ruidiaz SF, Elsborg JD, Boomsma W, Hendus-Altenburger R, Hartmann-Petersen R, Kragelund BB
Protein Sci 2023 Sep;32(9):e4733. doi: 10.1002/pro.4733. PMID: 37463013Free PMC Article
Hannaford A, Byth K, Pavey N, Henderson RD, Mathers S, Needham M, Schultz D, Menon P, Kiernan MC, Vucic S
Muscle Nerve 2023 Jan;67(1):17-24. Epub 2022 Oct 25 doi: 10.1002/mus.27736. PMID: 36214183
Hannaford A, Higashihara M, Pavey N, van den Bos M, Geevasinga N, Vucic S, Menon P
Clin Neurophysiol 2021 Sep;132(9):2130-2135. Epub 2021 Jun 25 doi: 10.1016/j.clinph.2021.06.008. PMID: 34284248
Wu DC, Goldman MP
Dermatol Surg 2018 Apr;44(4):534-541. doi: 10.1097/DSS.0000000000001325. PMID: 29406482

Prognosis

Dharmadasa T, Pavey N, Tu S, Menon P, Huynh W, Mahoney CJ, Timmins HC, Higashihara M, van den Bos M, Shibuya K, Kuwabara S, Grosskreutz J, Kiernan MC, Vucic S
Clin Neurophysiol 2024 Jul;163:68-89. Epub 2024 Apr 18 doi: 10.1016/j.clinph.2024.04.010. PMID: 38705104
Sakai Y, Kuwahara K
Pathol Int 2024 Mar;74(3):103-118. Epub 2024 Feb 27 doi: 10.1111/pin.13415. PMID: 38411330
Hannaford A, Byth K, Pavey N, Henderson RD, Mathers S, Needham M, Schultz D, Menon P, Kiernan MC, Vucic S
Muscle Nerve 2023 Jan;67(1):17-24. Epub 2022 Oct 25 doi: 10.1002/mus.27736. PMID: 36214183
Yang X, Lin X, Zhu Y, Luo J, Lin G
Mol Med Rep 2018 Jun;17(6):7553-7558. Epub 2018 Mar 29 doi: 10.3892/mmr.2018.8838. PMID: 29620206Free PMC Article
Digilio MC, Dallapiccola B
Orphanet J Rare Dis 2010 Sep 29;5:25. doi: 10.1186/1750-1172-5-25. PMID: 20920258Free PMC Article

Clinical prediction guides

Bertini A, Lenti S, Libelli G, Ronco R, Oliveri S, Montemagno K, Priori A, Bocci T
Neurol Sci 2024 Oct;45(10):4669-4677. Epub 2024 Jun 4 doi: 10.1007/s10072-024-07626-1. PMID: 38833097Free PMC Article
Truong BT, Shull LC, Zepeda BJ, Lencer E, Artinger KB
Birth Defects Res 2024 Mar;116(3):e2327. doi: 10.1002/bdr2.2327. PMID: 38456586Free PMC Article
Lemon R
Clin Neurophysiol 2024 Apr;160:56-67. Epub 2024 Feb 9 doi: 10.1016/j.clinph.2024.02.001. PMID: 38401191
Hannaford A, Byth K, Pavey N, Henderson RD, Mathers S, Needham M, Schultz D, Menon P, Kiernan MC, Vucic S
Muscle Nerve 2023 Jan;67(1):17-24. Epub 2022 Oct 25 doi: 10.1002/mus.27736. PMID: 36214183
Yang ZK, Yang JY, Xu ZZ, Yu WH
Chin Med J (Engl) 2018 Apr 5;131(7):845-851. doi: 10.4103/0366-6999.228229. PMID: 29578129Free PMC Article

Recent systematic reviews

Ahmad S, Ali MZ, Muzammal M, Mir FA, Khan MA
Mol Genet Genomics 2022 Sep;297(5):1195-1214. Epub 2022 Jul 30 doi: 10.1007/s00438-022-01930-1. PMID: 35907958
Hu N, Wang J, Liu M
J Clin Neurosci 2021 Aug;90:293-301. Epub 2021 Jun 21 doi: 10.1016/j.jocn.2021.06.015. PMID: 34275566

Supplemental Content

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