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Tumor Flare Reaction

MedGen UID:
398022
•Concept ID:
C2700092
•
Finding

Definition

A side effect of cancer treatment. It has been described in patients with chronic lymphocytic leukemia treated with lenalidomide, breast cancer patients during the initial phase of hormonal treatment, and in prostate cancer patients treated with luteinizing hormone-releasing hormone agonists. Symptoms include a sudden and painful increase in the tumor size, rash, low grade fever, bone pain, hypercalcemia, and an increase in the tumor markers levels. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTumor Flare Reaction

Professional guidelines

PubMed

Tumor flare reaction associated with lenalidomide treatment in patients with chronic lymphocytic leukemia predicts clinical response.
Pinto A, Corazzelli G, De Filippi R
Cancer 2012 Mar 15;118(6):1738; author reply 1739. Epub 2011 Jul 15 doi: 10.1002/cncr.26380. PMID: 21766303
Thalidomide and lenalidomide as new therapeutics for the treatment of chronic lymphocytic leukemia.
Awan FT, Johnson AJ, Lapalombella R, Hu W, Lucas M, Fischer B, Byrd JC
Leuk Lymphoma 2010 Jan;51(1):27-38. doi: 10.3109/10428190903350405. PMID: 20055657Free PMC Article

Recent clinical studies

Etiology

Sequential ofatumumab and lenalidomide for the treatment of relapsed and refractory chronic lymphocytic leukemia and small lymphocytic lymphoma.
Costa LJ, Fanning SR, Stephenson J Jr, Afrin LB, Kistner-Griffin E, Bentz TA, Stuart RK
Leuk Lymphoma 2015 Mar;56(3):645-9. doi: 10.3109/10428194.2014.935369. PMID: 25130476
Tumor flare reaction associated with lenalidomide treatment in patients with chronic lymphocytic leukemia predicts clinical response.
Chanan-Khan A, Miller KC, Lawrence D, Padmanabhan S, Miller A, Hernandez-Illatazurri F, Czuczman MS, Wallace PK, Zeldis JB, Lee K
Cancer 2011 May 15;117(10):2127-35. Epub 2010 Nov 29 doi: 10.1002/cncr.25748. PMID: 21523725
Myocarditis during lenalidomide therapy.
Carver JR, Nasta S, Chong EA, Stonecypher M, Wheeler JE, Ahmadi T, Schuster SJ
Ann Pharmacother 2010 Nov;44(11):1840-3. Epub 2010 Sep 28 doi: 10.1345/aph.1P044. PMID: 20876827
Similar frequency of testosterone surge after repeat injections of goserelin (Zoladex) 3.6 mg and 10.8 mg: results of a randomized open-label trial.
Zinner NR, Bidair M, Centeno A, Tomera K
Urology 2004 Dec;64(6):1177-81. doi: 10.1016/j.urology.2004.07.033. PMID: 15596193

Diagnosis

Tumor Flare Reaction in a Classic Hodgkin Lymphoma Patient Treated With Brentuximab Vedotin and Tislelizumab: A Case Report.
Zhu C, Zhao Y, Yu F, Huang W, Wu W, He J, Cai Z, He D
Front Immunol 2021;12:756583. Epub 2022 Jan 14 doi: 10.3389/fimmu.2021.756583. PMID: 35095839Free PMC Article
Transient atelectasis due to hilar lymph node swelling affected by lenalidomide-induced tumor flare reaction.
Suyama T, Yui T, Horiuchi A, Irie R, Osamura Y, Miyao N
J Clin Exp Hematop 2021 Mar 18;61(1):48-52. Epub 2021 Jan 8 doi: 10.3960/jslrt.20045. PMID: 33431741Free PMC Article
Myocarditis during lenalidomide therapy.
Carver JR, Nasta S, Chong EA, Stonecypher M, Wheeler JE, Ahmadi T, Schuster SJ
Ann Pharmacother 2010 Nov;44(11):1840-3. Epub 2010 Sep 28 doi: 10.1345/aph.1P044. PMID: 20876827

Therapy

Tumor Flare Reaction in a Classic Hodgkin Lymphoma Patient Treated With Brentuximab Vedotin and Tislelizumab: A Case Report.
Zhu C, Zhao Y, Yu F, Huang W, Wu W, He J, Cai Z, He D
Front Immunol 2021;12:756583. Epub 2022 Jan 14 doi: 10.3389/fimmu.2021.756583. PMID: 35095839Free PMC Article
Transient atelectasis due to hilar lymph node swelling affected by lenalidomide-induced tumor flare reaction.
Suyama T, Yui T, Horiuchi A, Irie R, Osamura Y, Miyao N
J Clin Exp Hematop 2021 Mar 18;61(1):48-52. Epub 2021 Jan 8 doi: 10.3960/jslrt.20045. PMID: 33431741Free PMC Article
Lenalidomide and chronic lymphocytic leukemia.
González-Rodríguez AP, Payer AR, Acebes-Huerta A, Huergo-Zapico L, Villa-Alvarez M, Gonzalez-García E, Gonzalez S
Biomed Res Int 2013;2013:932010. Epub 2013 Sep 19 doi: 10.1155/2013/932010. PMID: 24163824Free PMC Article
Lenalidomide alone and in combination for chronic lymphocytic leukemia.
Chen CI
Curr Hematol Malig Rep 2013 Mar;8(1):7-13. doi: 10.1007/s11899-012-0146-x. PMID: 23254517
Thalidomide and lenalidomide as new therapeutics for the treatment of chronic lymphocytic leukemia.
Awan FT, Johnson AJ, Lapalombella R, Hu W, Lucas M, Fischer B, Byrd JC
Leuk Lymphoma 2010 Jan;51(1):27-38. doi: 10.3109/10428190903350405. PMID: 20055657Free PMC Article

Prognosis

Tumor flare reaction associated with lenalidomide treatment in patients with chronic lymphocytic leukemia predicts clinical response.
Chanan-Khan A, Miller KC, Lawrence D, Padmanabhan S, Miller A, Hernandez-Illatazurri F, Czuczman MS, Wallace PK, Zeldis JB, Lee K
Cancer 2011 May 15;117(10):2127-35. Epub 2010 Nov 29 doi: 10.1002/cncr.25748. PMID: 21523725

Clinical prediction guides

Tumor Flare Reaction in a Classic Hodgkin Lymphoma Patient Treated With Brentuximab Vedotin and Tislelizumab: A Case Report.
Zhu C, Zhao Y, Yu F, Huang W, Wu W, He J, Cai Z, He D
Front Immunol 2021;12:756583. Epub 2022 Jan 14 doi: 10.3389/fimmu.2021.756583. PMID: 35095839Free PMC Article
Lenalidomide alone and in combination for chronic lymphocytic leukemia.
Chen CI
Curr Hematol Malig Rep 2013 Mar;8(1):7-13. doi: 10.1007/s11899-012-0146-x. PMID: 23254517
Tumor flare reaction associated with lenalidomide treatment in patients with chronic lymphocytic leukemia predicts clinical response.
Chanan-Khan A, Miller KC, Lawrence D, Padmanabhan S, Miller A, Hernandez-Illatazurri F, Czuczman MS, Wallace PK, Zeldis JB, Lee K
Cancer 2011 May 15;117(10):2127-35. Epub 2010 Nov 29 doi: 10.1002/cncr.25748. PMID: 21523725

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