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Hamartomatous stomach polyps

MedGen UID:
400021
Concept ID:
C1862304
Disease or Syndrome; Finding
Synonym: Hamartomatous polyp of stomach
SNOMED CT: Hamartomatous polyp of stomach (724524006)
 
HPO: HP:0004795

Definition

Polyp-like protrusions which are histologically hamartomas located in the stomach. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHamartomatous stomach polyps

Conditions with this feature

Gorlin syndrome
MedGen UID:
2554
Concept ID:
C0004779
Neoplastic Process
Nevoid basal cell carcinoma syndrome (NBCCS) is characterized by the development of multiple jaw keratocysts, frequently beginning in the second decade of life, and/or basal cell carcinomas (BCCs) usually from the third decade onward. Approximately 60% of individuals have a recognizable appearance with macrocephaly, frontal bossing, coarse facial features, and facial milia. Most individuals have skeletal anomalies (e.g., bifid ribs, wedge-shaped vertebrae). Ectopic calcification, particularly in the falx, is present in more than 90% of affected individuals by age 20 years. Cardiac and ovarian fibromas occur in approximately 2% and 20% of individuals respectively. Approximately 5% of all children with NBCCS develop medulloblastoma (primitive neuroectodermal tumor), generally the desmoplastic subtype. The risk of developing medulloblastoma is substantially higher in individuals with an SUFU pathogenic variant (33%) than in those with a PTCH1 pathogenic variant (<2%). Peak incidence is at age one to two years. Life expectancy in NBCCS is not significantly different from average.

Professional guidelines

PubMed

Castro R, Pimentel-Nunes P, Dinis-Ribeiro M
Best Pract Res Clin Gastroenterol 2017 Aug;31(4):381-387. Epub 2017 Jun 13 doi: 10.1016/j.bpg.2017.06.001. PMID: 28842047
Sweetser S, Ahlquist DA, Osborn NK, Sanderson SO, Smyrk TC, Chari ST, Boardman LA
Dig Dis Sci 2012 Feb;57(2):496-502. Epub 2011 Sep 1 doi: 10.1007/s10620-011-1874-9. PMID: 21881972
Corredor J, Wambach J, Barnard J
J Pediatr 2001 May;138(5):621-8. doi: 10.1067/mpd.2001.113619. PMID: 11343034

Recent clinical studies

Etiology

Stoffel EM
Gastroenterol Clin North Am 2016 Sep;45(3):509-27. doi: 10.1016/j.gtc.2016.04.008. PMID: 27546846
Jelsig AM
Dan Med J 2016 Aug;63(8) PMID: 27477802
Brosens LA, Wood LD, Offerhaus GJ, Arnold CA, Lam-Himlin D, Giardiello FM, Montgomery EA
Int J Surg Pathol 2016 May;24(3):185-99. Epub 2015 Dec 31 doi: 10.1177/1066896915620013. PMID: 26721304
Buck JL, Harned RK, Lichtenstein JE, Sobin LH
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Fabry TL, Frankel A, Waye JD
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Diagnosis

Castro R, Pimentel-Nunes P, Dinis-Ribeiro M
Best Pract Res Clin Gastroenterol 2017 Aug;31(4):381-387. Epub 2017 Jun 13 doi: 10.1016/j.bpg.2017.06.001. PMID: 28842047
Stoffel EM
Gastroenterol Clin North Am 2016 Sep;45(3):509-27. doi: 10.1016/j.gtc.2016.04.008. PMID: 27546846
Jelsig AM
Dan Med J 2016 Aug;63(8) PMID: 27477802
Buck JL, Harned RK, Lichtenstein JE, Sobin LH
Radiographics 1992 Mar;12(2):365-78. doi: 10.1148/radiographics.12.2.1561426. PMID: 1561426
Fabry TL, Frankel A, Waye JD
J Clin Gastroenterol 1982 Feb;4(1):23-7. doi: 10.1097/00004836-198202000-00004. PMID: 7077060

Therapy

Mauriz Barreiro V, Ramos Alonso M, Fernández López M, Rivera Castillo DA, Durana Tonder C, Pradera Cibreiro C
Rev Esp Enferm Dig 2024 Apr;116(4):223-224. doi: 10.17235/reed.2023.9652/2023. PMID: 37114421
Sweetser S, Ahlquist DA, Osborn NK, Sanderson SO, Smyrk TC, Chari ST, Boardman LA
Dig Dis Sci 2012 Feb;57(2):496-502. Epub 2011 Sep 1 doi: 10.1007/s10620-011-1874-9. PMID: 21881972
Triggiani V, Guastamacchia E, Renzulli G, Giagulli VA, Tafaro E, Licchelli B, Resta F, Sabbà C, Bagnulo R, Lastella P, Stella A, Resta N
Thyroid 2011 Nov;21(11):1273-7. Epub 2011 Aug 30 doi: 10.1089/thy.2011.0063. PMID: 21877933
Borch K, Skarsgård J, Franzén L, Mårdh S, Rehfeld JF
Dig Dis Sci 2003 Jul;48(7):1292-7. doi: 10.1023/a:1024150924457. PMID: 12870785
Declich P, Ambrosiani L, Grassini R, Tavani E, Bellone S, Bortoli A, Gozzini C, Prada A
Pol J Pathol 2000;51(1):3-8. PMID: 10833897

Prognosis

Shah ZA, Zeb M, Ilyas M, Hamid H, Fatima K, Batool M, Abbas M
J Med Case Rep 2024 Mar 5;18(1):86. doi: 10.1186/s13256-023-04335-9. PMID: 38438911Free PMC Article
Jelsig AM
Dan Med J 2016 Aug;63(8) PMID: 27477802
Rubio CA, Nesi G
Anticancer Res 2011 May;31(5):1789-93. PMID: 21617241
Georgescu EF, Stănescu L, Simionescu C, Georgescu I, Ionescu R, Florescu G
Rom J Morphol Embryol 2008;49(2):241-5. PMID: 18516333
Iishi H, Tatsuta M, Okuda S
Dig Dis Sci 1989 Jun;34(6):890-4. doi: 10.1007/BF01540275. PMID: 2721321

Clinical prediction guides

Zhu LP, Zhong WL, Wang ZG, Sun KD, Liu QLF, Zhao J, Zhao JW, Chen X, Wang BM
J Dig Dis 2021 Nov;22(11):663-671. doi: 10.1111/1751-2980.13062. PMID: 34697888
Buyukasik K, Sevinc MM, Gunduz UR, Ari A, Gurbulak B, Toros AB, Bektas H
Asian Pac J Cancer Prev 2015;16(7):2999-3001. doi: 10.7314/apjcp.2015.16.7.2999. PMID: 25854396
Triggiani V, Guastamacchia E, Renzulli G, Giagulli VA, Tafaro E, Licchelli B, Resta F, Sabbà C, Bagnulo R, Lastella P, Stella A, Resta N
Thyroid 2011 Nov;21(11):1273-7. Epub 2011 Aug 30 doi: 10.1089/thy.2011.0063. PMID: 21877933
Choi HS, Park YJ, Youk EG, Yoon KA, Ku JL, Kim NK, Kim SM, Kim YJ, Moon DJ, Min JS, Park CJ, Bae OS, Yang DH, Jun SH, Chung ES, Jung PM, Whang Y, Park JG
Int J Colorectal Dis 2000 Feb;15(1):35-8. doi: 10.1007/s003840050005. PMID: 10766089
Järvinen HJ, Sipponen P
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Recent systematic reviews

Singh AD, Gupta A, Mehta N, Heald B, Macaron C, Liska D, Bhatt A, Burke CA
Gastrointest Endosc 2023 Mar;97(3):407-414.e1. Epub 2022 Oct 18 doi: 10.1016/j.gie.2022.10.026. PMID: 36265529

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