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Malignant neoplasm of skin

MedGen UID:
40101
•Concept ID:
C0007114
•
Neoplastic Process
Synonyms: Malignant skin neoplasm; Skin cancer
SNOMED CT: Malignant neoplasm of skin (372130007); Skin cancer (372130007); Cancer of skin (372130007)
 
Monarch Initiative: MONDO:0002898

Definition

A primary or metastatic malignant neoplasm involving the skin. Primary malignant skin neoplasms most often are carcinomas (either basal cell or squamous cell carcinomas) or melanomas. Metastatic malignant neoplasms to the skin include carcinomas and lymphomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant neoplasm of skin

Professional guidelines

PubMed

European consensus-based interdisciplinary guideline for melanoma. Part 2: Treatment - Update 2022.
Garbe C, Amaral T, Peris K, Hauschild A, Arenberger P, Basset-Seguin N, Bastholt L, Bataille V, Del Marmol V, Dréno B, Fargnoli MC, Forsea AM, Grob JJ, Hoeller C, Kaufmann R, Kelleners-Smeets N, Lallas A, Lebbé C, Lytvynenko B, Malvehy J, Moreno-Ramirez D, Nathan P, Pellacani G, Saiag P, Stratigos AJ, Van Akkooi ACJ, Vieira R, Zalaudek I, Lorigan P; European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO), and the European Organization for Research and Treatment of Cancer (EORTC)
Eur J Cancer 2022 Jul;170:256-284. Epub 2022 May 24 doi: 10.1016/j.ejca.2022.04.018. PMID: 35623961
European consensus-based interdisciplinary guideline for melanoma. Part 1: Diagnostics: Update 2022.
Garbe C, Amaral T, Peris K, Hauschild A, Arenberger P, Basset-Seguin N, Bastholt L, Bataille V, Del Marmol V, Dréno B, Fargnoli MC, Forsea AM, Grob JJ, Höller C, Kaufmann R, Kelleners-Smeets N, Lallas A, Lebbé C, Lytvynenko B, Malvehy J, Moreno-Ramirez D, Nathan P, Pellacani G, Saiag P, Stratigos AJ, Van Akkooi ACJ, Vieira R, Zalaudek I, Lorigan P; European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO), and the European Organization for Research and Treatment of Cancer (EORTC)
Eur J Cancer 2022 Jul;170:236-255. Epub 2022 May 12 doi: 10.1016/j.ejca.2022.03.008. PMID: 35570085
Sebaceous carcinoma: evidence-based clinical practice guidelines.
Owen JL, Kibbi N, Worley B, Kelm RC, Wang JV, Barker CA, Behshad R, Bichakjian CK, Bolotin D, Bordeaux JS, Bradshaw SH, Cartee TV, Chandra S, Cho NL, Choi JN, Council ML, Demirci H, Eisen DB, Esmaeli B, Golda N, Huang CC, Ibrahim SF, Jiang SB, Kim J, Kuzel TM, Lai SY, Lawrence N, Lee EH, Leitenberger JJ, Maher IA, Mann MW, Minkis K, Mittal BB, Nehal KS, Neuhaus IM, Ozog DM, Petersen B, Rotemberg V, Samant S, Samie FH, Servaes S, Shields CL, Shin TM, Sobanko JF, Somani AK, Stebbins WG, Thomas JR, Thomas VD, Tse DT, Waldman AH, Wong MK, Xu YG, Yu SS, Zeitouni NC, Ramsay T, Reynolds KA, Poon E, Alam M
Lancet Oncol 2019 Dec;20(12):e699-e714. doi: 10.1016/S1470-2045(19)30673-4. PMID: 31797796

Curated

UK NICE Guideline NG12, Suspected cancer: recognition and referral, 2023

Suggested Reading

PubMed

Genetics of Skin Cancer (PDQ®): Health Professional Version.
PDQ Cancer Genetics Editorial Board
2002 PMID: 26389333
Cancer Genetics Risk Assessment and Counseling (PDQ®): Health Professional Version.
PDQ Cancer Genetics Editorial Board
2002 PMID: 26389258

Recent clinical studies

Etiology

Incidence of malignant tumours in patients with a non-functioning pituitary adenoma.
Olsson DS, Hammarstrand C, Bryngelsson IL, Nilsson AG, Andersson E, Johannsson G, Ragnarsson O
Endocr Relat Cancer 2017 May;24(5):227-235. Epub 2017 Mar 8 doi: 10.1530/ERC-16-0518. PMID: 28274953

Diagnosis

Dermatofibrosarcoma Protuberans of Breast.
Kumar D, Vallacha A
J Coll Physicians Surg Pak 2018 Aug;28(8):645-647. doi: 10.29271/jcpsp.2018.08.645. PMID: 30060798
Incidence of malignant tumours in patients with a non-functioning pituitary adenoma.
Olsson DS, Hammarstrand C, Bryngelsson IL, Nilsson AG, Andersson E, Johannsson G, Ragnarsson O
Endocr Relat Cancer 2017 May;24(5):227-235. Epub 2017 Mar 8 doi: 10.1530/ERC-16-0518. PMID: 28274953
Topical antibiotic trends from 1993 to 2007: use of topical antibiotics for non-evidence-based indications.
Lapolla WJ, Levender MM, Davis SA, Yentzer BA, Williford PM, Feldman SR
Dermatol Surg 2011 Oct;37(10):1427-33. Epub 2011 Sep 2 doi: 10.1111/j.1524-4725.2011.02122.x. PMID: 21895848
Basal cell carcinoma with prominent central palisading of epithelial cells mimicking schwannoma.
San Juan J, Monteagudo C, Navarro P, Terrádez JJ
J Cutan Pathol 1999 Nov;26(10):528-32. doi: 10.1111/j.1600-0560.1999.tb01801.x. PMID: 10599946
Only 33% of visits for skin disease in the US in 1995 were to dermatologists: is decreasing the number of dermatologists the appropriate response?
Thompson TT, Feldman SR, Fleischer AB Jr
Dermatol Online J 1998 Oct;4(1):3. PMID: 10217743

Therapy

Topical antibiotic trends from 1993 to 2007: use of topical antibiotics for non-evidence-based indications.
Lapolla WJ, Levender MM, Davis SA, Yentzer BA, Williford PM, Feldman SR
Dermatol Surg 2011 Oct;37(10):1427-33. Epub 2011 Sep 2 doi: 10.1111/j.1524-4725.2011.02122.x. PMID: 21895848

Prognosis

Incidence of malignant tumours in patients with a non-functioning pituitary adenoma.
Olsson DS, Hammarstrand C, Bryngelsson IL, Nilsson AG, Andersson E, Johannsson G, Ragnarsson O
Endocr Relat Cancer 2017 May;24(5):227-235. Epub 2017 Mar 8 doi: 10.1530/ERC-16-0518. PMID: 28274953

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2023
      UK NICE Guideline NG12, Suspected cancer: recognition and referral, 2023

    Consumer resources

    Reviews

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