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Non-small cell lung carcinoma(NSCLC)

MedGen UID:
40104
•Concept ID:
C0007131
•
Neoplastic Process
Synonyms: Non-small cell lung cancer; NSCLC
SNOMED CT: Non-small cell lung cancer (254637007); NSCLC - Non-small cell lung cancer (254637007)
 
HPO: HP:0030358
Monarch Initiative: MONDO:0005233
OMIM®: 211980
Orphanet: ORPHA488201

Definition

A group of at least three distinct histological types of lung cancer, including non-small cell squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. Non-small cell lung carcinomas have a poor response to conventional chemotherapy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNon-small cell lung carcinoma

Conditions with this feature

Lung cancer
MedGen UID:
66885
•Concept ID:
C0242379
•
Neoplastic Process
A primary or metastatic malignant neoplasm involving the lung.
See: Condition Record
Lung cancer

Suggested Reading

PubMed

National Working Group Meeting on ALK diagnostics in lung cancer.
Cooper W, Fox S, O'Toole S, Morey A, Frances G, Pavlakis N, O'Byrne K, Dettrick A, Leong T, Rathi V, Spagnolo D, Hemmings C, Singh M, Moffat D, Tsao MS, Wilner K, Buller R, Pitman Lowenthal S, Arifeen S, Binko J, Alam M
Asia Pac J Clin Oncol 2014 Apr;10 Suppl 2:11-7. doi: 10.1111/ajco.12190. PMID: 24673736

Recent clinical studies

Etiology

Impact of Antibiotics and Proton Pump Inhibitors on Efficacy and Tolerance of Anti-PD-1 Immune Checkpoint Inhibitors.
Giordan Q, Salleron J, Vallance C, Moriana C, Clement-Duchene C
Front Immunol 2021;12:716317. Epub 2021 Oct 27 doi: 10.3389/fimmu.2021.716317. PMID: 34777340Free PMC Article
N(6)-methyladenosine-modified circIGF2BP3 inhibits CD8(+) T-cell responses to facilitate tumor immune evasion by promoting the deubiquitination of PD-L1 in non-small cell lung cancer.
Liu Z, Wang T, She Y, Wu K, Gu S, Li L, Dong C, Chen C, Zhou Y
Mol Cancer 2021 Aug 20;20(1):105. doi: 10.1186/s12943-021-01398-4. PMID: 34416901Free PMC Article
Machine Learning for Early Lung Cancer Identification Using Routine Clinical and Laboratory Data.
Gould MK, Huang BZ, Tammemagi MC, Kinar Y, Shiff R
Am J Respir Crit Care Med 2021 Aug 15;204(4):445-453. doi: 10.1164/rccm.202007-2791OC. PMID: 33823116
Treatment of Brain Metastases of Non-Small Cell Lung Carcinoma.
Rybarczyk-Kasiuchnicz A, Ramlau R, Stencel K
Int J Mol Sci 2021 Jan 8;22(2) doi: 10.3390/ijms22020593. PMID: 33435596Free PMC Article
Identifying optimal first-line interventions for advanced non-small cell lung carcinoma according to PD-L1 expression: a systematic review and network meta-analysis.
Liu J, Li C, Seery S, Yu J, Meng X
Oncoimmunology 2020;9(1):1746112. Epub 2020 Apr 7 doi: 10.1080/2162402X.2020.1746112. PMID: 32313723Free PMC Article

Diagnosis

Liquid biopsy for early diagnosis of non-small cell lung carcinoma: recent research and detection technologies.
Chang L, Li J, Zhang R
Biochim Biophys Acta Rev Cancer 2022 May;1877(3):188729. Epub 2022 Apr 15 doi: 10.1016/j.bbcan.2022.188729. PMID: 35436521
Fusion-positive non-small cell lung carcinoma: Biological principles, clinical practice, and diagnostic implications.
Kazdal D, Hofman V, Christopoulos P, Ilié M, Stenzinger A, Hofman P
Genes Chromosomes Cancer 2022 May;61(5):244-260. Epub 2022 Jan 22 doi: 10.1002/gcc.23022. PMID: 34997651
Machine Learning for Early Lung Cancer Identification Using Routine Clinical and Laboratory Data.
Gould MK, Huang BZ, Tammemagi MC, Kinar Y, Shiff R
Am J Respir Crit Care Med 2021 Aug 15;204(4):445-453. doi: 10.1164/rccm.202007-2791OC. PMID: 33823116
Molecular Pathology of Primary Non-small Cell Lung Cancer.
Suster DI, Mino-Kenudson M
Arch Med Res 2020 Nov;51(8):784-798. Epub 2020 Aug 29 doi: 10.1016/j.arcmed.2020.08.004. PMID: 32873398
Current WHO guidelines and the critical role of immunohistochemical markers in the subclassification of non-small cell lung carcinoma (NSCLC): Moving from targeted therapy to immunotherapy.
Osmani L, Askin F, Gabrielson E, Li QK
Semin Cancer Biol 2018 Oct;52(Pt 1):103-109. Epub 2017 Nov 26 doi: 10.1016/j.semcancer.2017.11.019. PMID: 29183778Free PMC Article

Therapy

Fusion-positive non-small cell lung carcinoma: Biological principles, clinical practice, and diagnostic implications.
Kazdal D, Hofman V, Christopoulos P, Ilié M, Stenzinger A, Hofman P
Genes Chromosomes Cancer 2022 May;61(5):244-260. Epub 2022 Jan 22 doi: 10.1002/gcc.23022. PMID: 34997651
Brigatinib vs alectinib in crizotinib-resistant advanced anaplastic lymphoma kinase-positive non-small-cell lung cancer (ALTA-3).
Popat S, Liu G, Lu S, Song G, Ma X, Yang JC
Future Oncol 2021 Nov;17(32):4237-4247. Epub 2021 Aug 23 doi: 10.2217/fon-2021-0608. PMID: 34423676
Pembrolizumab plus pemetrexed-platinum for metastatic nonsquamous non-small-cell lung cancer: KEYNOTE-189 Japan Study.
Horinouchi H, Nogami N, Saka H, Nishio M, Tokito T, Takahashi T, Kasahara K, Hattori Y, Ichihara E, Adachi N, Noguchi K, Souza F, Kurata T
Cancer Sci 2021 Aug;112(8):3255-3265. Epub 2021 Jun 15 doi: 10.1111/cas.14980. PMID: 34036692Free PMC Article
Targeting HER2 expression in cancer: New drugs and new indications.
Vranić S, Bešlija S, Gatalica Z
Bosn J Basic Med Sci 2021 Feb 1;21(1):1-4. doi: 10.17305/bjbms.2020.4908. PMID: 32530388Free PMC Article
Incidence of Pneumonitis With Use of Programmed Death 1 and Programmed Death-Ligand 1 Inhibitors in Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis of Trials.
Khunger M, Rakshit S, Pasupuleti V, Hernandez AV, Mazzone P, Stevenson J, Pennell NA, Velcheti V
Chest 2017 Aug;152(2):271-281. Epub 2017 May 10 doi: 10.1016/j.chest.2017.04.177. PMID: 28499515

Prognosis

Immunotherapy and Prognosis of Non-small Cell Lung Carcinoma by Monomethoxy polyethylene glycol-hyaluronic acid-platinum Combined with Immune CT4+ and CT8+ Detection.
Ren X, Luo T, Ma H, Zhou M, Yu S
Cell Mol Biol (Noisy-le-grand) 2022 Jun 30;68(6):167-173. doi: 10.14715/cmb/2022.68.6.27. PMID: 36227659
Predictive testing in non-small cell lung carcinoma.
Dundr P, Matěj R, Němejcová K, Bártů M, Stružinská I
Klin Onkol 2021 Spring;34(Supplementum 1):29-34. doi: 10.48095/ccko2021S29. PMID: 34154327
Exploiting metabolic vulnerabilities of Non small cell lung carcinoma.
Majem B, Nadal E, Muñoz-Pinedo C
Semin Cell Dev Biol 2020 Feb;98:54-62. Epub 2019 Jul 2 doi: 10.1016/j.semcdb.2019.06.004. PMID: 31238096
Current WHO guidelines and the critical role of immunohistochemical markers in the subclassification of non-small cell lung carcinoma (NSCLC): Moving from targeted therapy to immunotherapy.
Osmani L, Askin F, Gabrielson E, Li QK
Semin Cancer Biol 2018 Oct;52(Pt 1):103-109. Epub 2017 Nov 26 doi: 10.1016/j.semcancer.2017.11.019. PMID: 29183778Free PMC Article
The International Association for the Study of Lung Cancer Lung Cancer Staging Project: Proposals for the Revision of the N Descriptors in the Forthcoming 8th Edition of the TNM Classification for Lung Cancer.
Asamura H, Chansky K, Crowley J, Goldstraw P, Rusch VW, Vansteenkiste JF, Watanabe H, Wu YL, Zielinski M, Ball D, Rami-Porta R; International Association for the Study of Lung Cancer Staging and Prognostic Factors Committee, Advisory Board Members, and Participating Institutions
J Thorac Oncol 2015 Dec;10(12):1675-84. doi: 10.1097/JTO.0000000000000678. PMID: 26709477

Clinical prediction guides

Obesity accelerates immune evasion of non-small cell lung carcinoma via TFEB-dependent upregulation of Siglec-15 and glycolytic reprogramming.
Zhang C, Zhou L, Li S, Zhao J, Meng X, Ma L, Wang Y, Li C, Zheng L, Ming L
Cancer Lett 2022 Dec 1;550:215918. Epub 2022 Sep 20 doi: 10.1016/j.canlet.2022.215918. PMID: 36150633
Immune checkpoint inhibitor-related thyroid dysfunction.
Iwama S, Kobayashi T, Yasuda Y, Arima H
Best Pract Res Clin Endocrinol Metab 2022 May;36(3):101660. Epub 2022 Apr 12 doi: 10.1016/j.beem.2022.101660. PMID: 35501263
Molecular Pathology of Primary Non-small Cell Lung Cancer.
Suster DI, Mino-Kenudson M
Arch Med Res 2020 Nov;51(8):784-798. Epub 2020 Aug 29 doi: 10.1016/j.arcmed.2020.08.004. PMID: 32873398
Immunocytochemistry for predictive biomarker testing in lung cancer cytology.
Jain D, Nambirajan A, Borczuk A, Chen G, Minami Y, Moreira AL, Motoi N, Papotti M, Rekhtman N, Russell PA, Savic Prince S, Yatabe Y, Bubendorf L; IASLC Pathology Committee
Cancer Cytopathol 2019 May;127(5):325-339. Epub 2019 May 3 doi: 10.1002/cncy.22137. PMID: 31050216Free PMC Article
Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immuno-Oncology Biomarkers Working Group: Part 2: TILs in Melanoma, Gastrointestinal Tract Carcinomas, Non-Small Cell Lung Carcinoma and Mesothelioma, Endometrial and Ovarian Carcinomas, Squamous Cell Carcinoma of the Head and Neck, Genitourinary Carcinomas, and Primary Brain Tumors.
Hendry S, Salgado R, Gevaert T, Russell PA, John T, Thapa B, Christie M, van de Vijver K, Estrada MV, Gonzalez-Ericsson PI, Sanders M, Solomon B, Solinas C, Van den Eynden GGGM, Allory Y, Preusser M, Hainfellner J, Pruneri G, Vingiani A, Demaria S, Symmans F, Nuciforo P, Comerma L, Thompson EA, Lakhani S, Kim SR, Schnitt S, Colpaert C, Sotiriou C, Scherer SJ, Ignatiadis M, Badve S, Pierce RH, Viale G, Sirtaine N, Penault-Llorca F, Sugie T, Fineberg S, Paik S, Srinivasan A, Richardson A, Wang Y, Chmielik E, Brock J, Johnson DB, Balko J, Wienert S, Bossuyt V, Michiels S, Ternes N, Burchardi N, Luen SJ, Savas P, Klauschen F, Watson PH, Nelson BH, Criscitiello C, O'Toole S, Larsimont D, de Wind R, Curigliano G, André F, Lacroix-Triki M, van de Vijver M, Rojo F, Floris G, Bedri S, Sparano J, Rimm D, Nielsen T, Kos Z, Hewitt S, Singh B, Farshid G, Loibl S, Allison KH, Tung N, Adams S, Willard-Gallo K, Horlings HM, Gandhi L, Moreira A, Hirsch F, Dieci MV, Urbanowicz M, Brcic I, Korski K, Gaire F, Koeppen H, Lo A, Giltnane J, Rebelatto MC, Steele KE, Zha J, Emancipator K, Juco JW, Denkert C, Reis-Filho J, Loi S, Fox SB
Adv Anat Pathol 2017 Nov;24(6):311-335. doi: 10.1097/PAP.0000000000000161. PMID: 28777143Free PMC Article

Recent systematic reviews

Systemic treatment for neuroendocrine non-small cell lung carcinoma: A cases series and a systematic review of the literature.
Jelli B, Brandão M, Mekinda Z, Durieux V, Berghmans T
Lung Cancer 2023 Jul;181:107232. Epub 2023 May 10 doi: 10.1016/j.lungcan.2023.107232. PMID: 37216840
Identifying optimal first-line interventions for advanced non-small cell lung carcinoma according to PD-L1 expression: a systematic review and network meta-analysis.
Liu J, Li C, Seery S, Yu J, Meng X
Oncoimmunology 2020;9(1):1746112. Epub 2020 Apr 7 doi: 10.1080/2162402X.2020.1746112. PMID: 32313723Free PMC Article
A systematic review and meta-analysis: Association between MGMT hypermethylation and the clinicopathological characteristics of non-small-cell lung carcinoma.
Chen L, Wang Y, Liu F, Xu L, Peng F, Zhao N, Fu B, Zhu Z, Shi Y, Liu J, Wu R, Wang C, Yao S, Li Y
Sci Rep 2018 Jan 23;8(1):1439. doi: 10.1038/s41598-018-19949-z. PMID: 29362385Free PMC Article
Clinical and Molecular Characteristics Associated With Survival Among Patients Treated With Checkpoint Inhibitors for Advanced Non-Small Cell Lung Carcinoma: A Systematic Review and Meta-analysis.
Lee CK, Man J, Lord S, Cooper W, Links M, Gebski V, Herbst RS, Gralla RJ, Mok T, Yang JC
JAMA Oncol 2018 Feb 1;4(2):210-216. doi: 10.1001/jamaoncol.2017.4427. PMID: 29270615Free PMC Article
Incidence of Pneumonitis With Use of Programmed Death 1 and Programmed Death-Ligand 1 Inhibitors in Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis of Trials.
Khunger M, Rakshit S, Pasupuleti V, Hernandez AV, Mazzone P, Stevenson J, Pennell NA, Velcheti V
Chest 2017 Aug;152(2):271-281. Epub 2017 May 10 doi: 10.1016/j.chest.2017.04.177. PMID: 28499515

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2022
      UK NICE guideline NG122, Lung cancer: diagnosis and management
    • NICE, 2013
      EGFR-TK mutation testing in adults with locally advanced or metastatic non-small-cell lung cancer
    • AHRQ, 2013
      Technology Assessment on Genetic Testing or Molecular Pathology Testing of Cancers with Unknown Primary Site to Determine Origin (ARCHIVED)

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • MeSH
      Related Medical Subject Headings
    • OMIM
      Related records in OMIM
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed
    • PubMed (OMIM)
      Related literature resources in PubMed

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