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Non-small cell lung carcinoma(NSCLC)

MedGen UID:
40104
Concept ID:
C0007131
Neoplastic Process
Synonyms: Non-small cell lung cancer; NSCLC
SNOMED CT: Non-small cell lung cancer (254637007); NSCLC - Non-small cell lung cancer (254637007)
 
HPO: HP:0030358
Monarch Initiative: MONDO:0005233
OMIM®: 211980
Orphanet: ORPHA488201

Definition

A group of at least three distinct histological types of lung cancer, including non-small cell squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. Non-small cell lung carcinomas have a poor response to conventional chemotherapy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNon-small cell lung carcinoma

Conditions with this feature

Lung cancer
MedGen UID:
66885
Concept ID:
C0242379
Neoplastic Process
A primary or metastatic malignant neoplasm involving the lung.

Suggested Reading

PubMed

Cooper W, Fox S, O'Toole S, Morey A, Frances G, Pavlakis N, O'Byrne K, Dettrick A, Leong T, Rathi V, Spagnolo D, Hemmings C, Singh M, Moffat D, Tsao MS, Wilner K, Buller R, Pitman Lowenthal S, Arifeen S, Binko J, Alam M
Asia Pac J Clin Oncol 2014 Apr;10 Suppl 2:11-7. doi: 10.1111/ajco.12190. PMID: 24673736

Recent clinical studies

Etiology

Liu Z, Wang T, She Y, Wu K, Gu S, Li L, Dong C, Chen C, Zhou Y
Mol Cancer 2021 Aug 20;20(1):105. doi: 10.1186/s12943-021-01398-4. PMID: 34416901Free PMC Article
Gould MK, Huang BZ, Tammemagi MC, Kinar Y, Shiff R
Am J Respir Crit Care Med 2021 Aug 15;204(4):445-453. doi: 10.1164/rccm.202007-2791OC. PMID: 33823116
Rybarczyk-Kasiuchnicz A, Ramlau R, Stencel K
Int J Mol Sci 2021 Jan 8;22(2) doi: 10.3390/ijms22020593. PMID: 33435596Free PMC Article
Coster JN, Groth SS
Surg Oncol Clin N Am 2020 Oct;29(4):543-554. doi: 10.1016/j.soc.2020.07.001. PMID: 32883457
Rancoule C, Vallard A, Guy JB, Espenel S, Diao P, Chargari C, Magné N
Crit Rev Oncol Hematol 2017 Aug;116:32-37. Epub 2017 May 20 doi: 10.1016/j.critrevonc.2017.05.007. PMID: 28693798

Diagnosis

Chang L, Li J, Zhang R
Biochim Biophys Acta Rev Cancer 2022 May;1877(3):188729. Epub 2022 Apr 15 doi: 10.1016/j.bbcan.2022.188729. PMID: 35436521
Dundr P, Matěj R, Němejcová K, Bártů M, Stružinská I
Klin Onkol 2021 Spring;34(Supplementum 1):29-34. doi: 10.48095/ccko2021S29. PMID: 34154327
Gould MK, Huang BZ, Tammemagi MC, Kinar Y, Shiff R
Am J Respir Crit Care Med 2021 Aug 15;204(4):445-453. doi: 10.1164/rccm.202007-2791OC. PMID: 33823116
Osmani L, Askin F, Gabrielson E, Li QK
Semin Cancer Biol 2018 Oct;52(Pt 1):103-109. Epub 2017 Nov 26 doi: 10.1016/j.semcancer.2017.11.019. PMID: 29183778Free PMC Article
Rao N
Semin Diagn Pathol 2014 Jul;31(4):271-7. Epub 2014 Jun 11 doi: 10.1053/j.semdp.2014.06.004. PMID: 25002356

Therapy

Horinouchi H, Nogami N, Saka H, Nishio M, Tokito T, Takahashi T, Kasahara K, Hattori Y, Ichihara E, Adachi N, Noguchi K, Souza F, Kurata T
Cancer Sci 2021 Aug;112(8):3255-3265. Epub 2021 Jun 15 doi: 10.1111/cas.14980. PMID: 34036692Free PMC Article
Gould MK, Huang BZ, Tammemagi MC, Kinar Y, Shiff R
Am J Respir Crit Care Med 2021 Aug 15;204(4):445-453. doi: 10.1164/rccm.202007-2791OC. PMID: 33823116
Vranić S, Bešlija S, Gatalica Z
Bosn J Basic Med Sci 2021 Feb 1;21(1):1-4. doi: 10.17305/bjbms.2020.4908. PMID: 32530388Free PMC Article
Ohe Y, Imamura F, Nogami N, Okamoto I, Kurata T, Kato T, Sugawara S, Ramalingam SS, Uchida H, Hodge R, Vowler SL, Walding A, Nakagawa K
Jpn J Clin Oncol 2019 Jan 1;49(1):29-36. doi: 10.1093/jjco/hyy179. PMID: 30508196Free PMC Article
Khunger M, Rakshit S, Pasupuleti V, Hernandez AV, Mazzone P, Stevenson J, Pennell NA, Velcheti V
Chest 2017 Aug;152(2):271-281. Epub 2017 May 10 doi: 10.1016/j.chest.2017.04.177. PMID: 28499515

Prognosis

Chen J, Wu Z, Deng W, Tang M, Wu L, Lin N, Chen L, Fu Y, Zhao M, Chen C, Li W
J Transl Med 2023 Jul 8;21(1):453. doi: 10.1186/s12967-023-04304-2. PMID: 37422632Free PMC Article
Dundr P, Matěj R, Němejcová K, Bártů M, Stružinská I
Klin Onkol 2021 Spring;34(Supplementum 1):29-34. doi: 10.48095/ccko2021S29. PMID: 34154327
Majem B, Nadal E, Muñoz-Pinedo C
Semin Cell Dev Biol 2020 Feb;98:54-62. Epub 2019 Jul 2 doi: 10.1016/j.semcdb.2019.06.004. PMID: 31238096
Osmani L, Askin F, Gabrielson E, Li QK
Semin Cancer Biol 2018 Oct;52(Pt 1):103-109. Epub 2017 Nov 26 doi: 10.1016/j.semcancer.2017.11.019. PMID: 29183778Free PMC Article
Kirson ED, Dbalý V, Tovarys F, Vymazal J, Soustiel JF, Itzhaki A, Mordechovich D, Steinberg-Shapira S, Gurvich Z, Schneiderman R, Wasserman Y, Salzberg M, Ryffel B, Goldsher D, Dekel E, Palti Y
Proc Natl Acad Sci U S A 2007 Jun 12;104(24):10152-7. Epub 2007 Jun 5 doi: 10.1073/pnas.0702916104. PMID: 17551011Free PMC Article

Clinical prediction guides

Sánchez-Magraner L, Gumuzio J, Miles J, Quimi N, Martínez Del Prado P, Abad-Villar MT, Pikabea F, Ortega L, Etxezarraga C, Martín-Algarra S, Lozano MD, Saiz-Camin M, Egurrola-Izquierdo M, Barredo-Santamaría I, Saiz-López A, Gomez-Mediavilla J, Segues-Merino N, Juaristi-Abaunz MA, Urruticoechea A, Geraedts EJ, van Elst K, Claessens NJM, Italiano A, Applebee CJ, Del Castillo S, Evans C, Aguirre F, Parker PJ, Calleja V
J Clin Oncol 2023 May 10;41(14):2561-2570. Epub 2023 Feb 23 doi: 10.1200/JCO.22.01748. PMID: 36821809Free PMC Article
Iwama S, Kobayashi T, Yasuda Y, Arima H
Best Pract Res Clin Endocrinol Metab 2022 May;36(3):101660. Epub 2022 Apr 12 doi: 10.1016/j.beem.2022.101660. PMID: 35501263
Yu Y, Zeng D, Ou Q, Liu S, Li A, Chen Y, Lin D, Gao Q, Zhou H, Liao W, Yao H
JAMA Netw Open 2019 Jul 3;2(7):e196879. doi: 10.1001/jamanetworkopen.2019.6879. PMID: 31290993Free PMC Article
Jain D, Nambirajan A, Borczuk A, Chen G, Minami Y, Moreira AL, Motoi N, Papotti M, Rekhtman N, Russell PA, Savic Prince S, Yatabe Y, Bubendorf L; IASLC Pathology Committee
Cancer Cytopathol 2019 May;127(5):325-339. Epub 2019 May 3 doi: 10.1002/cncy.22137. PMID: 31050216Free PMC Article
Hendry S, Salgado R, Gevaert T, Russell PA, John T, Thapa B, Christie M, van de Vijver K, Estrada MV, Gonzalez-Ericsson PI, Sanders M, Solomon B, Solinas C, Van den Eynden GGGM, Allory Y, Preusser M, Hainfellner J, Pruneri G, Vingiani A, Demaria S, Symmans F, Nuciforo P, Comerma L, Thompson EA, Lakhani S, Kim SR, Schnitt S, Colpaert C, Sotiriou C, Scherer SJ, Ignatiadis M, Badve S, Pierce RH, Viale G, Sirtaine N, Penault-Llorca F, Sugie T, Fineberg S, Paik S, Srinivasan A, Richardson A, Wang Y, Chmielik E, Brock J, Johnson DB, Balko J, Wienert S, Bossuyt V, Michiels S, Ternes N, Burchardi N, Luen SJ, Savas P, Klauschen F, Watson PH, Nelson BH, Criscitiello C, O'Toole S, Larsimont D, de Wind R, Curigliano G, André F, Lacroix-Triki M, van de Vijver M, Rojo F, Floris G, Bedri S, Sparano J, Rimm D, Nielsen T, Kos Z, Hewitt S, Singh B, Farshid G, Loibl S, Allison KH, Tung N, Adams S, Willard-Gallo K, Horlings HM, Gandhi L, Moreira A, Hirsch F, Dieci MV, Urbanowicz M, Brcic I, Korski K, Gaire F, Koeppen H, Lo A, Giltnane J, Rebelatto MC, Steele KE, Zha J, Emancipator K, Juco JW, Denkert C, Reis-Filho J, Loi S, Fox SB
Adv Anat Pathol 2017 Nov;24(6):311-335. doi: 10.1097/PAP.0000000000000161. PMID: 28777143Free PMC Article

Recent systematic reviews

Jelli B, Brandão M, Mekinda Z, Durieux V, Berghmans T
Lung Cancer 2023 Jul;181:107232. Epub 2023 May 10 doi: 10.1016/j.lungcan.2023.107232. PMID: 37216840
Ran R, Jin JW, Zhang WP
Dis Markers 2021;2021:5424623. Epub 2021 Nov 23 doi: 10.1155/2021/5424623. PMID: 34858541Free PMC Article
Chen L, Wang Y, Liu F, Xu L, Peng F, Zhao N, Fu B, Zhu Z, Shi Y, Liu J, Wu R, Wang C, Yao S, Li Y
Sci Rep 2018 Jan 23;8(1):1439. doi: 10.1038/s41598-018-19949-z. PMID: 29362385Free PMC Article
Khunger M, Rakshit S, Pasupuleti V, Hernandez AV, Mazzone P, Stevenson J, Pennell NA, Velcheti V
Chest 2017 Aug;152(2):271-281. Epub 2017 May 10 doi: 10.1016/j.chest.2017.04.177. PMID: 28499515
Song X, Shi K, Zhou SJ, Yu DP, Liu Z, Han Y
Drug Des Devel Ther 2016;10:1345-54. Epub 2016 Apr 6 doi: 10.2147/DDDT.S96766. PMID: 27103788Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2023
      UK NICE guideline NG122, Lung cancer: diagnosis and management, 2023
    • AHRQ, 2013
      Technology Assessment on Genetic Testing or Molecular Pathology Testing of Cancers with Unknown Primary Site to Determine Origin (ARCHIVED)

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