U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Catastrophic Illness

MedGen UID:
40139
•Concept ID:
C0007397
•
Disease or Syndrome
Synonyms: Catastrophic Illnesses; Illness, Catastrophic; Illnesses, Catastrophic

Definition

An acute or prolonged illness usually considered to be life-threatening or with the threat of serious residual disability. Treatment may be radical and is frequently costly. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCatastrophic Illness

Professional guidelines

PubMed

Advance care planning at life milestones.
Ludwick R, Bakerjian D, Zalon ML, Melander SD, Crist JD
Nurs Outlook 2022 May-Jun;70(3):451-457. Epub 2022 Apr 16 doi: 10.1016/j.outlook.2022.02.011. PMID: 35440365
Primary Sjogren's syndrome and the risk of acute pancreatitis: a nationwide cohort study.
Chang CC, Chang YS, Wang SH, Lin SY, Chen YH, Chen JH
BMJ Open 2017 Aug 11;7(8):e014807. doi: 10.1136/bmjopen-2016-014807. PMID: 28801391Free PMC Article
End-of-life decision making by adolescents, parents, and healthcare providers in pediatric oncology: research to evidence-based practice guidelines.
Hinds PS, Oakes L, Furman W, Quargnenti A, Olson MS, Foppiano P, Srivastava DK
Cancer Nurs 2001 Apr;24(2):122-34; quiz 135-6. doi: 10.1097/00002820-200104000-00007. PMID: 11318260

Recent clinical studies

Etiology

Eculizumab use in catastrophic antiphospholipid syndrome (CAPS): Descriptive analysis from the "CAPS Registry".
López-Benjume B, Rodríguez-Pintó I, Amigo MC, Erkan D, Shoenfeld Y, Cervera R, Espinosa G; on behalf the CAPS Registry Project Group/European Forum on Antiphospholipid Antibodies
Autoimmun Rev 2022 Apr;21(4):103055. Epub 2022 Jan 24 doi: 10.1016/j.autrev.2022.103055. PMID: 35085802
Preventing and managing catastrophic bleeding during extracorporeal circulation.
Karkouti K, Ho LTS
Hematology Am Soc Hematol Educ Program 2018 Nov 30;2018(1):522-529. doi: 10.1182/asheducation-2018.1.522. PMID: 30504353Free PMC Article
Treatment of catastrophic antiphospholipid syndrome.
Kazzaz NM, McCune WJ, Knight JS
Curr Opin Rheumatol 2016 May;28(3):218-27. doi: 10.1097/BOR.0000000000000269. PMID: 26927441Free PMC Article
Tools to Promote Shared Decision Making in Serious Illness: A Systematic Review.
Austin CA, Mohottige D, Sudore RL, Smith AK, Hanson LC
JAMA Intern Med 2015 Jul;175(7):1213-21. doi: 10.1001/jamainternmed.2015.1679. PMID: 25985438Free PMC Article
Life care planning.
Katz RT, Delaney GA
Phys Med Rehabil Clin N Am 2002 May;13(2):287-308, ix. doi: 10.1016/s1047-9651(01)00003-1. PMID: 12122848

Diagnosis

Catastrophic health expenditure among Chinese adults living alone with cognitive impairment: findings from the CHARLS.
Li C, Jin S, Cao X, Han L, Sun N, Allore H, Hoogendijk EO, Xu X, Feng Q, Liu X, Liu Z
BMC Geriatr 2022 Aug 4;22(1):640. doi: 10.1186/s12877-022-03341-8. PMID: 35922775Free PMC Article
Eculizumab use in catastrophic antiphospholipid syndrome (CAPS): Descriptive analysis from the "CAPS Registry".
López-Benjume B, Rodríguez-Pintó I, Amigo MC, Erkan D, Shoenfeld Y, Cervera R, Espinosa G; on behalf the CAPS Registry Project Group/European Forum on Antiphospholipid Antibodies
Autoimmun Rev 2022 Apr;21(4):103055. Epub 2022 Jan 24 doi: 10.1016/j.autrev.2022.103055. PMID: 35085802
The diagnosis and clinical management of the catastrophic antiphospholipid syndrome: A comprehensive review.
Cervera R, Rodríguez-Pintó I, Espinosa G
J Autoimmun 2018 Aug;92:1-11. Epub 2018 May 18 doi: 10.1016/j.jaut.2018.05.007. PMID: 29779928
Treatment of catastrophic antiphospholipid syndrome.
Kazzaz NM, McCune WJ, Knight JS
Curr Opin Rheumatol 2016 May;28(3):218-27. doi: 10.1097/BOR.0000000000000269. PMID: 26927441Free PMC Article
Tools to Promote Shared Decision Making in Serious Illness: A Systematic Review.
Austin CA, Mohottige D, Sudore RL, Smith AK, Hanson LC
JAMA Intern Med 2015 Jul;175(7):1213-21. doi: 10.1001/jamainternmed.2015.1679. PMID: 25985438Free PMC Article

Therapy

Metformin reduces hepatocellular carcinoma incidence after successful antiviral therapy in patients with diabetes and chronic hepatitis C in Taiwan.
Tsai PC, Kuo HT, Hung CH, Tseng KC, Lai HC, Peng CY, Wang JH, Chen JJ, Lee PL, Chien RN, Yang CC, Lo GH, Kao JH, Liu CJ, Liu CH, Yan SL, Bair MJ, Lin CY, Su WW, Chu CH, Chen CJ, Tung SY, Tai CM, Lin CW, Lo CC, Cheng PN, Chiu YC, Wang CC, Cheng JS, Tsai WL, Lin HC, Huang YH, Yeh ML, Huang CF, Hsieh MH, Huang JF, Dai CY, Chung WL, Chen CY, Yu ML; T-COACH Study Group
J Hepatol 2023 Feb;78(2):281-292. Epub 2022 Oct 5 doi: 10.1016/j.jhep.2022.09.019. PMID: 36208843
Eculizumab use in catastrophic antiphospholipid syndrome (CAPS): Descriptive analysis from the "CAPS Registry".
López-Benjume B, Rodríguez-Pintó I, Amigo MC, Erkan D, Shoenfeld Y, Cervera R, Espinosa G; on behalf the CAPS Registry Project Group/European Forum on Antiphospholipid Antibodies
Autoimmun Rev 2022 Apr;21(4):103055. Epub 2022 Jan 24 doi: 10.1016/j.autrev.2022.103055. PMID: 35085802
The diagnosis and clinical management of the catastrophic antiphospholipid syndrome: A comprehensive review.
Cervera R, Rodríguez-Pintó I, Espinosa G
J Autoimmun 2018 Aug;92:1-11. Epub 2018 May 18 doi: 10.1016/j.jaut.2018.05.007. PMID: 29779928
Treatment of catastrophic antiphospholipid syndrome.
Kazzaz NM, McCune WJ, Knight JS
Curr Opin Rheumatol 2016 May;28(3):218-27. doi: 10.1097/BOR.0000000000000269. PMID: 26927441Free PMC Article
Tools to Promote Shared Decision Making in Serious Illness: A Systematic Review.
Austin CA, Mohottige D, Sudore RL, Smith AK, Hanson LC
JAMA Intern Med 2015 Jul;175(7):1213-21. doi: 10.1001/jamainternmed.2015.1679. PMID: 25985438Free PMC Article

Prognosis

Metformin reduces hepatocellular carcinoma incidence after successful antiviral therapy in patients with diabetes and chronic hepatitis C in Taiwan.
Tsai PC, Kuo HT, Hung CH, Tseng KC, Lai HC, Peng CY, Wang JH, Chen JJ, Lee PL, Chien RN, Yang CC, Lo GH, Kao JH, Liu CJ, Liu CH, Yan SL, Bair MJ, Lin CY, Su WW, Chu CH, Chen CJ, Tung SY, Tai CM, Lin CW, Lo CC, Cheng PN, Chiu YC, Wang CC, Cheng JS, Tsai WL, Lin HC, Huang YH, Yeh ML, Huang CF, Hsieh MH, Huang JF, Dai CY, Chung WL, Chen CY, Yu ML; T-COACH Study Group
J Hepatol 2023 Feb;78(2):281-292. Epub 2022 Oct 5 doi: 10.1016/j.jhep.2022.09.019. PMID: 36208843
Preventing and managing catastrophic bleeding during extracorporeal circulation.
Karkouti K, Ho LTS
Hematology Am Soc Hematol Educ Program 2018 Nov 30;2018(1):522-529. doi: 10.1182/asheducation-2018.1.522. PMID: 30504353Free PMC Article
CAPS Registry.
Cervera R
Lupus 2012 Jun;21(7):755-7. doi: 10.1177/0961203312436866. PMID: 22635223
Acute liver failure.
Pathikonda M, Munoz SJ
Ann Hepatol 2010 Jan-Mar;9(1):7-14. PMID: 20308717
Catastrophic antiphospholipid syndrome.
Vora SK, Asherson RA, Erkan D
J Intensive Care Med 2006 May-Jun;21(3):144-59. doi: 10.1177/0885066606287041. PMID: 16672637

Clinical prediction guides

Metformin reduces hepatocellular carcinoma incidence after successful antiviral therapy in patients with diabetes and chronic hepatitis C in Taiwan.
Tsai PC, Kuo HT, Hung CH, Tseng KC, Lai HC, Peng CY, Wang JH, Chen JJ, Lee PL, Chien RN, Yang CC, Lo GH, Kao JH, Liu CJ, Liu CH, Yan SL, Bair MJ, Lin CY, Su WW, Chu CH, Chen CJ, Tung SY, Tai CM, Lin CW, Lo CC, Cheng PN, Chiu YC, Wang CC, Cheng JS, Tsai WL, Lin HC, Huang YH, Yeh ML, Huang CF, Hsieh MH, Huang JF, Dai CY, Chung WL, Chen CY, Yu ML; T-COACH Study Group
J Hepatol 2023 Feb;78(2):281-292. Epub 2022 Oct 5 doi: 10.1016/j.jhep.2022.09.019. PMID: 36208843
Catastrophic health expenditure among Chinese adults living alone with cognitive impairment: findings from the CHARLS.
Li C, Jin S, Cao X, Han L, Sun N, Allore H, Hoogendijk EO, Xu X, Feng Q, Liu X, Liu Z
BMC Geriatr 2022 Aug 4;22(1):640. doi: 10.1186/s12877-022-03341-8. PMID: 35922775Free PMC Article
Defining catastrophic brain injury in children leading to coma and disorders of consciousness and the scope of the problem.
LaRovere KL, Tasker RC
Curr Opin Pediatr 2020 Dec;32(6):750-758. doi: 10.1097/MOP.0000000000000951. PMID: 33009124
Preventing and managing catastrophic bleeding during extracorporeal circulation.
Karkouti K, Ho LTS
Hematology Am Soc Hematol Educ Program 2018 Nov 30;2018(1):522-529. doi: 10.1182/asheducation-2018.1.522. PMID: 30504353Free PMC Article
How to avoid catastrophic events on the ward.
Bein B, Seewald S, Gräsner JT
Best Pract Res Clin Anaesthesiol 2016 Jun;30(2):237-45. Epub 2016 May 3 doi: 10.1016/j.bpa.2016.04.003. PMID: 27396810

Recent systematic reviews

Palliative and end-of-life care needs, experiences, and preferences of LGBTQ+ individuals with serious illness: A systematic mixed-methods review.
Rosa WE, Roberts KE, Braybrook D, Harding R, Godwin K, Mahoney C, Mathew S, Atkinson TM, Banerjee SC, Haviland K, Hughes TL, Walters CB, Parker PA
Palliat Med 2023 Apr;37(4):460-474. Epub 2022 Dec 7 doi: 10.1177/02692163221124426. PMID: 36475950Free PMC Article
Catastrophic health expenditure in sub-Saharan Africa: systematic review and meta-analysis.
Eze P, Lawani LO, Agu UJ, Acharya Y
Bull World Health Organ 2022 May 1;100(5):337-351J. Epub 2022 Apr 4 doi: 10.2471/BLT.21.287673. PMID: 35521041Free PMC Article
Financial Protection Indexes and the Iranian Health Transformation Plan: A Systematic Review.
Darvishi B, Behzadifar M, Ghanbari MK, Ehsanzadeh SJ, Bakhtiari A, Behzadifar M, Azari S, Bragazzi NL
Yale J Biol Med 2021 Sep;94(3):465-476. Epub 2021 Sep 30 PMID: 34602884Free PMC Article
Tools to Promote Shared Decision Making in Serious Illness: A Systematic Review.
Austin CA, Mohottige D, Sudore RL, Smith AK, Hanson LC
JAMA Intern Med 2015 Jul;175(7):1213-21. doi: 10.1001/jamainternmed.2015.1679. PMID: 25985438Free PMC Article
The effect of new cooperative medical scheme on health outcomes and alleviating catastrophic health expenditure in China: a systematic review.
Liang X, Guo H, Jin C, Peng X, Zhang X
PLoS One 2012;7(8):e40850. Epub 2012 Aug 20 doi: 10.1371/journal.pone.0040850. PMID: 22916098Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...