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Central retinal artery occlusion

MedGen UID:
40177
Concept ID:
C0007688
Disease or Syndrome
Synonym: Central Retinal Artery Occlusion
SNOMED CT: CRAO - Central retinal artery occlusion (38742007); CRA - Central retinal artery occlusion (38742007); Central retinal artery occlusion (38742007)
 
HPO: HP:0025342
Monarch Initiative: MONDO:0001633

Definition

Blockage of the main artery in the retina. The typical presentation is one of profound monocular visual loss. [from HPO]

Term Hierarchy

Conditions with this feature

Familial antiphospholipid syndrome
MedGen UID:
419641
Concept ID:
C2930802
Disease or Syndrome
The designation 'antiphospholipid syndrome' was proposed for the association of arterial and venous thrombosis, recurrent fetal loss, and immune thrombocytopenia with a spectrum of autoantibodies directed against cellular phospholipid components. Anticardiolipin antibodies may react with cardiolipin and with other negatively charged phospholipids, including beta-2-glycoprotein I (B2GPI, APOH; 138700). The term 'lupus anticoagulant' refers to a heterogeneous group of antibodies, most commonly of the IgG type, that are detected by their inhibitory effect on coagulant-active phospholipid components of in vitro coagulation tests (summary by Matthey et al., 1989). Shoenfeld et al. (2008) noted that antiphospholipid syndrome is characterized by up to 30 different autoantibodies, including those against platelets, glycoproteins, coagulation factors, lamins, mitochondrial antigens, and cell surface markers. Some of these may have an additive effect on the prothrombotic tendency of the syndrome. Ruiz-Irastorza et al. (2010) reviewed pathophysiologic, clinical, diagnostic, and therapeutic advances related to the antiphospholipid syndrome. Various autoimmune disorders that cluster in families, including autoimmune thrombocytopenia (188030), are discussed elsewhere (e.g., 109100, 269200).

Professional guidelines

PubMed

Dumbrăveanu L, Cușnir V, Bobescu D
Rom J Ophthalmol 2021 Oct-Dec;65(4):315-329. doi: 10.22336/rjo.2021.66. PMID: 35087972Free PMC Article
Mac Grory B, Schrag M, Biousse V, Furie KL, Gerhard-Herman M, Lavin PJ, Sobrin L, Tjoumakaris SI, Weyand CM, Yaghi S; American Heart Association Stroke Council; Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Hypertension; and Council on Peripheral Vascular Disease
Stroke 2021 Jun;52(6):e282-e294. Epub 2021 Mar 8 doi: 10.1161/STR.0000000000000366. PMID: 33677974
Varma DD, Cugati S, Lee AW, Chen CS
Eye (Lond) 2013 Jun;27(6):688-97. Epub 2013 Mar 8 doi: 10.1038/eye.2013.25. PMID: 23470793Free PMC Article

Recent clinical studies

Etiology

Dumbrăveanu L, Cușnir V, Bobescu D
Rom J Ophthalmol 2021 Oct-Dec;65(4):315-329. doi: 10.22336/rjo.2021.66. PMID: 35087972Free PMC Article
Mac Grory B, Schrag M, Biousse V, Furie KL, Gerhard-Herman M, Lavin PJ, Sobrin L, Tjoumakaris SI, Weyand CM, Yaghi S; American Heart Association Stroke Council; Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Hypertension; and Council on Peripheral Vascular Disease
Stroke 2021 Jun;52(6):e282-e294. Epub 2021 Mar 8 doi: 10.1161/STR.0000000000000366. PMID: 33677974
Hayreh SS
Indian J Ophthalmol 2018 Dec;66(12):1684-1694. doi: 10.4103/ijo.IJO_1446_18. PMID: 30451166Free PMC Article
Sharma RA, Dattilo M, Newman NJ, Biousse V
Asia Pac J Ophthalmol (Phila) 2018 Jul-Aug;7(4):235-241. Epub 2018 May 2 doi: 10.22608/APO.201871. PMID: 29717825
Varma DD, Cugati S, Lee AW, Chen CS
Eye (Lond) 2013 Jun;27(6):688-97. Epub 2013 Mar 8 doi: 10.1038/eye.2013.25. PMID: 23470793Free PMC Article

Diagnosis

Spiegel SJ, Moss HE
Neurol Clin 2021 May;39(2):631-647. Epub 2021 Mar 31 doi: 10.1016/j.ncl.2021.01.004. PMID: 33896536Free PMC Article
Sen M, Honavar SG, Sharma N, Sachdev MS
Indian J Ophthalmol 2021 Mar;69(3):488-509. doi: 10.4103/ijo.IJO_297_21. PMID: 33595463Free PMC Article
Tran AQ, Staropoli P, Rong AJ, Lee WW
Facial Plast Surg Clin North Am 2019 Nov;27(4):557-564. doi: 10.1016/j.fsc.2019.07.010. PMID: 31587773
Hayreh SS
Indian J Ophthalmol 2018 Dec;66(12):1684-1694. doi: 10.4103/ijo.IJO_1446_18. PMID: 30451166Free PMC Article
Hayreh SS
Prog Retin Eye Res 2014 Jul;41:1-25. Epub 2014 Apr 21 doi: 10.1016/j.preteyeres.2014.04.001. PMID: 24769221Free PMC Article

Therapy

Dumbrăveanu L, Cușnir V, Bobescu D
Rom J Ophthalmol 2021 Oct-Dec;65(4):315-329. doi: 10.22336/rjo.2021.66. PMID: 35087972Free PMC Article
Mac Grory B, Schrag M, Biousse V, Furie KL, Gerhard-Herman M, Lavin PJ, Sobrin L, Tjoumakaris SI, Weyand CM, Yaghi S; American Heart Association Stroke Council; Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Hypertension; and Council on Peripheral Vascular Disease
Stroke 2021 Jun;52(6):e282-e294. Epub 2021 Mar 8 doi: 10.1161/STR.0000000000000366. PMID: 33677974
Tran AQ, Staropoli P, Rong AJ, Lee WW
Facial Plast Surg Clin North Am 2019 Nov;27(4):557-564. doi: 10.1016/j.fsc.2019.07.010. PMID: 31587773
Chronopoulos A, Schutz JS
Surv Ophthalmol 2019 Jul-Aug;64(4):443-451. Epub 2019 Jan 30 doi: 10.1016/j.survophthal.2019.01.011. PMID: 30707925
Varma DD, Cugati S, Lee AW, Chen CS
Eye (Lond) 2013 Jun;27(6):688-97. Epub 2013 Mar 8 doi: 10.1038/eye.2013.25. PMID: 23470793Free PMC Article

Prognosis

Shearer TR, Steinkamp PN, Parker M, Azuma M
PLoS One 2023;18(1):e0279920. Epub 2023 Jan 5 doi: 10.1371/journal.pone.0279920. PMID: 36603006Free PMC Article
Murphy-Lavoie H, Butler FK, Hagan C
Undersea Hyperb Med 2022 Fourth Quarter;49(4):533-547. doi: 10.22462/07.08.2022.12. PMID: 36446298
Dumbrăveanu L, Cușnir V, Bobescu D
Rom J Ophthalmol 2021 Oct-Dec;65(4):315-329. doi: 10.22336/rjo.2021.66. PMID: 35087972Free PMC Article
Shaban A, Leira EC
Handb Clin Neurol 2021;177:65-75. doi: 10.1016/B978-0-12-819814-8.00007-X. PMID: 33632458
Sharma RA, Dattilo M, Newman NJ, Biousse V
Asia Pac J Ophthalmol (Phila) 2018 Jul-Aug;7(4):235-241. Epub 2018 May 2 doi: 10.22608/APO.201871. PMID: 29717825

Clinical prediction guides

Fan W, Huang Y, Zhao Y, Yuan R
BMC Ophthalmol 2023 Oct 25;23(1):434. doi: 10.1186/s12886-023-03176-w. PMID: 37880636Free PMC Article
Lin JC, Song S, Ng SM, Scott IU, Greenberg PB
Cochrane Database Syst Rev 2023 Jan 30;1(1):CD001989. doi: 10.1002/14651858.CD001989.pub3. PMID: 36715340Free PMC Article
Shearer TR, Steinkamp PN, Parker M, Azuma M
PLoS One 2023;18(1):e0279920. Epub 2023 Jan 5 doi: 10.1371/journal.pone.0279920. PMID: 36603006Free PMC Article
Mac Grory B, Schrag M, Biousse V, Furie KL, Gerhard-Herman M, Lavin PJ, Sobrin L, Tjoumakaris SI, Weyand CM, Yaghi S; American Heart Association Stroke Council; Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Hypertension; and Council on Peripheral Vascular Disease
Stroke 2021 Jun;52(6):e282-e294. Epub 2021 Mar 8 doi: 10.1161/STR.0000000000000366. PMID: 33677974
Sen M, Honavar SG, Sharma N, Sachdev MS
Indian J Ophthalmol 2021 Mar;69(3):488-509. doi: 10.4103/ijo.IJO_297_21. PMID: 33595463Free PMC Article

Recent systematic reviews

Lin JC, Song S, Ng SM, Scott IU, Greenberg PB
Cochrane Database Syst Rev 2023 Jan 30;1(1):CD001989. doi: 10.1002/14651858.CD001989.pub3. PMID: 36715340Free PMC Article
Vilares-Morgado R, Nunes HMM, Dos Reis RS, Barbosa-Breda J
Graefes Arch Clin Exp Ophthalmol 2023 Jan;261(1):1-22. Epub 2022 Jul 15 doi: 10.1007/s00417-022-05747-x. PMID: 35838806
Huang L, Wang Y, Zhang R
J Neurol 2022 Apr;269(4):1825-1833. Epub 2021 Oct 9 doi: 10.1007/s00415-021-10838-6. PMID: 34625849
Hwang K
J Craniofac Surg 2016 Nov;27(8):2154-2155. doi: 10.1097/SCS.0000000000003089. PMID: 28005776
Zhou Y, Zhu W, Wang C
Medicine (Baltimore) 2016 Jun;95(26):e4075. doi: 10.1097/MD.0000000000004075. PMID: 27368050Free PMC Article

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