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Cerebellar disorder

MedGen UID:
40186
Concept ID:
C0007760
Disease or Syndrome
Synonym: Cerebellar disease
SNOMED CT: Cerebellar disorder (223176004); Cerebellar syndrome (224186005); Cerebellar deficiency syndrome (224186005)
 
Monarch Initiative: MONDO:0002427

Definition

Diseases that affect the structure or function of the cerebellum. Cardinal manifestations of cerebellar dysfunction include dysmetria, gait ataxia, and muscle hypotonia. [from MONDO]

Professional guidelines

PubMed

Strupp M, Kalla R, Glasauer S, Wagner J, Hüfner K, Jahn K, Brandt T
Prog Brain Res 2008;171:535-41. doi: 10.1016/S0079-6123(08)00676-6. PMID: 18718350

Recent clinical studies

Etiology

Nanetti L, Magri S, Fichera M, Castaldo A, Nigri A, Pinardi C, Mongelli A, Sarro L, Pareyson D, Grisoli M, Gellera C, Di Bella D, Mariotti C, Taroni F
Mov Disord 2023 Apr;38(4):665-675. Epub 2023 Feb 17 doi: 10.1002/mds.29352. PMID: 36799493
Mailankody S, Devlin SM, Landa J, Nath K, Diamonte C, Carstens EJ, Russo D, Auclair R, Fitzgerald L, Cadzin B, Wang X, Sikder D, Senechal B, Bermudez VP, Purdon TJ, Hosszu K, McAvoy DP, Farzana T, Mead E, Wilcox JA, Santomasso BD, Shah GL, Shah UA, Korde N, Lesokhin A, Tan CR, Hultcrantz M, Hassoun H, Roshal M, Sen F, Dogan A, Landgren O, Giralt SA, Park JH, Usmani SZ, Rivière I, Brentjens RJ, Smith EL
N Engl J Med 2022 Sep 29;387(13):1196-1206. doi: 10.1056/NEJMoa2209900. PMID: 36170501Free PMC Article
Liu M, Ren H, Fan S, Zhang W, Xu Y, Zhao W, Guan H; Encephalitis Collaborative Group
Neurol Neuroimmunol Neuroinflamm 2021 Nov;8(6) Epub 2021 Sep 27 doi: 10.1212/NXI.0000000000001077. PMID: 34580182Free PMC Article
Zanni G, Bertini E
Handb Clin Neurol 2018;155:175-189. doi: 10.1016/B978-0-444-64189-2.00011-1. PMID: 29891057
Zanni G, Bertini ES
Orphanet J Rare Dis 2011 May 15;6:24. doi: 10.1186/1750-1172-6-24. PMID: 21569638Free PMC Article

Diagnosis

Nanetti L, Magri S, Fichera M, Castaldo A, Nigri A, Pinardi C, Mongelli A, Sarro L, Pareyson D, Grisoli M, Gellera C, Di Bella D, Mariotti C, Taroni F
Mov Disord 2023 Apr;38(4):665-675. Epub 2023 Feb 17 doi: 10.1002/mds.29352. PMID: 36799493
Ishii S, Sugawara S, Yamakuni R, Sekino H, Ito H
Clin Nucl Med 2022 Feb 1;47(2):e149-e151. doi: 10.1097/RLU.0000000000003833. PMID: 34284475
Liu M, Ren H, Fan S, Zhang W, Xu Y, Zhao W, Guan H; Encephalitis Collaborative Group
Neurol Neuroimmunol Neuroinflamm 2021 Nov;8(6) Epub 2021 Sep 27 doi: 10.1212/NXI.0000000000001077. PMID: 34580182Free PMC Article
Yang MS, Kim CH, Cheong JH, Kim JM
Acta Neurochir Suppl 2012;113:161-5. doi: 10.1007/978-3-7091-0923-6_32. PMID: 22116444
Su CH, Young YH
Eur Arch Otorhinolaryngol 2011 Jun;268(6):923-30. Epub 2010 Dec 18 doi: 10.1007/s00405-010-1463-0. PMID: 21170655

Therapy

Mailankody S, Devlin SM, Landa J, Nath K, Diamonte C, Carstens EJ, Russo D, Auclair R, Fitzgerald L, Cadzin B, Wang X, Sikder D, Senechal B, Bermudez VP, Purdon TJ, Hosszu K, McAvoy DP, Farzana T, Mead E, Wilcox JA, Santomasso BD, Shah GL, Shah UA, Korde N, Lesokhin A, Tan CR, Hultcrantz M, Hassoun H, Roshal M, Sen F, Dogan A, Landgren O, Giralt SA, Park JH, Usmani SZ, Rivière I, Brentjens RJ, Smith EL
N Engl J Med 2022 Sep 29;387(13):1196-1206. doi: 10.1056/NEJMoa2209900. PMID: 36170501Free PMC Article
Isotalo E, Heikki A, Ilmari P
Auris Nasus Larynx 2009 Feb;36(1):36-41. Epub 2008 May 22 doi: 10.1016/j.anl.2008.03.010. PMID: 18501541
Strupp M, Kalla R, Glasauer S, Wagner J, Hüfner K, Jahn K, Brandt T
Prog Brain Res 2008;171:535-41. doi: 10.1016/S0079-6123(08)00676-6. PMID: 18718350
Furtado S, Payami H, Lockhart PJ, Hanson M, Nutt JG, Singleton AA, Singleton A, Bower J, Utti RJ, Bird TD, de la Fuente-Fernandez R, Tsuboi Y, Klimek ML, Suchowersky O, Hardy J, Calne DB, Wszolek ZK, Farrer M, Gwinn-Hardy K, Stoessl AJ
Mov Disord 2004 Jun;19(6):622-9. doi: 10.1002/mds.20074. PMID: 15197699
Bier JC, Dethy S, Hildebrand J, Jacquy J, Manto M, Martin JJ, Seeldrayers P
J Neurol 2003 Jun;250(6):693-7. doi: 10.1007/s00415-003-1061-9. PMID: 12796831

Prognosis

Nanetti L, Magri S, Fichera M, Castaldo A, Nigri A, Pinardi C, Mongelli A, Sarro L, Pareyson D, Grisoli M, Gellera C, Di Bella D, Mariotti C, Taroni F
Mov Disord 2023 Apr;38(4):665-675. Epub 2023 Feb 17 doi: 10.1002/mds.29352. PMID: 36799493
Algahtani H, Shirah B, Almatrafi S, Al-Qahtani MH, Abdulkareem AA, Naseer MI
Neurol Res 2021 Feb;43(2):141-147. Epub 2020 Oct 4 doi: 10.1080/01616412.2020.1831331. PMID: 33012273
Fitzpatrick LE, Crowe SF
Cerebellum 2013 Aug;12(4):520-33. doi: 10.1007/s12311-013-0461-3. PMID: 23436003
McKeon A, Tracy JA, Pittock SJ, Parisi JE, Klein CJ, Lennon VA
Arch Neurol 2011 Oct;68(10):1282-9. Epub 2011 Jun 13 doi: 10.1001/archneurol.2011.128. PMID: 21670387
Hottinger-Blanc PM, Ziegler AL, Deonna T
Eur J Paediatr Neurol 2002;6(3):143-52. doi: 10.1053/ejpn.2002.0582. PMID: 12363101

Clinical prediction guides

Nanetti L, Magri S, Fichera M, Castaldo A, Nigri A, Pinardi C, Mongelli A, Sarro L, Pareyson D, Grisoli M, Gellera C, Di Bella D, Mariotti C, Taroni F
Mov Disord 2023 Apr;38(4):665-675. Epub 2023 Feb 17 doi: 10.1002/mds.29352. PMID: 36799493
Mailankody S, Devlin SM, Landa J, Nath K, Diamonte C, Carstens EJ, Russo D, Auclair R, Fitzgerald L, Cadzin B, Wang X, Sikder D, Senechal B, Bermudez VP, Purdon TJ, Hosszu K, McAvoy DP, Farzana T, Mead E, Wilcox JA, Santomasso BD, Shah GL, Shah UA, Korde N, Lesokhin A, Tan CR, Hultcrantz M, Hassoun H, Roshal M, Sen F, Dogan A, Landgren O, Giralt SA, Park JH, Usmani SZ, Rivière I, Brentjens RJ, Smith EL
N Engl J Med 2022 Sep 29;387(13):1196-1206. doi: 10.1056/NEJMoa2209900. PMID: 36170501Free PMC Article
Liu M, Ren H, Fan S, Zhang W, Xu Y, Zhao W, Guan H; Encephalitis Collaborative Group
Neurol Neuroimmunol Neuroinflamm 2021 Nov;8(6) Epub 2021 Sep 27 doi: 10.1212/NXI.0000000000001077. PMID: 34580182Free PMC Article
Izquierdo-Serra M, Fernández-Fernández JM, Serrano M
Pflugers Arch 2020 Jul;472(7):791-809. Epub 2020 May 26 doi: 10.1007/s00424-020-02396-z. PMID: 32458086
Cyrulnik SE, Hinton VJ
Neurosci Biobehav Rev 2008;32(3):486-96. Epub 2007 Oct 4 doi: 10.1016/j.neubiorev.2007.09.001. PMID: 18022230

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