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Euglenozoa Infections

MedGen UID:
404001
•Concept ID:
C2717956
•
Disease or Syndrome
Synonyms: Euglenozoa Infection; Infection, Euglenozoa; Infections, Euglenozoa

Definition

Infections with the protozoa of the phylum EUGLENOZOA. [from MeSH]

Professional guidelines

PubMed

Cutaneous Leishmaniasis: A 2022 Updated Narrative Review into Diagnosis and Management Developments.
de Vries HJC, Schallig HD
Am J Clin Dermatol 2022 Nov;23(6):823-840. Epub 2022 Sep 14 doi: 10.1007/s40257-022-00726-8. PMID: 36103050Free PMC Article
Chagas cardiomyopathy and heart failure: From epidemiology to treatment.
Santos É, Menezes Falcão L
Rev Port Cardiol (Engl Ed) 2020 May;39(5):279-289. Epub 2020 Jun 10 doi: 10.1016/j.repc.2019.12.006. PMID: 32532535
Leishmaniasis: clinical syndromes and treatment.
McGwire BS, Satoskar AR
QJM 2014 Jan;107(1):7-14. Epub 2013 Jun 5 doi: 10.1093/qjmed/hct116. PMID: 23744570Free PMC Article

Recent clinical studies

Etiology

Tryp-ing Up Metabolism: Role of Metabolic Adaptations in Kinetoplastid Disease Pathogenesis.
Parab AR, McCall LI
Infect Immun 2021 Mar 17;89(4) doi: 10.1128/IAI.00644-20. PMID: 33526564Free PMC Article
Screening Marine Natural Products for New Drug Leads against Trypanosomatids and Malaria.
Álvarez-Bardón M, Pérez-Pertejo Y, Ordóñez C, Sepúlveda-Crespo D, Carballeira NM, Tekwani BL, Murugesan S, Martinez-Valladares M, García-Estrada C, Reguera RM, Balaña-Fouce R
Mar Drugs 2020 Mar 31;18(4) doi: 10.3390/md18040187. PMID: 32244488Free PMC Article
Small Molecule Inhibitors Targeting the Heat Shock Protein System of Human Obligate Protozoan Parasites.
Zininga T, Shonhai A
Int J Mol Sci 2019 Nov 25;20(23) doi: 10.3390/ijms20235930. PMID: 31775392Free PMC Article
Lipid metabolism in insect disease vectors.
Gondim KC, Atella GC, Pontes EG, Majerowicz D
Insect Biochem Mol Biol 2018 Oct;101:108-123. Epub 2018 Aug 29 doi: 10.1016/j.ibmb.2018.08.005. PMID: 30171905
Evolution of parasitism in kinetoplastid flagellates.
Lukeš J, Skalický T, Týč J, Votýpka J, Yurchenko V
Mol Biochem Parasitol 2014 Jul;195(2):115-22. Epub 2014 Jun 2 doi: 10.1016/j.molbiopara.2014.05.007. PMID: 24893339

Diagnosis

Tryp-ing Up Metabolism: Role of Metabolic Adaptations in Kinetoplastid Disease Pathogenesis.
Parab AR, McCall LI
Infect Immun 2021 Mar 17;89(4) doi: 10.1128/IAI.00644-20. PMID: 33526564Free PMC Article
Coinfection of Leptomonas seymouri and Leishmania donovani in Indian leishmaniasis.
Ghosh S, Banerjee P, Sarkar A, Datta S, Chatterjee M
J Clin Microbiol 2012 Aug;50(8):2774-8. Epub 2012 May 23 doi: 10.1128/JCM.00966-12. PMID: 22622439Free PMC Article

Therapy

Tryp-ing Up Metabolism: Role of Metabolic Adaptations in Kinetoplastid Disease Pathogenesis.
Parab AR, McCall LI
Infect Immun 2021 Mar 17;89(4) doi: 10.1128/IAI.00644-20. PMID: 33526564Free PMC Article
Screening Marine Natural Products for New Drug Leads against Trypanosomatids and Malaria.
Álvarez-Bardón M, Pérez-Pertejo Y, Ordóñez C, Sepúlveda-Crespo D, Carballeira NM, Tekwani BL, Murugesan S, Martinez-Valladares M, García-Estrada C, Reguera RM, Balaña-Fouce R
Mar Drugs 2020 Mar 31;18(4) doi: 10.3390/md18040187. PMID: 32244488Free PMC Article
Toward a Drug Against All Kinetoplastids: From LeishBox to Specific and Potent Trypanothione Reductase Inhibitors.
Ilari A, Genovese I, Fiorillo F, Battista T, De Ionna I, Fiorillo A, Colotti G
Mol Pharm 2018 Aug 6;15(8):3069-3078. Epub 2018 Jun 27 doi: 10.1021/acs.molpharmaceut.8b00185. PMID: 29897765
Nitro drugs for the treatment of trypanosomatid diseases: past, present, and future prospects.
Patterson S, Wyllie S
Trends Parasitol 2014 Jun;30(6):289-98. Epub 2014 Apr 26 doi: 10.1016/j.pt.2014.04.003. PMID: 24776300Free PMC Article
Targeting trypanothione metabolism in trypanosomatid human parasites.
Olin-Sandoval V, Moreno-Sánchez R, Saavedra E
Curr Drug Targets 2010 Dec;11(12):1614-30. doi: 10.2174/1389450111009011614. PMID: 20735352

Clinical prediction guides

Viral discovery and diversity in trypanosomatid protozoa with a focus on relatives of the human parasite Leishmania.
Grybchuk D, Akopyants NS, Kostygov AY, Konovalovas A, Lye LF, Dobson DE, Zangger H, Fasel N, Butenko A, Frolov AO, Votýpka J, d'Avila-Levy CM, Kulich P, Moravcová J, Plevka P, Rogozin IB, Serva S, Lukeš J, Beverley SM, Yurchenko V
Proc Natl Acad Sci U S A 2018 Jan 16;115(3):E506-E515. Epub 2017 Dec 28 doi: 10.1073/pnas.1717806115. PMID: 29284754Free PMC Article
Trypanosomatidae diseases: from the current therapy to the efficacious role of trypanothione reductase in drug discovery.
Bernardes LS, Zani CL, Carvalho I
Curr Med Chem 2013;20(21):2673-96. doi: 10.2174/0929867311320210005. PMID: 23410156
Application of magnetically induced hyperthermia in the model protozoan Crithidia fasciculata as a potential therapy against parasitic infections.
Grazú V, Silber AM, Moros M, Asín L, Torres TE, Marquina C, Ibarra MR, Goya GF
Int J Nanomedicine 2012;7:5351-60. Epub 2012 Oct 8 doi: 10.2147/IJN.S35510. PMID: 23071396Free PMC Article

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