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Vasoplegia

MedGen UID:
404002
•Concept ID:
C2717957
•
Pathologic Function
Synonym: Vasoplegias

Definition

Condition of low SYSTEMIC VASCULAR RESISTANCE that develops secondary to other conditions such as ANAPHYLAXIS; SEPSIS; SURGICAL SHOCK; and SEPTIC SHOCK. Vasoplegia that develops during or post surgery (e.g., CARDIOPULMONARY BYPASS) is called postoperative vasoplegic syndrome or vasoplegic syndrome. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVasoplegia

Professional guidelines

PubMed

Clinical management of postcardiotomy shock in adults.
Pérez Vela JL, Llanos Jorge C, Duerto Álvarez J, Jiménez Rivera JJ
Med Intensiva (Engl Ed) 2022 Jun;46(6):312-325. Epub 2022 May 12 doi: 10.1016/j.medine.2022.04.014. PMID: 35570187
Vasoplegic syndrome after cardiovascular surgery: A review of pathophysiology and outcome-oriented therapeutic management.
Datt V, Wadhhwa R, Sharma V, Virmani S, Minhas HS, Malik S
J Card Surg 2021 Oct;36(10):3749-3760. Epub 2021 Jul 12 doi: 10.1111/jocs.15805. PMID: 34251716
Cardiac vasoplegia syndrome: pathophysiology, risk factors and treatment.
Omar S, Zedan A, Nugent K
Am J Med Sci 2015 Jan;349(1):80-8. doi: 10.1097/MAJ.0000000000000341. PMID: 25247756

Recent clinical studies

Etiology

Vasoplegia: A Review.
Ratnani I, Ochani RK, Shaikh A, Jatoi HN
Methodist Debakey Cardiovasc J 2023;19(4):38-47. Epub 2023 Aug 1 doi: 10.14797/mdcvj.1245. PMID: 37547893Free PMC Article
Vasoplegia in patients following ventricular assist device explant and heart transplantation.
Emmanuel S, Pearman M, Jansz P, Hayward CS
Perfusion 2022 Mar;37(2):152-161. Epub 2021 Jan 22 doi: 10.1177/0267659121989229. PMID: 33482711
Vasoplegic syndrome after cardiovascular surgery: A review of pathophysiology and outcome-oriented therapeutic management.
Datt V, Wadhhwa R, Sharma V, Virmani S, Minhas HS, Malik S
J Card Surg 2021 Oct;36(10):3749-3760. Epub 2021 Jul 12 doi: 10.1111/jocs.15805. PMID: 34251716
Vasopressin versus Norepinephrine in Patients with Vasoplegic Shock after Cardiac Surgery: The VANCS Randomized Controlled Trial.
Hajjar LA, Vincent JL, Barbosa Gomes Galas FR, Rhodes A, Landoni G, Osawa EA, Melo RR, Sundin MR, Grande SM, Gaiotto FA, Pomerantzeff PM, Dallan LO, Franco RA, Nakamura RE, Lisboa LA, de Almeida JP, Gerent AM, Souza DH, Gaiane MA, Fukushima JT, Park CL, Zambolim C, Rocha Ferreira GS, Strabelli TM, Fernandes FL, Camara L, Zeferino S, Santos VG, Piccioni MA, Jatene FB, Costa Auler JO Jr, Filho RK
Anesthesiology 2017 Jan;126(1):85-93. doi: 10.1097/ALN.0000000000001434. PMID: 27841822
Cardiac vasoplegia syndrome: pathophysiology, risk factors and treatment.
Omar S, Zedan A, Nugent K
Am J Med Sci 2015 Jan;349(1):80-8. doi: 10.1097/MAJ.0000000000000341. PMID: 25247756

Diagnosis

Vasoplegia: A Review.
Ratnani I, Ochani RK, Shaikh A, Jatoi HN
Methodist Debakey Cardiovasc J 2023;19(4):38-47. Epub 2023 Aug 1 doi: 10.14797/mdcvj.1245. PMID: 37547893Free PMC Article
Vasoplegia During Cardiopulmonary Bypass: Current Literature and Rescue Therapy Options.
Ortoleva J, Shapeton A, Vanneman M, Dalia AA
J Cardiothorac Vasc Anesth 2020 Oct;34(10):2766-2775. Epub 2019 Dec 14 doi: 10.1053/j.jvca.2019.12.013. PMID: 31917073
Vasopressin in Vasodilatory Shock.
Ukor IF, Walley KR
Crit Care Clin 2019 Apr;35(2):247-261. Epub 2019 Jan 23 doi: 10.1016/j.ccc.2018.11.004. PMID: 30784607
Hydroxocobalamin for the Treatment of Vasoplegia: A Review of Current Literature and Considerations for Use.
Shapeton AD, Mahmood F, Ortoleva JP
J Cardiothorac Vasc Anesth 2019 Apr;33(4):894-901. Epub 2018 Aug 11 doi: 10.1053/j.jvca.2018.08.017. PMID: 30217583
Myocarditis and Kawasaki disease.
Dionne A, Dahdah N
Int J Rheum Dis 2018 Jan;21(1):45-49. Epub 2017 Nov 3 doi: 10.1111/1756-185X.13219. PMID: 29105303

Therapy

The Story of Nitric Oxide, Sepsis and Methylene Blue: A Comprehensive Pathophysiologic Review.
Saha BK, Burns SL
Am J Med Sci 2020 Oct;360(4):329-337. Epub 2020 Jun 6 doi: 10.1016/j.amjms.2020.06.007. PMID: 32631574
Vasoplegic syndrome following cardiothoracic surgery-review of pathophysiology and update of treatment options.
Busse LW, Barker N, Petersen C
Crit Care 2020 Feb 4;24(1):36. doi: 10.1186/s13054-020-2743-8. PMID: 32019600Free PMC Article
Vasoplegia During Cardiopulmonary Bypass: Current Literature and Rescue Therapy Options.
Ortoleva J, Shapeton A, Vanneman M, Dalia AA
J Cardiothorac Vasc Anesth 2020 Oct;34(10):2766-2775. Epub 2019 Dec 14 doi: 10.1053/j.jvca.2019.12.013. PMID: 31917073
Vasopressin in Vasodilatory Shock.
Ukor IF, Walley KR
Crit Care Clin 2019 Apr;35(2):247-261. Epub 2019 Jan 23 doi: 10.1016/j.ccc.2018.11.004. PMID: 30784607
Vasoplegia treatments: the past, the present, and the future.
Levy B, Fritz C, Tahon E, Jacquot A, Auchet T, Kimmoun A
Crit Care 2018 Feb 27;22(1):52. doi: 10.1186/s13054-018-1967-3. PMID: 29486781Free PMC Article

Prognosis

Myocardial dysfunction after cardiac arrest: tips and pitfalls.
Ortuno S, Geri G, Bouguoin W, Cariou A, Aissaoui N
Eur J Emerg Med 2022 Jun 1;29(3):188-194. Epub 2022 Feb 7 doi: 10.1097/MEJ.0000000000000904. PMID: 35135980
Vasoplegia Following Orthotopic Heart Transplantation: Prevalence, Predictors and Clinical Outcomes.
Batchelor RJ, Wong N, Liu DH, Chua C, William J, Tee SL, Sata Y, Bergin P, Hare J, Leet A, Taylor AJ, Patel HC, Burrell A, McGiffin D, Kaye DM
J Card Fail 2022 Apr;28(4):617-626. Epub 2021 Dec 30 doi: 10.1016/j.cardfail.2021.11.020. PMID: 34974975
Risk factors for vasoplegia after cardiac surgery: a meta-analysis.
Dayan V, Cal R, Giangrossi F
Interact Cardiovasc Thorac Surg 2019 Jun 1;28(6):838-844. doi: 10.1093/icvts/ivy352. PMID: 30649312
Characterizing Predictors and Severity of Vasoplegia Syndrome After Heart Transplantation.
Chan JL, Kobashigawa JA, Aintablian TL, Dimbil SJ, Perry PA, Patel JK, Kittleson MM, Czer LS, Zarrini P, Velleca A, Rush J, Arabia FA, Trento A, Esmailian F
Ann Thorac Surg 2018 Mar;105(3):770-777. Epub 2017 Dec 28 doi: 10.1016/j.athoracsur.2017.09.039. PMID: 29289367
Cardiac vasoplegia syndrome: pathophysiology, risk factors and treatment.
Omar S, Zedan A, Nugent K
Am J Med Sci 2015 Jan;349(1):80-8. doi: 10.1097/MAJ.0000000000000341. PMID: 25247756

Clinical prediction guides

Vasoplegia Following Orthotopic Heart Transplantation: Prevalence, Predictors and Clinical Outcomes.
Batchelor RJ, Wong N, Liu DH, Chua C, William J, Tee SL, Sata Y, Bergin P, Hare J, Leet A, Taylor AJ, Patel HC, Burrell A, McGiffin D, Kaye DM
J Card Fail 2022 Apr;28(4):617-626. Epub 2021 Dec 30 doi: 10.1016/j.cardfail.2021.11.020. PMID: 34974975
Myocarditis and Kawasaki disease.
Dionne A, Dahdah N
Int J Rheum Dis 2018 Jan;21(1):45-49. Epub 2017 Nov 3 doi: 10.1111/1756-185X.13219. PMID: 29105303
Perioperative anaphylaxis: what should be known?
Dewachter P, Mouton-Faivre C, Hepner DL
Curr Allergy Asthma Rep 2015 May;15(5):21. doi: 10.1007/s11882-015-0522-4. PMID: 26139330
Cardiac vasoplegia syndrome: pathophysiology, risk factors and treatment.
Omar S, Zedan A, Nugent K
Am J Med Sci 2015 Jan;349(1):80-8. doi: 10.1097/MAJ.0000000000000341. PMID: 25247756
Methylene blue and vasoplegia: who, when, and how?
Stawicki SP, Sims C, Sarani B, Grossman MD, Gracias VH
Mini Rev Med Chem 2008 May;8(5):472-90. doi: 10.2174/138955708784223477. PMID: 18473936

Recent systematic reviews

Hydroxocobalamin for Vasodilatory Hypotension in Shock: A Systematic Review With Meta-Analysis for Comparison to Methylene Blue.
Brokmeier HM, Seelhammer TG, Nei SD, Gerberi DJ, Mara KC, Wittwer ED, Wieruszewski PM
J Cardiothorac Vasc Anesth 2023 Sep;37(9):1757-1772. Epub 2023 Apr 7 doi: 10.1053/j.jvca.2023.04.006. PMID: 37147207
Efficacy and safety of angiotensin II in cardiogenic shock: A systematic review.
Bansal M, Mehta A, Wieruszewski PM, Belford PM, Zhao DX, Khanna AK, Vallabhajosyula S
Am J Emerg Med 2023 Apr;66:124-128. Epub 2023 Feb 1 doi: 10.1016/j.ajem.2023.01.050. PMID: 36753927
Vasoplegic syndrome after cardiovascular surgery: A review of pathophysiology and outcome-oriented therapeutic management.
Datt V, Wadhhwa R, Sharma V, Virmani S, Minhas HS, Malik S
J Card Surg 2021 Oct;36(10):3749-3760. Epub 2021 Jul 12 doi: 10.1111/jocs.15805. PMID: 34251716
Methylene blue for vasoplegic syndrome in cardiopulmonary bypass surgery: A systematic review and meta-analysis.
Perdhana F, Kloping NA, Witarto AP, Nugraha D, Yogiswara N, Luke K, Kloping YP, Rehatta NM
Asian Cardiovasc Thorac Ann 2021 Oct;29(8):717-728. Epub 2021 Mar 2 doi: 10.1177/0218492321998523. PMID: 33653154
Painful gynecologic and obstetric complications of female genital mutilation/cutting: A systematic review and meta-analysis.
Lurie JM, Weidman A, Huynh S, Delgado D, Easthausen I, Kaur G
PLoS Med 2020 Mar;17(3):e1003088. Epub 2020 Mar 31 doi: 10.1371/journal.pmed.1003088. PMID: 32231359Free PMC Article

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