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Vasoplegia

MedGen UID:
404002
•Concept ID:
C2717957
•
Pathologic Function
Synonym: Vasoplegias

Definition

Condition of low SYSTEMIC VASCULAR RESISTANCE that develops secondary to other conditions such as ANAPHYLAXIS; SEPSIS; SURGICAL SHOCK; and SEPTIC SHOCK. Vasoplegia that develops during or post surgery (e.g., CARDIOPULMONARY BYPASS) is called postoperative vasoplegic syndrome or vasoplegic syndrome. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVasoplegia

Professional guidelines

PubMed

Management of Vasoplegic Shock in the Cardiovascular Intensive Care Unit after Cardiac Surgery.
Suero OR, Park Y, Wieruszewski PM, Chatterjee S
Crit Care Clin 2024 Jan;40(1):73-88. Epub 2023 Sep 7 doi: 10.1016/j.ccc.2023.06.002. PMID: 37973358
HFSA Expert Consensus Statement on the Medical Management of Patients on Durable Mechanical Circulatory Support.
Trachtenberg B, Cowger J, Jennings DL, Grafton G, Loyaga-Rendon R, Cogswell R, Klein L, Shah P, Kiernan M, Vorovich E
J Card Fail 2023 Apr;29(4):479-502. Epub 2023 Feb 22 doi: 10.1016/j.cardfail.2023.01.009. PMID: 36828256
Cardiac vasoplegia syndrome: pathophysiology, risk factors and treatment.
Omar S, Zedan A, Nugent K
Am J Med Sci 2015 Jan;349(1):80-8. doi: 10.1097/MAJ.0000000000000341. PMID: 25247756

Recent clinical studies

Etiology

Vasoplegia: A Review.
Ratnani I, Ochani RK, Shaikh A, Jatoi HN
Methodist Debakey Cardiovasc J 2023;19(4):38-47. Epub 2023 Aug 1 doi: 10.14797/mdcvj.1245. PMID: 37547893Free PMC Article
Hydroxocobalamin for Vasodilatory Hypotension in Shock: A Systematic Review With Meta-Analysis for Comparison to Methylene Blue.
Brokmeier HM, Seelhammer TG, Nei SD, Gerberi DJ, Mara KC, Wittwer ED, Wieruszewski PM
J Cardiothorac Vasc Anesth 2023 Sep;37(9):1757-1772. Epub 2023 Apr 7 doi: 10.1053/j.jvca.2023.04.006. PMID: 37147207
HFSA Expert Consensus Statement on the Medical Management of Patients on Durable Mechanical Circulatory Support.
Trachtenberg B, Cowger J, Jennings DL, Grafton G, Loyaga-Rendon R, Cogswell R, Klein L, Shah P, Kiernan M, Vorovich E
J Card Fail 2023 Apr;29(4):479-502. Epub 2023 Feb 22 doi: 10.1016/j.cardfail.2023.01.009. PMID: 36828256
Vasopressin versus Norepinephrine in Patients with Vasoplegic Shock after Cardiac Surgery: The VANCS Randomized Controlled Trial.
Hajjar LA, Vincent JL, Barbosa Gomes Galas FR, Rhodes A, Landoni G, Osawa EA, Melo RR, Sundin MR, Grande SM, Gaiotto FA, Pomerantzeff PM, Dallan LO, Franco RA, Nakamura RE, Lisboa LA, de Almeida JP, Gerent AM, Souza DH, Gaiane MA, Fukushima JT, Park CL, Zambolim C, Rocha Ferreira GS, Strabelli TM, Fernandes FL, Camara L, Zeferino S, Santos VG, Piccioni MA, Jatene FB, Costa Auler JO Jr, Filho RK
Anesthesiology 2017 Jan;126(1):85-93. doi: 10.1097/ALN.0000000000001434. PMID: 27841822
Cardiac vasoplegia syndrome: pathophysiology, risk factors and treatment.
Omar S, Zedan A, Nugent K
Am J Med Sci 2015 Jan;349(1):80-8. doi: 10.1097/MAJ.0000000000000341. PMID: 25247756

Diagnosis

Management of Vasoplegic Shock in the Cardiovascular Intensive Care Unit after Cardiac Surgery.
Suero OR, Park Y, Wieruszewski PM, Chatterjee S
Crit Care Clin 2024 Jan;40(1):73-88. Epub 2023 Sep 7 doi: 10.1016/j.ccc.2023.06.002. PMID: 37973358
Vasoplegia: A Review.
Ratnani I, Ochani RK, Shaikh A, Jatoi HN
Methodist Debakey Cardiovasc J 2023;19(4):38-47. Epub 2023 Aug 1 doi: 10.14797/mdcvj.1245. PMID: 37547893Free PMC Article
Hydroxocobalamin for the Treatment of Vasoplegia: A Review of Current Literature and Considerations for Use.
Shapeton AD, Mahmood F, Ortoleva JP
J Cardiothorac Vasc Anesth 2019 Apr;33(4):894-901. Epub 2018 Aug 11 doi: 10.1053/j.jvca.2018.08.017. PMID: 30217583
Myocarditis and Kawasaki disease.
Dionne A, Dahdah N
Int J Rheum Dis 2018 Jan;21(1):45-49. Epub 2017 Nov 3 doi: 10.1111/1756-185X.13219. PMID: 29105303
Perioperative anaphylaxis: what should be known?
Dewachter P, Mouton-Faivre C, Hepner DL
Curr Allergy Asthma Rep 2015 May;15(5):21. doi: 10.1007/s11882-015-0522-4. PMID: 26139330

Therapy

HFSA Expert Consensus Statement on the Medical Management of Patients on Durable Mechanical Circulatory Support.
Trachtenberg B, Cowger J, Jennings DL, Grafton G, Loyaga-Rendon R, Cogswell R, Klein L, Shah P, Kiernan M, Vorovich E
J Card Fail 2023 Apr;29(4):479-502. Epub 2023 Feb 22 doi: 10.1016/j.cardfail.2023.01.009. PMID: 36828256
Multimodal strategy to counteract vasodilation in septic shock.
Leone M, Einav S, Antonucci E, Depret F, Lakbar I, Martin-Loeches I, Wieruszewski PM, Myatra SN, Khanna AK
Anaesth Crit Care Pain Med 2023 Jun;42(3):101193. Epub 2023 Jan 5 doi: 10.1016/j.accpm.2023.101193. PMID: 36621622
Review of Postoperative Care for Heart Transplant Recipients.
Hwang NC, Sivathasan C
J Cardiothorac Vasc Anesth 2023 Jan;37(1):112-126. Epub 2022 Sep 19 doi: 10.1053/j.jvca.2022.09.083. PMID: 36323595
Vasoplegia treatments: the past, the present, and the future.
Levy B, Fritz C, Tahon E, Jacquot A, Auchet T, Kimmoun A
Crit Care 2018 Feb 27;22(1):52. doi: 10.1186/s13054-018-1967-3. PMID: 29486781Free PMC Article
Cardiac vasoplegia syndrome: pathophysiology, risk factors and treatment.
Omar S, Zedan A, Nugent K
Am J Med Sci 2015 Jan;349(1):80-8. doi: 10.1097/MAJ.0000000000000341. PMID: 25247756

Prognosis

Review of Postoperative Care for Heart Transplant Recipients.
Hwang NC, Sivathasan C
J Cardiothorac Vasc Anesth 2023 Jan;37(1):112-126. Epub 2022 Sep 19 doi: 10.1053/j.jvca.2022.09.083. PMID: 36323595
Myocardial dysfunction after cardiac arrest: tips and pitfalls.
Ortuno S, Geri G, Bouguoin W, Cariou A, Aissaoui N
Eur J Emerg Med 2022 Jun 1;29(3):188-194. Epub 2022 Feb 7 doi: 10.1097/MEJ.0000000000000904. PMID: 35135980
Vasoplegia Following Orthotopic Heart Transplantation: Prevalence, Predictors and Clinical Outcomes.
Batchelor RJ, Wong N, Liu DH, Chua C, William J, Tee SL, Sata Y, Bergin P, Hare J, Leet A, Taylor AJ, Patel HC, Burrell A, McGiffin D, Kaye DM
J Card Fail 2022 Apr;28(4):617-626. Epub 2021 Dec 30 doi: 10.1016/j.cardfail.2021.11.020. PMID: 34974975
Defining Vasoplegia Following Durable, Continuous Flow Left Ventricular Assist Device Implantation.
Swan JT, Iso T, Rizk E, Trachtenberg BH, Krisl J, Varnado S, Suki WN, Frost AE, Suarez E, Uddin FS, Kassi M, Giesecke NM, Bhimaraj A, Masud FN
ASAIO J 2022 Jan 1;68(1):46-55. doi: 10.1097/MAT.0000000000001419. PMID: 34227791
Cardiac vasoplegia syndrome: pathophysiology, risk factors and treatment.
Omar S, Zedan A, Nugent K
Am J Med Sci 2015 Jan;349(1):80-8. doi: 10.1097/MAJ.0000000000000341. PMID: 25247756

Clinical prediction guides

Vasoplegia Following Orthotopic Heart Transplantation: Prevalence, Predictors and Clinical Outcomes.
Batchelor RJ, Wong N, Liu DH, Chua C, William J, Tee SL, Sata Y, Bergin P, Hare J, Leet A, Taylor AJ, Patel HC, Burrell A, McGiffin D, Kaye DM
J Card Fail 2022 Apr;28(4):617-626. Epub 2021 Dec 30 doi: 10.1016/j.cardfail.2021.11.020. PMID: 34974975
Myocarditis and Kawasaki disease.
Dionne A, Dahdah N
Int J Rheum Dis 2018 Jan;21(1):45-49. Epub 2017 Nov 3 doi: 10.1111/1756-185X.13219. PMID: 29105303
Perioperative anaphylaxis: what should be known?
Dewachter P, Mouton-Faivre C, Hepner DL
Curr Allergy Asthma Rep 2015 May;15(5):21. doi: 10.1007/s11882-015-0522-4. PMID: 26139330
Cardiac vasoplegia syndrome: pathophysiology, risk factors and treatment.
Omar S, Zedan A, Nugent K
Am J Med Sci 2015 Jan;349(1):80-8. doi: 10.1097/MAJ.0000000000000341. PMID: 25247756
Methylene blue and vasoplegia: who, when, and how?
Stawicki SP, Sims C, Sarani B, Grossman MD, Gracias VH
Mini Rev Med Chem 2008 May;8(5):472-90. doi: 10.2174/138955708784223477. PMID: 18473936

Recent systematic reviews

The role of hemoadsorption in cardiac surgery - a systematic review.
Matejic-Spasic M, Lindstedt S, Lebreton G, Dzemali O, Suwalski P, Folliguet T, Geidel S, Klautz RJM, Baufreton C, Livi U, Gunaydin S, Deliargyris EN, Wendt D, Thielmann M
BMC Cardiovasc Disord 2024 May 18;24(1):258. doi: 10.1186/s12872-024-03938-4. PMID: 38762715Free PMC Article
Vasoplegic syndrome during heart transplantation: A systematic review and meta-analysis.
Kumar N, Fitzsimons MG, Iyer MH, Essandoh M, Kumar JE, Dalia AA, Osho A, Sawyer TR, Bardia A
J Heart Lung Transplant 2024 Jun;43(6):931-943. Epub 2024 Feb 28 doi: 10.1016/j.healun.2024.02.1458. PMID: 38428755
Hydroxocobalamin for Vasodilatory Hypotension in Shock: A Systematic Review With Meta-Analysis for Comparison to Methylene Blue.
Brokmeier HM, Seelhammer TG, Nei SD, Gerberi DJ, Mara KC, Wittwer ED, Wieruszewski PM
J Cardiothorac Vasc Anesth 2023 Sep;37(9):1757-1772. Epub 2023 Apr 7 doi: 10.1053/j.jvca.2023.04.006. PMID: 37147207
Efficacy and safety of angiotensin II in cardiogenic shock: A systematic review.
Bansal M, Mehta A, Wieruszewski PM, Belford PM, Zhao DX, Khanna AK, Vallabhajosyula S
Am J Emerg Med 2023 Apr;66:124-128. Epub 2023 Feb 1 doi: 10.1016/j.ajem.2023.01.050. PMID: 36753927
Vasoplegic syndrome after cardiovascular surgery: A review of pathophysiology and outcome-oriented therapeutic management.
Datt V, Wadhhwa R, Sharma V, Virmani S, Minhas HS, Malik S
J Card Surg 2021 Oct;36(10):3749-3760. Epub 2021 Jul 12 doi: 10.1111/jocs.15805. PMID: 34251716

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