U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Poroma

MedGen UID:
404005
•Concept ID:
C2717981
•
Neoplastic Process
Synonyms: Poromas; Poromatoses; Poromatosis
 
HPO: HP:0031405

Definition

A benign, well circumscribed sweat gland neoplasm with eccrine or apocrine differentiation. It usually presents as a solitary, dome-shaped papule, nodule, or plaque on acral sites. It is characterized by a proliferation of uniform basaloid cells in the dermis and it is associated with the presence of focal ductal and cystic structures [NCIT:C27273]. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPoroma

Conditions with this feature

SchC6pf-Schulz-Passarge syndrome
MedGen UID:
347366
•Concept ID:
C1857069
•
Disease or Syndrome
Schopf-Schulz-Passarge syndrome (SSPS) is an autosomal recessive disorder characterized by a constellation of multiple eyelid cysts, hypodontia, hypotrichosis, palmoplantar hyperkeratosis, and onychodystrophy (summary by Mallaiah and Dickinson, 2001).
See: Condition Record
SchC6pf-Schulz-Passarge syndrome

Professional guidelines

PubMed

Intraepidermal Poroma (Hidroacanthoma Simplex) Versus Clonal Seborrheic Keratosis: Will GATA3 Immunohistochemistry Help in the Differential Diagnosis?
Schukow C, McCalmont TH, Surprenant D, Yang HH
Am J Dermatopathol 2023 Oct 1;45(10):728-730. Epub 2023 Jul 28 doi: 10.1097/DAD.0000000000002503. PMID: 37506277
Expression of lumican in hidroacanthoma simplex and clonal-type seborrheic keratosis as a potent differential diagnostic marker.
Takayama R, Ansai S, Ishiwata T, Yamamoto T, Matsuda Y, Naito Z, Kawana S
Am J Dermatopathol 2014 Aug;36(8):655-60. doi: 10.1097/DAD.0b013e31828b6bbf. PMID: 23656908
Expression of cytokeratin subtypes in intraepidermal malignancies: a guide for differentiation.
Aslan F, Demirkesen C, Cağatay P, Tüzüner N
J Cutan Pathol 2006 Aug;33(8):531-8. doi: 10.1111/j.1600-0560.2006.00466.x. PMID: 16919026

Recent clinical studies

Etiology

Combined Poroma and Verruca Plantaris.
Kneiber D, Cassarino DS
Am J Dermatopathol 2022 May 1;44(5):e51-e53. doi: 10.1097/DAD.0000000000002123. PMID: 35120031
Magnetic Resonance Imaging Characteristics of Poroma and Porocarcinoma.
Kawaguchi M, Kato H, Imada H, Miyazaki T, Matsuyama K, Seishima M, Matsuo M
J Comput Assist Tomogr 2021 May-Jun 01;45(3):447-451. doi: 10.1097/RCT.0000000000001146. PMID: 33797441
Morphologic Diversity of Merkel Cell Carcinoma.
Ogawa T, Donizy P, Wu CL, Cornejo KM, Ryś J, Hoang MP
Am J Dermatopathol 2020 Sep;42(9):629-640. doi: 10.1097/DAD.0000000000001548. PMID: 32833736
Poroma: a review of eccrine, apocrine, and malignant forms.
Sawaya JL, Khachemoune A
Int J Dermatol 2014 Sep;53(9):1053-61. Epub 2014 Apr 2 doi: 10.1111/ijd.12448. PMID: 24697501
Clinical, dermoscopic and histopathological features of eccrine poroid neoplasms.
Sgouros D, Piana S, Argenziano G, Longo C, Moscarella E, Karaarslan IK, Akalin T, Ozdemir F, Zalaudek I
Dermatology 2013;227(2):175-9. Epub 2013 Sep 24 doi: 10.1159/000354152. PMID: 24080919

Diagnosis

Generalized Reddish Skin Nodules.
Hamijoyo L, Yaddin DF, Wijaya I, Fianza PI, Usman HA, Hernowo BS, Ceana HY, Pangastuti M, Hartantri Y
Acta Med Indones 2023 Apr;55(2):223-225. PMID: 37524604
A systematic review of periungual eccrine neoplasms.
Rao EM, Knackstedt TJ
Int J Dermatol 2022 Jul;61(7):812-820. Epub 2021 Sep 8 doi: 10.1111/ijd.15893. PMID: 34494261
Morphologic Diversity of Merkel Cell Carcinoma.
Ogawa T, Donizy P, Wu CL, Cornejo KM, Ryś J, Hoang MP
Am J Dermatopathol 2020 Sep;42(9):629-640. doi: 10.1097/DAD.0000000000001548. PMID: 32833736
Reactive syringofibroadenoma.
Kumar P, Das A, Das PC
Indian J Dermatol Venereol Leprol 2020 Nov-Dec;86(6):681-682. doi: 10.4103/ijdvl.IJDVL_924_18. PMID: 31249214
Dermoscopy of Adnexal Tumors.
Zaballos P, Gómez-Martín I, Martin JM, Bañuls J
Dermatol Clin 2018 Oct;36(4):397-412. Epub 2018 Aug 16 doi: 10.1016/j.det.2018.05.007. PMID: 30201149

Therapy

Eccrine poromatosis following chemotherapy and radiation therapy.
Nguyen K, Kim G, Chiu M
Dermatol Online J 2019 Nov 15;25(11) PMID: 32045152
Multiple poromas in a bone marrow transplant recipient: A case report.
Nguyen BT, Lortscher DN, Lee RA
Dermatol Online J 2012 Jul 15;18(7):9. PMID: 22863631
Eccrine poromatosis associated with polychemotherapy.
Fujii K, Aochi S, Takeshima C, Ohtsuka M, Hamada T, Asagoe K, Aoyama Y, Morizane S, Iwatsuki K
Acta Derm Venereol 2012 Nov;92(6):687-90. doi: 10.2340/00015555-1279. PMID: 22294042
Eccrine porocarcinoma.
Brown CW Jr, Dy LC
Dermatol Ther 2008 Nov-Dec;21(6):433-8. doi: 10.1111/j.1529-8019.2008.00243.x. PMID: 19076620
New concepts on the histogenesis of eccrine neoplasia from keratin expression in the normal eccrine gland, syringoma and poroma.
Langbein L, Cribier B, Schirmacher P, Praetzel-Wunder S, Peltre B, Schweizer J
Br J Dermatol 2008 Sep;159(3):633-45. Epub 2008 Jul 19 doi: 10.1111/j.1365-2133.2008.08746.x. PMID: 18647305

Prognosis

Dermoscopy for the Identification of Amelanotic Acral Melanoma.
Koblinski JE, Ahrns HT, Morse MJ, Seiverling EV
J Am Podiatr Med Assoc 2022 Mar 16;112(1) doi: 10.7547/20-184. PMID: 36459055
Morphologic Diversity of Merkel Cell Carcinoma.
Ogawa T, Donizy P, Wu CL, Cornejo KM, Ryś J, Hoang MP
Am J Dermatopathol 2020 Sep;42(9):629-640. doi: 10.1097/DAD.0000000000001548. PMID: 32833736
Eccrine porocarcinoma of the head and neck: Meta-analysis of 120 cases.
Le NS, Janik S, Liu DT, Grasl S, Faisal M, Pammer J, Schickinger-Fischer B, Hamzavi JS, Seemann R, Erovic BM
Head Neck 2020 Sep;42(9):2644-2659. Epub 2020 Apr 21 doi: 10.1002/hed.26178. PMID: 32314845
Senile Purpura as a Stage of Dermatoporosis.
Karadag AS, Parish LC, Lambert WC
Skinmed 2017;15(2):91-92. Epub 2017 Apr 1 PMID: 28528600
Eccrine porocarcinoma (malignant eccrine poroma): a clinicopathologic study of 69 cases.
Robson A, Greene J, Ansari N, Kim B, Seed PT, McKee PH, Calonje E
Am J Surg Pathol 2001 Jun;25(6):710-20. doi: 10.1097/00000478-200106000-00002. PMID: 11395548

Clinical prediction guides

Molecular pathology of skin adnexal tumours.
Plotzke JM, Adams DJ, Harms PW
Histopathology 2022 Jan;80(1):166-183. doi: 10.1111/his.14441. PMID: 34197659
Magnetic Resonance Imaging Characteristics of Poroma and Porocarcinoma.
Kawaguchi M, Kato H, Imada H, Miyazaki T, Matsuyama K, Seishima M, Matsuo M
J Comput Assist Tomogr 2021 May-Jun 01;45(3):447-451. doi: 10.1097/RCT.0000000000001146. PMID: 33797441
Characteristic Clinical and Dermoscopic Features of Nonvolar Poroma.
Ha DL, Lee GW, Shin K, Kim HS, Ko HC, Kim BS, Kim MB
J Cutan Med Surg 2021 Mar-Apr;25(2):142-149. Epub 2020 Sep 3 doi: 10.1177/1203475420952432. PMID: 32880198
Morphologic Diversity of Merkel Cell Carcinoma.
Ogawa T, Donizy P, Wu CL, Cornejo KM, Ryś J, Hoang MP
Am J Dermatopathol 2020 Sep;42(9):629-640. doi: 10.1097/DAD.0000000000001548. PMID: 32833736
Dermoscopy of Adnexal Tumors.
Zaballos P, Gómez-Martín I, Martin JM, Bañuls J
Dermatol Clin 2018 Oct;36(4):397-412. Epub 2018 Aug 16 doi: 10.1016/j.det.2018.05.007. PMID: 30201149

Recent systematic reviews

A systematic review of periungual eccrine neoplasms.
Rao EM, Knackstedt TJ
Int J Dermatol 2022 Jul;61(7):812-820. Epub 2021 Sep 8 doi: 10.1111/ijd.15893. PMID: 34494261

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...