U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Malignant Pancreatic Gastrinoma

MedGen UID:
406818
•Concept ID:
C1881585
•
Neoplastic Process
Synonyms: Malignant G cell neoplasm of pancreas; Malignant gastrinoma of pancreas; Pancreatic G-Cell Carcinoma
SNOMED CT: Malignant G cell neoplasm of pancreas (1187519007); Malignant gastrinoma of pancreas (1187519007)

Definition

A gastrin-producing neuroendocrine tumor arising from the pancreas. It is characterized by inappropriate secretion of gastrin and associated with Zollinger Ellison syndrome. It displays vascular invasion and metastasizes to other anatomic sites. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Pancreatic Gastrinoma

Professional guidelines

PubMed

Gastrinoma and Zollinger Ellison syndrome: A roadmap for the management between new and old therapies.
Rossi RE, Elvevi A, Citterio D, Coppa J, Invernizzi P, Mazzaferro V, Massironi S
World J Gastroenterol 2021 Sep 21;27(35):5890-5907. doi: 10.3748/wjg.v27.i35.5890. PMID: 34629807Free PMC Article
The surgical and systemic management of neuroendocrine tumors of the pancreas.
Abood GJ, Go A, Malhotra D, Shoup M
Surg Clin North Am 2009 Feb;89(1):249-66, x. doi: 10.1016/j.suc.2008.10.001. PMID: 19186239
Surgical treatment of sporadic gastrinoma.
Lorenz K, Dralle H
Wien Klin Wochenschr 2007;119(19-20):597-601. doi: 10.1007/s00508-007-0882-4. PMID: 17985095

Recent clinical studies

Etiology

Supportive therapy in gastroenteropancreatic neuroendocrine tumors: Often forgotten but important.
Jin XF, Spampatti MP, Spitzweg C, Auernhammer CJ
Rev Endocr Metab Disord 2018 Jun;19(2):145-158. doi: 10.1007/s11154-018-9443-6. PMID: 29464446
Diagnosis and management of Zollinger-Ellison syndrome in 2018.
De Angelis C, Cortegoso Valdivia P, Venezia L, Bruno M, Pellicano R
Minerva Endocrinol 2018 Jun;43(2):212-220. Epub 2017 Sep 25 doi: 10.23736/S0391-1977.17.02745-6. PMID: 28949124
Pancreatic neuroendocrine tumors: contemporary diagnosis and management.
Parbhu SK, Adler DG
Hosp Pract (1995) 2016 Aug;44(3):109-19. Epub 2016 Jul 18 doi: 10.1080/21548331.2016.1210474. PMID: 27404266
Clinical Presentation and Diagnosis of Pancreatic Neuroendocrine Tumors.
Anderson CW, Bennett JJ
Surg Oncol Clin N Am 2016 Apr;25(2):363-74. Epub 2016 Feb 18 doi: 10.1016/j.soc.2015.12.003. PMID: 27013370
Pancreatic neuroendocrine tumours.
O'Grady HL, Conlon KC
Eur J Surg Oncol 2008 Mar;34(3):324-32. Epub 2007 Oct 29 doi: 10.1016/j.ejso.2007.07.209. PMID: 17967523

Diagnosis

Management of Functional Pancreatic Neuroendocrine Neoplasms.
Magi L, Marasco M, Rinzivillo M, Faggiano A, Panzuto F
Curr Treat Options Oncol 2023 Jul;24(7):725-741. Epub 2023 Apr 27 doi: 10.1007/s11864-023-01085-0. PMID: 37103745Free PMC Article
Perspectives on the current pharmacotherapeutic strategies for management of functional neuroendocrine tumor syndromes.
Ito T, Jensen RT
Expert Opin Pharmacother 2021 Apr;22(6):685-693. Epub 2020 Nov 11 doi: 10.1080/14656566.2020.1845651. PMID: 33131345Free PMC Article
Pharmacotherapy of Zollinger-Ellison syndrome.
Ito T, Igarashi H, Uehara H, Jensen RT
Expert Opin Pharmacother 2013 Feb;14(3):307-21. Epub 2013 Jan 30 doi: 10.1517/14656566.2013.767332. PMID: 23363383Free PMC Article
Gastrinoma.
Chambers AJ, Pasieka JL
Cancer Treat Res 2010;153:213-33. doi: 10.1007/978-1-4419-0857-5_12. PMID: 19957227
Gastrinoma--morphological aspects.
Klöppel G, Anlauf M
Wien Klin Wochenschr 2007;119(19-20):579-84. doi: 10.1007/s00508-007-0885-1. PMID: 17985091

Therapy

Treatment of symptomatic neuroendocrine tumor syndromes: recent advances and controversies.
Ito T, Lee L, Jensen RT
Expert Opin Pharmacother 2016 Nov;17(16):2191-2205. Epub 2016 Sep 23 doi: 10.1080/14656566.2016.1236916. PMID: 27635672Free PMC Article
Pharmacotherapy of Zollinger-Ellison syndrome.
Ito T, Igarashi H, Uehara H, Jensen RT
Expert Opin Pharmacother 2013 Feb;14(3):307-21. Epub 2013 Jan 30 doi: 10.1517/14656566.2013.767332. PMID: 23363383Free PMC Article
Zollinger-Ellison syndrome: a personal perspective.
Ellison EC
Am Surg 2008 Jul;74(7):563-71. PMID: 18646472
Pancreatic endocrine tumors.
Chun J, Doherty GM
Curr Opin Oncol 2001 Jan;13(1):52-6. doi: 10.1097/00001622-200101000-00010. PMID: 11148686
Octreotide.
Lancet 1989 Sep 2;2(8662):541-2. PMID: 2570240

Prognosis

Imaging of pancreatic neuroendocrine tumors: recent advances, current status, and controversies.
Lee L, Ito T, Jensen RT
Expert Rev Anticancer Ther 2018 Sep;18(9):837-860. Epub 2018 Jul 17 doi: 10.1080/14737140.2018.1496822. PMID: 29973077Free PMC Article
Imaging of pancreatic neoplasms.
Balachandran A, Bhosale PR, Charnsangavej C, Tamm EP
Surg Oncol Clin N Am 2014 Oct;23(4):751-88. doi: 10.1016/j.soc.2014.07.002. PMID: 25246049
Multiple endocrine neoplasms.
Falchetti A, Marini F, Luzi E, Tonelli F, Brandi ML
Best Pract Res Clin Rheumatol 2008 Mar;22(1):149-63. doi: 10.1016/j.berh.2007.11.010. PMID: 18328987
Pancreatic neuroendocrine tumours.
O'Grady HL, Conlon KC
Eur J Surg Oncol 2008 Mar;34(3):324-32. Epub 2007 Oct 29 doi: 10.1016/j.ejso.2007.07.209. PMID: 17967523
Gastrinoma--morphological aspects.
Klöppel G, Anlauf M
Wien Klin Wochenschr 2007;119(19-20):579-84. doi: 10.1007/s00508-007-0885-1. PMID: 17985091

Clinical prediction guides

How to treat gastrinomas in patients with multiple endocrine neoplasia type1: surgery or long-term proton pump inhibitors?
Imamura M, Komoto I, Taki Y
Surg Today 2023 Dec;53(12):1325-1334. Epub 2022 Dec 7 doi: 10.1007/s00595-022-02627-z. PMID: 36473964Free PMC Article
Sporadic pancreatic neuroendocrine tumor: Surgery of the primary tumor.
Deguelte S, de Mestier L, Hentic O, Cros J, Lebtahi R, Hammel P, Kianmanesh R
J Visc Surg 2018 Dec;155(6):483-492. Epub 2018 Nov 15 doi: 10.1016/j.jviscsurg.2018.08.010. PMID: 30448206
Imaging of pancreatic neoplasms.
Balachandran A, Bhosale PR, Charnsangavej C, Tamm EP
Surg Oncol Clin N Am 2014 Oct;23(4):751-88. doi: 10.1016/j.soc.2014.07.002. PMID: 25246049
The surgical management of pancreatic neuroendocrine tumors.
Azimuddin K, Chamberlain RS
Surg Clin North Am 2001 Jun;81(3):511-25. doi: 10.1016/s0039-6109(05)70140-7. PMID: 11459268
Hepatic gastrinoma.
Moriura S, Ikeda S, Hirai M, Naiki K, Fujioka T, Yokochi K, Gotou S
Cancer 1993 Sep 1;72(5):1547-50. doi: 10.1002/1097-0142(19930901)72:5<1547::aid-cncr2820720510>3.0.co;2-c. PMID: 8348490

Recent systematic reviews

Radioguided Surgery for Gastroenteropancreatic Neuroendocrine Tumours: a Systematic Literature Review.
Cockburn KC, Toumi Z, Mackie A, Julyan P
J Gastrointest Surg 2021 Dec;25(12):3244-3257. Epub 2021 Sep 10 doi: 10.1007/s11605-021-05115-w. PMID: 34506015Free PMC Article
Proteomics of Pancreatic Neuroendocrine Tumors: A Systematic Review.
Maiorano BA, Schinzari G, Chiloiro S, Visconti F, Milardi D, Bianchi A
Protein Pept Lett 2020;27(12):1276-1287. doi: 10.2174/0929866527666200504122116. PMID: 31804164
Liver transplantation for hepatic metastases of neuroendocrine pancreatic tumors: a survival-based analysis.
Máthé Z, Tagkalos E, Paul A, Molmenti EP, Kóbori L, Fouzas I, Beckebaum S, Sotiropoulos GC
Transplantation 2011 Mar 15;91(5):575-82. doi: 10.1097/TP.0b013e3182081312. PMID: 21200365

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...