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Venous thoracic outlet syndrome

MedGen UID:
408326
Concept ID:
C1956396
Disease or Syndrome
Synonym: Venous Thoracic Outlet Syndrome
SNOMED CT: Venous thoracic outlet syndrome (25981000119102); Paget Schrotter disease (25981000119102); Venous cervical rib syndrome (25981000119102); Effort subclavian vein thrombosis (25981000119102)
 
Monarch Initiative: MONDO:0018165
Orphanet: ORPHA357131

Definition

A form of thoracic outlet syndrome that manifests as unilateral (rarely bilateral) arm pain and cyanosis. The disease occurs in young adults, usually after excessive arm activity. The characteristic symptoms, caused by venous obstruction, are arm swelling, cyanosis and pain. Repetitive arm motion and compression of the subclavian vein in the neck (between the clavicle and the first rib) leads to scar tissue that can predispose to thrombosis due to narrowing of vessels. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVenous thoracic outlet syndrome

Professional guidelines

PubMed

Hoexum F, Hoebink M, Coveliers HME, Wisselink W, Jongkind V, Yeung KK
Eur J Vasc Endovasc Surg 2023 Dec;66(6):866-875. Epub 2023 Sep 6 doi: 10.1016/j.ejvs.2023.08.065. PMID: 37678659
Cook JR, Thompson RW
Thorac Surg Clin 2021 Feb;31(1):27-44. doi: 10.1016/j.thorsurg.2020.08.012. PMID: 33220769
Expert Panels on Vascular Imaging, Thoracic Imaging, and Neurological Imaging, Zurkiya O, Ganguli S, Kalva SP, Chung JH, Shah LM, Majdalany BS, Bykowski J, Carter BW, Chandra A, Collins JD, Gunn AJ, Kendi AT, Khaja MS, Liebeskind DS, Maldonado F, Obara P, Sutphin PD, Tong BC, Vijay K, Corey AS, Kanne JP, Dill KE
J Am Coll Radiol 2020 May;17(5S):S323-S334. doi: 10.1016/j.jacr.2020.01.029. PMID: 32370976

Recent clinical studies

Etiology

Ozsvath K, Raffetto JD, Lindner E, Murphy EH
Semin Vasc Surg 2023 Dec;36(4):550-559. Epub 2023 Oct 20 doi: 10.1053/j.semvascsurg.2023.10.006. PMID: 38030329
Miciura AL, Napier JA, Aziz A
Ann Vasc Surg 2023 Oct;96:335-346. Epub 2023 Apr 10 doi: 10.1016/j.avsg.2023.03.016. PMID: 37040840
Khan O, Marmaro A, Cohen DA
Postgrad Med 2021 Aug;133(sup1):3-10. Epub 2021 Mar 8 doi: 10.1080/00325481.2021.1892390. PMID: 33618595
Cai TY, Rajendran S, Saha P, Dubenec S
Phlebology 2020 Aug;35(7):461-471. Epub 2020 Feb 6 doi: 10.1177/0268355519898920. PMID: 32028850
Kim TI, Sarac TP, Orion KC
Ann Vasc Surg 2019 Jan;54:118-122. Epub 2018 Sep 11 doi: 10.1016/j.avsg.2018.08.077. PMID: 30217714

Diagnosis

Park SJ, Cho HJ
N Engl J Med 2023 Oct 19;389(16):e32. Epub 2023 Oct 14 doi: 10.1056/NEJMicm2301198. PMID: 37843133
Modi BP, Chewning R, Kumar R
Semin Pediatr Surg 2021 Dec;30(6):151125. Epub 2021 Oct 30 doi: 10.1016/j.sempedsurg.2021.151125. PMID: 34930589
Khan O, Marmaro A, Cohen DA
Postgrad Med 2021 Aug;133(sup1):3-10. Epub 2021 Mar 8 doi: 10.1080/00325481.2021.1892390. PMID: 33618595
Hussain MA, Aljabri B, Al-Omran M
Semin Thorac Cardiovasc Surg 2016 Spring;28(1):151-7. Epub 2015 Oct 28 doi: 10.1053/j.semtcvs.2015.10.008. PMID: 27568153
Moore R, Wei Lum Y
Vasc Med 2015 Apr;20(2):182-9. doi: 10.1177/1358863X14568704. PMID: 25832605

Therapy

Loh SA, Tonnessen BH
Semin Vasc Surg 2024 Mar;37(1):74-81. Epub 2024 Jan 28 doi: 10.1053/j.semvascsurg.2024.01.003. PMID: 38704187
Miciura AL, Napier JA, Aziz A
Ann Vasc Surg 2023 Oct;96:335-346. Epub 2023 Apr 10 doi: 10.1016/j.avsg.2023.03.016. PMID: 37040840
Cai TY, Rajendran S, Saha P, Dubenec S
Phlebology 2020 Aug;35(7):461-471. Epub 2020 Feb 6 doi: 10.1177/0268355519898920. PMID: 32028850
Farrar TA, Rankin G, Chatfield M
Curr Sports Med Rep 2014 Mar-Apr;13(2):81-5. doi: 10.1249/JSR.0000000000000035. PMID: 24614420
Feugier P, Chevalier JM
Acta Chir Belg 2005 May-Jun;105(3):256-64. doi: 10.1080/00015458.2005.11679713. PMID: 16018517

Prognosis

Lim S, Alarhayem AQ, Rowse JW, Caputo FJ, Smolock CJ, Lyden SP, Kirksey L, Hardy DM
J Vasc Surg Venous Lymphat Disord 2021 Nov;9(6):1473-1478. Epub 2021 Mar 3 doi: 10.1016/j.jvsv.2021.02.010. PMID: 33676044
Illig KA, Rodriguez-Zoppi E
Thorac Surg Clin 2021 Feb;31(1):11-17. doi: 10.1016/j.thorsurg.2020.09.001. PMID: 33220767
Kim TI, Sarac TP, Orion KC
Ann Vasc Surg 2019 Jan;54:118-122. Epub 2018 Sep 11 doi: 10.1016/j.avsg.2018.08.077. PMID: 30217714
Moore R, Wei Lum Y
Vasc Med 2015 Apr;20(2):182-9. doi: 10.1177/1358863X14568704. PMID: 25832605
Feugier P, Chevalier JM
Acta Chir Belg 2005 May-Jun;105(3):256-64. doi: 10.1080/00015458.2005.11679713. PMID: 16018517

Clinical prediction guides

Hoexum F, Jongkind V, Coveliers HM, Yeung KK, Wisselink W
Vascular 2022 Apr;30(2):217-224. Epub 2021 Apr 9 doi: 10.1177/1708538121997332. PMID: 33832359
Khan O, Marmaro A, Cohen DA
Postgrad Med 2021 Aug;133(sup1):3-10. Epub 2021 Mar 8 doi: 10.1080/00325481.2021.1892390. PMID: 33618595
Kim TI, Sarac TP, Orion KC
Ann Vasc Surg 2019 Jan;54:118-122. Epub 2018 Sep 11 doi: 10.1016/j.avsg.2018.08.077. PMID: 30217714
Hussain MA, Aljabri B, Al-Omran M
Semin Thorac Cardiovasc Surg 2016 Spring;28(1):151-7. Epub 2015 Oct 28 doi: 10.1053/j.semtcvs.2015.10.008. PMID: 27568153
Moore R, Wei Lum Y
Vasc Med 2015 Apr;20(2):182-9. doi: 10.1177/1358863X14568704. PMID: 25832605

Recent systematic reviews

Hoexum F, Hoebink M, Coveliers HME, Wisselink W, Jongkind V, Yeung KK
Eur J Vasc Endovasc Surg 2023 Dec;66(6):866-875. Epub 2023 Sep 6 doi: 10.1016/j.ejvs.2023.08.065. PMID: 37678659

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