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Paroxysmal nocturnal dyspnea

MedGen UID:
408332
•Concept ID:
C1956415
•
Disease or Syndrome
Synonyms: Dyspnea, Paroxysmal Nocturnal; Nocturnal Dyspnea, Paroxysmal; Paroxysmal Nocturnal Dyspnea
SNOMED CT: PND - Paroxysmal nocturnal dyspnea (55442000); Paroxysmal nocturnal dyspnea (55442000)
 
HPO: HP:0034807

Definition

Attacks of breathlessness that occur at night and may awaken the sleeping patient. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVParoxysmal nocturnal dyspnea

Professional guidelines

PubMed

Heart Failure with Preserved Ejection Fraction: Diagnosis and Management.
Gazewood JD, Turner PL
Am Fam Physician 2017 Nov 1;96(9):582-588. PMID: 29094875
Association of types of dyspnea including 'bendopnea' with cardiopulmonary disease in primary care.
Martínez Cerón DM, Garcia Rosa ML, Lagoeiro Jorge AJ, de Andrade Martins W, Tinoco Mesquita E, Di Calafriori Freire M, da Silva Correia DM, Kang HC
Rev Port Cardiol 2017 Mar;36(3):179-186. Epub 2017 Feb 15 doi: 10.1016/j.repc.2016.08.007. PMID: 28214151
Women and coronary disease: relationship between descriptors of signs and symptoms and diagnostic and treatment course.
Penque S, Halm M, Smith M, Deutsch J, Van Roekel M, McLaughlin L, Dzubay S, Doll N, Beahrs M
Am J Crit Care 1998 May;7(3):175-82. PMID: 9579242

Recent clinical studies

Etiology

Prognosis of acute heart failure based on clinical data of congestion.
Espinosa B, Llorens P, Gil V, Rossello X, Jacob J, Herrero P, Martín-Sánchez FJ, Alquézar-Arbé A, Masip J, Miró Ò; ICA-SEMES group
Rev Clin Esp (Barc) 2022 Jun-Jul;222(6):321-331. Epub 2021 Oct 29 doi: 10.1016/j.rceng.2021.07.004. PMID: 34756646
When to Suspect Sleep Apnea and What to Do About It.
Kimoff RJ
Can J Cardiol 2015 Jul;31(7):945-8. Epub 2015 Apr 28 doi: 10.1016/j.cjca.2015.04.020. PMID: 26112305
Cardiomyopathy: an overview.
Wexler RK, Elton T, Pleister A, Feldman D
Am Fam Physician 2009 May 1;79(9):778-84. PMID: 20141097Free PMC Article
Value of orthopnea, paroxysmal nocturnal dyspnea, and medications in prospective population studies of incident heart failure.
Ekundayo OJ, Howard VJ, Safford MM, McClure LA, Arnett D, Allman RM, Howard G, Ahmed A
Am J Cardiol 2009 Jul 15;104(2):259-64. Epub 2009 May 14 doi: 10.1016/j.amjcard.2009.03.025. PMID: 19576357Free PMC Article
Insomnia and chronic heart failure.
Hayes D Jr, Anstead MI, Ho J, Phillips BA
Heart Fail Rev 2009 Sep;14(3):171-82. Epub 2008 Aug 29 doi: 10.1007/s10741-008-9102-1. PMID: 18758945

Diagnosis

Congestive Heart Failure.
Chen J, Aronowitz P
Med Clin North Am 2022 May;106(3):447-458. Epub 2022 Apr 4 doi: 10.1016/j.mcna.2021.12.002. PMID: 35491065
Cardiomyopathies.
Precone V, Krasi G, Guerri G, Madureri A, Piazzani M, Michelini S, Barati S, Maniscalchi T, Bressan S, Bertelli M
Acta Biomed 2019 Sep 30;90(10-S):32-43. doi: 10.23750/abm.v90i10-S.8755. PMID: 31577251Free PMC Article
Signs and symptoms in adult patients with acute dyspnea: a systematic review and meta-analysis.
Renier W, Winckelmann KH, Verbakel JY, Aertgeerts B, Buntinx F
Eur J Emerg Med 2018 Feb;25(1):3-11. doi: 10.1097/MEJ.0000000000000429. PMID: 29252938
Cardiomyopathy: an overview.
Wexler RK, Elton T, Pleister A, Feldman D
Am Fam Physician 2009 May 1;79(9):778-84. PMID: 20141097Free PMC Article
Does this dyspneic patient in the emergency department have congestive heart failure?
Wang CS, FitzGerald JM, Schulzer M, Mak E, Ayas NT
JAMA 2005 Oct 19;294(15):1944-56. doi: 10.1001/jama.294.15.1944. PMID: 16234501

Therapy

Comparison of Ticagrelor and Clopidogrel in Elective Coronary Stenting: A Double Blind Randomized Clinical Trial.
Mehdizadeh Parizi M, Golchin Vafa R, Ahmadi A, Heydarzade R, Sadeghi M, Khademolhossseini A, Amiri F, Khoshnood Mansorkhani S, Tavan A, Hosseini N, Montaseri M, Hosseini SA, Kojuri J
J Interv Cardiol 2023;2023:5544440. Epub 2023 Dec 26 doi: 10.1155/2023/5544440. PMID: 38170033Free PMC Article
Burden of Heart Failure Signs and Symptoms, Prognosis, and Response to Therapy: The PARAGON-HF Trial.
Jering K, Claggett B, Redfield MM, Shah SJ, Anand IS, Martinez F, Sabarwal SV, Seferović PM, Kerr Saraiva JF, Katova T, Lefkowitz MP, Pfeffer MA, McMurray JJV, Solomon SD
JACC Heart Fail 2021 May;9(5):386-397. Epub 2021 Mar 10 doi: 10.1016/j.jchf.2021.01.011. PMID: 33714741
Signs and symptoms in adult patients with acute dyspnea: a systematic review and meta-analysis.
Renier W, Winckelmann KH, Verbakel JY, Aertgeerts B, Buntinx F
Eur J Emerg Med 2018 Feb;25(1):3-11. doi: 10.1097/MEJ.0000000000000429. PMID: 29252938
Heart Failure with Preserved Ejection Fraction: Diagnosis and Management.
Gazewood JD, Turner PL
Am Fam Physician 2017 Nov 1;96(9):582-588. PMID: 29094875
Cardiomyopathy: an overview.
Wexler RK, Elton T, Pleister A, Feldman D
Am Fam Physician 2009 May 1;79(9):778-84. PMID: 20141097Free PMC Article

Prognosis

Congestive Heart Failure.
Chen J, Aronowitz P
Med Clin North Am 2022 May;106(3):447-458. Epub 2022 Apr 4 doi: 10.1016/j.mcna.2021.12.002. PMID: 35491065
Prognosis of acute heart failure based on clinical data of congestion.
Espinosa B, Llorens P, Gil V, Rossello X, Jacob J, Herrero P, Martín-Sánchez FJ, Alquézar-Arbé A, Masip J, Miró Ò; ICA-SEMES group
Rev Clin Esp (Barc) 2022 Jun-Jul;222(6):321-331. Epub 2021 Oct 29 doi: 10.1016/j.rceng.2021.07.004. PMID: 34756646
Burden of Heart Failure Signs and Symptoms, Prognosis, and Response to Therapy: The PARAGON-HF Trial.
Jering K, Claggett B, Redfield MM, Shah SJ, Anand IS, Martinez F, Sabarwal SV, Seferović PM, Kerr Saraiva JF, Katova T, Lefkowitz MP, Pfeffer MA, McMurray JJV, Solomon SD
JACC Heart Fail 2021 May;9(5):386-397. Epub 2021 Mar 10 doi: 10.1016/j.jchf.2021.01.011. PMID: 33714741
Signs and symptoms in adult patients with acute dyspnea: a systematic review and meta-analysis.
Renier W, Winckelmann KH, Verbakel JY, Aertgeerts B, Buntinx F
Eur J Emerg Med 2018 Feb;25(1):3-11. doi: 10.1097/MEJ.0000000000000429. PMID: 29252938
Heart Failure with Preserved Ejection Fraction: Diagnosis and Management.
Gazewood JD, Turner PL
Am Fam Physician 2017 Nov 1;96(9):582-588. PMID: 29094875

Clinical prediction guides

Comparison of Ticagrelor and Clopidogrel in Elective Coronary Stenting: A Double Blind Randomized Clinical Trial.
Mehdizadeh Parizi M, Golchin Vafa R, Ahmadi A, Heydarzade R, Sadeghi M, Khademolhossseini A, Amiri F, Khoshnood Mansorkhani S, Tavan A, Hosseini N, Montaseri M, Hosseini SA, Kojuri J
J Interv Cardiol 2023;2023:5544440. Epub 2023 Dec 26 doi: 10.1155/2023/5544440. PMID: 38170033Free PMC Article
Skin Mottling as Clinical Manifestation of Cardiogenic Shock.
Ferly A, Firdaus I
Acta Med Indones 2022 Oct;54(4):645-646. PMID: 36624708
Prognosis of acute heart failure based on clinical data of congestion.
Espinosa B, Llorens P, Gil V, Rossello X, Jacob J, Herrero P, Martín-Sánchez FJ, Alquézar-Arbé A, Masip J, Miró Ò; ICA-SEMES group
Rev Clin Esp (Barc) 2022 Jun-Jul;222(6):321-331. Epub 2021 Oct 29 doi: 10.1016/j.rceng.2021.07.004. PMID: 34756646
Signs and symptoms in adult patients with acute dyspnea: a systematic review and meta-analysis.
Renier W, Winckelmann KH, Verbakel JY, Aertgeerts B, Buntinx F
Eur J Emerg Med 2018 Feb;25(1):3-11. doi: 10.1097/MEJ.0000000000000429. PMID: 29252938
Value of orthopnea, paroxysmal nocturnal dyspnea, and medications in prospective population studies of incident heart failure.
Ekundayo OJ, Howard VJ, Safford MM, McClure LA, Arnett D, Allman RM, Howard G, Ahmed A
Am J Cardiol 2009 Jul 15;104(2):259-64. Epub 2009 May 14 doi: 10.1016/j.amjcard.2009.03.025. PMID: 19576357Free PMC Article

Recent systematic reviews

Clinical significance of bendopnea in heart failure-Systematic review and meta-analysis.
Pranata R, Yonas E, Chintya V, Alkatiri AA, Budi Siswanto B
Indian Heart J 2019 May-Jun;71(3):277-283. Epub 2019 Jun 3 doi: 10.1016/j.ihj.2019.05.001. PMID: 31543202Free PMC Article
Signs and symptoms in adult patients with acute dyspnea: a systematic review and meta-analysis.
Renier W, Winckelmann KH, Verbakel JY, Aertgeerts B, Buntinx F
Eur J Emerg Med 2018 Feb;25(1):3-11. doi: 10.1097/MEJ.0000000000000429. PMID: 29252938

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