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Infection of bone

MedGen UID:
412197
•Concept ID:
C2242472
•
Disease or Syndrome
Synonyms: Bone infection; Bone Infection
SNOMED CT: Infection of bone (111253001); Bone infection (111253001)

Definition

An acute or chronic infectious process affecting the bones. [from NCI]

Professional guidelines

PubMed

Hydrogel-Based Strategies for the Management of Osteomyelitis.
Kuo CY, Lin TY, Yeh YC
ACS Biomater Sci Eng 2023 Apr 10;9(4):1843-1861. Epub 2023 Mar 30 doi: 10.1021/acsbiomaterials.2c01057. PMID: 36995966
Implantable drug delivery systems for the treatment of osteomyelitis.
Smith M, Roberts M, Al-Kassas R
Drug Dev Ind Pharm 2022 Oct;48(10):511-527. Epub 2022 Oct 24 doi: 10.1080/03639045.2022.2135729. PMID: 36222433
Understanding Diabetic Foot Infection and its Management.
Noor S, Khan RU, Ahmad J
Diabetes Metab Syndr 2017 Apr-Jun;11(2):149-156. Epub 2016 Jun 18 doi: 10.1016/j.dsx.2016.06.023. PMID: 27377687

Recent clinical studies

Etiology

A comprehensive review of bacterial osteomyelitis with emphasis on Staphylococcus aureus.
Nasser A, Azimi T, Ostadmohammadi S, Ostadmohammadi S
Microb Pathog 2020 Nov;148:104431. Epub 2020 Aug 12 doi: 10.1016/j.micpath.2020.104431. PMID: 32801004
Interactions of staphylococci with osteoblasts and phagocytes in the pathogenesis of implant-associated osteomyelitis.
Arciola CR, Hänsch GM, Visai L, Testoni F, Maurer S, Campoccia D, Selan L, Montanaro L
Int J Artif Organs 2012 Oct;35(10):713-26. doi: 10.5301/ijao.5000158. PMID: 23080215
Helicobacter pylori and gastric cancer.
Pritchard DM, Crabtree JE
Curr Opin Gastroenterol 2006 Nov;22(6):620-5. doi: 10.1097/01.mog.0000245539.50765.f6. PMID: 17053439
Hematopoietic stem cell deficiency resulting from cytomegalovirus infection of bone marrow stroma.
Reddehase MJ, Dreher-Stumpp L, Angele P, Balthesen M, Susa M
Ann Hematol 1992 Jun;64 Suppl:A125-7. doi: 10.1007/BF01715364. PMID: 1322181
Risk factors for osteomyelitis.
Wald ER
Am J Med 1985 Jun 28;78(6B):206-12. doi: 10.1016/0002-9343(85)90386-9. PMID: 3893117

Diagnosis

Microstructural analysis of bony alterations in a historic case of actinomycosis.
Schamall D, Nebot Valenzuela E, Pietschmann P, Tangl S, Edelmayer M, Dobsak T, Teschler-Nicola M
Int J Paleopathol 2020 Sep;30:1-9. Epub 2020 Feb 25 doi: 10.1016/j.ijpp.2019.12.009. PMID: 32109842
Nuclear medicine imaging of bone infections.
Prandini N, Lazzeri E, Rossi B, Erba P, Parisella MG, Signore A
Nucl Med Commun 2006 Aug;27(8):633-44. doi: 10.1097/00006231-200608000-00006. PMID: 16829764
The Mycobacterium avium complex.
Inderlied CB, Kemper CA, Bermudez LE
Clin Microbiol Rev 1993 Jul;6(3):266-310. doi: 10.1128/CMR.6.3.266. PMID: 8358707Free PMC Article
Subacute osteomyelitis.
Hayes CS, Heinrich SD, Craver R, MacEwen GD
Orthopedics 1990 Mar;13(3):363-6. doi: 10.3928/0147-7447-19900301-18. PMID: 2179915
Risk factors for osteomyelitis.
Wald ER
Am J Med 1985 Jun 28;78(6B):206-12. doi: 10.1016/0002-9343(85)90386-9. PMID: 3893117

Therapy

Mechanisms of Antibiotic Failure During Staphylococcus aureus Osteomyelitis.
Gimza BD, Cassat JE
Front Immunol 2021;12:638085. Epub 2021 Feb 12 doi: 10.3389/fimmu.2021.638085. PMID: 33643322Free PMC Article
Advances in the local and targeted delivery of anti-infective agents for management of osteomyelitis.
Ford CA, Cassat JE
Expert Rev Anti Infect Ther 2017 Sep;15(9):851-860. Epub 2017 Sep 1 doi: 10.1080/14787210.2017.1372192. PMID: 28837368Free PMC Article
Hepatitis C and neutropenia.
Sheehan VA, Weir A, Waters B
Curr Opin Hematol 2014 Jan;21(1):58-63. doi: 10.1097/MOH.0000000000000006. PMID: 24257097
Interactions of staphylococci with osteoblasts and phagocytes in the pathogenesis of implant-associated osteomyelitis.
Arciola CR, Hänsch GM, Visai L, Testoni F, Maurer S, Campoccia D, Selan L, Montanaro L
Int J Artif Organs 2012 Oct;35(10):713-26. doi: 10.5301/ijao.5000158. PMID: 23080215
HIV-1 infection of bone marrow hematopoietic progenitor cells and their role in trafficking and viral dissemination.
Alexaki A, Wigdahl B
PLoS Pathog 2008 Dec;4(12):e1000215. Epub 2008 Dec 26 doi: 10.1371/journal.ppat.1000215. PMID: 19112504Free PMC Article

Prognosis

Predicting the causative pathogen among children with osteomyelitis using Bayesian networks - improving antibiotic selection in clinical practice.
Wu Y, McLeod C, Blyth C, Bowen A, Martin A, Nicholson A, Mascaro S, Snelling T
Artif Intell Med 2020 Jul;107:101895. Epub 2020 Jun 3 doi: 10.1016/j.artmed.2020.101895. PMID: 32828444
Hepatitis C and neutropenia.
Sheehan VA, Weir A, Waters B
Curr Opin Hematol 2014 Jan;21(1):58-63. doi: 10.1097/MOH.0000000000000006. PMID: 24257097
HIV-1 infection of bone marrow hematopoietic progenitor cells and their role in trafficking and viral dissemination.
Alexaki A, Wigdahl B
PLoS Pathog 2008 Dec;4(12):e1000215. Epub 2008 Dec 26 doi: 10.1371/journal.ppat.1000215. PMID: 19112504Free PMC Article
Spread of human cytomegalovirus (HCMV) after infection of human hematopoietic progenitor cells: model of HCMV latency.
Zhuravskaya T, Maciejewski JP, Netski DM, Bruening E, Mackintosh FR, St Jeor S
Blood 1997 Sep 15;90(6):2482-91. PMID: 9310501
The Mycobacterium avium complex.
Inderlied CB, Kemper CA, Bermudez LE
Clin Microbiol Rev 1993 Jul;6(3):266-310. doi: 10.1128/CMR.6.3.266. PMID: 8358707Free PMC Article

Clinical prediction guides

Predicting the causative pathogen among children with osteomyelitis using Bayesian networks - improving antibiotic selection in clinical practice.
Wu Y, McLeod C, Blyth C, Bowen A, Martin A, Nicholson A, Mascaro S, Snelling T
Artif Intell Med 2020 Jul;107:101895. Epub 2020 Jun 3 doi: 10.1016/j.artmed.2020.101895. PMID: 32828444
Microstructural analysis of bony alterations in a historic case of actinomycosis.
Schamall D, Nebot Valenzuela E, Pietschmann P, Tangl S, Edelmayer M, Dobsak T, Teschler-Nicola M
Int J Paleopathol 2020 Sep;30:1-9. Epub 2020 Feb 25 doi: 10.1016/j.ijpp.2019.12.009. PMID: 32109842
Human immunodeficiency virus infection of bone marrow endothelium reduces induction of stromal hematopoietic growth factors.
Moses AV, Williams S, Heneveld ML, Strussenberg J, Rarick M, Loveless M, Bagby G, Nelson JA
Blood 1996 Feb 1;87(3):919-25. PMID: 8562963
In vitro infection of bone marrow-adherent cells by human immunodeficiency virus type 1 (HIV-1) does not alter their ability to support hematopoiesis.
Marandin A, Canque B, Coulombel L, Gluckman JC, Vainchenker W, Louache F
Virology 1995 Oct 20;213(1):245-8. doi: 10.1006/viro.1995.1565. PMID: 7483269
Absence of paramyxovirus RNA in cultures of pagetic bone cells and in pagetic bone.
Birch MA, Taylor W, Fraser WD, Ralston SH, Hart CA, Gallagher JA
J Bone Miner Res 1994 Jan;9(1):11-6. doi: 10.1002/jbmr.5650090103. PMID: 8154304

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