U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Kashin-Beck disease

MedGen UID:
412531
•Concept ID:
C2745963
•
Disease or Syndrome
Synonyms: Disease, Kashin-Beck; Kashin Beck Disease; Kashin-Beck Disease
SNOMED CT: Kashin-Beck disease (270505009); Endemic polyarthritis (270505009); Kaschin-Beck disease (270505009); Urov disease (270505009); Kashin-Bek disease (270505009)
 
Monarch Initiative: MONDO:0005610

Definition

Disabling osteochondrodysplasia with osteosclerosis, cone-shaped metaphysis, and shortening of the diaphysis. It is endemic in parts of Siberia and northern China. Mineral deficiencies (e.g., selenium, iodine), fungal cereal contamination, and water contamination may be contributing factors in its etiology. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVKashin-Beck disease

Professional guidelines

PubMed

Progress of Selenium Deficiency in the Pathogenesis of Arthropathies and Selenium Supplement for Their Treatment.
Deng H, Liu H, Yang Z, Bao M, Lin X, Han J, Qu C
Biol Trace Elem Res 2022 Oct;200(10):4238-4249. Epub 2021 Nov 15 doi: 10.1007/s12011-021-03022-4. PMID: 34779998
Changing Grains for the Prevention and Treatment of Kashin-Beck Disease in Children: a Meta-analysis.
Han J, Yu FF, Chang ZP, Yang B, Qu CJ, Zhou TT, Liu RY, Guo X
Biomed Environ Sci 2015 Apr;28(4):308-11. doi: 10.3967/bes2015.043. PMID: 25966758
Sodium selenite for treatment of Kashin-Beck disease in children: a systematic review of randomised controlled trials.
Jirong Y, Huiyun P, Zhongzhe Y, Birong D, Weimin L, Ming Y, Yi S
Osteoarthritis Cartilage 2012 Jul;20(7):605-13. Epub 2012 Feb 24 doi: 10.1016/j.joca.2012.02.012. PMID: 22370124

Recent clinical studies

Etiology

The Prevalence of Kashin-Beck Disease in China: a Systematic Review and Meta-analysis.
Xu J, Wang J, Zhao H
Biol Trace Elem Res 2023 Jul;201(7):3175-3184. Epub 2022 Sep 15 doi: 10.1007/s12011-022-03417-x. PMID: 36104539
Growth surveillance indices and Kashin-Beck Disease in children.
马玮娟 Ma Wei Juan
J Med Life 2022 Feb;15(2):292-297. doi: 10.25122/jml-2021-0125. PMID: 35419096Free PMC Article
Comparison of the major cell populations among osteoarthritis, Kashin-Beck disease and healthy chondrocytes by single-cell RNA-seq analysis.
Wang X, Ning Y, Zhang P, Poulet B, Huang R, Gong Y, Hu M, Li C, Zhou R, Lammi MJ, Guo X
Cell Death Dis 2021 May 27;12(6):551. doi: 10.1038/s41419-021-03832-3. PMID: 34045450Free PMC Article
Pathway-based network analyses and candidate genes associated with Kashin-Beck disease.
Zhang R, Guo H, Yang X, Zhang D, Li B, Li Z, Xiong Y
Medicine (Baltimore) 2019 May;98(18):e15498. doi: 10.1097/MD.0000000000015498. PMID: 31045836Free PMC Article
Selenium, iodine, and the relation with Kashin-Beck disease.
Yao Y, Pei F, Kang P
Nutrition 2011 Nov-Dec;27(11-12):1095-100. doi: 10.1016/j.nut.2011.03.002. PMID: 21967994

Diagnosis

Clinical and Radiographic Features of the Atlantoaxial Dislocation Associated With Kashin-Beck Disease.
Wang Y, Song C, Ji Y, Xia J, Chen C, Haque M, Zhuang J, Zhou C, Zu J, Li X, Yan J
World Neurosurg 2023 Mar;171:e1-e7. Epub 2022 Aug 29 doi: 10.1016/j.wneu.2022.08.108. PMID: 36049725
Growth surveillance indices and Kashin-Beck Disease in children.
马玮娟 Ma Wei Juan
J Med Life 2022 Feb;15(2):292-297. doi: 10.25122/jml-2021-0125. PMID: 35419096Free PMC Article
Identifying discriminative features for diagnosis of Kashin-Beck disease among adolescents.
Zhang Y, Wei X, Cao C, Yu F, Li W, Zhao G, Wei H, Zhang F, Meng P, Sun S, Lammi MJ, Guo X
BMC Musculoskelet Disord 2021 Sep 18;22(1):801. doi: 10.1186/s12891-021-04514-z. PMID: 34537022Free PMC Article
Comparison of the major cell populations among osteoarthritis, Kashin-Beck disease and healthy chondrocytes by single-cell RNA-seq analysis.
Wang X, Ning Y, Zhang P, Poulet B, Huang R, Gong Y, Hu M, Li C, Zhou R, Lammi MJ, Guo X
Cell Death Dis 2021 May 27;12(6):551. doi: 10.1038/s41419-021-03832-3. PMID: 34045450Free PMC Article
Pathway-based network analyses and candidate genes associated with Kashin-Beck disease.
Zhang R, Guo H, Yang X, Zhang D, Li B, Li Z, Xiong Y
Medicine (Baltimore) 2019 May;98(18):e15498. doi: 10.1097/MD.0000000000015498. PMID: 31045836Free PMC Article

Therapy

The Prevalence of Kashin-Beck Disease in China: a Systematic Review and Meta-analysis.
Xu J, Wang J, Zhao H
Biol Trace Elem Res 2023 Jul;201(7):3175-3184. Epub 2022 Sep 15 doi: 10.1007/s12011-022-03417-x. PMID: 36104539
Association of oxidative stress and Kashin-Beck disease integrated Meta and Bioinformatics analysis.
Ba Y, Sun L, Zuo J, Yu SY, Yang S, Ding LM, Feng ZC, Li ZY, Zhou GY, Yu FF
Osteoarthritis Cartilage 2022 Dec;30(12):1606-1615. Epub 2022 Sep 10 doi: 10.1016/j.joca.2022.08.018. PMID: 36096467
Endemic Kashin-Beck disease: A food-sourced osteoarthropathy.
Wang K, Yu J, Liu H, Liu Y, Liu N, Cao Y, Zhang X, Sun D
Semin Arthritis Rheum 2020 Apr;50(2):366-372. Epub 2019 Aug 2 doi: 10.1016/j.semarthrit.2019.07.014. PMID: 31548049
Selenium and thyroid.
Köhrle J, Gärtner R
Best Pract Res Clin Endocrinol Metab 2009 Dec;23(6):815-27. doi: 10.1016/j.beem.2009.08.002. PMID: 19942156
Kashin-Beck disease.
Kolsteren P
Ann Soc Belg Med Trop 1992 Jun;72(2):81-91. PMID: 1417163

Prognosis

A method for Kashin-Beck disease auxiliary diagnosis based on the features in regions of the potential lesion.
Qiao Y, Li H, Niu K, Wang L, Lin J, He Z
Med Phys 2023 Oct;50(10):6259-6268. Epub 2023 Apr 17 doi: 10.1002/mp.16424. PMID: 37067899
Growth surveillance indices and Kashin-Beck Disease in children.
马玮娟 Ma Wei Juan
J Med Life 2022 Feb;15(2):292-297. doi: 10.25122/jml-2021-0125. PMID: 35419096Free PMC Article
LncRNAs as a new regulator of chronic musculoskeletal disorder.
Huang H, Xing D, Zhang Q, Li H, Lin J, He Z, Lin J
Cell Prolif 2021 Oct;54(10):e13113. Epub 2021 Sep 8 doi: 10.1111/cpr.13113. PMID: 34498342Free PMC Article
Endemic Kashin-Beck disease: A food-sourced osteoarthropathy.
Wang K, Yu J, Liu H, Liu Y, Liu N, Cao Y, Zhang X, Sun D
Semin Arthritis Rheum 2020 Apr;50(2):366-372. Epub 2019 Aug 2 doi: 10.1016/j.semarthrit.2019.07.014. PMID: 31548049
Recent advances in the research of an endemic osteochondropathy in China: Kashin-Beck disease.
Guo X, Ma WJ, Zhang F, Ren FL, Qu CJ, Lammi MJ
Osteoarthritis Cartilage 2014 Nov;22(11):1774-83. Epub 2014 Aug 12 doi: 10.1016/j.joca.2014.07.023. PMID: 25106677

Clinical prediction guides

The Prevalence of Kashin-Beck Disease in China: a Systematic Review and Meta-analysis.
Xu J, Wang J, Zhao H
Biol Trace Elem Res 2023 Jul;201(7):3175-3184. Epub 2022 Sep 15 doi: 10.1007/s12011-022-03417-x. PMID: 36104539
Clinical and Radiographic Features of the Atlantoaxial Dislocation Associated With Kashin-Beck Disease.
Wang Y, Song C, Ji Y, Xia J, Chen C, Haque M, Zhuang J, Zhou C, Zu J, Li X, Yan J
World Neurosurg 2023 Mar;171:e1-e7. Epub 2022 Aug 29 doi: 10.1016/j.wneu.2022.08.108. PMID: 36049725
Growth surveillance indices and Kashin-Beck Disease in children.
马玮娟 Ma Wei Juan
J Med Life 2022 Feb;15(2):292-297. doi: 10.25122/jml-2021-0125. PMID: 35419096Free PMC Article
Prevalence of pediatric Kashin-Beck disease in Tibet.
Li H, Liu Q, Li Q, Zhao S, Guo M, Zhang S, Cheng X, Li Z, Yang Z, Qiu Y, Gong H, Lin J
Clin Rheumatol 2021 Sep;40(9):3717-3722. Epub 2021 Mar 5 doi: 10.1007/s10067-021-05669-9. PMID: 33674987
Proteoglycan metabolism, cell death and Kashin-Beck disease.
Li S, Cao J, Caterson B, Hughes CE
Glycoconj J 2012 Aug;29(5-6):241-8. Epub 2012 Jun 26 doi: 10.1007/s10719-012-9421-2. PMID: 22733148Free PMC Article

Recent systematic reviews

The Prevalence of Kashin-Beck Disease in China: a Systematic Review and Meta-analysis.
Xu J, Wang J, Zhao H
Biol Trace Elem Res 2023 Jul;201(7):3175-3184. Epub 2022 Sep 15 doi: 10.1007/s12011-022-03417-x. PMID: 36104539
Meta-analysis of Association Studies of Selenoprotein Gene Polymorphism and Kashin-Beck Disease: an Updated Systematic Review.
Yu FF, Sun L, Zhou GY, Ping ZG, Guo X, Ba Y
Biol Trace Elem Res 2022 Feb;200(2):543-550. Epub 2021 Apr 12 doi: 10.1007/s12011-021-02705-2. PMID: 33844169
The effectiveness of treatments for Kashin-Beck disease: a systematic review and network meta-analysis.
Zou K, Hu J, Zhou Q, Su J, Dong B, Zhang W
Clin Rheumatol 2019 Dec;38(12):3595-3607. Epub 2019 Aug 2 doi: 10.1007/s10067-019-04704-0. PMID: 31376086
Effects of five types of selenium supplementation for treatment of Kashin-Beck disease in children: a systematic review and network meta-analysis.
Xie D, Liao Y, Yue J, Zhang C, Wang Y, Deng C, Chen L
BMJ Open 2018 Mar 6;8(3):e017883. doi: 10.1136/bmjopen-2017-017883. PMID: 29511006Free PMC Article
Identified molecular mechanism of interaction between environmental risk factors and differential expression genes in cartilage of Kashin-Beck disease.
Yu FF, Zhang YX, Zhang LH, Li WR, Guo X, Lammi MJ
Medicine (Baltimore) 2016 Dec;95(52):e5669. doi: 10.1097/MD.0000000000005669. PMID: 28033256Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...