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Increased risk of myelodysplastic syndromes

MedGen UID:
413242
•Concept ID:
C2750177
•
Finding
Synonym: Increased risk for myelodysplastic syndrome

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased risk of myelodysplastic syndromes

Professional guidelines

PubMed

Risk of myelodysplastic syndrome and acute myeloid leukemia post radiation treatment for breast cancer: a population-based study.
Kaplan H, Malmgren J, De Roos AJ
Breast Cancer Res Treat 2013 Feb;137(3):863-7. Epub 2012 Dec 30 doi: 10.1007/s10549-012-2386-9. PMID: 23274844

Recent clinical studies

Etiology

Myelodysplastic syndromes.
Li H, Hu F, Gale RP, Sekeres MA, Liang Y
Nat Rev Dis Primers 2022 Nov 17;8(1):74. doi: 10.1038/s41572-022-00402-5. PMID: 36396662
Diagnosis and Treatment of Myelodysplastic Syndromes: A Review.
Sekeres MA, Taylor J
JAMA 2022 Sep 6;328(9):872-880. doi: 10.1001/jama.2022.14578. PMID: 36066514
The Genetics of Myelodysplastic Syndromes: Clinical Relevance.
Chiereghin C, Travaglino E, Zampini M, Saba E, Saitta C, Riva E, Bersanelli M, Della Porta MG
Genes (Basel) 2021 Jul 27;12(8) doi: 10.3390/genes12081144. PMID: 34440317Free PMC Article
Myelodysplastic syndromes: 2021 update on diagnosis, risk stratification and management.
Garcia-Manero G, Chien KS, Montalban-Bravo G
Am J Hematol 2020 Nov;95(11):1399-1420. doi: 10.1002/ajh.25950. PMID: 32744763
The Molecular Pathology of Myelodysplastic Syndrome.
Haferlach T
Pathobiology 2019;86(1):24-29. Epub 2018 May 23 doi: 10.1159/000488712. PMID: 29791902

Diagnosis

Myelodysplastic syndromes.
Li H, Hu F, Gale RP, Sekeres MA, Liang Y
Nat Rev Dis Primers 2022 Nov 17;8(1):74. doi: 10.1038/s41572-022-00402-5. PMID: 36396662
Diagnosis and Treatment of Myelodysplastic Syndromes: A Review.
Sekeres MA, Taylor J
JAMA 2022 Sep 6;328(9):872-880. doi: 10.1001/jama.2022.14578. PMID: 36066514
Progression of Myeloproliferative Neoplasms (MPN): Diagnostic and Therapeutic Perspectives.
Baumeister J, Chatain N, Sofias AM, Lammers T, Koschmieder S
Cells 2021 Dec 16;10(12) doi: 10.3390/cells10123551. PMID: 34944059Free PMC Article
Myelodysplastic syndromes: 2021 update on diagnosis, risk stratification and management.
Garcia-Manero G, Chien KS, Montalban-Bravo G
Am J Hematol 2020 Nov;95(11):1399-1420. doi: 10.1002/ajh.25950. PMID: 32744763
The Molecular Pathology of Myelodysplastic Syndrome.
Haferlach T
Pathobiology 2019;86(1):24-29. Epub 2018 May 23 doi: 10.1159/000488712. PMID: 29791902

Therapy

Myelodysplastic syndromes: 2023 update on diagnosis, risk-stratification, and management.
Garcia-Manero G
Am J Hematol 2023 Aug;98(8):1307-1325. Epub 2023 Jun 8 doi: 10.1002/ajh.26984. PMID: 37288607
Myelodysplastic syndromes.
Li H, Hu F, Gale RP, Sekeres MA, Liang Y
Nat Rev Dis Primers 2022 Nov 17;8(1):74. doi: 10.1038/s41572-022-00402-5. PMID: 36396662
Diagnosis and Treatment of Myelodysplastic Syndromes: A Review.
Sekeres MA, Taylor J
JAMA 2022 Sep 6;328(9):872-880. doi: 10.1001/jama.2022.14578. PMID: 36066514
Myelodysplastic syndromes: 2021 update on diagnosis, risk stratification and management.
Garcia-Manero G, Chien KS, Montalban-Bravo G
Am J Hematol 2020 Nov;95(11):1399-1420. doi: 10.1002/ajh.25950. PMID: 32744763
MDS overlap disorders and diagnostic boundaries.
Tanaka TN, Bejar R
Blood 2019 Mar 7;133(10):1086-1095. Epub 2019 Jan 22 doi: 10.1182/blood-2018-10-844670. PMID: 30670443

Prognosis

Myelodysplastic syndromes.
Li H, Hu F, Gale RP, Sekeres MA, Liang Y
Nat Rev Dis Primers 2022 Nov 17;8(1):74. doi: 10.1038/s41572-022-00402-5. PMID: 36396662
Diagnosis and Treatment of Myelodysplastic Syndromes: A Review.
Sekeres MA, Taylor J
JAMA 2022 Sep 6;328(9):872-880. doi: 10.1001/jama.2022.14578. PMID: 36066514
The Genetics of Myelodysplastic Syndromes: Clinical Relevance.
Chiereghin C, Travaglino E, Zampini M, Saba E, Saitta C, Riva E, Bersanelli M, Della Porta MG
Genes (Basel) 2021 Jul 27;12(8) doi: 10.3390/genes12081144. PMID: 34440317Free PMC Article
Myelodysplastic syndromes: 2021 update on diagnosis, risk stratification and management.
Garcia-Manero G, Chien KS, Montalban-Bravo G
Am J Hematol 2020 Nov;95(11):1399-1420. doi: 10.1002/ajh.25950. PMID: 32744763
The Molecular Pathology of Myelodysplastic Syndrome.
Haferlach T
Pathobiology 2019;86(1):24-29. Epub 2018 May 23 doi: 10.1159/000488712. PMID: 29791902

Clinical prediction guides

Myelodysplastic syndromes.
Li H, Hu F, Gale RP, Sekeres MA, Liang Y
Nat Rev Dis Primers 2022 Nov 17;8(1):74. doi: 10.1038/s41572-022-00402-5. PMID: 36396662
Diagnosis and Treatment of Myelodysplastic Syndromes: A Review.
Sekeres MA, Taylor J
JAMA 2022 Sep 6;328(9):872-880. doi: 10.1001/jama.2022.14578. PMID: 36066514
The Genetics of Myelodysplastic Syndromes: Clinical Relevance.
Chiereghin C, Travaglino E, Zampini M, Saba E, Saitta C, Riva E, Bersanelli M, Della Porta MG
Genes (Basel) 2021 Jul 27;12(8) doi: 10.3390/genes12081144. PMID: 34440317Free PMC Article
Myelodysplastic syndromes: 2021 update on diagnosis, risk stratification and management.
Garcia-Manero G, Chien KS, Montalban-Bravo G
Am J Hematol 2020 Nov;95(11):1399-1420. doi: 10.1002/ajh.25950. PMID: 32744763
The Molecular Pathology of Myelodysplastic Syndrome.
Haferlach T
Pathobiology 2019;86(1):24-29. Epub 2018 May 23 doi: 10.1159/000488712. PMID: 29791902

Recent systematic reviews

The efficacy and adverse events of venetoclax in combination with hypomethylating agents treatment for patients with acute myeloid leukemia and myelodysplastic syndrome: a systematic review and meta-analysis.
Liu B, Guo Y, Deng L, Qiao Y, Jian J
Hematology 2020 Dec;25(1):414-423. doi: 10.1080/16078454.2020.1843752. PMID: 33191860
Incidence and risk of hematologic toxicities with hypomethylating agents in the treatment of myelodysplastic syndromes and acute myeloid leukopenia: A systematic review and meta-analysis.
Gao C, Wang J, Li Y, Zhao H, Li R, Hou L, Zhang Y, Tian S, Liang H, Wang C, Chen X, Wang J
Medicine (Baltimore) 2018 Aug;97(34):e11860. doi: 10.1097/MD.0000000000011860. PMID: 30142779Free PMC Article
Safety and efficacy of thrombopoietin-receptor agonists in myelodysplastic syndromes: a systematic review and meta-analysis of randomized controlled trials.
Prica A, Sholzberg M, Buckstein R
Br J Haematol 2014 Dec;167(5):626-38. Epub 2014 Aug 26 doi: 10.1111/bjh.13088. PMID: 25155450
Risk of rash associated with lenalidomide in cancer patients: a systematic review of the literature and meta-analysis.
Nardone B, Wu S, Garden BC, West DP, Reich LM, Lacouture ME
Clin Lymphoma Myeloma Leuk 2013 Aug;13(4):424-9. Epub 2013 Jun 13 doi: 10.1016/j.clml.2013.03.006. PMID: 23769670
GSTT1 and GSTM1 polymorphisms and myelodysplastic syndrome risk: a systematic review and meta-analysis.
Dahabreh IJ, Giannouli S, Gota V, Voulgarelis M
Int J Cancer 2010 Apr 1;126(7):1716-23. doi: 10.1002/ijc.24940. PMID: 19816935

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