U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cramp in limb

MedGen UID:
41336
•Concept ID:
C0010263
•
Sign or Symptom
Synonyms: Cramp, Limb; Cramps, Limb; Limb Cramp; Limb Cramps
SNOMED CT: Cramp in limb (424647005); Cramp in extremity (424647005)

Definition

An involuntary contraction of a muscle in an extremity. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCramp in limb

Professional guidelines

PubMed

Diagnosis and Management of Cirrhosis and Its Complications: A Review.
Tapper EB, Parikh ND
JAMA 2023 May 9;329(18):1589-1602. doi: 10.1001/jama.2023.5997. PMID: 37159031Free PMC Article
Muscle cramps and contractures: causes and treatment.
Dijkstra JN, Boon E, Kruijt N, Brusse E, Ramdas S, Jungbluth H, van Engelen BGM, Walters J, Voermans NC
Pract Neurol 2023 Feb;23(1):23-34. Epub 2022 Dec 15 doi: 10.1136/pn-2022-003574. PMID: 36522175
Evidence-based clinical practice guidelines for Liver Cirrhosis 2020.
Yoshiji H, Nagoshi S, Akahane T, Asaoka Y, Ueno Y, Ogawa K, Kawaguchi T, Kurosaki M, Sakaida I, Shimizu M, Taniai M, Terai S, Nishikawa H, Hiasa Y, Hidaka H, Miwa H, Chayama K, Enomoto N, Shimosegawa T, Takehara T, Koike K
J Gastroenterol 2021 Jul;56(7):593-619. Epub 2021 Jul 7 doi: 10.1007/s00535-021-01788-x. PMID: 34231046Free PMC Article

Recent clinical studies

Etiology

Diagnosis and Management of Cirrhosis and Its Complications: A Review.
Tapper EB, Parikh ND
JAMA 2023 May 9;329(18):1589-1602. doi: 10.1001/jama.2023.5997. PMID: 37159031Free PMC Article
An Evidence-Based Review of the Pathophysiology, Treatment, and Prevention of Exercise-Associated Muscle Cramps.
Miller KC, McDermott BP, Yeargin SW, Fiol A, Schwellnus MP
J Athl Train 2022 Jan 1;57(1):5-15. doi: 10.4085/1062-6050-0696.20. PMID: 34185846Free PMC Article
Magnesium for skeletal muscle cramps.
Garrison SR, Korownyk CS, Kolber MR, Allan GM, Musini VM, Sekhon RK, Dugré N
Cochrane Database Syst Rev 2020 Sep 21;9(9):CD009402. doi: 10.1002/14651858.CD009402.pub3. PMID: 32956536Free PMC Article
Muscle Cramping During Exercise: Causes, Solutions, and Questions Remaining.
Maughan RJ, Shirreffs SM
Sports Med 2019 Dec;49(Suppl 2):115-124. doi: 10.1007/s40279-019-01162-1. PMID: 31696455Free PMC Article
Studies on the safety of creatine supplementation.
Kim HJ, Kim CK, Carpentier A, Poortmans JR
Amino Acids 2011 May;40(5):1409-18. Epub 2011 Mar 12 doi: 10.1007/s00726-011-0878-2. PMID: 21399917

Diagnosis

Diagnosis and Management of Cirrhosis and Its Complications: A Review.
Tapper EB, Parikh ND
JAMA 2023 May 9;329(18):1589-1602. doi: 10.1001/jama.2023.5997. PMID: 37159031Free PMC Article
Muscle cramps and contractures: causes and treatment.
Dijkstra JN, Boon E, Kruijt N, Brusse E, Ramdas S, Jungbluth H, van Engelen BGM, Walters J, Voermans NC
Pract Neurol 2023 Feb;23(1):23-34. Epub 2022 Dec 15 doi: 10.1136/pn-2022-003574. PMID: 36522175
Clinical practice guideline for the management of paediatric Charcot-Marie-Tooth disease.
Yiu EM, Bray P, Baets J, Baker SK, Barisic N, de Valle K, Estilow T, Farrar MA, Finkel RS, Haberlová J, Kennedy RA, Moroni I, Nicholson GA, Ramchandren S, Reilly MM, Rose K, Shy ME, Siskind CE, Yum SW, Menezes MP, Ryan MM, Burns J
J Neurol Neurosurg Psychiatry 2022 May;93(5):530-538. Epub 2022 Feb 9 doi: 10.1136/jnnp-2021-328483. PMID: 35140138
Neuromuscular hyperexcitability syndromes.
De Wel B, Claeys KG
Curr Opin Neurol 2021 Oct 1;34(5):714-720. doi: 10.1097/WCO.0000000000000963. PMID: 34914668
Evidence-based clinical practice guidelines for Liver Cirrhosis 2020.
Yoshiji H, Nagoshi S, Akahane T, Asaoka Y, Ueno Y, Ogawa K, Kawaguchi T, Kurosaki M, Sakaida I, Shimizu M, Taniai M, Terai S, Nishikawa H, Hiasa Y, Hidaka H, Miwa H, Chayama K, Enomoto N, Shimosegawa T, Takehara T, Koike K
J Gastroenterol 2021 Jul;56(7):593-619. Epub 2021 Jul 7 doi: 10.1007/s00535-021-01788-x. PMID: 34231046Free PMC Article

Therapy

Pickle Juice Intervention for Cirrhotic Cramps Reduction: The PICCLES Randomized Controlled Trial.
Tapper EB, Salim N, Baki J, Zhao Z, Sundaram V, Patwardhan V, Nikirk SJ
Am J Gastroenterol 2022 Jun 1;117(6):895-901. Epub 2022 Apr 13 doi: 10.14309/ajg.0000000000001781. PMID: 35416793
Magnesium for skeletal muscle cramps.
Garrison SR, Korownyk CS, Kolber MR, Allan GM, Musini VM, Sekhon RK, Dugré N
Cochrane Database Syst Rev 2020 Sep 21;9(9):CD009402. doi: 10.1002/14651858.CD009402.pub3. PMID: 32956536Free PMC Article
Symptomatic treatments for amyotrophic lateral sclerosis/motor neuron disease.
Ng L, Khan F, Young CA, Galea M
Cochrane Database Syst Rev 2017 Jan 10;1(1):CD011776. doi: 10.1002/14651858.CD011776.pub2. PMID: 28072907Free PMC Article
Leg cramps.
Young G
BMJ Clin Evid 2015 May 13;2015 PMID: 25970567Free PMC Article
Neuromyotonia.
Newsom-Davis J
Rev Neurol (Paris) 2004 May;160(5 Pt 2):S85-9. doi: 10.1016/s0035-3787(04)71010-3. PMID: 15269665

Prognosis

Evidence-based clinical practice guidelines for Liver Cirrhosis 2020.
Yoshiji H, Nagoshi S, Akahane T, Asaoka Y, Ueno Y, Ogawa K, Kawaguchi T, Kurosaki M, Sakaida I, Shimizu M, Taniai M, Terai S, Nishikawa H, Hiasa Y, Hidaka H, Miwa H, Chayama K, Enomoto N, Shimosegawa T, Takehara T, Koike K
J Gastroenterol 2021 Jul;56(7):593-619. Epub 2021 Jul 7 doi: 10.1007/s00535-021-01788-x. PMID: 34231046Free PMC Article
Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
RECOVERY Collaborative Group
Lancet 2021 May 1;397(10285):1637-1645. doi: 10.1016/S0140-6736(21)00676-0. PMID: 33933206Free PMC Article
Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
RECOVERY Collaborative Group
Lancet 2021 Feb 13;397(10274):605-612. Epub 2021 Feb 2 doi: 10.1016/S0140-6736(21)00149-5. PMID: 33545096Free PMC Article
Transradial Artery Access Complications.
Sandoval Y, Bell MR, Gulati R
Circ Cardiovasc Interv 2019 Nov;12(11):e007386. Epub 2019 Nov 1 doi: 10.1161/CIRCINTERVENTIONS.119.007386. PMID: 31672030
A prospective study of benign fasciculation syndrome and anxiety.
Filippakis A, Jara J, Ventura N, Scala S, Scopa C, Ruthazer R, Karakis I, Srinivasan J, Russell JA, Ho DT
Muscle Nerve 2018 Dec;58(6):852-854. Epub 2018 Sep 11 doi: 10.1002/mus.26193. PMID: 30028521

Clinical prediction guides

Diagnosis and Management of Cirrhosis and Its Complications: A Review.
Tapper EB, Parikh ND
JAMA 2023 May 9;329(18):1589-1602. doi: 10.1001/jama.2023.5997. PMID: 37159031Free PMC Article
Pickle Juice Intervention for Cirrhotic Cramps Reduction: The PICCLES Randomized Controlled Trial.
Tapper EB, Salim N, Baki J, Zhao Z, Sundaram V, Patwardhan V, Nikirk SJ
Am J Gastroenterol 2022 Jun 1;117(6):895-901. Epub 2022 Apr 13 doi: 10.14309/ajg.0000000000001781. PMID: 35416793
Evidence-based clinical practice guidelines for Liver Cirrhosis 2020.
Yoshiji H, Nagoshi S, Akahane T, Asaoka Y, Ueno Y, Ogawa K, Kawaguchi T, Kurosaki M, Sakaida I, Shimizu M, Taniai M, Terai S, Nishikawa H, Hiasa Y, Hidaka H, Miwa H, Chayama K, Enomoto N, Shimosegawa T, Takehara T, Koike K
J Gastroenterol 2021 Jul;56(7):593-619. Epub 2021 Jul 7 doi: 10.1007/s00535-021-01788-x. PMID: 34231046Free PMC Article
Effects of Coenzyme Q10 on Statin-Induced Myopathy: An Updated Meta-Analysis of Randomized Controlled Trials.
Qu H, Guo M, Chai H, Wang WT, Gao ZY, Shi DZ
J Am Heart Assoc 2018 Oct 2;7(19):e009835. doi: 10.1161/JAHA.118.009835. PMID: 30371340Free PMC Article
Leg cramps.
Young G
BMJ Clin Evid 2009 Mar 26;2009 PMID: 19445755Free PMC Article

Recent systematic reviews

Exertional Rhabdomyolysis in Athletes: Systematic Review and Current Perspectives.
Bäcker HC, Richards JT, Kienzle A, Cunningham J, Braun KF
Clin J Sport Med 2023 Mar 1;33(2):187-194. Epub 2022 Oct 20 doi: 10.1097/JSM.0000000000001082. PMID: 36877581
Magnesium for skeletal muscle cramps.
Garrison SR, Korownyk CS, Kolber MR, Allan GM, Musini VM, Sekhon RK, Dugré N
Cochrane Database Syst Rev 2020 Sep 21;9(9):CD009402. doi: 10.1002/14651858.CD009402.pub3. PMID: 32956536Free PMC Article
Symptomatic treatments for amyotrophic lateral sclerosis/motor neuron disease.
Ng L, Khan F, Young CA, Galea M
Cochrane Database Syst Rev 2017 Jan 10;1(1):CD011776. doi: 10.1002/14651858.CD011776.pub2. PMID: 28072907Free PMC Article
Leg cramps.
Young G
BMJ Clin Evid 2015 May 13;2015 PMID: 25970567Free PMC Article
Leg cramps.
Young G
BMJ Clin Evid 2009 Mar 26;2009 PMID: 19445755Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...