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Median cleft lip and palate

MedGen UID:
413888
•Concept ID:
C2750604
•
Congenital Abnormality; Finding
Synonyms: Medial cleft lip and palate; Median cleft lip/palate

Professional guidelines

PubMed

ALX-Related Frontonasal Dysplasias: Clinical Characteristics and Surgical Management.
Vargel I, Canter HI, Kucukguven A, Aydin A, Ozgur F
Cleft Palate Craniofac J 2022 May;59(5):637-643. Epub 2021 Jun 8 doi: 10.1177/10556656211019621. PMID: 34098755
Cleft Lip and Palate in Newborns Diagnosed With Neonatal Abstinence Syndrome.
Danis DO 3rd, Bachrach K, Piraquive J, Marston AP, Levi JR
Otolaryngol Head Neck Surg 2021 Jan;164(1):199-205. Epub 2020 Jul 21 doi: 10.1177/0194599820944899. PMID: 32689883
The prenatal diagnosis and classification of cleft palate: the role and value of magnetic resonance imaging.
Zheng W, Li B, Zou Y, Lou F
Eur Radiol 2019 Oct;29(10):5600-5606. Epub 2019 Mar 18 doi: 10.1007/s00330-019-06089-9. PMID: 30887208

Recent clinical studies

Etiology

Variability and Excess in Opioid Prescribing Patterns After Cleft and Craniosynostosis Repairs.
Zubovic E, Skolnick GB, AuBuchon JD, Waters EA, Snyder-Warwick AK, Patel KB
Cleft Palate Craniofac J 2023 Jul;60(7):833-842. Epub 2022 Feb 28 doi: 10.1177/10556656221083082. PMID: 35226537
Socioeconomic Disparities in Cleft Lip Care.
Kalmar CL, Malphrus EL, Kosyk MS, Zapatero ZD, Taylor JA
Cleft Palate Craniofac J 2023 Jun;60(6):657-662. Epub 2022 Feb 7 doi: 10.1177/10556656221078488. PMID: 35125021
Cleft Lip and Palate YouTube Videos: Content Usefulness and Sentiment Analysis.
Bozkurt AP, Aras I
Cleft Palate Craniofac J 2021 Mar;58(3):362-368. Epub 2020 Aug 19 doi: 10.1177/1055665620948722. PMID: 32812449
Cleft Lip and Palate in Newborns Diagnosed With Neonatal Abstinence Syndrome.
Danis DO 3rd, Bachrach K, Piraquive J, Marston AP, Levi JR
Otolaryngol Head Neck Surg 2021 Jan;164(1):199-205. Epub 2020 Jul 21 doi: 10.1177/0194599820944899. PMID: 32689883
Rare Facial Clefts.
Fijałkowska M, Antoszewski B
Pol Przegl Chir 2015 Aug;87(8):389-94. doi: 10.1515/pjs-2015-0077. PMID: 26495914

Diagnosis

Median Cleft Lip.
Menderes A, Ateşşahin FB, Babahan T, Terzi M, Atalmiş SE, Çağli HB
J Craniofac Surg 2023 Nov-Dec 01;34(8):e780-e781. Epub 2023 Aug 21 doi: 10.1097/SCS.0000000000009647. PMID: 37603894
Cleft Lip and Palate YouTube Videos: Content Usefulness and Sentiment Analysis.
Bozkurt AP, Aras I
Cleft Palate Craniofac J 2021 Mar;58(3):362-368. Epub 2020 Aug 19 doi: 10.1177/1055665620948722. PMID: 32812449
Cleft Lip and Palate in Newborns Diagnosed With Neonatal Abstinence Syndrome.
Danis DO 3rd, Bachrach K, Piraquive J, Marston AP, Levi JR
Otolaryngol Head Neck Surg 2021 Jan;164(1):199-205. Epub 2020 Jul 21 doi: 10.1177/0194599820944899. PMID: 32689883
Unilateral Cleft Lip and Palate Surgical Protocols and Facial Growth Outcomes.
Pereira RMR, Siqueira N, Costa E, Vale DD, Alonso N
J Craniofac Surg 2018 Sep;29(6):1562-1568. doi: 10.1097/SCS.0000000000004810. PMID: 30373095
Holoprosencephaly.
Dubourg C, Bendavid C, Pasquier L, Henry C, Odent S, David V
Orphanet J Rare Dis 2007 Feb 2;2:8. doi: 10.1186/1750-1172-2-8. PMID: 17274816Free PMC Article

Therapy

US air pollution is associated with increased incidence of non-syndromic cleft lip/palate.
Krakauer KN, Cevallos PC, Amakiri UO, Saldana GM, Lipman KJ, Howell LK, Wan DC, Khosla RK, Nazerali R, Sheckter CC
J Plast Reconstr Aesthet Surg 2024 Jan;88:344-351. Epub 2023 Nov 19 doi: 10.1016/j.bjps.2023.11.012. PMID: 38064913
Heel bone mineral density and various oral diseases: a bidirectional Mendelian randomization.
Zhou YS, Song JK, Zheng ZJ, Li SY, Liu JG, Peng JX
J Bone Miner Metab 2023 Sep;41(5):673-681. Epub 2023 Jul 28 doi: 10.1007/s00774-023-01443-w. PMID: 37507596
Variability and Excess in Opioid Prescribing Patterns After Cleft and Craniosynostosis Repairs.
Zubovic E, Skolnick GB, AuBuchon JD, Waters EA, Snyder-Warwick AK, Patel KB
Cleft Palate Craniofac J 2023 Jul;60(7):833-842. Epub 2022 Feb 28 doi: 10.1177/10556656221083082. PMID: 35226537
Institutional Trends in Opioid Prescribing and Utilization after Primary Cleft Lip and Palate Repair.
Sacks GN, Makar KG, Harbaugh CM, Cooper KA, Vercler CJ, Kasten SJ, Buchman SR, Waljee JF
Plast Reconstr Surg 2022 Oct 1;150(4):847e-853e. Epub 2022 Jul 29 doi: 10.1097/PRS.0000000000009498. PMID: 35921649
Unilateral Cleft Lip and Palate Surgical Protocols and Facial Growth Outcomes.
Pereira RMR, Siqueira N, Costa E, Vale DD, Alonso N
J Craniofac Surg 2018 Sep;29(6):1562-1568. doi: 10.1097/SCS.0000000000004810. PMID: 30373095

Prognosis

US air pollution is associated with increased incidence of non-syndromic cleft lip/palate.
Krakauer KN, Cevallos PC, Amakiri UO, Saldana GM, Lipman KJ, Howell LK, Wan DC, Khosla RK, Nazerali R, Sheckter CC
J Plast Reconstr Aesthet Surg 2024 Jan;88:344-351. Epub 2023 Nov 19 doi: 10.1016/j.bjps.2023.11.012. PMID: 38064913
Median Cleft Lip.
Menderes A, Ateşşahin FB, Babahan T, Terzi M, Atalmiş SE, Çağli HB
J Craniofac Surg 2023 Nov-Dec 01;34(8):e780-e781. Epub 2023 Aug 21 doi: 10.1097/SCS.0000000000009647. PMID: 37603894
Cleft Lip and Palate in Newborns Diagnosed With Neonatal Abstinence Syndrome.
Danis DO 3rd, Bachrach K, Piraquive J, Marston AP, Levi JR
Otolaryngol Head Neck Surg 2021 Jan;164(1):199-205. Epub 2020 Jul 21 doi: 10.1177/0194599820944899. PMID: 32689883
Rare Facial Clefts.
Fijałkowska M, Antoszewski B
Pol Przegl Chir 2015 Aug;87(8):389-94. doi: 10.1515/pjs-2015-0077. PMID: 26495914
Holoprosencephaly.
Dubourg C, Bendavid C, Pasquier L, Henry C, Odent S, David V
Orphanet J Rare Dis 2007 Feb 2;2:8. doi: 10.1186/1750-1172-2-8. PMID: 17274816Free PMC Article

Clinical prediction guides

Heel bone mineral density and various oral diseases: a bidirectional Mendelian randomization.
Zhou YS, Song JK, Zheng ZJ, Li SY, Liu JG, Peng JX
J Bone Miner Metab 2023 Sep;41(5):673-681. Epub 2023 Jul 28 doi: 10.1007/s00774-023-01443-w. PMID: 37507596
Cleft Lip and Palate YouTube Videos: Content Usefulness and Sentiment Analysis.
Bozkurt AP, Aras I
Cleft Palate Craniofac J 2021 Mar;58(3):362-368. Epub 2020 Aug 19 doi: 10.1177/1055665620948722. PMID: 32812449
Cleft Lip and Palate in Newborns Diagnosed With Neonatal Abstinence Syndrome.
Danis DO 3rd, Bachrach K, Piraquive J, Marston AP, Levi JR
Otolaryngol Head Neck Surg 2021 Jan;164(1):199-205. Epub 2020 Jul 21 doi: 10.1177/0194599820944899. PMID: 32689883
Rare Facial Clefts.
Fijałkowska M, Antoszewski B
Pol Przegl Chir 2015 Aug;87(8):389-94. doi: 10.1515/pjs-2015-0077. PMID: 26495914
Holoprosencephaly.
Dubourg C, Bendavid C, Pasquier L, Henry C, Odent S, David V
Orphanet J Rare Dis 2007 Feb 2;2:8. doi: 10.1186/1750-1172-2-8. PMID: 17274816Free PMC Article

Recent systematic reviews

Dental development in cleft lip and palate patients: A systematic review.
Van Dyck J, Cadenas de Llano-Pérula M, Willems G, Verdonck A
Forensic Sci Int 2019 Jul;300:63-74. Epub 2019 Apr 17 doi: 10.1016/j.forsciint.2019.04.011. PMID: 31075568
Economic Analysis of Children's Surgical Care in Low- and Middle-Income Countries: A Systematic Review and Analysis.
Saxton AT, Poenaru D, Ozgediz D, Ameh EA, Farmer D, Smith ER, Rice HE
PLoS One 2016;11(10):e0165480. Epub 2016 Oct 28 doi: 10.1371/journal.pone.0165480. PMID: 27792792Free PMC Article
Cost-effectiveness of surgery and its policy implications for global health: a systematic review and analysis.
Chao TE, Sharma K, Mandigo M, Hagander L, Resch SC, Weiser TG, Meara JG
Lancet Glob Health 2014 Jun;2(6):e334-45. Epub 2014 May 21 doi: 10.1016/S2214-109X(14)70213-X. PMID: 25103302

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