U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Therapy-Related Leukemia

MedGen UID:
414619
•Concept ID:
C2825306
•
Neoplastic Process
Synonym: Therapy Related Leukemia

Definition

A leukemia arising as a result of the mutagenic effect of chemotherapy agents that are used for the treatment of a malignant tumor or exposure to ionizing radiation. [from NCI]

Professional guidelines

PubMed

Mechanisms of Secondary Leukemia Development Caused by Treatment with DNA Topoisomerase Inhibitors.
Lomov NA, Viushkov VS, Rubtsov MA
Biochemistry (Mosc) 2023 Jul;88(7):892-911. doi: 10.1134/S0006297923070040. PMID: 37751862
Therapy-related leukemia and myelodysplasia: evolving concepts of pathogenesis and treatment.
Rund D, Ben-Yehuda D
Hematology 2004 Jun;9(3):179-87. doi: 10.1080/10245330410001701503. PMID: 15204099
Therapy-related malignancies following treatment of germ cell cancer.
Kollmannsberger C, Hartmann JT, Kanz L, Bokemeyer C
Int J Cancer 1999 Dec 10;83(6):860-3. doi: 10.1002/(sici)1097-0215(19991210)83:6<860::aid-ijc32>3.0.co;2-l. PMID: 10597212

Recent clinical studies

Etiology

Chronic Myeloid Leukemia following Exposure to Radioactive Iodine (I131): A Systematic Review.
Ali Hailan YM, Al-Dubai HN, Yassin MA
Oncology 2023;101(6):362-368. Epub 2023 May 9 doi: 10.1159/000530463. PMID: 37231874
Nationwide survey of therapy-related leukemia in childhood in Japan.
Imamura T, Taga T, Takagi M, Kawasaki H, Koh K, Taki T, Adachi S, Manabe A, Ishida Y; Leukemia/Lymphoma Committee; Japanese Society of Pediatric Hematology Oncology (JSPHO)
Int J Hematol 2018 Jul;108(1):91-97. Epub 2018 Mar 24 doi: 10.1007/s12185-018-2439-x. PMID: 29574603
Global characteristics of childhood acute promyelocytic leukemia.
Zhang L, Samad A, Pombo-de-Oliveira MS, Scelo G, Smith MT, Feusner J, Wiemels JL, Metayer C
Blood Rev 2015 Mar;29(2):101-25. Epub 2014 Sep 30 doi: 10.1016/j.blre.2014.09.013. PMID: 25445717Free PMC Article
Therapy-related myelodysplasia and acute myeloid leukemia.
Bhatia S
Semin Oncol 2013 Dec;40(6):666-75. doi: 10.1053/j.seminoncol.2013.09.013. PMID: 24331189Free PMC Article
Therapy-related leukemia and myelodysplasia: evolving concepts of pathogenesis and treatment.
Rund D, Ben-Yehuda D
Hematology 2004 Jun;9(3):179-87. doi: 10.1080/10245330410001701503. PMID: 15204099

Diagnosis

Bone Marrow Surveillance of Pediatric Cancer Survivors Identifies Clones that Predict Therapy-Related Leukemia.
Spitzer B, Rutherford KD, Gundem G, McGovern EM, Millard NE, Arango Ossa JE, Cheung IY, Gao T, Levine MF, Zhang Y, Medina-Martínez JS, Feng Y, Ptashkin RN, Bolton KL, Farnoud N, Zhou Y, Patel MA, Asimomitis G, Cobbs CC, Mohibullah N, Huberman KH, Arcilla ME, Kushner BH, Modak S, Kung AL, Zehir A, Levine RL, Armstrong SA, Cheung NKV, Papaemmanuil E
Clin Cancer Res 2022 Apr 14;28(8):1614-1627. doi: 10.1158/1078-0432.CCR-21-2451. PMID: 35078859Free PMC Article
KMT2A-MAML2 rearrangement emerged and regressed during neuroblastoma therapy without leukemia after 12.8-year follow-up.
Felix CA, Slater DJ, Davenport JW, Yu X, Gregory BD, Li MM, Rappaport EF, Cheung NV
Pediatr Blood Cancer 2022 Jan;69(1):e29344. Epub 2021 Sep 22 doi: 10.1002/pbc.29344. PMID: 34550633Free PMC Article
Nationwide survey of therapy-related leukemia in childhood in Japan.
Imamura T, Taga T, Takagi M, Kawasaki H, Koh K, Taki T, Adachi S, Manabe A, Ishida Y; Leukemia/Lymphoma Committee; Japanese Society of Pediatric Hematology Oncology (JSPHO)
Int J Hematol 2018 Jul;108(1):91-97. Epub 2018 Mar 24 doi: 10.1007/s12185-018-2439-x. PMID: 29574603
Global characteristics of childhood acute promyelocytic leukemia.
Zhang L, Samad A, Pombo-de-Oliveira MS, Scelo G, Smith MT, Feusner J, Wiemels JL, Metayer C
Blood Rev 2015 Mar;29(2):101-25. Epub 2014 Sep 30 doi: 10.1016/j.blre.2014.09.013. PMID: 25445717Free PMC Article
Therapy-related leukemia: a panmyelosis.
Foucar K, McKenna RW, Bloomfield CD, Bowers TK, Brunning RD
Cancer 1979 Apr;43(4):1285-96. doi: 10.1002/1097-0142(197904)43:4<1285::aid-cncr2820430416>3.0.co;2-j. PMID: 445330

Therapy

Chronic Myeloid Leukemia following Exposure to Radioactive Iodine (I131): A Systematic Review.
Ali Hailan YM, Al-Dubai HN, Yassin MA
Oncology 2023;101(6):362-368. Epub 2023 May 9 doi: 10.1159/000530463. PMID: 37231874
Therapy-related myelodysplasia and acute myeloid leukemia.
Bhatia S
Semin Oncol 2013 Dec;40(6):666-75. doi: 10.1053/j.seminoncol.2013.09.013. PMID: 24331189Free PMC Article
Mechanism of generation of therapy related leukemia in response to anti-topoisomerase II agents.
Cowell IG, Austin CA
Int J Environ Res Public Health 2012 Jun;9(6):2075-91. Epub 2012 May 31 doi: 10.3390/ijerph9062075. PMID: 22829791Free PMC Article
Therapy-related leukemia and myelodysplasia: evolving concepts of pathogenesis and treatment.
Rund D, Ben-Yehuda D
Hematology 2004 Jun;9(3):179-87. doi: 10.1080/10245330410001701503. PMID: 15204099
Therapy-related myeloid leukemia.
Thirman MJ, Larson RA
Hematol Oncol Clin North Am 1996 Apr;10(2):293-320. doi: 10.1016/s0889-8588(05)70340-3. PMID: 8707757

Prognosis

Nationwide survey of therapy-related leukemia in childhood in Japan.
Imamura T, Taga T, Takagi M, Kawasaki H, Koh K, Taki T, Adachi S, Manabe A, Ishida Y; Leukemia/Lymphoma Committee; Japanese Society of Pediatric Hematology Oncology (JSPHO)
Int J Hematol 2018 Jul;108(1):91-97. Epub 2018 Mar 24 doi: 10.1007/s12185-018-2439-x. PMID: 29574603
Global characteristics of childhood acute promyelocytic leukemia.
Zhang L, Samad A, Pombo-de-Oliveira MS, Scelo G, Smith MT, Feusner J, Wiemels JL, Metayer C
Blood Rev 2015 Mar;29(2):101-25. Epub 2014 Sep 30 doi: 10.1016/j.blre.2014.09.013. PMID: 25445717Free PMC Article
Therapy-related myelodysplasia and acute myeloid leukemia.
Bhatia S
Semin Oncol 2013 Dec;40(6):666-75. doi: 10.1053/j.seminoncol.2013.09.013. PMID: 24331189Free PMC Article
Therapy-related leukemia and myelodysplasia: susceptibility and incidence.
Leone G, Pagano L, Ben-Yehuda D, Voso MT
Haematologica 2007 Oct;92(10):1389-98. doi: 10.3324/haematol.11034. PMID: 17768113
Therapy-related leukemia and myelodysplasia: evolving concepts of pathogenesis and treatment.
Rund D, Ben-Yehuda D
Hematology 2004 Jun;9(3):179-87. doi: 10.1080/10245330410001701503. PMID: 15204099

Clinical prediction guides

Global characteristics of childhood acute promyelocytic leukemia.
Zhang L, Samad A, Pombo-de-Oliveira MS, Scelo G, Smith MT, Feusner J, Wiemels JL, Metayer C
Blood Rev 2015 Mar;29(2):101-25. Epub 2014 Sep 30 doi: 10.1016/j.blre.2014.09.013. PMID: 25445717Free PMC Article
Therapy-related myelodysplasia and acute myeloid leukemia.
Bhatia S
Semin Oncol 2013 Dec;40(6):666-75. doi: 10.1053/j.seminoncol.2013.09.013. PMID: 24331189Free PMC Article
Therapy-related leukemia and myelodysplasia: evolving concepts of pathogenesis and treatment.
Rund D, Ben-Yehuda D
Hematology 2004 Jun;9(3):179-87. doi: 10.1080/10245330410001701503. PMID: 15204099
The p53 gene in pediatric therapy-related leukemia and myelodysplasia.
Felix CA, Hosler MR, Provisor D, Salhany K, Sexsmith EA, Slater DJ, Cheung NK, Winick NJ, Strauss EA, Heyn R, Lange BJ, Malkin D
Blood 1996 May 15;87(10):4376-81. PMID: 8639798
Secondary myelodysplastic syndromes and leukemias.
Giles FJ, Koeffler HP
Curr Opin Hematol 1994 Jul;1(4):256-60. PMID: 9371291

Recent systematic reviews

Chronic Myeloid Leukemia following Exposure to Radioactive Iodine (I131): A Systematic Review.
Ali Hailan YM, Al-Dubai HN, Yassin MA
Oncology 2023;101(6):362-368. Epub 2023 May 9 doi: 10.1159/000530463. PMID: 37231874

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...