U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Therapy-Related Leukemia

MedGen UID:
414619
•Concept ID:
C2825306
•
Neoplastic Process
Synonym: Therapy Related Leukemia

Definition

A leukemia arising as a result of the mutagenic effect of chemotherapy agents that are used for the treatment of a malignant tumor or exposure to ionizing radiation. [from NCI]

Professional guidelines

PubMed

Mechanisms of Secondary Leukemia Development Caused by Treatment with DNA Topoisomerase Inhibitors.
Lomov NA, Viushkov VS, Rubtsov MA
Biochemistry (Mosc) 2023 Jul;88(7):892-911. doi: 10.1134/S0006297923070040. PMID: 37751862
Therapy-related leukemia and myelodysplasia: evolving concepts of pathogenesis and treatment.
Rund D, Ben-Yehuda D
Hematology 2004 Jun;9(3):179-87. doi: 10.1080/10245330410001701503. PMID: 15204099
Therapy-related malignancies following treatment of germ cell cancer.
Kollmannsberger C, Hartmann JT, Kanz L, Bokemeyer C
Int J Cancer 1999 Dec 10;83(6):860-3. doi: 10.1002/(sici)1097-0215(19991210)83:6<860::aid-ijc32>3.0.co;2-l. PMID: 10597212

Recent clinical studies

Etiology

Chronic Myeloid Leukemia following Exposure to Radioactive Iodine (I131): A Systematic Review.
Ali Hailan YM, Al-Dubai HN, Yassin MA
Oncology 2023;101(6):362-368. Epub 2023 May 9 doi: 10.1159/000530463. PMID: 37231874
Nationwide survey of therapy-related leukemia in childhood in Japan.
Imamura T, Taga T, Takagi M, Kawasaki H, Koh K, Taki T, Adachi S, Manabe A, Ishida Y; Leukemia/Lymphoma Committee; Japanese Society of Pediatric Hematology Oncology (JSPHO)
Int J Hematol 2018 Jul;108(1):91-97. Epub 2018 Mar 24 doi: 10.1007/s12185-018-2439-x. PMID: 29574603
Global characteristics of childhood acute promyelocytic leukemia.
Zhang L, Samad A, Pombo-de-Oliveira MS, Scelo G, Smith MT, Feusner J, Wiemels JL, Metayer C
Blood Rev 2015 Mar;29(2):101-25. Epub 2014 Sep 30 doi: 10.1016/j.blre.2014.09.013. PMID: 25445717Free PMC Article
Therapy-related myelodysplasia and acute myeloid leukemia.
Bhatia S
Semin Oncol 2013 Dec;40(6):666-75. doi: 10.1053/j.seminoncol.2013.09.013. PMID: 24331189Free PMC Article
Therapy-related leukemia and myelodysplasia: evolving concepts of pathogenesis and treatment.
Rund D, Ben-Yehuda D
Hematology 2004 Jun;9(3):179-87. doi: 10.1080/10245330410001701503. PMID: 15204099

Diagnosis

KMT2A-MAML2 rearrangement emerged and regressed during neuroblastoma therapy without leukemia after 12.8-year follow-up.
Felix CA, Slater DJ, Davenport JW, Yu X, Gregory BD, Li MM, Rappaport EF, Cheung NV
Pediatr Blood Cancer 2022 Jan;69(1):e29344. Epub 2021 Sep 22 doi: 10.1002/pbc.29344. PMID: 34550633Free PMC Article
Nationwide survey of therapy-related leukemia in childhood in Japan.
Imamura T, Taga T, Takagi M, Kawasaki H, Koh K, Taki T, Adachi S, Manabe A, Ishida Y; Leukemia/Lymphoma Committee; Japanese Society of Pediatric Hematology Oncology (JSPHO)
Int J Hematol 2018 Jul;108(1):91-97. Epub 2018 Mar 24 doi: 10.1007/s12185-018-2439-x. PMID: 29574603
Global characteristics of childhood acute promyelocytic leukemia.
Zhang L, Samad A, Pombo-de-Oliveira MS, Scelo G, Smith MT, Feusner J, Wiemels JL, Metayer C
Blood Rev 2015 Mar;29(2):101-25. Epub 2014 Sep 30 doi: 10.1016/j.blre.2014.09.013. PMID: 25445717Free PMC Article
DNA damage and repair in human cancer: molecular mechanisms and contribution to therapy-related leukemias.
Casorelli I, Bossa C, Bignami M
Int J Environ Res Public Health 2012 Aug;9(8):2636-57. Epub 2012 Jul 27 doi: 10.3390/ijerph9082636. PMID: 23066388Free PMC Article
Specific chromosomal translocations and therapy-related leukemia induced by bimolane therapy for psoriasis.
Xue Y, Lu D, Guo Y, Lin B
Leuk Res 1992 Nov;16(11):1113-23. doi: 10.1016/0145-2126(92)90050-h. PMID: 1434747

Therapy

Chronic Myeloid Leukemia following Exposure to Radioactive Iodine (I131): A Systematic Review.
Ali Hailan YM, Al-Dubai HN, Yassin MA
Oncology 2023;101(6):362-368. Epub 2023 May 9 doi: 10.1159/000530463. PMID: 37231874
Global characteristics of childhood acute promyelocytic leukemia.
Zhang L, Samad A, Pombo-de-Oliveira MS, Scelo G, Smith MT, Feusner J, Wiemels JL, Metayer C
Blood Rev 2015 Mar;29(2):101-25. Epub 2014 Sep 30 doi: 10.1016/j.blre.2014.09.013. PMID: 25445717Free PMC Article
Why is there so much therapy-related AML and MDS and so little therapy-related CML?
Gale RP, Hlatky L, Sachs RK, Radivoyevitch T
Leuk Res 2014 Oct;38(10):1162-4. Epub 2014 Aug 11 doi: 10.1016/j.leukres.2014.08.002. PMID: 25175829
Therapy-related myelodysplasia and acute myeloid leukemia.
Bhatia S
Semin Oncol 2013 Dec;40(6):666-75. doi: 10.1053/j.seminoncol.2013.09.013. PMID: 24331189Free PMC Article
Therapy-related myeloid leukemia.
Thirman MJ, Larson RA
Hematol Oncol Clin North Am 1996 Apr;10(2):293-320. doi: 10.1016/s0889-8588(05)70340-3. PMID: 8707757

Prognosis

Nationwide survey of therapy-related leukemia in childhood in Japan.
Imamura T, Taga T, Takagi M, Kawasaki H, Koh K, Taki T, Adachi S, Manabe A, Ishida Y; Leukemia/Lymphoma Committee; Japanese Society of Pediatric Hematology Oncology (JSPHO)
Int J Hematol 2018 Jul;108(1):91-97. Epub 2018 Mar 24 doi: 10.1007/s12185-018-2439-x. PMID: 29574603
Global characteristics of childhood acute promyelocytic leukemia.
Zhang L, Samad A, Pombo-de-Oliveira MS, Scelo G, Smith MT, Feusner J, Wiemels JL, Metayer C
Blood Rev 2015 Mar;29(2):101-25. Epub 2014 Sep 30 doi: 10.1016/j.blre.2014.09.013. PMID: 25445717Free PMC Article
Therapy-related myelodysplasia and acute myeloid leukemia.
Bhatia S
Semin Oncol 2013 Dec;40(6):666-75. doi: 10.1053/j.seminoncol.2013.09.013. PMID: 24331189Free PMC Article
Therapy-related leukemia and myelodysplasia: susceptibility and incidence.
Leone G, Pagano L, Ben-Yehuda D, Voso MT
Haematologica 2007 Oct;92(10):1389-98. doi: 10.3324/haematol.11034. PMID: 17768113
Therapy-related leukemia and myelodysplasia: evolving concepts of pathogenesis and treatment.
Rund D, Ben-Yehuda D
Hematology 2004 Jun;9(3):179-87. doi: 10.1080/10245330410001701503. PMID: 15204099

Clinical prediction guides

Global characteristics of childhood acute promyelocytic leukemia.
Zhang L, Samad A, Pombo-de-Oliveira MS, Scelo G, Smith MT, Feusner J, Wiemels JL, Metayer C
Blood Rev 2015 Mar;29(2):101-25. Epub 2014 Sep 30 doi: 10.1016/j.blre.2014.09.013. PMID: 25445717Free PMC Article
Therapy-related myelodysplasia and acute myeloid leukemia.
Bhatia S
Semin Oncol 2013 Dec;40(6):666-75. doi: 10.1053/j.seminoncol.2013.09.013. PMID: 24331189Free PMC Article
Chromatin structural elements and chromosomal translocations in leukemia.
Zhang Y, Rowley JD
DNA Repair (Amst) 2006 Sep 8;5(9-10):1282-97. Epub 2006 Aug 7 doi: 10.1016/j.dnarep.2006.05.020. PMID: 16893685
Therapy-related leukemia and myelodysplasia: evolving concepts of pathogenesis and treatment.
Rund D, Ben-Yehuda D
Hematology 2004 Jun;9(3):179-87. doi: 10.1080/10245330410001701503. PMID: 15204099
The p53 gene in pediatric therapy-related leukemia and myelodysplasia.
Felix CA, Hosler MR, Provisor D, Salhany K, Sexsmith EA, Slater DJ, Cheung NK, Winick NJ, Strauss EA, Heyn R, Lange BJ, Malkin D
Blood 1996 May 15;87(10):4376-81. PMID: 8639798

Recent systematic reviews

Chronic Myeloid Leukemia following Exposure to Radioactive Iodine (I131): A Systematic Review.
Ali Hailan YM, Al-Dubai HN, Yassin MA
Oncology 2023;101(6):362-368. Epub 2023 May 9 doi: 10.1159/000530463. PMID: 37231874

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...