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Small Lymphocytic Lymphoma Variant

MedGen UID:
414951
Concept ID:
C2826613
Neoplastic Process

Definition

A term referring to cases of small lymphocytic lymphomas with an increased number of paraimmunoblasts or with signet-ring-like lymphocytes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSmall Lymphocytic Lymphoma Variant

Professional guidelines

PubMed

Hess B, Kalmuk J, Znoyko I, Schandl CA, Wagner-Johnston N, Mazzoni S, Hendrickson L, Chiad Z, Greenwell IB, Wolff DJ
Cancer Genet 2022 Jan;260-261:18-22. Epub 2021 Oct 28 doi: 10.1016/j.cancergen.2021.10.003. PMID: 34808593Free PMC Article
Rossi D, Spina V, Gaidano G
Blood 2018 Jun 21;131(25):2761-2772. Epub 2018 Apr 24 doi: 10.1182/blood-2018-01-791376. PMID: 29692342
Condoluci A, Rossi D
Curr Treat Options Oncol 2017 Nov 21;18(12):75. doi: 10.1007/s11864-017-0512-y. PMID: 29159711

Recent clinical studies

Etiology

Brown JR
J Natl Compr Canc Netw 2024 Apr;22(3) doi: 10.6004/jnccn.2024.7020. PMID: 38626793
Bonfiglio S, Sutton LA, Ljungström V, Capasso A, Pandzic T, Weström S, Foroughi-Asl H, Skaftason A, Gellerbring A, Lyander A, Gandini F, Gaidano G, Trentin L, Bonello L, Reda G, Bödör C, Stavroyianni N, Tam CS, Marasca R, Forconi F, Panayiotidis P, Ringshausen I, Jaksic O, Frustaci AM, Iyengar S, Coscia M, Mulligan SP, Ysebaert L, Strugov V, Pavlovsky C, Walewska R, Österborg A, Cortese D, Ranghetti P, Baliakas P, Stamatopoulos K, Scarfò L, Rosenquist R, Ghia P
Blood Adv 2023 Jun 27;7(12):2794-2806. doi: 10.1182/bloodadvances.2022008821. PMID: 36696464Free PMC Article
Robbe P, Ridout KE, Vavoulis DV, Dréau H, Kinnersley B, Denny N, Chubb D, Appleby N, Cutts A, Cornish AJ, Lopez-Pascua L, Clifford R, Burns A, Stamatopoulos B, Cabes M, Alsolami R, Antoniou P, Oates M, Cavalieri D; Genomics England Research Consortium; CLL pilot consortium, Gibson J, Prabhu AV, Schwessinger R, Jennings D, James T, Maheswari U, Duran-Ferrer M, Carninci P, Knight SJL, Månsson R, Hughes J, Davies J, Ross M, Bentley D, Strefford JC, Devereux S, Pettitt AR, Hillmen P, Caulfield MJ, Houlston RS, Martín-Subero JI, Schuh A
Nat Genet 2022 Nov;54(11):1675-1689. Epub 2022 Nov 4 doi: 10.1038/s41588-022-01211-y. PMID: 36333502Free PMC Article
Schmieg JJ, Muir JM, Aguilera NS, Auerbach A
Curr Oncol 2021 Dec 4;28(6):5124-5147. doi: 10.3390/curroncol28060430. PMID: 34940069Free PMC Article
Condoluci A, Rossi D
Curr Treat Options Oncol 2017 Nov 21;18(12):75. doi: 10.1007/s11864-017-0512-y. PMID: 29159711

Diagnosis

Brown JR
J Natl Compr Canc Netw 2024 Apr;22(3) doi: 10.6004/jnccn.2024.7020. PMID: 38626793
Laurent C, Cook JR, Yoshino T, Quintanilla-Martinez L, Jaffe ES
Virchows Arch 2023 Jan;482(1):149-162. Epub 2022 Nov 17 doi: 10.1007/s00428-022-03432-2. PMID: 36394631Free PMC Article
Rossi D, Spina V, Gaidano G
Blood 2018 Jun 21;131(25):2761-2772. Epub 2018 Apr 24 doi: 10.1182/blood-2018-01-791376. PMID: 29692342
Condoluci A, Rossi D
Curr Treat Options Oncol 2017 Nov 21;18(12):75. doi: 10.1007/s11864-017-0512-y. PMID: 29159711
Wahner-Roedler DL, Kyle RA
Best Pract Res Clin Haematol 2005;18(4):729-46. doi: 10.1016/j.beha.2005.01.029. PMID: 16026747

Therapy

Tam C, Thompson PA
Blood Adv 2024 May 14;8(9):2300-2309. doi: 10.1182/bloodadvances.2023012221. PMID: 38478390Free PMC Article
Rossi D, Spina V, Gaidano G
Blood 2018 Jun 21;131(25):2761-2772. Epub 2018 Apr 24 doi: 10.1182/blood-2018-01-791376. PMID: 29692342
Condoluci A, Rossi D
Curr Treat Options Oncol 2017 Nov 21;18(12):75. doi: 10.1007/s11864-017-0512-y. PMID: 29159711
Vose JM
Am J Hematol 2015 Aug;90(8):739-45. doi: 10.1002/ajh.24094. PMID: 26103436
Keating MJ
Semin Oncol 1999 Oct;26(5 Suppl 14):107-14. PMID: 10561025

Prognosis

Robbe P, Ridout KE, Vavoulis DV, Dréau H, Kinnersley B, Denny N, Chubb D, Appleby N, Cutts A, Cornish AJ, Lopez-Pascua L, Clifford R, Burns A, Stamatopoulos B, Cabes M, Alsolami R, Antoniou P, Oates M, Cavalieri D; Genomics England Research Consortium; CLL pilot consortium, Gibson J, Prabhu AV, Schwessinger R, Jennings D, James T, Maheswari U, Duran-Ferrer M, Carninci P, Knight SJL, Månsson R, Hughes J, Davies J, Ross M, Bentley D, Strefford JC, Devereux S, Pettitt AR, Hillmen P, Caulfield MJ, Houlston RS, Martín-Subero JI, Schuh A
Nat Genet 2022 Nov;54(11):1675-1689. Epub 2022 Nov 4 doi: 10.1038/s41588-022-01211-y. PMID: 36333502Free PMC Article
Qiu L, Xu J, Tang G, Wang SA, Lin P, Ok CY, Garces S, Yin CC, Khanlari M, Vega F, Medeiros LJ, Li S
Hum Pathol 2022 Jan;119:59-68. Epub 2021 Nov 9 doi: 10.1016/j.humpath.2021.11.001. PMID: 34767860
Rossi D, Spina V, Gaidano G
Blood 2018 Jun 21;131(25):2761-2772. Epub 2018 Apr 24 doi: 10.1182/blood-2018-01-791376. PMID: 29692342
Wahner-Roedler DL, Kyle RA
Best Pract Res Clin Haematol 2005;18(4):729-46. doi: 10.1016/j.beha.2005.01.029. PMID: 16026747
Keating MJ
Semin Oncol 1999 Oct;26(5 Suppl 14):107-14. PMID: 10561025

Clinical prediction guides

Robbe P, Ridout KE, Vavoulis DV, Dréau H, Kinnersley B, Denny N, Chubb D, Appleby N, Cutts A, Cornish AJ, Lopez-Pascua L, Clifford R, Burns A, Stamatopoulos B, Cabes M, Alsolami R, Antoniou P, Oates M, Cavalieri D; Genomics England Research Consortium; CLL pilot consortium, Gibson J, Prabhu AV, Schwessinger R, Jennings D, James T, Maheswari U, Duran-Ferrer M, Carninci P, Knight SJL, Månsson R, Hughes J, Davies J, Ross M, Bentley D, Strefford JC, Devereux S, Pettitt AR, Hillmen P, Caulfield MJ, Houlston RS, Martín-Subero JI, Schuh A
Nat Genet 2022 Nov;54(11):1675-1689. Epub 2022 Nov 4 doi: 10.1038/s41588-022-01211-y. PMID: 36333502Free PMC Article
Shamim H, Riemer C, Weenig R, Sokumbi O, Sciallis G, McEvoy M, Mischke D, Comfere N
Am J Dermatopathol 2021 Feb 1;43(2):85-92. doi: 10.1097/DAD.0000000000001698. PMID: 33492839
Vose JM
Am J Hematol 2017 Aug;92(8):806-813. doi: 10.1002/ajh.24797. PMID: 28699667
Vose JM
Am J Hematol 2015 Aug;90(8):739-45. doi: 10.1002/ajh.24094. PMID: 26103436
Vose JM
Am J Hematol 2013 Dec;88(12):1082-8. doi: 10.1002/ajh.23615. PMID: 24273091

Recent systematic reviews

Benna C, Helfrich-Förster C, Rajendran S, Monticelli H, Pilati P, Nitti D, Mocellin S
Oncotarget 2017 Apr 4;8(14):23978-23995. doi: 10.18632/oncotarget.15074. PMID: 28177907Free PMC Article
Sava GP, Speedy HE, Houlston RS
Leuk Lymphoma 2014 Jan;55(1):160-7. Epub 2013 Jun 24 doi: 10.3109/10428194.2013.800197. PMID: 23647060

Supplemental Content

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